APOE related alterations in cerebral activation even at college age
Open accessAbstract
BACKGROUND: Associations between the APOE genotype and various medical conditions have been documented at a very young age. The association between the APOE genotype and cognitive performance varies at different ages. APOE related changes in brain activation have been recently reported for middle aged and elderly subjects. OBJECTIVE: To explore APOE related alterations during cognitive activation in a population of young adults. METHODS: Using H2(15)O positron emission tomography (PET), imaging was carried out in 20 healthy young adults (age 19 to 28 years; four epsilon4 carriers and 16 non-epsilon4 carriers) during a non-verbal memory task. Voxel-wise multiple regression analyses were undertaken, with the activation difference PET counts as the dependent variable and the APOE genotype as the independent variable. RESULTS: Brain regions were identified where epsilon4 carriers showed significantly lower or higher activation than non-carriers. CONCLUSIONS: The results suggest that APOE dependent modulation of cerebral flow may be present even at a young age. This may reflect an APOE related physiological heterogeneity which may or may not predispose to brain disease in the ensuing decades or, less likely, the effect of very early Alzheimer's disease related pathological changes.
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AβPs and NFTs are present well over a decade before death.
“The interval between initial ADD clinical diagnosis and death is approximately 8 years (129), but AβPs and NFTs are present well over a decade before death (130-138).”
From Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature (2012) · cites this paper as [130]
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- Authors
- Scarmeas, N.
- Affiliations
- Columbia University Irving Medical Center (US)
- Corresponding author
- Scarmeas, N
- ORCID
- Scarmeas, N
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 2005-10-01
- Volume
- 76
- Issue
- 10
- Pages
- 1440-1444
- ISSN
- 0022-3050 (ISSN-L)
- PMC
- PMC1739360
- OpenAlex
- W2005961815
- Cited by
- 97
- References
- 35
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 1 · 2021: 1 · 2020: 1 · 2019: 5 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 3 · 2013: 3 · 2012: 8
- FWCI
- 5.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Columbia Academic Commons (Columbia University)
- Funders
- National Institute on Aging (AG14671, R01AG014671)
- National Center for Research Resources (RR 00645, M01RR000645)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Keywords
- APOE ε4, APOE genotype, cerebral blood flow, brain activation, young adults, cognitive activation, Alzheimer's disease risk
- MeSH terms
- Adult, Alleles, Alzheimer Disease, Apolipoproteins E, Brain, Cognition, Female, Genotype, Humans, Male, Universities, Positron-Emission Tomography
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