Cited by 97Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsCognitive Abilities and Testing

APOE related alterations in cerebral activation even at college age

Open access
Scarmeas, N·2005·Journal of Neurology, Neurosurgery & Psychiatry

Abstract

BACKGROUND: Associations between the APOE genotype and various medical conditions have been documented at a very young age. The association between the APOE genotype and cognitive performance varies at different ages. APOE related changes in brain activation have been recently reported for middle aged and elderly subjects. OBJECTIVE: To explore APOE related alterations during cognitive activation in a population of young adults. METHODS: Using H2(15)O positron emission tomography (PET), imaging was carried out in 20 healthy young adults (age 19 to 28 years; four epsilon4 carriers and 16 non-epsilon4 carriers) during a non-verbal memory task. Voxel-wise multiple regression analyses were undertaken, with the activation difference PET counts as the dependent variable and the APOE genotype as the independent variable. RESULTS: Brain regions were identified where epsilon4 carriers showed significantly lower or higher activation than non-carriers. CONCLUSIONS: The results suggest that APOE dependent modulation of cerebral flow may be present even at a young age. This may reflect an APOE related physiological heterogeneity which may or may not predispose to brain disease in the ensuing decades or, less likely, the effect of very early Alzheimer's disease related pathological changes.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1136/jnnp.2004.053645

Cites

36 of 36 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Cites

Flagged first, then by citations

Research works printed but not linked: 1

  1. DeCarli C, Atack, JR, Ball MJ, et al. Post-mortem regional neurofibrillary tangle densities but not senile plaque densities are related to regional cerebral metabolic rates for glucose during life in Alzheimer's disease patients. Neurodegeneration 1992;1:113-21.

Cited by

Sorted by citations

Authors
Scarmeas, N.
Affiliations
Columbia University Irving Medical Center (US)
Corresponding author
Scarmeas, N
Venue
Journal of Neurology, Neurosurgery & Psychiatry
Publisher
BMJ
Published
2005-10-01
Volume
76
Issue
10
Pages
1440-1444
ISSN
0022-3050 (ISSN-L)
OpenAlex
W2005961815
Cited by
97
References
35
Citations by year
2026: 1 · 2025: 1 · 2024: 3 · 2023: 1 · 2021: 1 · 2020: 1 · 2019: 5 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 3 · 2013: 3 · 2012: 8
FWCI
5.81
Type
journal article
Language
en
Open access
Locations
  • Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (submittedVersion)
  • Columbia Academic Commons (Columbia University)
Funders
  • National Institute on Aging (AG14671, R01AG014671)
  • National Center for Research Resources (RR 00645, M01RR000645)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
Keywords
APOE ε4, APOE genotype, cerebral blood flow, brain activation, young adults, cognitive activation, Alzheimer's disease risk
MeSH terms
Adult, Alleles, Alzheimer Disease, Apolipoproteins E, Brain, Cognition, Female, Genotype, Humans, Male, Universities, Positron-Emission Tomography

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review