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Androgens, ApoE, and Alzheimer's Disease

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ApoE ɛ4 Genotype Is Accompanied by Lower Metabolic Activity in Nucleus Basalis of Meynert Neurons in Alzheimer Patients and Controls as Indicated by the Size of the Golgi Apparatus

Dubelaar, E. J. G., Verwer, R. W. H., Hofman, M. A., van Heerikhuize, J. J., Ravid, R., & Swaab, D. F. (2004) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/63.2.159 · Cited by 45 · see citing works

APOE E4 is a determinant for Alzheimer type pathology in progressive supranuclear palsy

Tsuboi, Y., Josephs, K., Cookson, N., & Dickson, D. (2003) · Neurology · doi:10.1212/01.wnl.0000044340.37138.a9 · Cited by 46 · see citing works

Incidence of dementia in very elderly individuals: a clinical, neuropathological and molecular genetic study

Polvikoski, T., Sulkava, R., Rastas, S., Sutela, A., Niinistö, L., Notkola, I.-L., Verkkoniemi, A., Viramo, P., Juva, K., & Haltia, M. (2006) · Neuroepidemiology · doi:10.1159/000090252 · Cited by 43 · see citing works

Apolipoprotein E variants and cognition in healthy individuals: A critical opinion

Savitz, J. B., Solms, M., & Ramesar, R. (2005) · Brain Research Reviews · doi:10.1016/j.brainresrev.2005.10.006 · Cited by 39 · see citing works

Dementia, asymmetry of temporal lobe structures, and Apolipoprotein E genotype: Relationships to cerebral atrophy and neuropsychological impairment

Bigler, E. D., Tate, D. F., Miller, M. J., Rice, S. A., Hessel, C. D., Earl, H. D., Tschanz, J. T., Plassman, B. L., & Welsh-Bohmer, K. A. (2002) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617702870072 · Cited by 41 · see citing works

Functional magnetic resonance imaging of semantic memory as a presymptomatic biomarker of Alzheimer's disease risk

Sugarman, M. A., Woodard, J. L., Nielson, K. A., Seidenberg, M., Smith, J. C., Durgerian, S., & Rao, S. M. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.09.016 · Cited by 40 · see citing works

Imaging studies and APOE genotype in persons at risk for Alzheimer’s disease

Scarmeas, N., & Stern, Y. (2006) · Current Psychiatry Reports · doi:10.1007/s11920-006-0076-1 · Cited by 39 · see citing works

Apolipoprotein E ε4 Modulates Cognitive Profiles, Hippocampal Volume, and Resting-State Functional Connectivity in Alzheimer's Disease

Wang, X., Wang, J., He, Y., Li, H., Yuan, H., Evans, A. C., Yu, X., Yong He, A., & Wang, H. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142556 · Cited by 38 · see citing works

The presence of apoE4, not the absence of apoE3, contributes to AD pathology

Teter, B., Raber, J., Nathan, B., & Crutcher, K. A. (2002) · Journal of Alzheimer's Disease · doi:10.3233/jad-2002-4305 · Cited by 37 · see citing works

Does possession of apolipoprotein E ɛ4 benefit cognitive function in healthy young adults?

Bunce, D. J., Anstey, K. J., Burns, R. A., Christensen, H. M., & Easteal, S. (2011) · Neuropsychologia · doi:10.1016/j.neuropsychologia.2011.02.042 · Cited by 37 · see citing works

Scaling of visuospatial attention undergoes differential longitudinal change as a function of APOE genotype prior to old age: Results from the NIMH BIOCARD Study.

Greenwood, P. M., Sunderland, T., Putnam, K. T., Levy, J., & Parasuraman, R. (2005) · Neuropsychology · doi:10.1037/0894-4105.19.6.830 · Cited by 37 · see citing works

Altered PET Functional Brain Responses in Cognitively Intact Elderly Persons at Risk for Alzheimer Disease (Carriers of the 4 Allele)

Scarmeas, N., Habeck, C. G., Anderson, K. E., Hilton, J., Devanand, D. P., Pelton, G. H., Tabert, M. H., Flynn, J., Park, A., Ciappa, A., et al. (2004) · American Journal of Geriatric Psychiatry · doi:10.1176/appi.ajgp.12.6.596 · Cited by 37 · see citing works

Mapping the Effect of the Apolipoprotein E Genotype on 4-Year Atrophy Rates in an Alzheimer Disease–related Brain Network

Hostage, C. A., Choudhury, K. R., Doraiswamy, P. M., Petrella, J. R., & Initiative, A. D. N. (2014) · Radiology · doi:10.1148/radiol.13131041 · Cited by 34 · see citing works

Some evolutionary perspectives on Alzheimer's disease pathogenesis and pathology

Glass, D. J., & Arnold, S. E. (2012) · Alzheimer's &amp; Dementia · doi:10.1016/j.jalz.2011.05.2408 · Cited by 29 · see citing works

Apolipoprotein E ε4 and Later-Life Decline in Cognitive Function and Grip Strength

Batterham, P. J., Bunce, D. J., Cherbuin, N., & Christensen, H. M. (2013) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2013.01.035 · Cited by 26 · see citing works

Imaging and In Vivo Quantitation of β-Amyloid: An Exemplary Biomarker for Alzheimer’s Disease?

Nichols, L. M., Pike, V. W., Cai, L., & Innis, R. B. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.12.004 · Cited by 26 · see citing works

Age-dependent association between butyrylcholinesterase K-variant and Alzheimer disease-related neuropathology in human brains

Ghebremedhin, E., Thal, D. R., Schultz, C., & Braak, H. (2002) · Neuroscience Letters · doi:10.1016/s0304-3940(02)00014-9 · Cited by 26 · see citing works

Transgenic Drosophila model to study apolipoprotein E4-induced neurodegeneration

Haddadi, M., Nongthomba, U., Jahromi, S. R., & Ramesh, S. (2015) · Behavioural Brain Research · doi:10.1016/j.bbr.2015.12.022 · Cited by 20 · see citing works

Age- and genotype-related neurophysiologic reactivity to oxidative stress in healthy adults

Пономарева, Н. В., Goltsov, A. Y., Kunijeva, S. S., Scheglova, N. S., Malina, D. D., Алексеевич, М. А., Boikova, T. I., & Rogaev, E. I. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.11.013 · Cited by 19 · see citing works

Sequence and trajectory of early Alzheimer’s disease-related tau inclusions in the hippocampal formation of cases without amyloid-β deposits

Braak, H., Mayer, B., Feldengut, S., Schön, M., & Tredici, K. D. (2025) · Acta Neuropathologica · doi:10.1007/s00401-025-02862-x · Cited by 20 · see citing works

Possible positive effect of the APOE ε2 allele on cognition in early to mid-adult life

Sinclair, L. I., Pleydell-Pearce, C. W., & Day, I. N. M. (2017) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2017.10.008 · Cited by 18 · see citing works

APOE4, Age, and Sex Regulate Respiratory Plasticity Elicited by Acute Intermittent Hypercapnic-Hypoxia

Nair, J., Welch, J. F., Marciante, A. B., Hou, T., Lu, Q. L., Fox, E. J., & Mitchell, G. S. (2023) · Function · doi:10.1093/function/zqad026 · Cited by 18 · see citing works

Apolipoprotein E4 Affects Topographical Changes in Hippocampal and Cortical Atrophy in Alzheimer's Disease Dementia: A Five-Year Longitudinal Study

Kim, Y. J., Cho, H., Kim, Y. J., Ki, C., Chung, S. J., Ye, B. S., Kim, H. J., Kim, J., Kim, S. T., Lee, K. H., et al. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-141773 · Cited by 18 · see citing works

CRP gene variation affects early development of Alzheimer's disease-related plaques

Kok, E., Alanne-Kinnunen, M., Isotalo, K., Luoto, T., Haikonen, S., Goebeler, S., Perola, M., Hurme, M. A., Haapasalo, H., & Karhunen, P. J. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-96 · Cited by 16 · see citing works

Alzheimer's Disease

Noroozıan, M. (2015) · Neurologic Clinics · doi:10.1016/j.ncl.2015.08.005 · Cited by 16 · see citing works

Tract Based Spatial Statistic Reveals No Differences in White Matter Microstructural Organization between Carriers and Non-Carriers of the APOE ɛ4 and ɛ2 Alleles in Young Healthy Adolescents

Dell’Acqua, F., Khan, W., Gottlieb, N., Giampietro, V., Ginestet, C. E., Bouls, D., Newhouse, S., Dobson, R., Banaschewski, T., Barker, G. J., et al. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-140519 · Cited by 14 · see citing works

Apolipoprotein ε4 Is Associated with Lower Brain Volume in Cognitively Normal Chinese but Not White Older Adults

Yokoyama, J. S., Lee, A. K. L., Takada, L. T., Busovaca, E., Bonham, L. W., Chao, S. Z., Tse, M., He, J., Schwarz, C. G., Carmichael, O. T., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118338 · Cited by 15 · see citing works

Aberrant accentuation of neurofibrillary degeneration in the hippocampus of Alzheimer's disease with amyloid precursor protein 717 and presenilin-1 gene mutations

Sudo, S., Shiozawa, M., Cairns, N. J., & Wada, Y. (2005) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2005.03.043 · Cited by 14 · see citing works

Should the ApoE genotype be a covariate for clinical trials in Alzheimer disease?

Farlow, M. R. (2010) · Alzheimer s Research & Therapy · doi:10.1186/alzrt39 · Cited by 14 · see citing works

Impact of APOE on amyloid and tau accumulation in argyrophilic grain disease and Alzheimer’s disease

Raulin, A., Doss, S. V., Heckman, M. G., Craver, E. C., Li, Z., Ikezu, T. C., Sekiya, H., Liu, C., Martens, Y. A., Rosenberg, C. L., et al. (2024) · Acta Neuropathologica Communications · doi:10.1186/s40478-024-01731-0 · Cited by 14 · see citing works

The impact of diabetes mellitus on the development of psychiatric and neurological disorders

Kelly, O., Sullivan, J., Carris, N., Geci, S., Martinez, A., Liashenko, V., Colvin, J., Misko, E., Vanderlaan, G., He, L., et al. (2024) · Brain Disorders · doi:10.1016/j.dscb.2024.100135 · Cited by 16 · see citing works

Apolipoprotein E and Intellectual Achievement

Caselli, R. J., Hentz, J. G., Osborne, D., Graff‐Radford, N. R., Barbieri, C. J., Alexander, G. E., Hall, G. R., Reiman, E. M., Hardy, J., & Saunders, A. M. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50007.x · Cited by 13 · see citing works

Apolipoprotein E isoform does not influence trans-synaptic spread of tau pathology in a mouse model

Davies, C., Tulloch, J., Yip, E., Currie, L., Colom‐Cadena, M., Wegmann, S., Hyman, B. T., Wilkins, L., Hooley, M., Tzioras, M., et al. (2023) · Brain and Neuroscience Advances · doi:10.1177/23982128231191046 · Cited by 11 · see citing works

Path integration selectively predicts midlife risk of Alzheimer’s diseasePreprint

Newton, C., Pope, M., Rua, C., Henson, R. N., Ji, Z., Burgess, N., Rodgers, C. T., Stangl, M., Dounavi, M., Castegnaro, A., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.31.526473 · Cited by 12 · see citing works

Early CA2 Tau Inclusions Do Not Distinguish an Age-Related Tauopathy from Early Alzheimer’s Disease

Tredici, K. D., Schön, M., Feldengut, S., Ghebremedhin, E., Kaufman, S. K., Wiesner, D., Roselli, F., Mayer, B., Amunts, K., & Braak, H. (2024) · Journal of Alzheimer s Disease · doi:10.3233/jad-240483 · Cited by 11 · see citing works

Conscientiousness is Negatively Associated with Grey Matter Volume in Young APOE ɛ4-Carriers

Kunz, L., Reuter, M., Axmacher, N., & Montag, C. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-160854 · Cited by 11 · see citing works

Eyeblink Classical Conditioning to Auditory and Olfactory Stimuli: Performance Among Older Adults With and Without the Apolipoprotein E ε4 Allele.

MOORE, A. B., Bondi, M. W., Salmon, D. P., & Murphy, C. (2005) · Neuropsychology · doi:10.1037/0894-4105.19.4.437 · Cited by 11 · see citing works

Genotype-related differences of hippocampal apolipoprotein E levels only in early stages of neuropathological changes in Alzheimer’s disease

Glöckner, F., Meske, V., & Ohm, T. G. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00178-1 · Cited by 35 · see citing works

Apolipoprotein E isoforms and the development of low and high Braak stages of Alzheimer’s disease-related lesions

Ohm, T., Scharnagl, H., März, W., & Bohl, J. (1999) · Acta Neuropathologica · doi:10.1007/s004010051080 · Cited by 112 · see citing works

Apolipoprotein E polymorphism influences not only cerebral senile plaque load but also Alzheimer-type neurofibrillary tangle formation

Ohm, T. G., Kirca, M., Bohl, J., Scharnagl, H., Groβ, W., & März, W. (1995) · Neuroscience · doi:10.1016/0306-4522(94)00596-w · Cited by 157 · see citing works

Clinical and pathological correlates of apolipoprotein E ε4 in Alzheimer's disease

Gomez‐Isla, T., West, H. L., Rebeck, G. W., Harr, S. D., Growdon, J. H., Locascio, J. J., Perls, T. T., Lipsitz, L. A., & Hyman, B. T. (1996) · Annals of Neurology · doi:10.1002/ana.410390110 · Cited by 378 · see citing works

Apolipoprotein E4 Promotes Incipient Alzheimer Pathology in the Elderly

Warzok, R., Kessler, C., Apel, G., Schwarz, A., Egensperger, R., Schreiber, D., Herbst, E. W., Wolf, E., Walther, R., & Walker, L. C. (1998) · Alzheimer Disease & Associated Disorders · doi:10.1097/00002093-199803000-00005 · Cited by 67 · see citing works