Cited by 3,481Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and SignalingDeep Brain Stimulation and Movement Disorders

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The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.

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Gibb, W R, Lees, A J·1988·Journal of Neurology, Neurosurgery & Psychiatry

DOI 10.1136/jnnp.51.6.745PMC PMC1033142

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Abstract

The Lewy body is a distinctive neuronal inclusion that is always found in the substantia nigra and other specific brain regions in Parkinson's disease. It is mainly composed of structurally altered neurofilament, and occurs wherever there is excessive loss of neurons. It occurs in some elderly individuals and rarely in other degenerative diseases of the central nervous system. In 273 brains of patients dying from disorders other than Parkinson's disease, the age-specific prevalence of Lewy bodies increased from 3.8% to 12.8% between the sixth and ninth decades. Associated pathological findings suggest that these cases of incidental Lewy body disease are presymptomatic cases of Parkinson's disease, and confirm the importance of age (time) in the evolution of the disease. In view of the common and widespread occurrence of this disorder we propose that endogenous mechanisms operating in early life may be more important than environmental agents in the pathogenesis of Lewy bodies and Parkinson's disease.

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Authors: Gibb, W. R., & Lees, A. J.
ORCID: Gibb, W R
Lees, A J
Venue: Journal of Neurology, Neurosurgery & Psychiatry
Publisher: BMJ
Published: 1988-06-01
Volume: 51
Issue: 6
Pages: 745-752
ISSN: 0022-3050 (ISSN-L)
DOI: 10.1136/jnnp.51.6.745
PMC: PMC1033142
OpenAlex: W2132881915
Semantic Scholar: 354cd1cf28ad23a8038bb3c576ff7791b3c74543
Cited by: 3,481
References: 39
Citations by year: 2026: 78 · 2025: 130 · 2024: 152 · 2023: 143 · 2022: 131 · 2021: 158 · 2020: 164 · 2019: 152 · 2018: 138 · 2017: 156 · 2016: 163 · 2015: 115 · 2014: 149 · 2013: 123 · 2012: 138
FWCI: 3.24
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
PubMed Central (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
HighWire Press Open Archive (submittedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
Keywords: Lewy bodies, Parkinson's disease, pathogenesis, neurofilaments, substantia nigra, incidental Lewy body disease, age-related prevalence, neuronal loss
MeSH terms: Adolescent, Adult, Aged, Aged, 80 and over, Brain, Brain Damage, Chronic, Inclusion Bodies, Child, Humans, Middle Aged, Nerve Degeneration, Parkinson Disease, Substantia Nigra

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The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.

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