The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.
Open accessAbstract
The Lewy body is a distinctive neuronal inclusion that is always found in the substantia nigra and other specific brain regions in Parkinson's disease. It is mainly composed of structurally altered neurofilament, and occurs wherever there is excessive loss of neurons. It occurs in some elderly individuals and rarely in other degenerative diseases of the central nervous system. In 273 brains of patients dying from disorders other than Parkinson's disease, the age-specific prevalence of Lewy bodies increased from 3.8% to 12.8% between the sixth and ninth decades. Associated pathological findings suggest that these cases of incidental Lewy body disease are presymptomatic cases of Parkinson's disease, and confirm the importance of age (time) in the evolution of the disease. In view of the common and widespread occurrence of this disorder we propose that endogenous mechanisms operating in early life may be more important than environmental agents in the pathogenesis of Lewy bodies and Parkinson's disease.
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Cites
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Frontal deficits differentiate progressive supranuclear palsy from Parkinson's disease
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Wahl, C., Kautzmann, S., Krebiehl, G., Strauss, K., Woitalla, D., Müller, T., Bauer, P., Riess, O., & Krüger, R. (2008) · Journal of Neural Transmission · doi:10.1007/s00702-008-0054-3 · Cited by 22
Snyder, A., Gruber-Baldini, A. L., Rainer von Coelln, F., Savitt, J. M., Reich, S. G., Armstrong, M. J., & Shulman, L. M. (2021) · Journal of Parkinson's Disease · doi:10.3233/jpd-212705 · Cited by 20
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“Be diagnosed with PD according to UK PD Brain Bank Criteria [25, 26] by a neurologist or geriatrician Have a computer and internet access at home”
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Loo, R. T. J., Pavelka, L., Mangone, G., Khoury, F., Vidailhet, M., Corvol, J.-C., Glaab, E., On behalf of the NCER-PD Consortium, Acharya, G., Aguayo, G., et al. (2025) · npj Digital Medicine · doi:10.1038/s41746-025-01862-1 · Cited by 9
Sushkova, O. S., Gabova, A. V., Karabanov, A. V., Kershner, I. A., Obukhov, K. Y., & Obukhov, Y. V. (2015) · Journal of Communications Technology and Electronics · doi:10.1134/s1064226915100113 · Cited by 9
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“Inclusion criteria for patient participants consisted of (1) a diagnosis of idiopathic PD within 3 years based on the UK PD Brain Bank criteria (Gibb & Lees, 1988); (2) stage II or III according to the Hoehn and Yahr Parkinson’s Disease Severity Scale (Hoehn & Yahr, 1998); (3) adequate cognitive…”
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Mahali, M. I., Leu, J.-S., Avian, C., Darmawan, J. T., Faisal, M., Putro, N. A. S., & Prakosa, S. W. (2025) · Clinical Biomechanics · doi:10.1016/j.clinbiomech.2025.106599 · Cited by 1
Increased activity of surviving locus ceruleus neurons in Alzheimer's disease
Moser (1999) · Pure Amsterdam UMC · doi:10.1002/1531-8249(199901)45:1
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Correlation of Parkinson's disease severity and duration with123I-FP-CIT SPECT striatal uptake
Benamer, H. T. S., Patterson, J., Wyper, D. J., Hadley, D. M., Macphee, G. J. A., & Grosset, D. G. (2000) · Movement Disorders · doi:10.1002/1531-8257(200007)15:4
Metadata
- Authors
- Gibb, W. R., & Lees, A. J.
- Venue
- Journal of Neurology, Neurosurgery & Psychiatry
- Publisher
- BMJ
- Published
- 1988-06-01
- Volume
- 51
- Issue
- 6
- Pages
- 745-752
- ISSN
- 0022-3050 (ISSN-L)
- PMC
- PMC1033142
- OpenAlex
- W2132881915
- Semantic Scholar
- 354cd1cf28ad23a8038bb3c576ff7791b3c74543
- Cited by
- 3,481
- References
- 39
- Citations by year
- 2026: 78 · 2025: 130 · 2024: 152 · 2023: 143 · 2022: 131 · 2021: 158 · 2020: 164 · 2019: 152 · 2018: 138 · 2017: 156 · 2016: 163 · 2015: 115 · 2014: 149 · 2013: 123 · 2012: 138
- FWCI
- 3.24
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
- PubMed Central (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- HighWire Press Open Archive (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Keywords
- Lewy bodies, Parkinson's disease, pathogenesis, neurofilaments, substantia nigra, incidental Lewy body disease, age-related prevalence, neuronal loss
- MeSH terms
- Adolescent, Adult, Aged, Aged, 80 and over, Brain, Brain Damage, Chronic, Inclusion Bodies, Child, Humans, Middle Aged, Nerve Degeneration, Parkinson Disease, Substantia Nigra
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