Cited by 3,481Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and SignalingDeep Brain Stimulation and Movement Disorders

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The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.

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Gibb, W R, Lees, A J·1988·Journal of Neurology, Neurosurgery & Psychiatry

DOI 10.1136/jnnp.51.6.745PMC PMC1033142

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Abstract

The Lewy body is a distinctive neuronal inclusion that is always found in the substantia nigra and other specific brain regions in Parkinson's disease. It is mainly composed of structurally altered neurofilament, and occurs wherever there is excessive loss of neurons. It occurs in some elderly individuals and rarely in other degenerative diseases of the central nervous system. In 273 brains of patients dying from disorders other than Parkinson's disease, the age-specific prevalence of Lewy bodies increased from 3.8% to 12.8% between the sixth and ninth decades. Associated pathological findings suggest that these cases of incidental Lewy body disease are presymptomatic cases of Parkinson's disease, and confirm the importance of age (time) in the evolution of the disease. In view of the common and widespread occurrence of this disorder we propose that endogenous mechanisms operating in early life may be more important than environmental agents in the pathogenesis of Lewy bodies and Parkinson's disease.

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Bernheimer, H., Birkmayer, W., Hornykiewicz, O., Jellinger, K. A., & SEITELBERGER, F. (1973) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(73)90175-5 · Cited by 2,650
Basal forebrain neurons in the dementia of Parkinson disease
Whitehouse, P. J., Hedreen, J. C., White, C. L., & Price, D. L. (1983) · Annals of Neurology · doi:10.1002/ana.410130304 · Cited by 535
AETIOLOGY OF PARKINSON'S DISEASE
Calne, D., & Langston, J. W. (1983) · The Lancet · doi:10.1016/s0140-6736(83)90802-4 · Cited by 469
Diffuse type of Lewy body disease: progressive dementia with abundant cortical Lewy bodies and senile changes of varying degree--a new disease?
Kosaka, K., Yoshimura, M., Ikeda, K., & Budka, H. (1984) · PubMed · Cited by 401
Locus ceruleus lesions and eosinophilic inclusions in MPTP‐treated monkeys
Forno, L. S., Langston, J. W., DeLanney, L. E., Irwin, I., & Ricaurte, G. A. (1986) · Annals of Neurology · doi:10.1002/ana.410200403 · Cited by 351
Parkinson's disease in 65 pairs of twins and in a set of quadruplets
Ward, C. D., Duvoisin, R. C., Ince, S. E., Nutt, J., Eldridge, R., & Calne, D. B. (1983) · Neurology · doi:10.1212/wnl.33.7.815 · Cited by 347
PHASE AND ELECTRON MICROSCOPIC OBSERVATIONS OF LEWY BODIES AND MELANIN GRANULES IN THE SUBSTANTIA NIGRA AND LOCUS CAERULEUS IN PARKINSONʼS DISEASE
Duffy, P. E., & Tennyson, V. M. (1965) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-196507000-00003 · Cited by 345
THE SIGNIFICANCE OF THE LEWY BODY IN THE DIAGNOSIS OF IDIOPATHIC PARKINSON'S DISEASE
Gibb, W. R. G., & Lees, A. J. (1989) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1989.tb01147.x · Cited by 325
Self-citation
Esophageal Lewy bodies associated with ganglion cell loss in achalasia
Qualman, S. J., Haupt, H. M., Yang, P. H., & Hamilton, S. R. (1984) · Gastroenterology · doi:10.1016/0016-5085(84)90079-9 · Cited by 305
Esophageal Lewy bodies associated with ganglion cell loss in achalasia. Similarity to Parkinson's disease.
Qualman, S. J., Haupt, H. M., Yang, P. H., & Hamilton, S. R. (1984) · PubMed · Cited by 295

Show all 39 references

Research works printed but not linked: 7

Gibb WRG. The Lewy body and Parkinson's disease. In: Clifford Rose F, ed. Parkinson's Disease: Clinical and Experimental Advances. London: John Libbey and Co, 1987:3-11.
Oppenheimer D. Neuropathology of progressive autonomic failure. In: Bannister R, ed. Autonomic failure. Oxford University Press, London, 1983:267-83.
Sigwald J, Lapresle J, Raverdy P, Recondo NJ. Atrophie cerebelleuse familiale avec association de lesions nigeriennes et spinales. Presse Med 1964;72:557-62.
Vogt C, Vogt 0. Erkrankungen der GroBhirnrinde im Lichte der Topistik, Pathoklise und Pathoarchitektonik. J Psychol Neurol 1922;28:1-171.
Hamada S, Ishii T. The Lewy body in the brain of the aged. Adv Neurol Sci 1963;7:184-6.
Hirai S. Ageing of the substantia nigra. Adv Neurol Sci 1968;12:845-9.
Hassler R. Zur Pathologie der Paralysis agitans und des postenzephalitischen Parkinsonismus. J Psychol Neurol 1938;48:387-476.

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Vanacore, N., Bonifati, V., Fabbrini, G., Colosimo, C., Marconi, R., Nicholl, D. J., Bonuccelli, U., Stocchi, F., Lamberti, P., Volpe, G., et al. (2000) · Neurology · doi:10.1212/wnl.54.1.114 · Cited by 79
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Authors: Gibb, W. R., & Lees, A. J.
ORCID: Gibb, W R
Lees, A J
Venue: Journal of Neurology, Neurosurgery & Psychiatry
Publisher: BMJ
Published: 1988-06-01
Volume: 51
Issue: 6
Pages: 745-752
ISSN: 0022-3050 (ISSN-L)
DOI: 10.1136/jnnp.51.6.745
PMC: PMC1033142
OpenAlex: W2132881915
Semantic Scholar: 354cd1cf28ad23a8038bb3c576ff7791b3c74543
Cited by: 3,481
References: 39
Citations by year: 2026: 78 · 2025: 130 · 2024: 152 · 2023: 143 · 2022: 131 · 2021: 158 · 2020: 164 · 2019: 152 · 2018: 138 · 2017: 156 · 2016: 163 · 2015: 115 · 2014: 149 · 2013: 123 · 2012: 138
FWCI: 3.24
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
PubMed Central (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
HighWire Press Open Archive (submittedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
Keywords: Lewy bodies, Parkinson's disease, pathogenesis, neurofilaments, substantia nigra, incidental Lewy body disease, age-related prevalence, neuronal loss
MeSH terms: Adolescent, Adult, Aged, Aged, 80 and over, Brain, Brain Damage, Chronic, Inclusion Bodies, Child, Humans, Middle Aged, Nerve Degeneration, Parkinson Disease, Substantia Nigra

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The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.

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