Cited by 3,481Parkinson's Disease Mechanisms and TreatmentsNuclear Receptors and SignalingDeep Brain Stimulation and Movement Disorders

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.

Open access

Gibb, W R, Lees, A J·1988·Journal of Neurology, Neurosurgery & Psychiatry

DOI 10.1136/jnnp.51.6.745PMC PMC1033142

Open this paper in CoChat — free account Open PDF

Abstract

The Lewy body is a distinctive neuronal inclusion that is always found in the substantia nigra and other specific brain regions in Parkinson's disease. It is mainly composed of structurally altered neurofilament, and occurs wherever there is excessive loss of neurons. It occurs in some elderly individuals and rarely in other degenerative diseases of the central nervous system. In 273 brains of patients dying from disorders other than Parkinson's disease, the age-specific prevalence of Lewy bodies increased from 3.8% to 12.8% between the sixth and ninth decades. Associated pathological findings suggest that these cases of incidental Lewy body disease are presymptomatic cases of Parkinson's disease, and confirm the importance of age (time) in the evolution of the disease. In view of the common and widespread occurrence of this disorder we propose that endogenous mechanisms operating in early life may be more important than environmental agents in the pathogenesis of Lewy bodies and Parkinson's disease.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1136/jnnp.51.6.745

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Brain dopamine and the syndromes of Parkinson and Huntington Clinical, morphological and neurochemical correlations
Bernheimer, H., Birkmayer, W., Hornykiewicz, O., Jellinger, K. A., & SEITELBERGER, F. (1973) · Journal of the Neurological Sciences · doi:10.1016/0022-510x(73)90175-5 · Cited by 2,650
Basal forebrain neurons in the dementia of Parkinson disease
Whitehouse, P. J., Hedreen, J. C., White, C. L., & Price, D. L. (1983) · Annals of Neurology · doi:10.1002/ana.410130304 · Cited by 535
AETIOLOGY OF PARKINSON'S DISEASE
Calne, D., & Langston, J. W. (1983) · The Lancet · doi:10.1016/s0140-6736(83)90802-4 · Cited by 469
Diffuse type of Lewy body disease: progressive dementia with abundant cortical Lewy bodies and senile changes of varying degree--a new disease?
Kosaka, K., Yoshimura, M., Ikeda, K., & Budka, H. (1984) · PubMed · Cited by 401
Locus ceruleus lesions and eosinophilic inclusions in MPTP‐treated monkeys
Forno, L. S., Langston, J. W., DeLanney, L. E., Irwin, I., & Ricaurte, G. A. (1986) · Annals of Neurology · doi:10.1002/ana.410200403 · Cited by 351
Parkinson's disease in 65 pairs of twins and in a set of quadruplets
Ward, C. D., Duvoisin, R. C., Ince, S. E., Nutt, J., Eldridge, R., & Calne, D. B. (1983) · Neurology · doi:10.1212/wnl.33.7.815 · Cited by 347
PHASE AND ELECTRON MICROSCOPIC OBSERVATIONS OF LEWY BODIES AND MELANIN GRANULES IN THE SUBSTANTIA NIGRA AND LOCUS CAERULEUS IN PARKINSONʼS DISEASE
Duffy, P. E., & Tennyson, V. M. (1965) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-196507000-00003 · Cited by 345
THE SIGNIFICANCE OF THE LEWY BODY IN THE DIAGNOSIS OF IDIOPATHIC PARKINSON'S DISEASE
Gibb, W. R. G., & Lees, A. J. (1989) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.1989.tb01147.x · Cited by 325
Self-citation
Esophageal Lewy bodies associated with ganglion cell loss in achalasia
Qualman, S. J., Haupt, H. M., Yang, P. H., & Hamilton, S. R. (1984) · Gastroenterology · doi:10.1016/0016-5085(84)90079-9 · Cited by 305
Esophageal Lewy bodies associated with ganglion cell loss in achalasia. Similarity to Parkinson's disease.
Qualman, S. J., Haupt, H. M., Yang, P. H., & Hamilton, S. R. (1984) · PubMed · Cited by 295

Show all 39 references

Research works printed but not linked: 7

Gibb WRG. The Lewy body and Parkinson's disease. In: Clifford Rose F, ed. Parkinson's Disease: Clinical and Experimental Advances. London: John Libbey and Co, 1987:3-11.
Oppenheimer D. Neuropathology of progressive autonomic failure. In: Bannister R, ed. Autonomic failure. Oxford University Press, London, 1983:267-83.
Sigwald J, Lapresle J, Raverdy P, Recondo NJ. Atrophie cerebelleuse familiale avec association de lesions nigeriennes et spinales. Presse Med 1964;72:557-62.
Vogt C, Vogt 0. Erkrankungen der GroBhirnrinde im Lichte der Topistik, Pathoklise und Pathoarchitektonik. J Psychol Neurol 1922;28:1-171.
Hamada S, Ishii T. The Lewy body in the brain of the aged. Adv Neurol Sci 1963;7:184-6.
Hirai S. Ageing of the substantia nigra. Adv Neurol Sci 1968;12:845-9.
Hassler R. Zur Pathologie der Paralysis agitans und des postenzephalitischen Parkinsonismus. J Psychol Neurol 1938;48:387-476.

Sorted by citations

Items 201–300 of 1,022

Olfaction and color vision identify impending neurodegeneration in rapid eye movement sleep behavior disorder
Postuma, R. B., Gagnon, J., Vendette, M., Desjardins, C., & Montplaisir, J. Y. (2010) · Annals of Neurology · doi:10.1002/ana.22282 · Cited by 242
The Role of α-Synuclein Oligomers in Parkinson’s Disease
Du, X.-Y., Xie, X.-X., & Liu, R.-T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228645 · Cited by 234
Cognitive impairment in Parkinson's disease
Verbaan, D., Marinus, J., Jeukens‐Visser, M., van Rooden, S. M., Stiggelbout, A. M., Middelkoop, H. A. M., & van Hilten, J. J. (2007) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2006.112367 · Cited by 240
Autonomic dysfunction in dementia
Allan, L. M., Ballard, C. G., Allen, J., Murray, A., Davidson, A. W., McKeith, I. G., & Kenny, R. A. (2006) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2006.102343 · Cited by 238
The identification of Parkinson's disease subtypes using cluster analysis: A systematic review
van Rooden, S. M., Heiser, W. J., Kok, J. N., Verbaan, D., van Hilten, J. J., & Marinus, J. (2010) · Movement Disorders · doi:10.1002/mds.23116 · Cited by 238
Plasma chain-breaking antioxidants in Alzheimer's disease, vascular dementia and Parkinson's disease
Foy, C. J. (1999) · QJM · doi:10.1093/qjmed/92.1.39 · Cited by 235
Cognitive function in early Parkinson’s disease: a population‐based study
Elgh, E., Domellöf, M., Linder, J., Edström, M., Stenlund, H. C., & Forsgren, L. (2009) · European Journal of Neurology · doi:10.1111/j.1468-1331.2009.02707.x · Cited by 235
The natural history of treated Parkinson's disease in an incident, community based cohort
Evans, J., Mason, S., Williams‐Gray, C. H., Foltynie, T., Brayne, C., Robbins, T. W., & Barker, R. (2011) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2011.240366 · Cited by 235
The diagnosis of manganese-induced parkinsonism
Cersosimo, M. G., & Koller, W. C. (2005) · NeuroToxicology · doi:10.1016/j.neuro.2005.10.006 · Cited by 234
Anatomical Pathways Involved in Generating and Sensing Rhythmic Whisker Movements
Bosman, L. W. J., Houweling, A. R., Owens, C. B., Tanke, N., Shevchouk, O. T., Rahmati, N., Teunissen, W. H. T., Ju, C., Gong, W., Koekkoek, S. K. E., et al. (2011) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2011.00053 · Cited by 245
Plasma Ceramide and Glucosylceramide Metabolism Is Altered in Sporadic Parkinson's Disease and Associated with Cognitive Impairment: A Pilot Study
Mielke, M. M., Maetzler, W., Haughey, N. J., Bandaru, V. V. R., Savica, R., Deuschle, C., Gasser, T., Hauser, A., Gräber‐Sultan, S., Schleicher, E. D., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073094 · Cited by 241
A critical evaluation of current staging of α-synuclein pathology in Lewy body disorders
Jellinger, K. A. (2008) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2008.07.006 · Cited by 247
A critical reappraisal of current staging of Lewy-related pathology in human brain
Jellinger, K. A. (2008) · Acta Neuropathologica · doi:10.1007/s00401-008-0406-y · Cited by 240
Neuropathological basis of nonmotor manifestations of Parkinson's disease
Adler, C. H., & Beach, T. G. (2016) · Movement Disorders · doi:10.1002/mds.26605 · Cited by 242
Biomedical features and therapeutic potential of rosmarinic acid
Noor, S., Mohammad, T., Rub, M. A., Raza, A., Azum, N., Yadav, D. K., Hassan, M. I., & Asiri, A. M. (2022) · Archives of Pharmacal Research · doi:10.1007/s12272-022-01378-2 · Cited by 230
Levels of plasma neurofilament light chain and cognitive function in patients with Alzheimer or Parkinson disease
Lin, Y.-S., Lee, W.-J., Wang, S.-J., & Fuh, J.-L. (2018) · Scientific Reports · doi:10.1038/s41598-018-35766-w · Cited by 251
Clinical subtypes of Parkinson's disease
van Rooden, S. M., Colas, F., Martínez‐Martín, P., Jeukens‐Visser, M., Verbaan, D., Marinus, J., Chaudhuri, К. R., Kok, J. N., & van Hilten, J. J. (2010) · Movement Disorders · doi:10.1002/mds.23346 · Cited by 228
Parkinson’s Disease: A Review from Pathophysiology to Treatment
Marino, B. L. B., de Souza, L. R., Sousa, K. P. A., Ferreira, J. V., Padilha, E. C., da Silva, C. H. T. D. P., Taft, C. A., & Hage-Melim, L. I. D. S. (2019) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557519666191104110908 · Cited by 239
Saccadic eye movement changes in Parkinson's disease dementia and dementia with Lewy bodies
Mosimann, U. P., Müri, R. M., Burn, D. J., Felblinger, J., O'Brien, J. T., & McKeith, I. G. (2005) · Brain · doi:10.1093/brain/awh484 · Cited by 227
Progression of gait dysfunction in incident Parkinson's disease: Impact of medication and phenotype
Galna, B., Lord, S., Burn, D. J., & Rochester, L. (2014) · Movement Disorders · doi:10.1002/mds.26110 · Cited by 226
Quetiapine for agitation or psychosis in patients with dementia and parkinsonism
Kurlan, R., Cummings, J. L., Raman, R., & Thal, L. J. (2007) · Neurology · doi:10.1212/01.wnl.0000260060.60870.89 · Cited by 225
Distribution, type, and origin of Parkin mutations: Review and case studies
Hedrich, K., Eskelson, C., Wilmot, B., Marder, K. S., Harris, J. M., Garrels, J., Meija‐Santana, H., Vieregge, P., Jacobs, H., Bressman, S., et al. (2004) · Movement Disorders · doi:10.1002/mds.20234 · Cited by 224
Reliability and validity of the Beck depression inventory in patients with Parkinson's disease
Jeukens‐Visser, M., Leentjens, A. F. G., Marinus, J., Stiggelbout, A. M., & van Hilten, J. J. (2006) · Movement Disorders · doi:10.1002/mds.20792 · Cited by 223
Handwriting as an objective tool for Parkinson’s disease diagnosis
Rosenblum, S., Samuel, M., Zlotnik, S., Erikh, I., & Schlesinger, I. (2013) · Journal of Neurology · doi:10.1007/s00415-013-6996-x · Cited by 223
Supplementary and Primary Sensory Motor Area Activity in Parkinson's Disease
Rascol, O. (1992) · Archives of Neurology · doi:10.1001/archneur.1992.00530260044017 · Cited by 223
Physiotherapy for Parkinson's disease: a comparison of techniques
Tomlinson, C. L., Herd, C. P., Clarke, C. E., Meek, C., Patel, S., Stowe, R. L., Deane, K. H., Shah, L., Sackley, C. M., Wheatley, K., et al. (2014) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002815.pub2 · Cited by 241
Repetitive training of compensatory steps: a therapeutic approach for postural instability in Parkinson's disease
Jöbges, M. (2004) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2003.016550 · Cited by 222
Levodopa raises objective pain threshold in Parkinson's disease: a RIII reflex study
Gerdelat-Mas, A., Simonetta‐Moreau, M., Thalamas, C., Ory‐Magne, F., Slaoui, T., Rascol, O., & Brefel‐Courbon, C. (2007) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2007.120212 · Cited by 222
Neuropsychological, neurological and functional outcome following pallidotomy for Parkinson's disease. A consecutive series of eight simultaneous bilateral and twelve unilateral procedures
Scott, R. (1998) · Brain · doi:10.1093/brain/121.4.659 · Cited by 223
Expression profile of transcripts in Alzheimer's disease tangle-bearing CA1 neurons
Ginsberg, S. D., Hemby, S. E., Lee, V. M. ‐., Eberwine, J. H., & Trojanowski, J. Q. (2000) · Annals of Neurology · doi:10.1002/1531-8249(200007)48:1 · Cited by 315
Mortality in Parkinson's disease and its association with dementia and depression
Hughes, T. A., Ross, H., Mindham, R. H. S., & SPOKES, E. G. S. (2004) · Acta Neurologica Scandinavica · doi:10.1111/j.1600-0404.2004.00292.x · Cited by 219
Characteristics of apathy in Parkinson's disease
Dujardin, K., Sockeel, P., Devos, D., Delliaux, M., Krystkowiak, P. C., Destée, A., & Defebvre, L. (2007) · Movement Disorders · doi:10.1002/mds.21316 · Cited by 221
White and gray matter abnormalities in idiopathic rapid eye movement sleep behavior disorder: A diffusion‐tensor imaging and voxel‐based morphometry study
Scherfler, C., Frauscher, B., Schocke, M. F. H., Iranzo, Á., Gschliesser, V., Seppi, K., Santamaría, J., TOLOSA, E. S., Högl, B., Poewe, W. H., et al. (2010) · Annals of Neurology · doi:10.1002/ana.22245 · Cited by 231
c-Abl phosphorylates α-synuclein and regulates its degradation: implication for α-synuclein clearance and contribution to the pathogenesis of Parkinson's disease
Mahul‐Mellier, A., Fauvet, B., Gysbers, A. M., Dikiy, I., Oueslati, A., Georgeon, S., Lamontanara, A. J., Bisquertt, A., Eliezer, D., Masliah, E., et al. (2014) · Human Molecular Genetics · doi:10.1093/hmg/ddt674 · Cited by 227
Cardiac MIBG scintigraphy is a sensitive tool for detecting cardiac sympathetic denervation in Parkinson's disease
Courbon, F., Brefel‐Courbon, C., Thalamas, C., Mj, A., Berry, I., Montastruc, J., Rascol, O., & Sénard, J. (2003) · Movement Disorders · doi:10.1002/mds.10461 · Cited by 220
Neurogenesis in aging and age-related neurodegenerative diseases
Čulig, L., Chu, X., & Bohr, V. A. (2022) · Ageing Research Reviews · doi:10.1016/j.arr.2022.101636 · Cited by 235
The changing face of Parkinson's disease‐associated psychosis: A cross‐sectional study based on the new NINDS‐NIMH criteria
Fénelon, G., Soulas, T., Zenasni, F., & de Langavant, L. C. (2010) · Movement Disorders · doi:10.1002/mds.22839 · Cited by 218
Role of DAT‐SPECT in the diagnostic work up of Parkinsonism
Scherfler, C., Schwarz, J., Antonini, A., Grosset, D. G., Valldeoriola, F., MAREK, K. L., Oertel, W. H., TOLOSA, E. S., Lees, A. J., & Poewe, W. H. (2007) · Movement Disorders · doi:10.1002/mds.21505 · Cited by 219
Self-citation
Influence of chronic bilateral stimulation of the subthalamic nucleus on cognitive function in Parkinson's disease
Dujardin, K., Defebvre, L., Krystkowiak, P. C., Blond, S., & Destée, A. (2001) · Journal of Neurology · doi:10.1007/s004150170139 · Cited by 218
Longitudinal MRI in progressive supranuclear palsy and multiple system atrophy: rates and regions of atrophy
Paviour, D. C., Price, S. L., Jahanshahi, M., Lees, A. J., & Fox, N. C. (2006) · Brain · doi:10.1093/brain/awl021 · Cited by 217
Self-citation
Association of GBA Mutations and the E326K Polymorphism With Motor and Cognitive Progression in Parkinson Disease
Davis, M. Y., Johnson, C. O., Leverenz, J. B., Weintraub, D. A., Trojanowski, J. Q., Chen‐Plotkin, A. S., Deerlin, V. M. V., Quinn, J. F., Chung, K. A., Peterson‐Hiller, A. L., et al. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2016.2245 · Cited by 219
Prevalence and correlates of neuropsychiatric symptoms in Parkinson's disease without dementia
Kulisevsky, J., Pagonabarraga, J., Pascual‐Sedano, B., García‐Sánchez, C., Gironell, A., & Trapecio Group Study (2008) · Movement Disorders · doi:10.1002/mds.22246 · Cited by 216
Movement-Related Changes in Local and Long-Range Synchronization in Parkinson's Disease Revealed by Simultaneous Magnetoencephalography and Intracranial Recordings
Vladimir Litvak, A., Eusébio, A., Jha, A., Oostenveld, R., Barnes, G. R., Foltynie, T., Limousin, P. D., Zrinzo, L. U., Hariz, M. I., Friston, K. J., et al. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0767-12.2012 · Cited by 210
Magnesium Inhibits Spontaneous and Iron-induced Aggregation of α-Synuclein
Golts, N., Snyder, H. M., Frasier, M. A., Theisler, C. M., Choi, P., & Wolozin, B. L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m107866200 · Cited by 221
Ubiquitin–proteasome system and Parkinson's disease
Olanow, C. W., & McNaught, K. S. P. (2006) · Movement Disorders · doi:10.1002/mds.21013 · Cited by 219
Constipation preceding Parkinson's disease: a systematic review and meta-analysis
Adams-Carr, K. L., Bestwick, J. P., Shribman, S., Lees, A., Schrag, A., & Noyce, A. J. (2016) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp-2015-311680 · Cited by 228
Self-citation
Glutathione and Parkinson's disease: Is this the elephant in the room?
Zeevalk, G. D., Razmpour, R., & Bernard, L. P. (2008) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2008.01.017 · Cited by 217
Symptoms and duration of the prodromal phase in parkinson's disease
Gonera, E. G., Hof, M. V., Berger, H. J. C., van Weel, C., & Horstink, M. W. I. M. (1997) · Movement Disorders · doi:10.1002/mds.870120607 · Cited by 212
Parkinson disease, 10 years after its genetic revolution: Multiple clues to a complex disorder
Klein, C., & Schlossmacher, M. G. (2007) · Neurology · doi:10.1212/01.wnl.0000271880.27321.a7 · Cited by 212
Lewy Body Pathology in Normal Elderly Subjects
Markesbery, W. R., Jicha, G. A., Liu, H., & Schmitt, F. A. (2009) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/nen.0b013e3181ac10a7 · Cited by 210
The nature of dual-task interference during gait in incident Parkinson’s disease
Rochester, L., Galna, B., Lord, S., & Burn, D. J. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.01.041 · Cited by 210
Meta-analysis of brain iron levels of Parkinson’s disease patients determined by postmortem and MRI measurements
Wang, J., Zhuang, Q.-Q., Zhu, L.-B., Zhu, H., Li, T., Li, R., Chen, S., Huang, C.-P., Zhang, X., & Zhu, J. (2016) · Scientific Reports · doi:10.1038/srep36669 · Cited by 210
CSF amyloid-β-peptides in Alzheimer's disease, dementia with Lewy bodies and Parkinson's disease dementia
Bibl, M., Mollenhauer, B., Esselmann, H., Lewczuk, P., Klafki, H., Sparbier, K., Av, S., Cepek, L., Trenkwalder, C., Rüther, E., et al. (2006) · Brain · doi:10.1093/brain/awl063 · Cited by 212
Glucocerebrosidase Gene Mutations
Mata, I. F., Samii, A., Schneer, S. H., Roberts, J. W., Griffith, A., Leis, B. C., Schellenberg, G. D., Sidransky, E., Bird, T. D., Leverenz, J. B., et al. (2008) · Archives of Neurology · doi:10.1001/archneurol.2007.68 · Cited by 207
Phosphorylated α‐synuclein can be detected in blood plasma and is potentially a useful biomarker for Parkinson's disease
Foulds, P. G., Mitchell, J. D., Parker, A., Turner, R., Green, G., Diggle, P. J., Hasegawa, M., Taylor, M., Mann, D. M. A., & Allsop, D. (2011) · The FASEB Journal · doi:10.1096/fj.10-179192 · Cited by 210
Doença de Parkinson: Revisão Clínica e Atualização
Cabreira, V., & Massano, J. (2019) · Acta Médica Portuguesa · doi:10.20344/amp.11978 · Cited by 207
Altered Proteins in the Aging Brain
Elobeid, A., Libard, S., Leino, M., Popova, S. N., & Alafuzoff, I. (2016) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlw002 · Cited by 202
Prognostic factors for the progression of Parkinson's disease: A systematic review
Post, B., Merkus, M. P., de Haan, R. J., Speelman, J. D., & CARPA Study Group (2007) · Movement Disorders · doi:10.1002/mds.21537 · Cited by 206
APOE,MAPT, andSNCAGenes and Cognitive Performance in Parkinson Disease
Mata, I. F., Leverenz, J. B., Weintraub, D. A., Trojanowski, J. Q., Hurtig, H. I., Deerlin, V. M. V., Ritz, B. R., Rausch, R., Rhodes, S. L., Factor, S. A., et al. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2014.1455 · Cited by 203
A short scale for the assessment of motor impairments and disabilities in Parkinson's disease: the SPES/SCOPA
Marinus, J. (2004) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2003.017509 · Cited by 205
The relationship between dementia and direct involvement of the hippocampus and amygdala in Parkinson's disease
Churchyard, A., & Lees, A. J. (1997) · Neurology · doi:10.1212/wnl.49.6.1570 · Cited by 207
Self-citation
Proteolytic stress: A unifying concept for the etiopathogenesis of Parkinson’s disease
McNaught, K. S. P., & Olanow, C. W. (2003) · Annals of Neurology · doi:10.1002/ana.10512 · Cited by 203
Overexpression of human α-synuclein causes dopamine neuron death in rat primary culture and immortalized mesencephalon-derived cells
Zhou, W., Hurlbert, M. S., Schaack, J. B., Prasad, K. N., & Freed, C. R. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02215-0 · Cited by 207
Bowel movement frequency in late‐life and incidental Lewy bodies
Abbott, R. D., Ross, G. W., Petrovitch, H., Tanner, C. M., Davis, D. G., Masaki, K., Launer, L. J., Curb, J. D., & White, L. R. (2007) · Movement Disorders · doi:10.1002/mds.21560 · Cited by 203
Neuropathology of autonomic dysfunction in synucleinopathies
Coon, E. A., Cutsforth‐Gregory, J. K., & Benarroch, E. E. (2018) · Movement Disorders · doi:10.1002/mds.27186 · Cited by 210
Diffuse Lewy body disease: light and electron microscopic immunocytochemistry of senile plaques
Dickson, D. W., Crystal, H., Mattiace, L. A., Kress, Y., Schwagerl, A. L., Ksiȩżak-Reding, H., Davies, P., & Yen, S. H. (1989) · Acta Neuropathologica · doi:10.1007/bf00691284 · Cited by 203
Environmental, life-style, and physical precursors of clinical Parkinson?s disease: recent findings from the Honolulu-Asia Aging Study
Abbott, R. D., Ross, G. W., White, L. R., Sanderson, W. T., Burchfiel, C. M., Kashon, M. L., Sharp, D. S., Masaki, K., Curb, J. D., & Petrovitch, H. (2003) · Journal of Neurology · doi:10.1007/s00415-003-1306-7 · Cited by 200
Parkinson's disease and α‐synuclein expression
Devine, M. J., Gwinn, K. A., Singleton, A., & Hardy, J. (2011) · Movement Disorders · doi:10.1002/mds.23948 · Cited by 207
Helicobacter pylori eradication and l-dopa absorption in patients with PD and motor fluctuations
Pierantozzi, M., Pietroiusti, A., Brusa, L., Galati, S., Stefani, A., Lunardi, G., Fedele, E., Sancesario, G., Bernardi, G., Bergamaschi, A., et al. (2006) · Neurology · doi:10.1212/01.wnl.0000221672.01272.ba · Cited by 199
Clinical and subclinical dopaminergic dysfunction in PARK6‐linked parkinsonism: An 18F‐dopa PET study
Khan, N. L., Valente, E. M., Bentivoglio, A. R., Wood, N. W., Albanese, A., Brooks, D. J., & Piccini, P. P. (2002) · Annals of Neurology · doi:10.1002/ana.10417 · Cited by 199
Rivastigmine in apathetic but dementia and depression-free patients with Parkinson's disease: a double-blind, placebo-controlled, randomised clinical trial
Devos, D., Moreau, C., Maltête, D., Lefaucheur, R., Kreisler, A., Eusébio, A., Defer, G. L., Ouk, T., Azulay, J.-P., Krystkowiak, P. C., et al. (2013) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2013-306439 · Cited by 199
A randomised controlled study comparing bromocriptine to which levodopa was later added, with levodopa alone in previously untreated patients with Parkinson's disease: a five year follow up.
Montastruc, J., Rascol, O., Sénard, J., & Rascol, A. (1994) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.57.9.1034 · Cited by 198
Evaluation of the Hospital Anxiety and Depression Scale in Patients With Parkinson's Disease
Marinus, J., Leentjens, A. F. G., Visser, M., Stiggelbout, A. M., & van Hilten, J. J. (2002) · Clinical Neuropharmacology · doi:10.1097/00002826-200211000-00008 · Cited by 197
Metabolic profiling of Parkinson's disease: evidence of biomarker from gene expression analysis and rapid neural network detection
Ahmed, S. S. S. J., Santosh, W., Kumar, S., & Christlet, H. T. T. (2009) · Journal of Biomedical Science · doi:10.1186/1423-0127-16-63 · Cited by 197
A Survey of Pain in Idiopathic Parkinson's Disease
Lee, M. A., Walker, R. W., Hildreth, T.-J., & Prentice, W. M. (2006) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2006.05.020 · Cited by 197
Incidental Lewy Body Disease and Preclinical Parkinson Disease
DelleDonne, A., Klos, K. J., Fujishiro, H., Ahmed, Z., Parisi, J. E., Josephs, K. A., Frigerio, R., Burnett, M. S., Wszołek, Z. K., Uitti, R. J., et al. (2008) · Archives of Neurology · doi:10.1001/archneur.65.8.1074 · Cited by 197
Patient profile, indications, efficacy and safety of duodenal levodopa infusion in advanced Parkinson's disease
Devos, D., & for the French DUODOPA Study Group (2009) · Movement Disorders · doi:10.1002/mds.22450 · Cited by 197
Response of parkinsonian swallowing dysfunction to dopaminergic stimulation
Hunter, P. C., Crameri, J., Austin, S., Woodward, M. C., & Hughes, A. J. (1997) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.63.5.579 · Cited by 197
Effects of dyskinesias in Parkinson's disease on quality of life and health‐related costs: a prospective European study
Péchevis, M., Clarke, C. E., Vieregge, P., Khoshnood, B., Deschaseaux, C., Berdeaux, G., Ziegler, M., & on behalf of the Trial Study Group (2005) · European Journal of Neurology · doi:10.1111/j.1468-1331.2005.01096.x · Cited by 197
Deficits in decoding emotional facial expressions in Parkinson's disease
Dujardin, K. (2003) · Neuropsychologia · doi:10.1016/s0028-3932(03)00154-4 · Cited by 204
Clinical Features of Parkinson’s Disease: The Evolution of Critical Symptoms
Váradi, C. (2020) · Biology · doi:10.3390/biology9050103 · Cited by 196
Subthalamic nucleus phase–amplitude coupling correlates with motor impairment in Parkinson’s disease
van Wijk, B. C. M., Beudel, M., Jha, A., Oswal, A., Foltynie, T., Hariz, M. I., Limousin, P. D., Zrinzo, L. U., Aziz, T. Z., Green, A. L., et al. (2016) · Clinical Neurophysiology · doi:10.1016/j.clinph.2016.01.015 · Cited by 195
Association of olfactory dysfunction with incidental Lewy bodies
Ross, G. W., Abbott, R. D., Petrovitch, H., Tanner, C. M., Davis, D. G., Nelson, J. R., Markesbery, W. R., Hardman, J. M., Masaki, K., Launer, L. J., et al. (2006) · Movement Disorders · doi:10.1002/mds.21076 · Cited by 194
Physiotherapy versus placebo or no intervention in Parkinson's disease
Tomlinson, C. L., Patel, S., Meek, C., Clarke, C. E., Stowe, R. L., Shah, L., Sackley, C. M., Deane, K. H., Wheatley, K., & Ives, N. J. (2001) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002817 · Cited by 194
The midbrain to pons ratio
Massey, L. A., Jäger, H. R., Paviour, D. C., O’Sullivan, S. S., Ling, H., Williams, D. R., Kallis, C., Holton, J. L., Révész, T., Burn, D. J., et al. (2013) · Neurology · doi:10.1212/wnl.0b013e318292a2d2 · Cited by 195
Self-citation
Natural history and syndromic associations of orthostatic tremor: A review of 41 patients
Gerschlager, W., Münchau, A. M., Katzenschlager, R., Brown, P., Rothwell, J. C., Quinn, N. P., Lees, A. J., & Bhatia, K. P. (2004) · Movement Disorders · doi:10.1002/mds.20132 · Cited by 192
Self-citation
Methylphenidate for gait hypokinesia and freezing in patients with Parkinson's disease undergoing subthalamic stimulation: a multicentre, parallel, randomised, placebo-controlled trial
Moreau, C., Delval, A., Defebvre, L., Dujardin, K., Duhamel, A., Petyt, G., Vuillaume, I., Corvol, J., Brefel‐Courbon, C., Ory‐Magne, F., et al. (2012) · The Lancet Neurology · doi:10.1016/s1474-4422(12)70106-0 · Cited by 191
Characteristics of Visual Hallucinations in Parkinson Disease Dementia and Dementia With Lewy Bodies
Mosimann, U. P., Rowan, E. N., Partington, C. E., Collerton, D., Littlewood, E., O'Brien, J. T., Burn, D. J., & McKeith, I. G. (2006) · The American Journal of Geriatric Psychiatry · doi:10.1097/01.jgp.0000192480.89813.80 · Cited by 188
Diffusion Tensor Imaging in Idiopathic REM Sleep Behavior Disorder Reveals Microstructural Changes in the Brainstem, Substantia Nigra, Olfactory Region, and Other Brain Regions
Unger, M. M., Belke, M., Menzler, K., Heverhagen, J. T., Keil, B. R., Stiasny‐Kolster, K., Rosenow, F., Diederich, N. J., Mayer, G., Möller, J. C., et al. (2010) · SLEEP · doi:10.1093/sleep/33.6.767 · Cited by 198
Ambulatory activity in incident Parkinson’s: more than meets the eye?
Lord, S., Godfrey, A., Galna, B., Mhiripiri, D., Burn, D. J., & Rochester, L. (2013) · Journal of Neurology · doi:10.1007/s00415-013-7037-5 · Cited by 194
The role of levodopa in the management of dementia with Lewy bodies
Molloy, S. (2005) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.2004.052332 · Cited by 186
A longitudinal study on α-synuclein in blood plasma as a biomarker for Parkinson's disease
Foulds, P. G., Diggle, P. J., Mitchell, J. D., Parker, A., Hasegawa, M., Masuda‐Suzukake, M., Mann, D. M. A., & Allsop, D. (2013) · Scientific Reports · doi:10.1038/srep02540 · Cited by 191
Fortnightly Review: Parkinsonism—recognition and differential diagnosis
Quinn, N. P. (1995) · BMJ · doi:10.1136/bmj.310.6977.447 · Cited by 186
Ropinirole in the treatment of early Parkinson's disease: A 6‐month interim report of a 5‐year levodopa‐controlled study
Rascol, O., Brooks, D. J., Brunt, E. R., Korczyn, A. D., Poewe, W. H., & Stocchi, F. (1998) · Movement Disorders · doi:10.1002/mds.870130111 · Cited by 186
Diagnostic accuracy of parkinsonism syndromes by general neurologists
Joutsa, J., Gardberg, M., Röyttä, M., & Kaasinen, V. (2014) · Parkinsonism & Related Disorders · doi:10.1016/j.parkreldis.2014.04.019 · Cited by 185
Lewy pathology and neurodegeneration in premotor Parkinson's disease
Tredici, K. D., & Braak, H. (2012) · Movement Disorders · doi:10.1002/mds.24921 · Cited by 187
Arm swing as a potential new prodromal marker of Parkinson's disease
Mirelman, A., Bernad‐Elazari, H., Thaler, A., Giladi, E., Gurevich, T., Gana‐Weisz, M., Saunders-Pullman, R. J., Raymond, D., Doan, N., Bressman, S., et al. (2016) · Movement Disorders · doi:10.1002/mds.26720 · Cited by 187
DJ-1 (PARK7) mutations are less frequent than Parkin (PARK2) mutations in early-onset Parkinson disease
Hedrich, K., Djarmati, A., Schäfer, N., Hering, R., Wellenbrock, C., Weiss, P. H., Hilker, R., Vieregge, P., Ozelius, L. J., Heutink, P., et al. (2004) · Neurology · doi:10.1212/01.wnl.0000113022.51739.88 · Cited by 185
Differential diagnosis of Parkinson's disease, multiple system atrophy, and Steele-Richardson-Olszewski syndrome: discriminant analysis of striatal 18F-dopa PET data.
Burn, D. J., Sawle, G. V., & Brooks, D. J. (1994) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp.57.3.278 · Cited by 185
Gut microbiome dysbiosis across early Parkinson’s disease, REM sleep behavior disorder and their first-degree relatives
Huang, B., Chau, S. W. H., Liu, Y., Chan, J. W. Y., Wang, J., Ma, S. L., Zhang, J., Chan, P. K. S., Yeoh, Y. K., Chen, Z., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-38248-4 · Cited by 187

Authors: Gibb, W. R., & Lees, A. J.
ORCID: Gibb, W R
Lees, A J
Venue: Journal of Neurology, Neurosurgery & Psychiatry
Publisher: BMJ
Published: 1988-06-01
Volume: 51
Issue: 6
Pages: 745-752
ISSN: 0022-3050 (ISSN-L)
DOI: 10.1136/jnnp.51.6.745
PMC: PMC1033142
OpenAlex: W2132881915
Semantic Scholar: 354cd1cf28ad23a8038bb3c576ff7791b3c74543
Cited by: 3,481
References: 39
Citations by year: 2026: 78 · 2025: 130 · 2024: 152 · 2023: 143 · 2022: 131 · 2021: 158 · 2020: 164 · 2019: 152 · 2018: 138 · 2017: 156 · 2016: 163 · 2015: 115 · 2014: 149 · 2013: 123 · 2012: 138
FWCI: 3.24
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
PubMed Central (publishedVersion)
Europe PMC (PubMed Central) (publishedVersion)
PubMed (publishedVersion)
UCL Discovery (University College London) (submittedVersion)
HighWire Press Open Archive (submittedVersion)
Topics: Health Sciences › Medicine › Clinical Neurology › Parkinson's Disease Mechanisms and Treatments
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Nuclear Receptors and Signaling
Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
Keywords: Lewy bodies, Parkinson's disease, pathogenesis, neurofilaments, substantia nigra, incidental Lewy body disease, age-related prevalence, neuronal loss
MeSH terms: Adolescent, Adult, Aged, Aged, 80 and over, Brain, Brain Damage, Chronic, Inclusion Bodies, Child, Humans, Middle Aged, Nerve Degeneration, Parkinson Disease, Substantia Nigra

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The relevance of the Lewy body to the pathogenesis of idiopathic Parkinson's disease.

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks