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Cited by 115Fetal and Pediatric Neurological DisordersSchizophrenia research and treatmentAutism Spectrum Disorder Research

Severe psychiatric disturbance and abnormalities of the corpus callosum: Review and case series

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David, A S, Wacharasindhu, A, Lishman, W A·1993·Journal of Neurology, Neurosurgery & Psychiatry
DOI 10.1136/jnnp.56.1.85PMC PMC1014772
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Abstract

The association between developmental defects of the corpus callosum and major psychiatric disturbance is discussed with a review of published cases. Seven new cases are presented, of which four had clear psychotic symptoms, two receiving a diagnosis of schizophrenia. Of the remainder, one had a developmental disorder affecting social interaction and speech which could be classed as Asperger's syndrome, one had a personality disorder with depressive and conversion symptoms, and the last was an adolescent boy with severe behavioural problems. The difficulties in determining the precise relevance of the callosal anomalies to these clinical manifestations are discussed especially since the prevalence of such anomalies in the population is uncertain.

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Crossref · 10.1136/jnnp.56.1.85

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  • Several cognitive and social deficits observed in autism have also been described in individuals with agenesis of the corpus callosum.

    “Several cognitive and social deficits observed in autism have also been described in individuals with agenesis of the CC, although not all individuals with these deficits meet full DSM-IV-TR criteria for autistic disorder.”

    From A Meta-Analysis of the Corpus Callosum in Autism (2009) · cites this paper as [57]

  • The results are consistent with evidence from investigations of individuals with agenesis of the corpus callosum.

    “Results reported here are consistent with evidence from investigations examining individuals with agenesis of the CC, pointing to the role that this structure plays in complex brain functions.”

    From A Meta-Analysis of the Corpus Callosum in Autism (2009) · cites this paper as [57]

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Research works printed but not linked: 11

  1. Aicardi J, Chevrie JJ, Baraton J. Agenesis of the corpus callosum. In: Myriantholopolus NC, ed. Handbook of clinical neurology vol 6: malformations. Amsterdam: Else- vier, North Holland Biomedical Press, 1987;149-73.
  2. Kolodny EH. Agenesis of the corpus callosum: a marker of inherited metabolic disease? Neurology 1989;39:847-8.
  3. Scheibel A, Weschler A, eds. Neurobiology of higher cognitive functioning. New York: Guilford Press, 1990.
  4. Thieffry S, Lefebvre J, Lepoutre J, Faure C, Masselin S. Contribution a l'etude radiologique des malformations du plan sagittal interhemispherique. Acta Radiol 1958; 50:242-52.
  5. Courville CB. Congenital malformations and abnormalities of the central nervous system. Pathology of the central 92 on July 12, 2023 by guest. Protected by copyright. http://jnnp.bmj.com/ J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp.56.1.85 on 1 January 1993. Downloaded from Severe psychiatric disturbance and abnormalities of the corpus callosum: review and case series nervous system, 3rd ed. Califomia: Pacific Press, 1950; 63-94.
  6. Myrianthopoulos NC. Epidemiology of CNS Malforma- tions, In: Vinken PJ, Bruyn G, Klawans HL, eds. Malformations. Handbook of neurology, rev series 6. Amsterdam: Elsevier Science Publishers, 1987:49-70.
  7. Reveley AM, Reveley MA. Aqueduct stenosis and schizo- phrenia. 7 Neurol Neurosurg Psychiatry 1983;46: 18-22.
  8. Beaumont JG. Dimond SJ. Brain disconnection and schizo- phrenia. Brit Jf Psychiat 1973;123:661-2.
  9. David AS. Reading about the split brain syndrome. Brit Jf Psychiat 1989;154:422-5.
  10. Green P, Hallet S, Hunter M. Abnormal interhemispheric integration and hemisphere specialization in schizo- phrenics and high-risk children. In: Gruzelier JH, Flor- Henry P, eds. Laterality and psychopathology. Amsterdam: Elsevier, 1986:443-70.
  11. Nasrallah HA. The unintegrated right cerebral hemispheric consciousness as alien intruder. Comp Psychiat 1985;26: 273-82.

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Authors
David, A. S., Wacharasindhu, A., & Lishman, W. A.
ORCID
David, A S
Venue
Journal of Neurology, Neurosurgery & Psychiatry
Publisher
BMJ
Published
1993-01-01
Volume
56
Issue
1
Pages
85-93
ISSN
0022-3050 (ISSN-L)
DOI
10.1136/jnnp.56.1.85
PMC
PMC1014772
OpenAlex
W2092026060
Cited by
115
References
57
Citations by year
2024: 2 · 2023: 5 · 2022: 3 · 2021: 7 · 2020: 2 · 2019: 4 · 2018: 9 · 2017: 3 · 2016: 2 · 2015: 4 · 2014: 5 · 2013: 5 · 2012: 5
FWCI
5.64
Type
journal article
Language
en
Open access
Locations
  • Journal of Neurology Neurosurgery & Psychiatry (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • HighWire Press Open Archive (publishedVersion)
Topics
  • Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Fetal and Pediatric Neurological Disorders
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
Keywords
corpus callosum abnormalities, psychiatric disturbances, psychosis, schizophrenia, Asperger syndrome, personality disorders, conversion disorder, behavioral problems, adolescents, case series
MeSH terms
Adult, Mental Disorders, Brain, Epilepsy, Female, Humans, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Schizophrenia, Tomography, X-Ray Computed, Agenesis of Corpus Callosum

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