Increased Intestinal Permeability and Parkinson Disease Patients: Chicken or Egg?
Open accessAbstract
UNLABELLED: Gastrointestinal involvement is a frequent and early event in the course of Parkinson Disease (PD), and may have a prominent role in the early pathophysiology of the disease. On the other hand, derangement in intestinal permeability could also result from the involvement of the gastrointestinal tract over the course of the disease. PATIENTS AND METHODS: The intestinal permeability of 12 non-selected PD patients was studied using a validated, non-invasive test; these results were compared to predefined age-adjusted reference values. RESULTS: 4/12 PD patients had abnormal gastrointestinal permeability; two had both an abnormal lactulose/mannitol ratio and an abnormal sucrose concentration, and two an isolated abnormal result. An increased lactulose/mannitol ratio is consistent with defect of either the enterocytes or the tight junctions between them. CONCLUSION: Intestinal permeability is increased in a significant proportion of unselected PD patients with minimal gastrointestinal symptoms. The significance of this finding needs to be further evaluated.
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Abnormal lactulose/mannitol ratio and sucrose concentration values found in subjects with Parkinson's disease have been associated with tight junction alterations.
“abnormal lactulose/mannitol ratio and sucrose concentration values found in subjects with PD have been associated with tight junction alterations [138,139]”
From The Interplay between Gut Microbiota and Parkinson’s Disease: Implications on Diagnosis and Treatment (2022) · cites this paper as [138]
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- Authors
- Salat-Foix, D., Tran, K., Ranawaya, R., Meddings, J., & Suchowersky, O.
- Affiliations
- University of Calgary (CA)
- University of Alberta (CA)
- Corresponding author
- Salat-Foix, D.
- Venue
- Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
- Publisher
- Cambridge University Press (CUP)
- Published
- 2012-03
- Volume
- 39
- Issue
- 2
- Pages
- 185-188
- ISSN
- 0317-1671 (ISSN-L)
- 2057-0155
- OpenAlex
- W2322057494
- Cited by
- 80
- References
- 30
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 4 · 2023: 6 · 2022: 10 · 2021: 11 · 2020: 8 · 2019: 4 · 2018: 8 · 2017: 8 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 3 · 2012: 2
- FWCI
- 2.29
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Keywords
- Parkinson's disease, intestinal permeability, lactulose/mannitol ratio, sucrose concentration, tight junctions, enterocytes, gastrointestinal involvement
- MeSH terms
- Aged, Aged, 80 and over, Female, Humans, Intestinal Absorption, Intestinal Mucosa, Lactulose, Male, Mannitol, Middle Aged, Parkinson Disease, Permeability, Sucrose
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