Cited by 80Parkinson's Disease Mechanisms and TreatmentsGastrointestinal motility and disordersBarrier Structure and Function Studies

Increased Intestinal Permeability and Parkinson Disease Patients: Chicken or Egg?

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Salat-Foix, D., Tran, K., Ranawaya, R., Meddings, J., Suchowersky, O.·2012·Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques

Abstract

UNLABELLED: Gastrointestinal involvement is a frequent and early event in the course of Parkinson Disease (PD), and may have a prominent role in the early pathophysiology of the disease. On the other hand, derangement in intestinal permeability could also result from the involvement of the gastrointestinal tract over the course of the disease. PATIENTS AND METHODS: The intestinal permeability of 12 non-selected PD patients was studied using a validated, non-invasive test; these results were compared to predefined age-adjusted reference values. RESULTS: 4/12 PD patients had abnormal gastrointestinal permeability; two had both an abnormal lactulose/mannitol ratio and an abnormal sucrose concentration, and two an isolated abnormal result. An increased lactulose/mannitol ratio is consistent with defect of either the enterocytes or the tight junctions between them. CONCLUSION: Intestinal permeability is increased in a significant proportion of unselected PD patients with minimal gastrointestinal symptoms. The significance of this finding needs to be further evaluated.

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Authors
Salat-Foix, D., Tran, K., Ranawaya, R., Meddings, J., & Suchowersky, O.
Affiliations
  • University of Calgary (CA)
  • University of Alberta (CA)
Corresponding author
Salat-Foix, D.
Venue
Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
Published
2012-03
Volume
39
Issue
2
Pages
185-188
ISSN
  • 0317-1671 (ISSN-L)
  • 2057-0155
OpenAlex
W2322057494
Cited by
80
References
30
Citations by year
2026: 3 · 2025: 5 · 2024: 4 · 2023: 6 · 2022: 10 · 2021: 11 · 2020: 8 · 2019: 4 · 2018: 8 · 2017: 8 · 2016: 2 · 2015: 4 · 2014: 2 · 2013: 3 · 2012: 2
FWCI
2.29
Type
journal article
Language
en
Open access
Locations
  • Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Keywords
Parkinson's disease, intestinal permeability, lactulose/mannitol ratio, sucrose concentration, tight junctions, enterocytes, gastrointestinal involvement
MeSH terms
Aged, Aged, 80 and over, Female, Humans, Intestinal Absorption, Intestinal Mucosa, Lactulose, Male, Mannitol, Middle Aged, Parkinson Disease, Permeability, Sucrose

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