The DOI matches its Crossref record; 233 of the 233 references it cites were found in a registry or an index.
Gut microbiota, obesity and diabetes
Open accessAbstract
The central role of the intestinal microbiota in the progression and, equally, prevention of metabolic dysfunction is becoming abundantly apparent. The symbiotic relationship between intestinal microbiota and host ensures appropriate development of the metabolic system in humans. However, disturbances in composition and, in turn, functionality of the intestinal microbiota can disrupt gut barrier function, a trip switch for metabolic endotoxemia. This low-grade chronic inflammation, brought about by the influx of inflammatory bacterial fragments into circulation through a malfunctioning gut barrier, has considerable knock-on effects for host adiposity and insulin resistance. Conversely, recent evidence suggests that there are certain bacterial species that may interact with host metabolism through metabolite-mediated stimulation of enteric hormones and other systems outside of the gastrointestinal tract, such as the endocannabinoid system. When the abundance of these keystone species begins to decline, we see a collapse of the symbiosis, reflected in a deterioration of host metabolic health. This review will investigate the intricate axis between the microbiota and host metabolism, while also addressing the promising and novel field of probiotics as metabolic therapies.
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“with studies indicating that probiotics can contribute to weight loss and an improvement in cardiometabolic parameters.”
From The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties (2024) · cites this paper as [136]
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“For this reason, the fundamental role of gut microbiomes in appetite regulation and the resulting effect on obesity is now clear [136]”
From The Potential Impact of Probiotics on Human Health: An Update on Their Health-Promoting Properties (2024) · cites this paper as [136]
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Metadata
- Authors
- Patterson, E., Ryan, P. M., Cryan, J. F., Dinan, T. G., Ross, R. P., Fitzgerald, G. F., & Stanton, C.
- Affiliations
- Teagasc - The Irish Agriculture and Food Development Authority (IE)
- University College Cork (IE)
- Corresponding author
- Stanton, Catherine
- Venue
- Postgraduate Medical Journal
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-02-24
- Volume
- 92
- Issue
- 1087
- Pages
- 286-300
- ISSN
- 0032-5473 (ISSN-L)
- 1469-0756
- OpenAlex
- W2298848525
- Cited by
- 552
- References
- 233
- Citations by year
- 2026: 24 · 2025: 42 · 2024: 83 · 2023: 86 · 2022: 91 · 2021: 74 · 2020: 54 · 2019: 38 · 2018: 20 · 2017: 29 · 2016: 10
- FWCI
- 2.92
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Postgraduate Medical Journal (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- T-Stór (Teagasc) (submittedVersion, cc-by-nc-sa)
- Funders
- Science Foundation Ireland (SFI/12/RC/, 12/RC/2273, 12/RC/, SFI/12/RC/2273.)
- Teagasc
- APC Microbiome Institute (SFI/12/RC/2273)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- gut microbiota, obesity, diabetes mellitus, intestinal barrier, endotoxemia, low-grade inflammation, insulin resistance, adiposity, bacterial metabolites, endocannabinoid system, probiotics, metabolic therapy, host-microbe symbiosis
- MeSH terms
- Gastrointestinal Microbiome, Diabetes Mellitus, Humans, Inflammation, Obesity, Disease Progression, Probiotics, Gastrointestinal Tract
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