Risk of hospital admission for COPD following smoking cessation and reduction: a Danish population study
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BACKGROUND: Little is known about the effects of changes in smoking habits on the subsequent risk of chronic obstructive pulmonary disease (COPD). The aim of this study was to investigate the relationship between smoking cessation and reduction and admission to hospital for COPD in a general population sample. METHODS: A total of 19,709 participants from three prospective population studies in Copenhagen were followed with record linkage for date of first hospital admission for COPD until 1998 (mean follow up 14 years). Heavy smokers (>/=15 cigarettes/day) who reduced their tobacco consumption by at least 50% between the two initial examinations without quitting and smokers who stopped smoking during this time were compared with continuous heavy smokers using a Cox proportional hazards model. RESULTS: During the follow up period 1,260 subjects (741 men and 519 women) were admitted to hospital for COPD. After multivariate adjustment, quitting smoking was associated with a significant reduction in the risk of hospital admission. The relative hazard (HR) was 0.57 (95% confidence interval (CI) 0.33 to 0.99). Those who reduced smoking did not show a significantly lower risk of hospitalisation than continuing heavy smokers (HR 0.93 (95% CI 0.73 to 1.18)). Exclusion of events during the first 5 study years, detailed adjustment for lung function, or restriction of analyses to participants with impaired pulmonary function did not reverse the observed trend. CONCLUSIONS: Self-reported smoking cessation is associated with a reduction in the risk of COPD morbidity of approximately 40%; the benefit of smoking reduction is questionable.
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Cigarette reductions of 50% or greater do not lead to significantly reduced risk for hospitalizations for chronic obstructive pulmonary disease (HR 0.9, 95% CI 0.7 to 1.2).
“or reduced risk for hospitalizations for chronic obstructive pulmonary disease (HR 0.9, 95% CI 0.7, 1.2) (129).”
From Tobacco addiction (2008) · cites this paper as [129]
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- Authors
- Godtfredsen, N. S.
- Affiliations
- Copenhagen University Hospital (DK)
- Corresponding author
- Godtfredsen, N S
- ORCID
- Godtfredsen, N S
- Venue
- Thorax
- Publisher
- BMJ
- Published
- 2002-11-01
- Volume
- 57
- Issue
- 11
- Pages
- 967-972
- ISSN
- 0040-6376 (ISSN-L)
- PMC
- PMC1746230
- OpenAlex
- W2126384628
- Cited by
- 203
- References
- 36
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 3 · 2023: 4 · 2022: 12 · 2021: 3 · 2020: 6 · 2019: 6 · 2018: 7 · 2017: 8 · 2016: 13 · 2015: 13 · 2014: 14 · 2013: 6 · 2012: 9
- FWCI
- 5.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Thorax (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
- Funders
- Danmarks Lungeforening
- Gentofte Hospital
- Ministeriet Sundhed Forebyggelse
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Chronic Obstructive Pulmonary Disease (COPD) Research
- Health Sciences › Medicine › Physiology › Smoking Behavior and Cessation
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Keywords
- chronic obstructive pulmonary disease, smoking cessation, smoking reduction, hospitalization, COPD morbidity, heavy smokers, tobacco use, lung function
- MeSH terms
- Adult, Aged, Aged, 80 and over, Female, Follow-Up Studies, Hospitalization, Humans, Male, Middle Aged, Prospective Studies, Regression Analysis, Risk Factors, Cohort Studies, Smoking Cessation, Pulmonary Disease, Chronic Obstructive
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