The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index; 7 of the 31 sources its claims cite were checked for support.
Prevalence of depression and anxiety in patients with cystic fibrosis and parent caregivers: results of The International Depression Epidemiological Study across nine countries
Open accessAbstract
BACKGROUND: Individuals with chronic diseases and parent caregivers are at increased risk for symptoms of depression and anxiety. Prevalence of psychological symptoms was evaluated in adolescents and adults with cystic fibrosis (CF) and parent caregivers across nine countries. METHODS: Patients with CF, ages 12 years and older, and caregivers of children with CF, birth to18 years of age, completed measures of depression and anxiety across 154 CF centres in Europe and the USA. Psychological symptoms were compared across countries using χ(2). Logistic regression examined extent of comorbid symptoms, predictors of depression and anxiety, and concordance between parent and adolescent symptomatology. RESULTS: Psychological symptoms were reported by 6088 patients with CF and 4102 parents. Elevated symptoms of depression were found in 10% of adolescents, 19% of adults, 37% of mothers and 31% of fathers. Elevations in anxiety were found in 22% of adolescents, 32% of adults, 48% of mothers and 36% of fathers. Overall, elevations were 2-3 times those of community samples. Participants reporting elevated anxiety were more likely to report depression (ORs: adolescents=14.97, adults=13.64, mothers=15.52, fathers=9.20). Significant differences in reports of depression and anxiety were found by patient age and parent respondent. Concordance between 1122 parent-teen dyads indicated that adolescents whose parents reported depression were more likely to be elevated on depression (OR=2.32). Similarly, adolescents whose parents reported anxiety were more likely to score in the elevated range on the anxiety measure (OR=2.22). CONCLUSIONS: Symptoms of depression and anxiety were elevated in both patients with CF and parents across several European countries and the USA. Annual screening of psychological symptoms is recommended for both patients and parents.
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Claims the paper makes
77 Own result · 12 No full text of the sources · 7 Own interpretation · 5 Own method · 4 Partly supported · 4 Sources not found · 1 Supported so far · 1 No basis given · accuracy not yet measured
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“rates of anxiety from 30% to 33%.”
§ Prevalence of depression and anxiety in patients with cystic fibrosis and parent caregivers: results of The International Depression Epidemiological Study across nine countries > Why read on?
What the sources say
- Partly supportedcites [8] Havermans, 2008, Quality of life in patients with Cystic Fibrosis: association with anxiety and depression, J Cyst Fibros sourceExperimental — accuracy not yet measured
Section 3.2 (HADS) reports that 18 of 57 adult patients with cystic fibrosis (30%) scored in the borderline/clinical anxiety category. Our copy does not report a 33% rate, so it supports the lower end of the stated range but not the upper end. (LLM, conf=0.88)
- Supportedcites [10] Yohannes, 2012, Relationship between anxiety, depression, and quality of life in adult patients with cystic fibrosis, Respir Care source
The Introduction reports that 30% of adults with cystic fibrosis in an earlier study scored with anxiety symptoms. The paper’s Anxiety in Adult CF Subjects section reports anxiety symptoms in 33% of its own adult sample. Page numbers were not provided in our copy. (LLM, conf=0.94)
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Partly supported
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“Instead, the vast majority of items on the HADS-D measured anhedonia (72%), which represents lack of enjoyment and pleasure in activities.36”
§ Prevalence of depression and anxiety in patients with cystic fibrosis and parent caregivers: results of The International Depression Epidemiological Study across nine countries > DISCUSSION
What the sources say
- Partly supportedcites [36] American Psychiatric Association, 2013 sourceExperimental — accuracy not yet measured
The Symptoms and patterns passage (section dated 11 September 2026; no page given) describes loss of pleasure or interest in activities, supporting the sentence’s explanation of anhedonia. It does not discuss HADS-D items or report that 72% measure anhedonia; searches for those terms found no such passage. (LLM, conf=0.82)
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Partly supported
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Elevations in anxiety were found in 22% of adolescents, 32% of adults, 48% of mothers and 36% of fathers.”
- Also stated in: § Prevalence of symptoms of anxiety · plain
“Symptoms of anxiety were prevalent in patients and parents: adolescents 22%, adults 32%, mothers 48% and fathers 36% (see table 1 and figure 1).”
§ Prevalence of depression and anxiety in patients with cystic fibrosis and parent caregivers: results of The International Depression Epidemiological Study across nine countries > Abstract
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Also stated in: § Prevalence of symptoms of anxiety · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Elevations in anxiety were found in 22% of adolescents, 32% of adults, 48% of mothers and 36% of fathers.”
- Also stated in: § Prevalence of symptoms of anxiety · plain
“Symptoms of anxiety were prevalent in patients and parents: adolescents 22%, adults 32%, mothers 48% and fathers 36% (see table 1 and figure 1).”
§ Prevalence of depression and anxiety in patients with cystic fibrosis and parent caregivers: results of The International Depression Epidemiological Study across nine countries > Abstract
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Also stated in: § Prevalence of symptoms of anxiety · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Elevated symptoms of depression were found in 10% of adolescents, 19% of adults, 37% of mothers and 31% of fathers.”
§ Prevalence of depression and anxiety in patients with cystic fibrosis and parent caregivers: results of The International Depression Epidemiological Study across nine countries > Abstract
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Participants reporting elevated anxiety were more likely to report depression (ORs: adolescents=14.97,adults=13.64,mothers=15.52,fathers=9.20).”
§ Prevalence of depression and anxiety in patients with cystic fibrosis and parent caregivers: results of The International Depression Epidemiological Study across nine countries > Abstract
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Participants reporting elevated anxiety were more likely to report depression (ORs: adolescents=14.97,adults=13.64,mothers=15.52,fathers=9.20).”
§ Prevalence of depression and anxiety in patients with cystic fibrosis and parent caregivers: results of The International Depression Epidemiological Study across nine countries > Abstract
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Elevations in anxiety were found in 22% of adolescents, 32% of adults, 48% of mothers and 36% of fathers.”
- Also stated in: § Prevalence of symptoms of anxiety · plain
“Symptoms of anxiety were prevalent in patients and parents: adolescents 22%, adults 32%, mothers 48% and fathers 36% (see table 1 and figure 1).”
§ Prevalence of depression and anxiety in patients with cystic fibrosis and parent caregivers: results of The International Depression Epidemiological Study across nine countries > Abstract
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Also stated in: § Prevalence of symptoms of anxiety · plain
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Participants reporting elevated anxiety were more likely to report depression (ORs: adolescents=14.97,adults=13.64,mothers=15.52,fathers=9.20).”
§ Prevalence of depression and anxiety in patients with cystic fibrosis and parent caregivers: results of The International Depression Epidemiological Study across nine countries > Abstract
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Elevations in anxiety were found in 22% of adolescents, 32% of adults, 48% of mothers and 36% of fathers.”
- Also stated in: § Prevalence of symptoms of anxiety · plain
“Symptoms of anxiety were prevalent in patients and parents: adolescents 22%, adults 32%, mothers 48% and fathers 36% (see table 1 and figure 1).”
§ Prevalence of depression and anxiety in patients with cystic fibrosis and parent caregivers: results of The International Depression Epidemiological Study across nine countries > Abstract
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
- Also stated in: § Prevalence of symptoms of anxiety · plain
- It may state two separate claims as one. 12
- Probably not a substantial claim. 13
- The quote only partly states this claim. 2
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“Psychological distress in patients with CF has been associated with a number of negative consequences and health outcomes, including worse adherence, 7 14 worse pulmonary function, 10 15 increased hospitalisations and healthcare costs, 16 and decreased health-related quality of life.8 9”
§ Prevalence of depression and anxiety in patients with cystic fibrosis and parent caregivers: results of The International Depression Epidemiological Study across nine countries > Why read on?
What the sources say
- Not checked — no full text of the sourcecites [7] Smith, 2010, Depressive symptoms in children with cystic fibrosis and parents and its effects on adherence to airway clearance, Pediatr Pulmonol source
- Partly supportedcites [14] Grenard, 2011, Depression and medication adherence in the treatment of chronic diseases in the United States: a meta-analysis, J Gen Intern Med sourceExperimental — accuracy not yet measured
The Results report a significant association between depression and worse medication adherence across chronic diseases. The citation to this paper is attached to “worse adherence,” not the sentence’s other outcomes. Our copy does not establish that association specifically in patients with cystic fibrosis. (LLM, conf=0.84)
- Supportedcites [10] Yohannes, 2012, Relationship between anxiety, depression, and quality of life in adult patients with cystic fibrosis, Respir Care source
The citation to this paper is attached to decreased health-related quality of life, not to the sentence’s separate claims about adherence, hospitalisations, or costs. The Discussion reports that anxiety and depression in adults with CF were associated with impaired quality of life; it does not establish a causal direction. (LLM, conf=0.92)
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
The sources with a verdict support this claim; the rest weren’t checked yet, have no full text we could read, or their verdicts aren’t rated yet.
In the paper
“Among parent caregivers, elevations in psychological distress have also been found, with depression ranging from 20% to 35%.”
§ Prevalence of depression and anxiety in patients with cystic fibrosis and parent caregivers: results of The International Depression Epidemiological Study across nine countries > Why read on?
What the sources say
- Not checked — no full text of the sourcecites [7] Smith, 2010, Depressive symptoms in children with cystic fibrosis and parents and its effects on adherence to airway clearance, Pediatr Pulmonol source
- Not checked — no full text of the sourcecites [11] Latchford, 2013, Screening for depression in a single CF centre, J Cyst Fibros source
- Supportedcites [12] Besier, 2011, Anxiety, depression, and life satisfaction in parents caring for children with cystic fibrosis, Pediatr Pulmonol source
The Pediatric Pulmonology introductory passage reports high psychological distress among parents caring for children with cystic fibrosis and elevated depressive symptoms in 23% of fathers and 35% of mothers, consistent with the approximate 20%–35% range. The “Depressive symptoms in parents” section cautions that prevalence depends on the screening cutoff used; these figures describe elevated symptoms, not clinical diagnoses. Page numbers are unavailable in our copy. (LLM, conf=0.84)
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
The cited sources support only part of this claim — read each source’s verdict below.
In the paper
“For adults with CF, rates of depression have ranged from 13% to 30%”
§ Prevalence of depression and anxiety in patients with cystic fibrosis and parent caregivers: results of The International Depression Epidemiological Study across nine countries > Why read on?
What the sources say
- Partly supportedcites [8] Havermans, 2008, Quality of life in patients with Cystic Fibrosis: association with anxiety and depression, J Cyst Fibros sourceExperimental — accuracy not yet measured
Section 3.2 (HADS; page not provided) reports that 13% of the adult CF patients scored in the borderline/clinical category for depression. Its 30% figure refers to anxiety, not depression, so the claimed upper end of the depression range is unsupported. (LLM, conf=0.91)
- Not checked — no full text of the sourcecites [9] Riekert, 2007, The association between depression, lung function, and health-related quality of life among adults with cystic fibrosis, Chest source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
- Partly supported
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“CES-D=52%”
§ Prevalence of depression and anxiety in patients with cystic fibrosis and parent caregivers: results of The International Depression Epidemiological Study across nine countries > Prevalence of symptoms of depression
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
The quote only partly states this claim.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Statistically significant differences were found by age, with 22% of adolescents vs. 32% of adults (p<0.001)reporting elevations in anxiety above the cut-off score”
§ Prevalence of depression and anxiety in patients with cystic fibrosis and parent caregivers: results of The International Depression Epidemiological Study across nine countries > Prevalence of symptoms of anxiety
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Rates of depression varied depending on age and screening tool: adolescents 5%-19%, adults 13%-29%, mothers 20%-34% and fathers 18%-25% (table 1 and figure 1).”
§ Prevalence of depression and anxiety in patients with cystic fibrosis and parent caregivers: results of The International Depression Epidemiological Study across nine countries > Prevalence of symptoms of depression
plaincorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Analyses by country indicated high rates of anxiety among patients (mean 30%), with moderate variability across countries (14%-35%; Turkey falls within this range).”
§ Prevalence of depression and anxiety in patients with cystic fibrosis and parent caregivers: results of The International Depression Epidemiological Study across nine countries > Prevalence of symptoms of anxiety
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“Rates of anxiety were also elevated in patients and caregivers, with 30% of patients and 36%-48% of parents above the clinical cut-off.”
§ Prevalence of depression and anxiety in patients with cystic fibrosis and parent caregivers: results of The International Depression Epidemiological Study across nine countries > DISCUSSION
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A result the paper reports from its own data — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“comparisons indicated that the HADS-D underestimated symptoms of depression by a factor of two.”
§ Prevalence of depression and anxiety in patients with cystic fibrosis and parent caregivers: results of The International Depression Epidemiological Study across nine countries > DISCUSSION
hedgeddirect- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
The quote only partly states this claim.
In the paper
“Meta-analyses and systematic reviews have indicated that children and adults with chronic diseases, as well as parent caregivers, are at increased risk for depression and anxiety.”
§ Prevalence of depression and anxiety in patients with cystic fibrosis and parent caregivers: results of The International Depression Epidemiological Study across nine countries > INTRODUCTION
What the sources say
- Not matchedcites [1][2][3]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
hedgedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim.
- Not matched
The paper states this without a source or data behind it here, so there is nothing to check it against. The quote shows it is in the paper.
In the paper
“Studies evaluating depression and anxiety in patients with CF have generally found a high prevalence of psychological distress.”
§ Prevalence of depression and anxiety in patients with cystic fibrosis and parent caregivers: results of The International Depression Epidemiological Study across nine countries > INTRODUCTION
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: fails — The paper may give no reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. The paper may give no reason why it holds.
In the paper
“Cystic fibrosis (CF) is the most common genetic, life-limiting chronic disease among Caucasian populations”
§ Prevalence of depression and anxiety in patients with cystic fibrosis and parent caregivers: results of The International Depression Epidemiological Study across nine countries > INTRODUCTION
What the sources say
- Not checked — no full text of the sourcecites [4] Sawicki, 2011, Longitudinal assessment of health-related quality of life in an observational cohort of patients with cystic fibrosis, Pediatr Pulmonol source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“In analyses that pooled data across countries, this nesting was accounted for by including country as a fixed effect (i.e., different intercept for each country) in the models.”
§ Prevalence of depression and anxiety in patients with cystic fibrosis and parent caregivers: results of The International Depression Epidemiological Study across nine countries > Nesting of participants within country
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Because few participant responses were missing, this was unlikely to significantly bias the results, and we opted to use complete cases in all analyses.”
§ Prevalence of depression and anxiety in patients with cystic fibrosis and parent caregivers: results of The International Depression Epidemiological Study across nine countries > Missing data
hedged- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“It has extensive reliability and validity data, and was designed specifically for patients with chronic medical conditions (i.e., removal of somatic items).”
§ Prevalence of depression and anxiety in patients with cystic fibrosis and parent caregivers: results of The International Depression Epidemiological Study across nine countries > Hospital Anxiety and Depression Scale
What the sources say
- Not checked — no full text of the sourcecites [18] Zigmond, 1983, The hospital anxiety and depression scale, Acta Psychiatric Scand source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
In the paper
“The CES-D is a well-established self-report measure of depressive symptomatology for community samples.”
§ Prevalence of depression and anxiety in patients with cystic fibrosis and parent caregivers: results of The International Depression Epidemiological Study across nine countries > Center for Epidemiologic Studies-Depression scale
What the sources say
- Not checked — no full text of the sourcecites [19] Radloff, 1991, The use of the Center for Epidemiologic Studies Depression Scale in adolescents and young adults, J Youth Adolesc source
boosted- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“requires a treatment regimen that takes between 2 and 4 h per day.”
§ Prevalence of depression and anxiety in patients with cystic fibrosis and parent caregivers: results of The International Depression Epidemiological Study across nine countries > INTRODUCTION
What the sources say
- Not checked — no full text of the sourcecites [4] Sawicki, 2011, Longitudinal assessment of health-related quality of life in an observational cohort of patients with cystic fibrosis, Pediatr Pulmonol source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
In the paper
“It has 20 items measuring symptoms of depression that reflect diagnostic criteria on the DSM-IV and has correlated well with diagnostic interviews.”
§ Prevalence of depression and anxiety in patients with cystic fibrosis and parent caregivers: results of The International Depression Epidemiological Study across nine countries > Center for Epidemiologic Studies-Depression scale
What the sources say
- Not checked — no full text of the sourcecites [19] Radloff, 1991, The use of the Center for Epidemiologic Studies Depression Scale in adolescents and young adults, J Youth Adolesc source
boostedcorrelational- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it. It may state two separate claims as one.
What the paper did — it cites no source for this, so there is none to check. The quote shows it is in the paper.
In the paper
“Study protocols were approved by national and local ethics committees or institutional review boards at all CF centres.”
§ Prevalence of depression and anxiety in patients with cystic fibrosis and parent caregivers: results of The International Depression Epidemiological Study across nine countries > METHODS Procedure
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A claim is checked only against the cited paper’s full text, never its abstract, and none is available for its sources.
In the paper
“37% of mothers and 31% of fathers reported clinically elevated depression, which is three times the rate in community samples.23 24”
§ Prevalence of depression and anxiety in patients with cystic fibrosis and parent caregivers: results of The International Depression Epidemiological Study across nine countries > DISCUSSION
What the sources say
- Not checked — no full text of the sourcecites [23] Martin, 2006, Validity of the brief patient health questionnaire mood scale (PHQ-9) in the general population, Gen Hosp Psychiatry source
- Not checked — no full text of the sourcecites [24] Pignone, 2002, Screening for depression in adults: a summary of the evidence for the US Preventive Services Task Force, Ann Intern Med source
plain- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“it is possible that this sample is not representative of the larger international population.”
§ Prevalence of depression and anxiety in patients with cystic fibrosis and parent caregivers: results of The International Depression Epidemiological Study across nine countries > Limitations and future directions
hedgedn = 3- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: fails — The paper’s conclusions may not depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. The paper’s conclusions may not depend on it.
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“As found in prior studies, comorbidity of anxious and depressive symptoms within individuals was high, suggesting that elevations in anxiety confer a heightened risk for depression.”
§ Prevalence of depression and anxiety in patients with cystic fibrosis and parent caregivers: results of The International Depression Epidemiological Study across nine countries > DISCUSSION
hedgedconditional- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: unclear — It is unclear whether the paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
It may state two separate claims as one.
In the paper
“more recent evidence has clearly shown that this screening tool has significant problems, including lack of sensitivity, underestimation of symptoms and a threefactor, rather than two-factor structure, and is not recommended for screening.”
§ Prevalence of depression and anxiety in patients with cystic fibrosis and parent caregivers: results of The International Depression Epidemiological Study across nine countries > DISCUSSION
What the sources say
- Not matchedcites [33][34][35]
Couldn’t be matched to a paper in Crossref, so it can’t be checked.
boosted- Asserted: passes — The authors put it forward as true.
- Checkable: passes — It can be checked against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. It may state two separate claims as one.
- Not matched
A conclusion the paper draws from its own results — it cites no other source for it, so there is none to check. The quote shows it is in the paper.
In the paper
“These results highlight the importance of measuring and treating mental health issues in patients and families coping with serious, chronic illnesses.”
§ Prevalence of depression and anxiety in patients with cystic fibrosis and parent caregivers: results of The International Depression Epidemiological Study across nine countries > Limitations and future directions
plain- Asserted: passes — The authors put it forward as true.
- Checkable: fails — It may be too vague to check against evidence.
- Load-bearing: passes — The paper’s conclusions depend on it.
- Based: passes — The paper gives a reason why it holds.
Probably not a substantial claim. It may be too vague to check against evidence.
The paper relies on this without support.
Prior studies of depression and anxiety in cystic fibrosis have been limited by small sample sizes and different screening or diagnostic tools, making interpretation of the results difficult.
“however, these studies have been limited by small sample sizes and different screening or diagnostic tools, which have made interpretation of the results difficult.”
The paper relies on this without support.
The majority of studies have only assessed symptoms of depression but not anxiety in cystic fibrosis.
“Additionally, the majority of studies have only assessed symptoms of depression but not anxiety.”
The paper relies on this without support.
The Center for Epidemiologic Studies-Depression scale includes items representing the full spectrum of depressive symptoms underlying the construct.
“By contrast, the CES-D included items representing the full spectrum of depressive symptoms underlying this construct.”
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“These results are similar to those found in the TIDES study [12], in which only IVs and other markers of pulmonary exacerbations and events, such as hemoptysis, were related to depression and anxiety.”
From Rates of depression and anxiety in Italian patients with cystic fibrosis and parent caregivers: Implementation of the Mental Health Guidelines (2020) · cites this paper as [12]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Like most chronic conditions, PwCF and their families are at greater risk of mental health issues due to multiple factors (22).”
From Virtual monitoring in CF – the importance of continuous monitoring in a multi-organ chronic condition (2023) · cites this paper as [22]
Experimental — accuracy not yet measuredThe cited source says what the claim attributes to it.
In the citing paper
“Elevated symptoms of anxiety were found in 32% of adults, 22% of adolescents, 48% of mothers and 36% of fathers [12].”
From Rates of depression and anxiety in Italian patients with cystic fibrosis and parent caregivers: Implementation of the Mental Health Guidelines (2020) · cites this paper as [12]
The cited source says what the claim attributes to it.
In the citing paper
“In the largest mental health screening study to date in nine countries, which included 6088 individuals with CF and 4102 parent caregivers, a substantial proportion reported elevated symptoms of depression and anxiety.Elevated symptoms of depression were found in 19% of adults, 10% of adolescents, 37% of mothers and 31% of fathers.”
From Rates of depression and anxiety in Italian patients with cystic fibrosis and parent caregivers: Implementation of the Mental Health Guidelines (2020) · cites this paper as [12]
The cited source says what the claim attributes to it.
In the citing paper
“These Italian prevalence statistics are higher than those published in the TIDES study [12] most likely because the screening tools recommended in the guidelines are more sensitive to these symptoms [33].”
From Rates of depression and anxiety in Italian patients with cystic fibrosis and parent caregivers: Implementation of the Mental Health Guidelines (2020) · cites this paper as [12]
The cited source says what the claim attributes to it.
In the citing paper
“These results converge with those reported in the TIDES study [12], and suggest that both depression and anxiety should be a focus of interventions.”
From Rates of depression and anxiety in Italian patients with cystic fibrosis and parent caregivers: Implementation of the Mental Health Guidelines (2020) · cites this paper as [12]
The cited source says what the claim attributes to it.
In the citing paper
“Average lung function for the sample of 113 adults was 76% predicted (SD = 23), which is substantially higher than the average lung function reported by both the Quon et al.'s in the US [34] and the TIDES study [12].”
From Rates of depression and anxiety in Italian patients with cystic fibrosis and parent caregivers: Implementation of the Mental Health Guidelines (2020) · cites this paper as [12]
The cited source says what the claim attributes to it.
In the citing paper
“In the Quon study of adults, mean FEV 1 % pred was 54.8% and in the TIDES study across 9 countries, mean lung function for adults was 62.3% pred.”
From Rates of depression and anxiety in Italian patients with cystic fibrosis and parent caregivers: Implementation of the Mental Health Guidelines (2020) · cites this paper as [12]
The cited source says what the claim attributes to it.
In the citing paper
“Anxiety and depressive symptoms are 2 to 3 times more common among individuals with cystic fibrosis (CF) than the general population [1]”
From ACT with CF: A telehealth and in-person feasibility study to address anxiety and depressive symptoms among people with cystic fibrosis (2021) · cites this paper as [1]
The cited source says what the claim attributes to it.
In the citing paper
“It is important to note that previous studies found symptoms of depression were elevated in people with CF, with Quittner et al. [20] reporting that among 6088 patients with CF, 5–19% of adolescents and 13–29% of adults had elevated symptoms of depression.”
The cited source says what the claim attributes to it.
In the citing paper
“While people with CF experience depression and anxiety at a rate 2-3 × greater than the general population [20]”
From Real-world safety and effectiveness of elexacaftor/tezacaftor/ivacaftor in people with cystic fibrosis: Interim results of a long-term registry-based study (2023) · cites this paper as [20]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
Each contradiction between two passages listed here was confirmed by an independent check.
Rated major: it would touch a result — a value a result rests on, reported and recomputed p-values on opposite sides of the significance level, two passages that conflict with no sign which is right, or a cited work retracted before this paper was published.
In the paper
§ Prevalence of depression and anxiety in patients with cystic fibrosis and parent caregivers: results of The International Depression Epidemiological Study across nine countries > Predictors of depression and anxiety
“Characteristics associated with elevated symptoms of anxiety were: older age, being female, lower BMI, lower FEV 1 , haemoptysis/pneumothorax, listed for transplant, taking psychiatric medications and receiving psychotherapy.”
§ Prevalence of depression and anxiety in patients with cystic fibrosis and parent caregivers: results of The International Depression Epidemiological Study across nine countries > Limitations and future directions
“| BMI | 0.99 (0.95 to 1.04) | 0.793 1.03 (1.01 to 1.05) | 0.003 0.99 (0.97 to 1.02) | 0.504 0.98 (0.94 to 1.03) | 0.530 | | | |”
Rated minor: it would not touch a result — a value no result rests on, a p-value that stays on the same side of the significance level, or a conflict that is clerical, resolved elsewhere in the paper, or outside its own findings.
In the paper
§ Prevalence of depression and anxiety in patients with cystic fibrosis and parent caregivers: results of The International Depression Epidemiological Study across nine countries > Abstract
“adolescents whose parents reported depression were more likely to be elevated on depression (OR=2.32)”
§ Prevalence of depression and anxiety in patients with cystic fibrosis and parent caregivers: results of The International Depression Epidemiological Study across nine countries > Concordance between parent and adolescent depression and anxiety
“adolescents were 2.39 times more likely be above the cut-off for depression if at least one of their parents had elevated symptoms”
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Self-citationPiloting a more intensive 8‐week mindfulness programme in early‐ and mid‐adolescent school students
Johnson, C., & Wade, T. D. (2019) · Early Intervention in Psychiatry · doi:10.1111/eip.12801 · Cited by 25
“Lesson length in a previous RCT testing this curriculum (Raes et al., 2014) was 100 minutes, which we shortened to 90 minutes to suit school timetables inclusive of a 10-minute mid-lesson break.”
BackgroundWellness for Families of Children With Chronic Health Disorders
Boat, T. F., Filigno, S. S., & Amin, R. S. (2017) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/jamapediatrics.2017.1682 · Cited by 25
Descriptions of the Pain Experience in Adults and Adolescents with Cystic Fibrosis
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“Individuals living with CF are at risk for developing symptoms of anxiety and depression (Quittner et al., 2014).”
BackgroundMethodInfluentialSelf-citationBathgate, C. J., Kilbourn, K. M., Murphy, N. H., Wamboldt, F. S., & Holm, K. E. (2021) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2021.07.012 · Cited by 24
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“Much of the delivery of health care in CF focuses on treating physical problems; however screening and treating mental health issues are just as important for individuals living with a chronic condition [26].”
BackgroundClinical communication preferences in cystic fibrosis and strategies to optimize care
Cooley, L., Hudson, J. N., Potter, E., Raymond, K. F., George, C., & Georgiopoulos, A. M. (2020) · Pediatric Pulmonology · doi:10.1002/ppul.24655 · Cited by 25
Positive mental health and wellbeing in adults with cystic fibrosis: a cross sectional study
Cronly, J., Duff, A., Riekert, K., Horgan, A., Lehane, E., Perry, I., Fitzgerald, A., Howe, B., Chroinin, M. N., & Savage, E. (2019) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2018.11.016 · Cited by 24
Symptom Burden and Unmet Existential Needs in Adults With Cystic Fibrosis
Trandel, E. T., Pilewski, J. M., Dellon, E. P., Moreines, L. T., Yabes, J. G., Jeong, K., Arnold, R. M., & Kavalieratos, D. (2019) · Western Journal of Nursing Research · doi:10.1177/0193945919852585 · Cited by 23
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“The prevalence of depression and anxiety symptoms in pwCF is 2–3 times that of the general population, with more frequent elevations in adults than adolescents.(2) For pwCF endorsing mild symptoms during routine depression/anxiety screen-”
BackgroundSelf-citationJohnson, C., & Wade, T. (2021) · Mindfulness · doi:10.1007/s12671-021-01716-3 · Cited by 22
Evaluation of Anxiety, Depression and Burden on Caregivers of Children with Cerebral Palsy
Barutçu, A., Barutçu, S., Kolkiran, S., & Özdener, F. (2021) · Developmental Neurorehabilitation · doi:10.1080/17518423.2021.1917718 · Cited by 21
“Despite the higher global prevalence of depression in comparison to anxiety, other caregiver studies showed that depression is less prevalent (34% versus 44%.(29), 184% versus 47%.”
ResultLived experiences of individuals with cystic fibrosis on CFTR-modulators
Page, A., Goldenberg, A. J., & Matthews, A. L. (2022) · BMC Pulmonary Medicine · doi:10.1186/s12890-022-01825-2 · Cited by 22
“Some studies show that individuals with cystic fibrosis are not at more risk to have mental illness such as anxiety and depression than their peers [15], while other studies have shown that symptoms of depression are prevalent among young adults with CF [16].”
BackgroundKelada, L., Wakefield, C. E., Muppavaram, N., Lingappa, L., & Chittem, M. (2020) · Psychology and Health · doi:10.1080/08870446.2020.1859113 · Cited by 23
“(Quittner et al., 2014; van Oers et al., 2014).”
Suicide and suicidality in children and adolescents with chronic illness: A systematic review
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Psychiatric morbidity and quality of life in children and adolescents with cystic fibrosis
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Management of Mental Health in Cystic Fibrosis
Bathgate, C. J., Hjelm, M., Filigno, S. S., Smith, B. A., & Georgiopoulos, A. M. (2022) · Clinics in Chest Medicine · doi:10.1016/j.ccm.2022.06.014 · Cited by 21
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Documenting an epidemic of suffering: low health-related quality of life among transgender youth
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Prevention of anxiety and depression in cystic fibrosis
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Verkleij, M., Appelman, I., Altenburg, J., Twisk, J. W. R., Quittner, A. L., & Haarman, E. G. (2021) · ERJ Open Research · doi:10.1183/23120541.00274-2021 · Cited by 21
Self-citationKauser, S., Keyte, R., Regan, A., Nash, E. F., Fitch, G., Mantzios, M., & Egan, H. H. (2021) · Journal of Clinical Psychology in Medical Settings · doi:10.1007/s10880-021-09831-y · Cited by 28
“Psychological comorbidities of depression and anxiety are extremely prevalent across the CF population (Quittner et al., 2014).”
BackgroundFood insecurity and mental health during the COVID‐19 pandemic in cystic fibrosis households
Lim, J. T., Ly, N. P., Willen, S. M., Iwanaga, K., Gibb, E. R., Chan, M., Church, G. D., Neemuchwala, F., & McGarry, M. E. (2022) · Pediatric Pulmonology · doi:10.1002/ppul.25850 · Cited by 20
“Because there is increased food insecurity, depression, and anxiety in people with CF, they are vulnerable to experiencing worsening food insecurity and mental health during the pandemic.(5,9) The impact of the pandemic on food insecurity, mental health, and self‐care in people with CF is not clear.”
BackgroundGraziano, S., Ullmann, N., Rusciano, R., Allegorico, A., Boldrini, F., Rosito, L., Quittner, A. L., Cutrera, R., & Tabarini, P. (2022) · Respiratory Medicine · doi:10.1016/j.rmed.2022.107095 · Cited by 21
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“Parents raising children with another chronic, life-threatening, genetic condition, cystic fibrosis, have noted elevated depression and anxiety across several European countries and the USA (Quittner et al. 2014).”
BackgroundMowla, F., Khanjari, S., & Inanlou, M. (2017) · Journal of Pediatric Nursing · doi:10.1016/j.pedn.2017.02.037 · Cited by 20
“…overwhelming guilt and uncertainty, loss of control, and dwindling positive adaptation (Cassidy & McLaughlin, 2015; Churchill, Villareale, Monaghan, Sharp, & Kieckhefer, 2010; Khanjari, Oskouie, & Langius-Eklof, 2012; Khanna, Prabhakaran, Patel, Ganjiwale, & Nimbalkar, 2015; Quittner et al., 2014).”
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Prevalence of unmet pain and symptom management needs in adults with cystic fibrosis
Dubin, E. H., Lowers, J., Dellon, E. P., Hempstead, S. E., Faro, A., Tallarico, E., Fitzpatrick, A. M., Hunt, W. R., & Kavalieratos, D. (2022) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2022.08.006 · Cited by 19
Assessing psychosocial risk in pediatric cystic fibrosis
Filigno, S. S., Miller, J. L., Moore, S., Peugh, J., Weiland, J., Backstrom, J., & Borschuk, A. P. (2019) · Pediatric Pulmonology · doi:10.1002/ppul.24414 · Cited by 19
Cognitive functioning and mental health in mitochondrial disease: A systematic scoping review
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Racial inequities and rare CFTR variants: Impact on cystic fibrosis diagnosis and treatment
Wu, M., Davis, J. D., Zhao, C., Daley, T. C., & Oliver, K. E. (2024) · Journal of Clinical & Translational Endocrinology · doi:10.1016/j.jcte.2024.100344 · Cited by 19
Johnson, D. A., Meltzer, L. J., Zhang, T., Lü, M., Cassidy‐Bushrow, A. E., Stokes‐Buzzelli, S., Duffy, E. A., McKinnon, B., Mahajan, P., Redline, S. S., et al. (2017) · Sleep Health · doi:10.1016/j.sleh.2017.11.003 · Cited by 18
Acute and chronic non-pulmonary complications in adults with cystic fibrosis
Regard, L., Martin, C., Chassagnon, G., & Burgel, P. (2018) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2019.1552832 · Cited by 18
“(13–33%) [181], the symptoms of which can have a negative”
BackgroundRe-imagining cystic fibrosis care: next generation thinking
Rang, C., Keating, D., Wilson, J. W., & Kotsimbos, T. C. (2020) · European Respiratory Journal · doi:10.1183/13993003.02443-2019 · Cited by 18
Liu, F. F., Lew, A., Andes, E., McNamara, S., Cassidy, J., Whitmore, S., Plunkett, R., & Ong, T. (2020) · Pediatric Pulmonology · doi:10.1002/ppul.24951 · Cited by 17
Assessment of treatment burden and complexity in cystic fibrosis: A quality improvement project
Hente, E. A., Weiland, J., Mullen, L., Hawke, J. L., Schuler, C. L., Filigno, S. S., & Siracusa, C. M. (2021) · Pediatric Pulmonology · doi:10.1002/ppul.25361 · Cited by 17
Cystic fibrosis-related diabetes (CFRD) and cognitive function in adults with cystic fibrosis
Chadwick, H. K., Abbott, J., Hurley, M. A., Dye, L., Lawton, C. L., Mansfield, M. W., & Peckham, D. G. (2021) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2021.04.014 · Cited by 17
Self-citationObstructive sleep apnea and nocturnal hypoxemia in adult patients with cystic fibrosis
Welsner, M., Dietz-Terjung, S., Stehling, F., Schulte, T., Niehammer, U., Gahbiche, F.-E., Taube, C., Straßburg, S., Schoebel, C., Weinreich, G., et al. (2022) · BMC Pulmonary Medicine · doi:10.1186/s12890-022-02243-0 · Cited by 17
“Depression and anxiety are well known comorbidities in pwCF [56], and these can impact on sleep quality [24, 54].”
BackgroundFajac, I., & Burgel, P. (2023) · La Presse Médicale · doi:10.1016/j.lpm.2023.104169 · Cited by 16
The treatment of the pulmonary and extrapulmonary manifestations of cystic fibrosis
Chin, M., Aaron, S. D., & Bell, S. C. (2017) · La Presse Médicale · doi:10.1016/j.lpm.2016.11.030 · Cited by 16
Friedman, D., Linnemann, R. W., Altstein, L. L., Georgiopoulos, A. M., Islam, S., Bach, K., John, A. S., Fracchia, M. S., Neuringer, I. P., Lapey, A., et al. (2019) · Pediatric Pulmonology · doi:10.1002/ppul.24311 · Cited by 17
Depression in Medically Ill Children and Adolescents
Malas, N., Plioplys, S., & Pao, M. (2019) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2019.02.005 · Cited by 18
Duff, A. J. A. (2015) · Paediatric Respiratory Reviews · doi:10.1016/j.prrv.2015.07.006 · Cited by 17
“if a parent was also elevated [15].”
BackgroundInfluentialGeorgiopoulos, A. M., Friedman, D., Porter, E. A., Krasner, A., Kakarala, S. P., Glaeser, B. K., Napoleon, S. C., & Wozniak, J. R. (2017) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2017.08.011 · Cited by 17
Current perspectives of physical activity in cystic fibrosis
Cox, N. S., & Holland, A. E. (2018) · Expert Review of Respiratory Medicine · doi:10.1080/17476348.2019.1552833 · Cited by 17
“For people with CF, who report elevated symptoms of depression and anxiety 2–3 times more often than community samples [52], regular physical activity participation could potentially play a crucial role in alleviating psychological distress.”
BackgroundParental Depression Screening in Pediatric Health Care Settings: A Scoping Review
Hunt, A., Uthirasamy, N., Porter, S., & Jiménez, M. E. (2022) · PEDIATRICS · doi:10.1542/peds.2021-055804 · Cited by 17
Allgood, S., Levy, R., Bubaris, D., Riekert, K. A., Psoter, K. J., & Lechtzin, N. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e20110 · Cited by 17
“These non-pulmonary complications include pain [4,5], fatigue [6], sinus disease [7], gastrointestinal problems [8], depression [9], anxiety [10], and sleep disturbance [11].”
Backström-Eriksson, L., Sorjonen, K., Brucefors, A. B., Hjelte, L., & Melin, B. (2015) · BMC Pulmonary Medicine · doi:10.1186/s12890-015-0117-9 · Cited by 16
“The three largest CF centres (out of four) in Sweden recruited participants to the study; these were the adult patients in the Swedish arm of TIDES.”
BackgroundMethodResultInfluentialSelf-citationMartínez, P., Rojas, G., Rosemarie Fritsch, M., Martínez, V., Vöhringer, P. A., & Castro, A. (2017) · Revista médica de Chile · doi:10.4067/s0034-98872017000100004 · Cited by 20
Mental Health Screening of Medically-Admitted Patients With Cystic Fibrosis
García, G., Snell, C., Sawicki, G. S., & Simons, L. E. (2017) · Psychosomatics · doi:10.1016/j.psym.2017.08.010 · Cited by 15
“TIDES found that a significant proportion of patients with CF report elevated levels of global depression (10% of adolescents and 19% of adults) and anxiety (22% of adolescents and 32% of adults).(5) This represents a two-fold to three-fold increase in risk for depression and anxiety for both age groups relative to th…”
BackgroundMethodResultInfluentialBreathlessness catastrophizing relates to poorer quality of life in adults with cystic fibrosis
Maras, D., Balfour, L., Tasca, G. A., Gaudet, E., Aaron, S. D., Cameron, D. W., & Pakhale, S. S. (2018) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2018.08.008 · Cited by 16
Bell, S. C., Mainz, J. G., MacGregor, G., Madge, S. L., Macey, J., Fridman, M., Suthoff, E. D., Narayanan, S., & Kinnman, N. (2019) · BMC Pulmonary Medicine · doi:10.1186/s12890-019-0887-6 · Cited by 16
Promoting emotional wellness in children with cystic fibrosis, Part I: Child and family resilience
Prieur, M. G., Christon, L., Mueller, A., Smith, B. A., Georgiopoulos, A. M., Boat, T. F., & Filigno, S. S. (2020) · Pediatric Pulmonology · doi:10.1002/ppul.24958 · Cited by 16
“In one study, lower levels of negative friendship qualities were associated with more treatment adherence, and higher levels of positive friendship qualities were associated with higher health‐related quality of life but with lower levels of treatment adherence, potentially as positive friendship quality is linked to…”
BackgroundInfluentialVirtual Peer Support for People With Cystic Fibrosis and Their Family Members: A Program Evaluation
Jeffrey, A., Andracchio, L., Dvorak, M., et al. (2020) · Journal of Patient Experience · doi:10.1177/2374373520974322 · Cited by 16
“As outlined by the CDC, we (1) engaged stakeholders; (2) described the program; (3) focused the evaluation design; (4) gathered credible evidence; and (5) drew conclusions and submitted this manuscript to share findings and lessons learned (https://www.”
BackgroundSelf-reported alcohol use in the cystic fibrosis community
Lowery, E. M., Afshar, M., West, N. E., Kovacs, E. J., Smith, B. A., & Joyce, C. (2019) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2019.06.004 · Cited by 16
“28 High school/GED 183 (25) 44 (26) 20 (39)”
Goldbeck, L., Fidika, A., Herle, M., & Quittner, A. L. (2015) · Thorax · doi:10.1136/thoraxjnl-2015-207297 · Cited by 16
Self-citationRacial Disparities in Mental Health Disorders in Youth with Chronic Medical Conditions
Gonzalez, V. J., Kimbro, R. T., Shabosky, J. C., Kostelyna, S. P., Fasipe, T., Villafranco, N. M., Cutitta, K. E., & Lopez, K. N. (2023) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2023.113411 · Cited by 15
“8,31 The relationship between caregiver and childhood mental illness is likely bidirectional in nature, influenced by cultural norms and race, given that the majority of patients with CF are non-Hispanic White, and that this group tends to have better access to and less stigma associated with…”
Experiences of adults with cystic fibrosis in adhering to medication regimens
Macdonald, M., Martin‐Misener, R., Helwig, M., Smith, L. J., Godfrey, C. M., Curran, J., & Murphy, A. L. (2016) · The JBI Database of Systematic Reviews and Implementation Reports · doi:10.11124/jbisrir-2016-002362 · Cited by 15
“Women reported experiencing depression, and Quittner et al.5 recently confirmed this in a nine-country study involving 4739 adults in which depression rates were double that of the general population and women experienced higher rates than men.”
BackgroundResultAnxiety and Depression in Parent Caregivers of Children with Cystic Fibrosis
Cronly, J., Horgan, A. M., Lehane, E. A., Howe, B., Duff, A. J. A., Riekert, K. A., Perry, I. J., Fitzgerald, T., Chróinín, M. N., & Savage, E. (2019) · Journal of Child and Family Studies · doi:10.1007/s10826-019-01349-0 · Cited by 15
Self-citationWy, S., Choe, S., Lee, Y. J., Bak, E., Jang, M., Lee, S. C., Ha, A., Jeoung, J. W., Park, K. H., & Kim, Y. K. (2022) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2022.01.025 · Cited by 15
van de Kamp, J. M., Bökenkamp, A., Smith, D. E. C., Wamelink, M. M. C., Jansen, E. E. W., Struys, E. A., Waisfisz, Q., Verkleij, M., Hartmann, M. F., Wang, R., et al. (2022) · Clinical Genetics · doi:10.1111/cge.14239 · Cited by 12
Friedman, D., Kaskas, M. M., Quittner, A. L., Smith, B. A., & Georgiopoulos, A. M. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.937189 · Cited by 15
“The prevalence of depression and anxiety in people with cystic fibrosis (pwCF) is 2 to 3 times the general population (Quittner et al., 2014).”
BackgroundSelf-citationBullying and mental health amongst Australian children and young people with cystic fibrosis.
Branch‐Smith, C., Shaw, T., Lin, A. P., Runions, K., Payne, D., Nguyen, R. L., Hugo, H., Balding, L., & CROSS, D. S. (2018) · American Journal of Orthopsychiatry · doi:10.1037/ort0000289 · Cited by 15
Sherman, A. C., Simonton-Atchley, S., O’Brien, C. E., Campbell, D., Reddy, R. M., Guinee, B., Wagner, L. D., & Anderson, P. J. (2021) · Journal of Religion and Health · doi:10.1007/s10943-021-01185-x · Cited by 15
Telemedicine in cystic fibrosis
Desimone, M. E., Sherwood, J. S., Soltman, S., & Moran, A. (2021) · Journal of Clinical & Translational Endocrinology · doi:10.1016/j.jcte.2021.100270 · Cited by 14
Acaster, S., Mukuria, C., Rowen, D., Brazier, J. E., Wainwright, C. E., Quon, B. S., Duckers, J. M., Quittner, A. L., Lou, Y., Sosnay, P. R., et al. (2022) · Value in Health · doi:10.1016/j.jval.2022.12.002 · Cited by 14
Self-citationTrajectories of caregiver burden in families of adult cystic fibrosis patients
Wojtaszczyk, A., Glajchen, M., Portenoy, R. K., Berdella, M. N., Walker, P., Barrett, M., Chen, J., Plachta, A., Balzano, J. E., Fresenius, A., et al. (2017) · Palliative & Supportive Care · doi:10.1017/s1478951517000918 · Cited by 15
“Prior studies on caregivers of children with CF show that 19–37% report anxiety, depression, and impaired life satisfaction (Besier et al., 2011; Quittner et al., 2014).”
BackgroundLiving with cystic fibrosis – a qualitative study of a life coaching intervention
Knudsen, K. B., Boisen, K. A., Katzenstein, T. L., Mortensen, L. H., Pressler, T., Skov, M., & Jarden, M. (2018) · Patient Preference and Adherence · doi:10.2147/ppa.s159306 · Cited by 14
“Several studies have found that people with CF have low adherence to treatment and an increased prevalence of anxiety and depression.(3,5,6) Psychological health problems are burdensome in themselves; besides, they may negatively affect quality of life, and furthermore reduce adherence to treatment.”
BackgroundRegard, L., Lafoeste, H., Martin, C., Chassagnon, G., & Burgel, P. (2018) · Revue de Pneumologie Clinique · doi:10.1016/j.pneumo.2018.09.012 · Cited by 14
Noij, L. C. E., Haarman, E. G., Hashimoto, S., Terheggen‐Lagro, S. W. J., Altenburg, J., Twisk, J. W. R., & Verkleij, M. (2023) · Pediatric Pulmonology · doi:10.1002/ppul.26427 · Cited by 14
“Due to the progressive nature and burden of disease and treatments, the prevalence of symptoms of depression and anxiety in PwCF has shown to be two to three times higher than in community samples,(10) which has been associated with negative health outcomes including worse adherence, increased hospitalizations, and de…”
BackgroundIntegrating Patient-Reported Outcomes Into Research and Clinical Practice
Quittner, A. L., Nicolais, C. J., & Saez-Flores, E. (2019) · Elsevier eBooks · doi:10.1016/b978-0-323-44887-1.00013-4 · Cited by 15
Self-citationMueller, A., Georgiopoulos, A. M., Reno, K., Roach, C. M., Kvam, C. M., Quittner, A. L., Lomas, P., Smith, B. A., & Filigno, S. S. (2020) · Health & Social Work · doi:10.1093/hsw/hlaa009 · Cited by 14
Self-citationCystic fibrosis – Ten promising therapeutic approaches in the current era of care
Somayaji, R., Nichols, D. P., & Bell, S. C. (2020) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2020.1805733 · Cited by 12
Glasscoe, C., Hope, H. F., Lancaster, G., McCray, G., West, K., Patel, L. B., Patel, T., Hill, J., Quittner, A. L., & Southern, K. W. (2022) · Psychology and Health · doi:10.1080/08870446.2021.2013483 · Cited by 13
Self-citationPsychosocial needs and interventions for young children with cystic fibrosis and their families
Li, S., Douglas, T. A., & Fitzgerald, D. A. (2023) · Paediatric Respiratory Reviews · doi:10.1016/j.prrv.2023.04.002 · Cited by 13
Panthi, V. K., Fairfull‐Smith, K. E., & Islam, N. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.105517 · Cited by 14
Schmid‐Mohler, G., Caress, A., Spirig, R., & Yorke, J. (2019) · Journal of Advanced Nursing · doi:10.1111/jan.13968 · Cited by 13
“Thus, patients who experience severe deterioration of their chronic condition suffer increased levels of anxiety and depressive symptoms in the longer term (Man et al., 2015; Olveira et al., 2016; Quittner et al., 2014; Snell, Fernandes, Bujoreanu, & Garcia, 2014; Teixeira et al., 2015).”
BackgroundLaunois, C., Ravoninjatovo, B., Guguen, C., et al. (2021) · BMC Pulmonary Medicine · doi:10.1186/s12890-021-01473-y · Cited by 13
“Methods: Twenty-eight CF patients (18M/10F), with a median age of 27 (22-34) (median (interquartile range) years and a median of forced expiratory volume in one second of 72 (39-93) % predicted completed questionnaires on insomnia (Insomnia Severity Index, ISI), sleep quality (PSQI), daytime sleepiness (Epworth), rest…”
BackgroundMethodAssociation between insurance variability and early lung function in children with cystic fibrosis
Dickinson, K. M., Psoter, K. J., Riekert, K. A., & Collaco, J. M. (2021) · Journal of Cystic Fibrosis · doi:10.1016/j.jcf.2021.06.006 · Cited by 13
Drug interactions and treatment burden as survival improves
Nichols, D. P., Kuk, K. N., & Nick, J. A. (2015) · Current Opinion in Pulmonary Medicine · doi:10.1097/mcp.0000000000000212 · Cited by 13
Current Concepts of Transition of Care in Cystic Fibrosis
Patel, A., Dowell, M. L., & Giles, B. L. (2017) · Pediatric Annals · doi:10.3928/19382359-20170425-02 · Cited by 13
Parent knowledge of disease management in cystic fibrosis: Assessing behavioral treatment management
Nicolais, C. J., Bernstein, R. M., Riekert, K. A., & Quittner, A. L. (2017) · Pediatric Pulmonology · doi:10.1002/ppul.23916 · Cited by 13
“adolescents with CF and parents are at elevated risk for depression and anxiety.(36) Given the gaps in parent knowledge identified in this study, we recommend that parents complete the KDM-CF-P annually, with”
BackgroundSelf-citationElce, V., Pizzo, L. G. D., Nigro, E., Frisso, G., Martiniello, L., Daniele, A., & Elce, A. (2020) · Diagnostics · doi:10.3390/diagnostics10070489 · Cited by 13
“The International Depression/Anxiety Study (TIDES) reported a high prevalence of psychological diseases, such as anxiety and depression, in both adults and adolescents with CF [21].”
BackgroundO'Hayer, C. V., Smith, P. J., Drescher, C. F., Bruschwein, H., Nurse, C. N., Kushner, H. M., Ingle, K., Stephen, M. J., & Hoag, J. B. (2024) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2024.11.011 · Cited by 12
Patient acceptance and outcome of mental health screening in Swedish adults with cystic fibrosis
Järvholm, S., Ericson, P., & Gilljam, M. (2020) · Quality of Life Research · doi:10.1007/s11136-020-02417-5 · Cited by 11
Psychosocial and mental health in cystic fibrosis in the modern era of care: time to evolve
Harrigan, M., Georgiopoulos, A. M., Quittner, A. L., Smith, B. A., & Douglas, T. A. (2025) · BMJ Open Respiratory Research · doi:10.1136/bmjresp-2024-002606 · Cited by 11
“…in the CF community have led to the integration of standardised anxiety and depression screening and management procedures into routine CF care, 8 13 14 providing a harmo-nised approach to mental health management in CF. 13 Currently, few such recommendations or standardised approaches exist…”
Self-citationLandau, E., Verkleij, M., Graziano, S., Quittner, A. L., Georgiopoulos, A. M., Smith, B. A., Schechter, M. S., & Abbott, J. (2022) · Respiratory Medicine · doi:10.1016/j.rmed.2022.106955 · Cited by 12
Self-citationQuittner, A. L., Barker, D., Graziano, S., Georgiopoulos, A. M., Muther, E., Verkleij, M., Schechter, M. S., Tillman, L., Mueller, A., Lomas, P., et al. (2023) · Pediatric Pulmonology · doi:10.1002/ppul.26400 · Cited by 12
“First, survey questions assessing each CF Program's experience were grouped into 1 of the 5 primary domains of the CFIR model: (1) Intervention characteristics—annual mental health screening, provision of psychological interventions by CF care team members, referrals for treatment; (2) Outer setting—educational materi…”
MethodInfluentialSelf-citationPsychiatric Aspects of Organ Transplantation in Critical Care
Sher, Y. I., & Zimbrean, P. C. (2017) · Critical Care Clinics · doi:10.1016/j.ccc.2017.03.009 · Cited by 12
Beyond the Lungs—Emerging Challenges in Adult Cystic Fibrosis Care
Mulrennan, S. A., Sapru, K., Tewkesbury, D. H., & Jones, A. M. (2022) · Seminars in Respiratory and Critical Care Medicine · doi:10.1055/s-0042-1758734 · Cited by 12
Pilot trial of light therapy for depression in hospitalized patients with cystic fibrosis
Kopp, B. T., Hayes, D., Ghera, P., Patel, A. V., Kirkby, S. E., Kowatch, R. A., & Splaingard, M. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.08.056 · Cited by 12
“We found that depressive symptoms are much more common in acutely ill CF patients than reported in clinically stable settings (Quittner et al., 2014; Quon et al., 2014).”
Background
Metadata
- Authors
- Quittner, A. L., Goldbeck, L., Abbott, J., Duff, A., Lambrecht, P., Solé, A., Tibosch, M. M., Bergsten Brucefors, A., Yüksel, H., Catastini, P., Blackwell, L., & Barker, D.
- Affiliations
- University of Miami (US)
- University Hospital Ulm (DE)
- University of Lancashire (GB)
- Leeds Teaching Hospitals NHS Trust (GB)
- Université Libre de Bruxelles (BE)
- Radboud University Nijmegen (NL)
- Manisa Celal Bayar University (TR)
- Meyer Children's Hospital (IT)
- Boston Children's Hospital (US)
- Brown University (US)
- Corresponding author
- Quittner, Alexandra L
- ORCID
- Venue
- Thorax
- Publisher
- BMJ
- Published
- 2014-09-21
- Volume
- 69
- Issue
- 12
- Pages
- 1090-1097
- ISSN
- 0040-6376 (ISSN-L)
- 1468-3296
- OpenAlex
- W2107382266
- Cited by
- 524
- References
- 42
- Citations by year
- 2026: 29 · 2025: 37 · 2024: 42 · 2023: 60 · 2022: 74 · 2021: 65 · 2020: 50 · 2019: 33 · 2018: 44 · 2017: 32 · 2016: 24 · 2015: 31 · 2014: 2
- FWCI
- 23.76
- Type
- journal article
- Language
- en
- Open access
- green
- thorax.bmj.com
- Locations
- Thorax (publishedVersion)
- PubMed (publishedVersion)
- CLOK (University of Central Lancashire) (acceptedVersion)
- HighWire Press Open Archive (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cystic Fibrosis Research Advances
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Keywords
- cystic fibrosis, depression, anxiety, parental caregivers, caregiver burden, adolescents, adults, comorbidities, cross-national comparison, psychological screening
- MeSH terms
- Adolescent, Adult, Anxiety, Child, Cystic Fibrosis, Depression, Europe, Family Health, Female, Humans, Male, Middle Aged, Parents, Psychiatric Status Rating Scales, Risk Factors, Turkey, United States, Comorbidity, Prevalence, Caregivers, Young Adult
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