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Design and methods of the Population Assessment of Tobacco and Health (PATH) Study
Open accessAbstract
BACKGROUND: This paper describes the methods and conceptual framework for Wave 1 of the Population Assessment of Tobacco and Health (PATH) Study data collection. The National Institutes of Health, through the National Institute on Drug Abuse, is partnering with the Food and Drug Administration's (FDA) Center for Tobacco Products to conduct the PATH Study under a contract with Westat. METHODS: The PATH Study is a nationally representative, longitudinal cohort study of 45 971 adults and youth in the USA, aged 12 years and older. Wave 1 was conducted from 12 September 2013 to 15 December 2014 using Audio Computer-Assisted Self-Interviewing to collect information on tobacco-use patterns, risk perceptions and attitudes towards current and newly emerging tobacco products, tobacco initiation, cessation, relapse behaviours and health outcomes. The PATH Study's design allows for the longitudinal assessment of patterns of use of a spectrum of tobacco products, including initiation, cessation, relapse and transitions between products, as well as factors associated with use patterns. Additionally, the PATH Study collects biospecimens from consenting adults aged 18 years and older and measures biomarkers of exposure and potential harm related to tobacco use. CONCLUSIONS: The cumulative, population-based data generated over time by the PATH Study will contribute to the evidence base to inform FDA's regulatory mission under the Family Smoking Prevention and Tobacco Control Act and efforts to reduce the Nation's burden of tobacco-related death and disease.
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“We used data from the Population Assessment of Tobacco and Health (PATH) study, which is a nationally representative, longitudinal cohort of adolescents.15”
From Associations Between Time Spent Using Social Media and Internalizing and Externalizing Problems Among US Youth. (2019) · cites this paper as [15]
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“Survey Population ThePATHstudy includes anationally representative longitudinal cohort of 13651USyouth ages 12 to 17 years at baselinewith follow-up1year later.(13)WeusedPATHdatatotest thehypothesis thatamongyouthwhohadnevertriedacigaretteatbaseline,ever andpast 30-dayuseof e-cigarettes, hookah,noncigarette combustibl…”
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“Additional details about the sample design can be found elsewhere.(14) In the current investigation, we analyzed wave 1 data from adults 18 years of age or older who responded to the questions about sexual orientation identity (N = 15,996 for men; N = 15,552 for women) and attraction (N = 15,963 for men; N = 15,489 fo…”
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“Participants were drawn from the public-use files of waves 1 and 2 of the Population Assessment of Tobacco and Health (PATH) Study, a nationally representative prospective cohort study of US adolescents (ages 12–17 years).(21) Wave 1 (baseline) data were collected from September 2013 to December 2014; participants wer…”
MethodConway, K., Green, V. R., Kasza, K., Silveira, M., Borek, N., Kimmel, H., Sargent, J., Stanton, C., Lambert, E. Y., Hilmi, N., et al. (2017) · Addictive Behaviours · doi:10.1016/j.addbeh.2017.08.009 · Cited by 113
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Self-citationPredictors of youth e-cigarette use susceptibility in a U.S. nationally representative sample
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Self-citationRecommended core items to assess e-cigarette use in population-based surveys
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“Ascertainment of Study Population Our study focused on the adult population of the PATH database contained in the Wave 1 Adult Interview [September 12, 2013 to December 14, 2014] (28).”
MethodStrong, D. R., Myers, M. G., Pulvers, K. M., Noble, M. L., Brikmanis, K., & Doran, N. (2018) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2017.12.044 · Cited by 95
Youth or Young Adults: Which Group Is at Highest Risk for Tobacco Use Onset?
Perry, C., Pérez, A., Bluestein, M. A., Garza, N., Obinwa, U. C., Jackson, C. D., Clendennen, S. L., Loukas, A., & Harrell, M. B. (2018) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2018.04.011 · Cited by 92
“PATH data are also standardized by design of the national study [25].”
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“7 In previous reports, biomarker concentrations indicate that self-reporting is valid.”
InfluentialSelf-citationMental health problems and onset of tobacco use among 12- to 24-year-olds in the PATH study.
Green, V. R., Conway, K. P., Silveira, M. L., Kasza, K. A., Cohn, A., Cummings, K. M., Stanton, C. A., Callahan-Lyon, P., Slavit, W., Sargent, J. D., et al. (2018) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2018.06.029 · Cited by 86
“Further details regarding the PATH Study design and methods are published elsewhere.(19) Population and replicate weights were created that adjusted for the complex study design characteristics (eg, oversampling at Wave 1) and nonresponse at Waves 1 and 2.”
MethodSelf-citationAdolescents and e-cigarettes: Objects of concern may appear larger than they are
Kozlowski, L. T., & Warner, K. E. (2017) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2017.01.001 · Cited by 89
E-cigarette Marketing Exposure and Subsequent Experimentation Among Youth and Young Adults
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“In this study, we used data from wave 2 (2014–2015) and wave 3 (2015–2016) youth and adult survey public-use files of the PATH Study, which includes nationally representative, longitudinal cohorts of civilian, noninstitutionalized youth and adults in the United States.(28) The PATH Study’s weighted response rates at w…”
BackgroundMethodInfluentialSelf-citationOnline Tobacco Marketing and Subsequent Tobacco Use
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Trinidad, D., Pierce, J., Sargent, J., White, M., Strong, D., Portnoy, D. B., Green, V. R., Stanton, C., Choi, K., Bansal-Travers, M., et al. (2017) · Preventive Medicine · doi:10.1016/j.ypmed.2017.05.010 · Cited by 75
“This manuscript is supported with Federal funds from the National Institute on Drug Abuse, National Institutes of Health, and the Food and Drug Administration, Department of Health and Human Services, under a contract to Westat (Contract No.”
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“With relapse to smoking still considerable through 12 months after a quit attempt,(33) these findings need to be confirmed through at least another year (e.g. Wave 3 of the PATH Study).”
BackgroundInfluentialSelf-citationNicotine and Toxicant Exposure among Concurrent Users ("Co-users") of Tobacco and Cannabis.
Smith, D. M., O'Connor, R., Wei, B., Travers, M., Hyland, A., & Goniewicz, M. (2019) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntz122 · Cited by 73
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Self-citationTobacco Product Harm Perceptions and New Use
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“More details about the PATH study design and methods are published elsewhere [25].”
MethodAssociations of Flavored e-Cigarette Uptake With Subsequent Smoking Initiation and Cessation
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“Further details regarding the PATH Study design and methods are available elsewhere.(34) This study used de-identified data available from the restricted use files hosted by the National Addiction & HIV Data Archive Program (NAHDAP) (http://goo.”
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“A detailed methodology for the PATH study is described elsewhere (Hyland et al., 2016).”
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Self-citationRural vs. Urban Use of Traditional and Emerging Tobacco Products in the United States, 2013–2014
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“The Population Assessment of Tobacco and Health (PATH) Study [12] is a large, nationally representative longitudinal study that collects detailed measures of tobacco use and related information annually.”
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Soneji, S. S., Knutzen, K. E., Tan, A. S. L., Moran, M. B., Yang, J.-W., Sargent, J. D., & Choi, K. (2019) · Addictive Behaviors · doi:10.1016/j.addbeh.2019.03.015 · Cited by 83
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“Further details on the PATH study design and methodology are published elsewhere (Hyland et al., 2017).”
MethodPreferred Reporting Items for Complex Sample Survey Analysis (PRICSSA)
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Bidirectional Association Between Bullying Perpetration and Internalizing Problems Among Youth
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Self-citationUse of E-cigarettes and Other Tobacco Products and Progression to Daily Cigarette Smoking
Pierce, J., Chen, R., Leas, E., White, M., Kealey, S., Stone, M. D., Benmarhnia, T., Trinidad, D., Strong, D., & Messer, K. (2021) · Pediatrics · doi:10.1542/peds.2020-025122 · Cited by 58
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“Detailed methodological information about the study design and protocol is available elsewhere [24] and at https://doi.”
Self-citationWang, Y., Duan, Z., Weaver, S. R., Self‐Brown, S., Ashley, D. L., Emery, S., & Huang, J. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.33938 · Cited by 63
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Longitudinal Uses of the Population Assessment of Tobacco and Health Study
Piesse, A., Opsomer, J., Dohrmann, S., Digaetano, R., Morganstein, D., Taylor, K. A., Carusi, C., & Hyland, A. (2021) · Tobacco Regulatory Science · doi:10.18001/trs.7.1.1 · Cited by 57
“We can estimate the following 4 quantities: (1) percentage of individuals reporting the behavior in both Wave 1 and Wave 2, (2) percentage of individuals reporting the behavior in Wave 1 but not in Wave 2, (3) percentage of individuals not reporting the behavior in Wave 1 but doing so in Wave 2, and (4) percentage of…”
MethodSelf-citationAssari, S., Boyce, S., Bazargan, M., Caldwell, C. H., & Zimmerman, M. A. (2020) · Frontiers in Education · doi:10.3389/feduc.2020.00030 · Cited by 46
“Building on the MDRs literature (Assari, 2017, 2018a) and using a national sample of United States adolescents (Hyland et al., 2017; Tourangeau et al., 2018), we compared the effect of parental education level on adolescents’ educational outcomes based on neighborhood quality.”
Rostron, B., Cheng, Y.-C., Gardner, L. D., & Ambrose, B. K. (2020) · American Journal of Health Behavior · doi:10.5993/ajhb.44.1.8 · Cited by 57
Self-citationStrong, D., Leas, E., Elton-Marshall, T., Wackowski, O., Travers, M., Bansal-Travers, M., Hyland, A., White, M., Noble, M. L., Cummings, K., et al. (2019) · Preventive Medicine · doi:10.1016/j.ypmed.2019.03.017 · Cited by 57
Self-citationStanton, C., Sharma, E., Edwards, K. C., Halenar, M. J., Taylor, K. A., Kasza, K., Day, H. R., Anic, G. M., Gardner, L. D., Hammad, H. T., et al. (2020) · Tobacco Control · doi:10.1136/tobaccocontrol-2019-055574 · Cited by 56
Self-citationAdult E-Cigarettes Use Associated with a Self-Reported Diagnosis of COPD
Perez, M. F., Atuegwu, N., Mead, E., Oncken, C., & Mortensen, E. (2019) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph16203938 · Cited by 56
“For this study, publicly available adult data was used from the first wave of the Population Assessment of Tobacco and Health (PATH) cohort study conducted from 12 September 2013 to 15 December 2014 [34].”
MethodSmith, D. M., Christensen, C. H., van Bemmel, D. M., Borek, N., Ambrose, B. K., Erives, G., Niaura, R., Edwards, K. C., Stanton, C., Blount, B., et al. (2021) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntaa252 · Cited by 55
Self-citationCavazos‐Rehg, P. A., Li, X., Kasson, E. M., Kaiser, N., Borodovsky, J. T., Grucza, R. A., Chen, L., & Bierut, L. J. (2020) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntaa113 · Cited by 69
Stanton, C. A., Sharma, E., Seaman, E. L., Kasza, K. A., Edwards, K. C., Halenar, M. J., Taylor, K. A., Day, H., Anic, G. M., Hull, L. C., et al. (2020) · Tobacco Control · doi:10.1136/tobaccocontrol-2019-055573 · Cited by 59
Self-citationPersoskie, A., O'Brien, E. K., & Poonai, K. (2019) · Addiction · doi:10.1111/add.14730 · Cited by 54
Dependence on e‐cigarettes and cigarettes in a cross‐sectional study of US adults
Shiffman, S., & Sembower, M. (2020) · Addiction · doi:10.1111/add.15060 · Cited by 53
“PATH is a nationally representative survey of tobacco use with annual waves of data collection with a four-stage, stratified probability sample of noninstitutionalized, civilian US adults (approved by the Westat Institutional Review Board) [25].”
Carey, F. R., Rogers, S. M., Cohn, E. A., Harrell, M. B., Wilkinson, A. V., & Perry, C. L. (2018) · Addictive Behaviors · doi:10.1016/j.addbeh.2018.09.002 · Cited by 58
“, the Population Assessment of Tobacco and Health (PATH)) study (Hyland et al., 2017) that have been shown to be reliable and valid.”
BackgroundSilveira, M., Conway, K. P., Green, V. R., Kasza, K., Sargent, J., Borek, N., Stanton, C. A., Cohn, A. M., Hilmi, N., Cummings, K., et al. (2018) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2018.06.018 · Cited by 53
Self-citationCompton, W., Flannagan, K. S. J., Silveira, M., Creamer, M. R., Kimmel, H., Kanel, M., Blanco, C., & Volkow, N. (2023) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.54566 · Cited by 52
Self-citationE-cigarette Use Among US Adults: Population Assessment of Tobacco and Health (PATH) Study
Rodu, B., & Plurphanswat, N. (2018) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntx194 · Cited by 52
Chen, J. C. (2018) · Substance Use & Misuse · doi:10.1080/10826084.2018.1455704 · Cited by 52
“The PATH Study is a nationally representative, longitudinal cohort study of adults and youth in the U.S. Waves 1 and 2 data of the PATH Study were collected between 2013–2014 and 2014–2015, respectively.”
BackgroundInfluentialTobacco and Nicotine Delivery Product Use in a U.S. National Sample of Women of Reproductive Age
Lopez, A., Redner, R., Kurti, A., Keith, D., Villanti, A., Stanton, C., Gaalema, D., Bunn, J., Doogan, N., Cepeda-Benito, A., et al. (2018) · Preventive Medicine · doi:10.1016/j.ypmed.2018.03.001 · Cited by 52
Engagement With Online Tobacco Marketing and Associations With Tobacco Product Use Among U.S. Youth
Soneji, S. S., Pierce, J. P., Choi, K., Portnoy, D. B., Margolis, K. A., Stanton, C. A., Moore, R. J., Bansal‐Travers, M., Carusi, C., Hyland, A. J., et al. (2017) · Journal of Adolescent Health · doi:10.1016/j.jadohealth.2017.01.023 · Cited by 59
“[16] and on the PATH Study’s Web site [17].”
BackgroundSelf-citationInterest in Quitting E-Cigarettes among Adults in the United States.
Rosen, R. L., & Steinberg, M. (2019) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntz062 · Cited by 51
Vora, M., & Chaffee, B. (2019) · The Journal of the American Dental Association (1939) · doi:10.1016/j.adaj.2018.12.004 · Cited by 51
“Detailed methodological information about the study design and protocol is available elsewhere [15].”
BackgroundLongitudinal e-Cigarette and Cigarette Use Among US Youth in the PATH Study (2013–2015)
Stanton, C. A., Bansal‐Travers, M., Johnson, A. L., Sharma, E., Katz, L., Ambrose, B. K., Silveira, M. L., Day, H., Sargent, J. D., Borek, N., et al. (2019) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djz006 · Cited by 52
“Further details regarding the PATH Study design and methods are published elsewhere (19).”
MethodSelf-citationTobacco and E-cigarette use among cancer survivors in the United States
Salloum, R. G., Huo, J. S., Lee, J., Lee, J., Dallery, J., George, T. J., & Warren, G. W. (2019) · PLoS ONE · doi:10.1371/journal.pone.0226110 · Cited by 51
“population including adjustments for oversampling and nonresponse.[13] The weighted interview response rate for adults in Wave 1 was 74.”
BackgroundWang, Y., Wong, L.-Y., Meng, L., Pittman, E. N., Trinidad, D. A., Hubbard, K., Etheredge, A. A., Valle-Pinero, A. D. D., Zamoiski, R. D., van Bemmel, D. M., et al. (2018) · Environment International · doi:10.1016/j.envint.2018.11.068 · Cited by 50
“Study design and participants Data used in this current analysis are from Wave 1 of the PATH Study, collected from September 12, 2013 to December 15, 2014.”
BackgroundMethodInfluentialSelf-citationDiminished Returns of Educational Attainment on Heart Disease among Black Americans
Assari, S., Cobb, S., Saqib, M., & Bazargan, M. (2020) · Open Cardiovascular Medicine Journal · doi:10.2174/1874192402014010005 · Cited by 49
Moran, M., Heley, K., Czaplicki, L., Weiger, C., Strong, D., & Pierce, J. (2020) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntaa275 · Cited by 48
Self-citationSawyer, A. N., Bono, R. S., Kaplan, B., & Breland, A. B. (2022) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2022.109268 · Cited by 54
Xia, B., Blount, B., Guillot, T., Brosius, C., Li, Y., van Bemmel, D. M., Kimmel, H., Chang, C. M., Borek, N., Edwards, K. C., et al. (2020) · Nicotine & Tobacco Research · doi:10.1093/ntr/ntaa110 · Cited by 47
Self-citationBuckell, J., & Hess, S. (2019) · Journal of Health Economics · doi:10.1016/j.jhealeco.2019.03.011 · Cited by 49
“, 2018) and Population Assessment of Tobacco and Health (PATH) – a large, nationally-collected tobacco use data set (Hyland et al., 2017).”
BackgroundMethodAkinkugbe, A. (2018) · JDR Clinical & Translational Research · doi:10.1177/2380084418806870 · Cited by 47
Mental Health and Oral Health in a Nationally Representative Cohort
Kalaigian, A., & Chaffee, B. W. (2023) · Journal of dentistry research · doi:10.1177/00220345231171108 · Cited by 46
Holt, N. M., Shiffman, S., Black, R. A., Goldenson, N., Sembower, M., & Oldham, M. (2023) · Scientific Reports · doi:10.1038/s41598-023-34427-x · Cited by 46
Chen-Sankey, J., Mead-Morse, E., Le, D., Rose, S., Quisenberry, A. J., Delnevo, C., & Choi, K. (2021) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2020.07.005 · Cited by 46
Chen, R., Pierce, J., Leas, E., White, M., Kealey, S., Strong, D., Trinidad, D., Benmarhnia, T., & Messer, K. (2020) · American Journal of Epidemiology · doi:10.1093/aje/kwaa161 · Cited by 46
“We used the Population Assessment of Tobacco and Health Study to compare long-term abstinence between matched US smokers who tried to quit with and without use of e-cigarettes as a cessation aid.”
MethodInfluentialSelf-citationJohnson, S. E., O’Brien, E. K., Coleman, B., Tessman, G. K., Hoffman, L., & Delahanty, J. C. (2019) · American Journal of Preventive Medicine · doi:10.1016/j.amepre.2019.03.021 · Cited by 58
Self-citationFong, G., Elton-Marshall, T., Driezen, P., Kaufman, A. R., Cummings, K., Choi, K., Kwan, J., Koblitz, A. R., Hyland, A., Bansal-Travers, M., et al. (2018) · Addictive Behaviours · doi:10.1016/j.addbeh.2018.11.023 · Cited by 46
Self-citation
Metadata
- Authors
- Hyland, A., Ambrose, B. K., Conway, K. P., Borek, N., Lambert, E., Carusi, C., Taylor, K., Crosse, S., Fong, G. T., Cummings, K. M., Abrams, D., Pierce, J. P., Sargent, J., Messer, K., Bansal-Travers, M., Niaura, R., Vallone, D., Hammond, D., Hilmi, N., Kwan, J., Piesse, A., Kalton, G., Lohr, S., Pharris-Ciurej, N., Castleman, V., Green, V. R., Tessman, G., Kaufman, A., Lawrence, C., van Bemmel, D. M., Kimmel, H. L., Blount, B., Yang, L., O'Brien, B., Tworek, C., Alberding, D., Hull, L. C., Cheng, Y.-C., Maklan, D., Backinger, C. L., & Compton, W. M.
- Affiliations
- Roswell Park Comprehensive Cancer Center (US)
- United States Food and Drug Administration (US)
- National Institutes of Health (US)
- Westat (United States) (US)
- Ontario Institute for Cancer Research (CA)
- Medical University of South Carolina (US)
- Truth Initiative (US)
- University of California San Diego (US)
- Dartmouth College (US)
- Centers for Disease Control and Prevention (US)
- Corresponding author
- Hyland, Andrew
- ORCID
- Hyland, Andrew
- Ambrose, Bridget K
- Conway, Kevin P
- Carusi, Charles
- Taylor, Kristie
- Fong, Geoffrey T
- Cummings, K Michael
- Abrams, David
- Pierce, John P
- Sargent, James
- Messer, Karen
- Vallone, Donna
- Hammond, David
- Kwan, Jonathan
- Piesse, Andrea
- Kalton, Graham
- Lohr, Sharon
- Kaufman, Annette
- Lawrence, Charles
- van Bemmel, Dana M
- Kimmel, Heather L
- Yang, Ling
- Cheng, Yu-Ching
- Compton, Wilson M
- Venue
- Tobacco Control
- Publisher
- BMJ
- Published
- 2016-08-08
- Volume
- 26
- Issue
- 4
- Pages
- 371-378
- ISSN
- 0964-4563 (ISSN-L)
- 1468-3318
- PMC
- PMC5299069
- OpenAlex
- W2518934199
- Cited by
- 872
- References
- 45
- Citations by year
- 2026: 55 · 2025: 74 · 2024: 101 · 2023: 103 · 2022: 116 · 2021: 105 · 2020: 115 · 2019: 94 · 2018: 69 · 2017: 36 · 2016: 3
- FWCI
- 54.22
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Tobacco Control (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- U.S. Department of Health and Human Services (HHSN271201100027 C)
- National Institutes of Health (Contract No. HHSN271201100027C, HHSN271201100027C)
- Centers for Disease Control and Prevention
- National Institute on Drug Abuse (HHSN271201100027C)
- National Cancer Institute (P30CA023100, P30CA023108)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Smoking Behavior and Cessation
- Health Sciences › Medicine › Epidemiology › Substance Abuse Treatment and Outcomes
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Global Public Health Policies and Epidemiology
- Keywords
- tobacco use patterns, tobacco initiation, tobacco cessation, relapse, risk perception, biological specimen, biomarkers of tobacco exposure, longitudinal cohort, audio computer-assisted self-interviewing, Family Smoking Prevention and Tobacco Control Act, tobacco regulation
- MeSH terms
- Adolescent, Adult, Aged, Child, Female, Humans, Health Knowledge, Attitudes, Practice, Longitudinal Studies, Male, Middle Aged, Public Health, Research Design, Smoking, United States, Young Adult
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