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Cited by 106Diet and metabolism studiesMuscle metabolism and nutritionCardiovascular and exercise physiology

The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.

Nutritional ketone salts increase fat oxidation but impair high-intensity exercise performance in healthy adult males

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O’Malley, Trevor, Myette-Cote, Etienne, Durrer, Cody, Little, Jonathan P.·2017·Applied Physiology, Nutrition, and Metabolism
DOI 10.1139/apnm-2016-0641
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Abstract

This study investigated the impact of raising plasma beta-hydroxybutyrate (β-OHB) through ingestion of ketone salts on substrate oxidation and performance during cycling exercise. Ten healthy adult males (age, 23 ± 3 years; body mass index, 25 ± 3 kg/m 2, peak oxygen uptake, 45 ± 10 mL/(kg·min)−1) were recruited to complete 2 experimental trials. Before enrollment in the experimental conditions, baseline anthropometrics and cardiorespiratory fitness (peak oxygen uptake) were assessed and familiarization to the study protocol was provided. On experimental days, participants reported to the laboratory in the fasted state and consumed either 0.3 g/kg β-OHB ketone salts or a flavour-matched placebo at 30 min prior to engaging in cycling exercise. Subjects completed steady-state exercise at 30%, 60%, and 90% ventilatory threshold (VT) followed by a 150-kJ cycling time-trial. Respiratory exchange ratio (RER) and total substrate oxidation were derived from indirect calorimetry. Plasma glucose, lactate, and ketones were measured at baseline, 30 min post-supplement, post–steady-state exercise, and immediately following the time-trial. Plasma β-OHB was elevated from baseline and throughout the entire protocol in the ketone condition (p < 0.05). RER was lower at 30% and 60% VT in the ketone compared with control condition. Total fat oxidation was greater in the ketone versus control (p = 0.05). Average time-trial power output was ∼7% lower (–16 W, p = 0.029) in the ketone condition. Ingestion of ketone salts prior to exercise increases fat oxidation during steady-state exercise but impairs high-intensity exercise performance.

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  1. Randle P.J., 1963, Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet, 1, 785

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Metadata

Authors
O’Malley, T., Myette-Cote, E., Durrer, C., & Little, J. P.
Affiliations
  • University of British Columbia, Okanagan Campus (CA)
  • School of Health and Exercise Sciences, University of British Columbia Okanagan, Kelowna, BC V1V 1V7, Canada.
Corresponding author
Little, Jonathan P.
ORCID
Venue
Applied Physiology, Nutrition, and Metabolism
Publisher
Canadian Science Publishing
Published
2017-10
Volume
42
Issue
10
Pages
1031-1035
ISSN
  • 1715-5312 (ISSN-L)
  • 1715-5320
DOI
10.1139/apnm-2016-0641
OpenAlex
W2739936777
Semantic Scholar
3ef8bbbb5f5f98f52513ae2e781a6ee1b86c7720
Cited by
106
References
24
Citations by year
2025: 7 · 2024: 8 · 2023: 16 · 2022: 12 · 2021: 9 · 2020: 21 · 2019: 24 · 2018: 7 · 2017: 1
FWCI
10.76
Type
journal article
Language
en
Open access
Licence
www.nrcresearchpress.com/page/about/CorporateTextAndDataMining (tdm)
Locations
  • Applied Physiology Nutrition and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • TSpace (University of Toronto) (acceptedVersion)
Funders
Natural Sciences and Engineering Research Council of Canada
Topics
  • Health Sciences › Medicine › Physiology (medical) › Diet and metabolism studies
  • Health Sciences › Nursing › Nutrition and Dietetics › Muscle metabolism and nutrition
  • Health Sciences › Medicine › Physiology (medical) › Cardiovascular and exercise physiology
Keywords
ketone salts, beta-hydroxybutyrate, fat oxidation, high-intensity exercise performance, cycling time trial, substrate oxidation, respiratory exchange ratio, exercise supplementation, plasma ketones, lactate, output power
MeSH terms
Adult, Bicycling, Blood Glucose, British Columbia, Double-Blind Method, Humans, Ketones, Male, Muscle Contraction, Oxidation-Reduction, Oxygen Consumption, Physical Endurance, Time Factors, Exercise, Up-Regulation, Treatment Outcome, Muscle, Skeletal, Cross-Over Studies, Lactic Acid, Dietary Supplements, 3-Hydroxybutyric Acid, Lipid Metabolism, Muscle Strength, Young Adult

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