Zinc supplementation reduces diet-induced obesity and improves insulin sensitivity in rats
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Rates of obesity have been growing at alarming rates, compromising the health of the world population. Thus, the search for interventions that address the metabolic repercussions of obesity are necessary. Here we evaluated the metabolic and antioxidant effects of zinc and branched-chain amino acids (BCAA) supplementation on obese rats. Male Wistar rats were fed either a high-fat/high-fructose diet (HFD) or a standard diet (SD) for 19 weeks. From the fifteenth week until the end of the experiment, HFD- and SD-fed rats received zinc (6 mg/kg) or BCAA (750 mg/kg) supplementation. Body weight, abdominal fat, lipid profile, blood glucose, insulin, leptin, and hepatic transaminases were evaluated. In the liver, superoxide dismutase and catalase activities and lipid peroxidation were also analyzed. HFD-fed animals showed increased weight gain, abdominal fat pad, plasma insulin, leptin, and triglycerides levels in comparison with SD-fed rats. Zinc supplementation reduced all these parameters, suggesting a beneficial role for the treatment of obesity. BCAA, on the other hand, did not show any beneficial effect. Liver antioxidant enzymes and hepatic transaminases plasma levels did not change among groups. Lipid peroxidation was higher in HFD-fed rats and was not reverted by zinc or BCAA supplementation. In conclusion, zinc supplementation may be a useful strategy for the treatment of the metabolic dysfunction associated with obesity.
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Evidence from preclinical and clinical studies indicates that omega-3 polyunsaturated fatty acids may enhance the metabolic benefits of GLP-1 receptor agonists and attenuate lean mass loss, primarily via anti-inflammatory pathways and modulation of protein synthesis.
“Evidence from preclinical and clinical studies indicates that omega-3 polyunsaturated fatty acids may enhance the metabolic benefits of GLP-1RAs and attenuate lean mass loss, primarily via anti-inflammatory pathways and modulation of protein synthesis”
From Nutritional Approaches to Enhance GLP-1 Analogue Therapy in Obesity: A Narrative Review (2025) · cites this paper as [186]
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- Authors
- Thoen, R. U., Barther, N. N., Schemitt, E., Bona, S., Fernandes, S., Coral, G., Marroni, N. P., Tovo, C., Guedes, R. P., & Porawski, M.
- Affiliations
- Universidade Federal de Ciências da Saúde de Porto Alegre (BR)
- Universidade Federal do Rio Grande do Sul (BR)
- ORCID
- Venue
- Applied Physiology, Nutrition, and Metabolism
- Publisher
- Canadian Science Publishing
- Published
- 2019-06
- Volume
- 44
- Issue
- 6
- Pages
- 580-586
- ISSN
- 1715-5312 (ISSN-L)
- 1715-5320
- OpenAlex
- W2896216801
- Cited by
- 43
- References
- 55
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 6 · 2023: 6 · 2022: 6 · 2021: 5 · 2020: 8
- FWCI
- 2.69
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Locations
- Applied Physiology Nutrition and Metabolism (publishedVersion)
- PubMed (publishedVersion)
- TSpace (University of Toronto) (acceptedVersion)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diet, Metabolism, and Disease
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Keywords
- zinc supplementation, branched-chain amino acids, diet-induced obesity, high-fat high-fructose diet, insulin sensitivity, leptin, abdominal fat, lipid peroxidation, antioxidant enzymes, hepatic transaminases, metabolic dysfunction
- MeSH terms
- Amino Acids, Branched-Chain, Animals, Antioxidants, Blood Glucose, Insulin, Insulin Resistance, Lipids, Male, Obesity, Random Allocation, Zinc, Lipid Peroxidation, Rats, Wistar, Dietary Supplements, Leptin, Diet, High-Fat
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