The immune system and the impact of zinc during aging
Open accessAbstract
The trace element zinc is essential for the immune system, and zinc deficiency affects multiple aspects of innate and adaptive immunity. There are remarkable parallels in the immunological changes during aging and zinc deficiency, including a reduction in the activity of the thymus and thymic hormones, a shift of the T helper cell balance toward T helper type 2 cells, decreased response to vaccination, and impaired functions of innate immune cells. Many studies confirm a decline of zinc levels with age. Most of these studies do not classify the majority of elderly as zinc deficient, but even marginal zinc deprivation can affect immune function. Consequently, oral zinc supplementation demonstrates the potential to improve immunity and efficiently downregulates chronic inflammatory responses in the elderly. These data indicate that a wide prevalence of marginal zinc deficiency in elderly people may contribute to immunosenescence.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Zinc deficiency can cause decreased levels of serum thymulin, a zinc-dependent peptide hormone produced by thymic epithelial cells, whose activity is progressively reduced with age and peaks in pre-adolescence.
“Zinc deficiency can cause decreased levels of serum thymulin, a zinc dependent peptide hormone produced by thymic epithelial cells, with an activity that is progressively reduced with age, with a peak in pre-adolescence (78, 104, 108).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [104]
Even slight deficiencies in zinc can have important consequences.
“Even slight deficiencies in zinc can have important consequences (104–107).”
From Immunosenescence and Its Hallmarks: How to Oppose Aging Strategically? A Review of Potential Options for Therapeutic Intervention (2019) · cites this paper as [104]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The biochemical basis of zinc physiology
Vallée, B. L., & Falchuk, K. H. (1993) · Physiological Reviews · doi:10.1152/physrev.1993.73.1.79 · Cited by 3,005 · see citing works
Zinc requirements and the risks and benefits of zinc supplementation
Maret, W., & Sandstead, H. H. (2006) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2006.01.006 · Cited by 1,122 · see citing works
Counting the Zinc-Proteins Encoded in the Human Genome
Andreini, C., Banci, L., Bertini, I., & Rosato, A. (2006) · Journal of Proteome Research · doi:10.1021/pr050361j · Cited by 1,109 · see citing works
Posnett, D. N., Sinha, R., Kabak, S., & Russo, C. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.2.609 · Cited by 761 · see citing works
Mammalian Zinc Transporters: Nutritional and Physiologic Regulation
Lichten, L. A., & Cousins, R. J. (2009) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-033009-083312 · Cited by 732 · see citing works
Mammalian Zinc Transport, Trafficking, and Signals
Cousins, R. J., Liuzzi, J. P., & Lichten, L. A. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.r600011200 · Cited by 705 · see citing works
Increased cytokine production in mononuclear cells of healthy elderly people
Fagiolo, U., Cossarizza, A., Scala, E., Fanales‐Belasio, E., Ortolani, C., Cozzi, E., Monti, D., Franceschi, C., & Paganelli, R. (1993) · European Journal of Immunology · doi:10.1002/eji.1830230950 · Cited by 665 · see citing works
Letter: Hypoglycaemia in propranolol-treated dialysis patients.
Jensen, H. A., Bjaeldager, P., & Broch‐Møller, B. (1976) · PubMed · Cited by 649 · see citing works
The Incidence of Herpes Zoster
Donahue, J. G. (1995) · Archives of Internal Medicine · doi:10.1001/archinte.1995.00430150071008 · Cited by 618 · see citing works
Ibs, K.-H., & Rink, L. (2003) · Journal of Nutrition · doi:10.1093/jn/133.5.1452s · Cited by 602 · see citing works
Self-citationLiuzzi, J. P., Lichten, L. A., Rivera, S., Blanchard, R. K., Aydemir, T. B., Knutson, M. D., Ganz, T., & Cousins, R. J. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502257102 · Cited by 594 · see citing works
Liuzzi, J. P., & Cousins, R. J. (2004) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.24.012003.132402 · Cited by 590 · see citing works
Tersmette, M. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92628-7 · Cited by 579 · see citing works
Cancer burden in the aged: an epidemiologic and demographic overview.
Yancik, R. (1997) · PubMed · Cited by 558 · see citing works
Identification of SLC39A4, a gene involved in acrodermatitis enteropathica
Küry, S., Dréno, B., Bezieau, S., Giraudet, S., Kharfi, M., Kamoun, R., & Moisan, J. (2002) · Nature Genetics · doi:10.1038/ng913 · Cited by 531 · see citing works
The immunology of exceptional individuals: the lesson of centenarians
Franceschi, C., Monti, D., Sansoni, P., & Cossarizza, A. (1995) · Immunology Today · doi:10.1016/0167-5699(95)80064-6 · Cited by 531 · see citing works
Beisel, W. R. (1982) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/35.2.417 · Cited by 517 · see citing works
Prasad, A. S., Beck, F. W., Bao, B., Fitzgerald, J. T., Snell, D. C., Steinberg, J. D., & Cardozo, L. J. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/85.3.837 · Cited by 516 · see citing works
A novel member of a zinc transporter family is defective in acrodermatitis enteropathica
Wang, K., Zhou, B., Kuo, Y.-M., Zemansky, J., & Gitschier, J. (2002) · The American Journal of Human Genetics · doi:10.1086/341125 · Cited by 491 · see citing works
AGEING, IMMUNE RESPONSE, AND MORTALITY
Roberts-Thomson, I., Youngchaiyud, U., Whittingham, S., & Mackay, I. (1974) · The Lancet · doi:10.1016/s0140-6736(74)91755-3 · Cited by 477 · see citing works
Reprogramming of the immune system during zinc deficiency
Fraker, P. J., & King, L. E. (2004) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.24.012003.132454 · Cited by 470 · see citing works
The role of zinc in caspase activation and apoptotic cell death
Truong-Tran, A. Q., Carter, J., Ruffin, R. E., & Zalewski, P. D. (2001) · BioMetals · doi:10.1023/a:1012993017026 · Cited by 454 · see citing works
Zinc and diabetes — clinical links and molecular mechanisms
Jansen, J., Karges, W., & Rink, L. (2009) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2009.01.009 · Cited by 443 · see citing works
Self-citationZinc deficiency and immune function.
Keen, C. L., & Gershwin, M. (1990) · Annual review of nutrition · doi:10.1146/annurev.nu.10.070190.002215 · Cited by 400 · see citing works
Effects of Zinc Deficiency on Th1 and Th2 Cytokine Shifts
Prasad, A. S. (2000) · The Journal of Infectious Diseases · doi:10.1086/315916 · Cited by 396 · see citing works
Insights into thymic aging and regeneration
Taub, D. D., & Longo, D. L. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00275.x · Cited by 393 · see citing works
Altered cytokine production in the elderly
Rink, L., Cakman, I., & Kirchner, H. (1998) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(97)00153-x · Cited by 378 · see citing works
Self-citationHypocupremia induced by zinc therapy in adults
Prasad, A. S. (1978) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1978.03290200044019 · Cited by 373 · see citing works
Pawelec, G. (1998) · Frontiers in bioscience · doi:10.2741/a266 · Cited by 357 · see citing works
Dietary intake and cognitive function in a group of elderly people
Ortega, R., Requejo, A. M., Andrés, P., López-Sobaler, A. M., Quintas, M. E., Redondo, M. R., Navia, B., & Rivas, T. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.4.803 · Cited by 350 · see citing works
Hotz, C. S., Peerson, J. M., & Brown, K. H. (2003) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.4.756 · Cited by 346 · see citing works
Beck, F. W., Prasad, A. S., Kaplan, J., Fitzgerald, J. T., & Brewer, G. J. (1997) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1997.272.6.e1002 · Cited by 345 · see citing works
Serum thymulin in human zinc deficiency
Prasad, A. S., Meftah, S., Abdallah, J., Kaplan, J., Brewer, G. J., Bach, J. F., & Dardenne, M. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113717 · Cited by 335 · see citing works
Functional Significance of Zinc-Related Signaling Pathways in Immune Cells
Haase, H., & Rink, L. (2009) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-080508-141119 · Cited by 323 · see citing works
Self-citationZinc Therapy of Acrodermatitis Enteropathica
Neldner, K. H., & Hambidge, K. M. (1975) · New England Journal of Medicine · doi:10.1056/nejm197504242921702 · Cited by 308 · see citing works
Rink, L., & Haase, H. (2006) · Trends in Immunology · doi:10.1016/j.it.2006.11.005 · Cited by 292 · see citing works
Self-citationGirodon, F. (1999) · Archives of Internal Medicine · doi:10.1001/archinte.159.7.748 · Cited by 290 · see citing works
Zinc Signals Are Essential for Lipopolysaccharide-Induced Signal Transduction in Monocytes
Haase, H., Ober-Blöbaum, J. L., Engelhardt, G., Hebel, S., Heit, A., Heine, H., & Rink, L. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.9.6491 · Cited by 287 · see citing works
Self-citationNK and NK/T cells in human senescence
Solana, R., & Mariani, E. (2000) · Vaccine · doi:10.1016/s0264-410x(99)00495-8 · Cited by 279 · see citing works
NK phenotypic markers and IL2 response in NK cells from elderly people
Borrego, F., Alonso, M. C., Galiani, M. D., Carracedo, J., Ramı́rez, R., Ostos, B., Peña, J., & Solana, R. (1999) · Experimental Gerontology · doi:10.1016/s0531-5565(98)00076-x · Cited by 278 · see citing works
A Zinc Clasp Structure Tethers Lck to T Cell Coreceptors CD4 and CD8
Kim, P. W., Sun, Z.-Y. J., Blacklow, S. C., Wagner, G., & Eck, M. J. (2003) · Science · doi:10.1126/science.1085643 · Cited by 275 · see citing works
Laity, J. H., & Andrews, G. K. (2007) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2007.03.019 · Cited by 267 · see citing works
Beneficial effects of oral zinc supplementation on the immune response of old people
Duchateau, J., Delepesse, G., Vrijens, R., & Collet, H. (1981) · The American Journal of Medicine · doi:10.1016/0002-9343(81)90849-4 · Cited by 267 · see citing works
Maret, W. (2009) · BioMetals · doi:10.1007/s10534-008-9186-z · Cited by 261 · see citing works
Bacteremia With Streptococcus pneumoniae
Plouffe, J. F. (1996) · JAMA · doi:10.1001/jama.1996.03530270034028 · Cited by 253 · see citing works
Briefel, R. R., Bialostosky, K., Kennedy-Stephenson, J., McDowell, M. A., Ervin, R. B., & Wright, J. D. (2000) · The Journal of Nutrition · doi:10.1093/jn/130.5.1367s · Cited by 252 · see citing works
WALDENSTRÖM, J. G. (1984) · Acta Medica Scandinavica · doi:10.1111/j.0954-6820.1984.tb05032.x · Cited by 248 · see citing works
Zinc deficiency in elderly patients.
Prasad, A. S., Fitzgerald, J. T., Hess, J. W., Kaplan, J., Pelen, F., & Dardenne, M. (1993) · PubMed · Cited by 244 · see citing works
Dardenne, M. (2002) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1601479 · Cited by 241 · see citing works
Taylor, K. M., Vichova, P., Jordan, N., Hiscox, S., Hendley, R., & Nicholson, R. I. (2008) · Endocrinology · doi:10.1210/en.2008-0351 · Cited by 236 · see citing works
Zinc transporter ZIP8 (SLC39A8) and zinc influence IFN-γ expression in activated human T cells
Aydemir, T. B., Liuzzi, J. P., McClellan, S., & Cousins, R. J. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.1208759 · Cited by 229 · see citing works
Thyroid and other organ-specific autoantibodies in healthy ceritenarians
Mariotti, S., Barbesino, G., Caturegli, P., Giacomelli, T., Pinchera, A., Monti, D., Cossarizza, A., Franceschi, C., Sansoni, P., Passeri, G., et al. (1992) · The Lancet · doi:10.1016/0140-6736(92)91265-a · Cited by 227 · see citing works
Plouffe, J. F. (1996) · JAMA · doi:10.1001/jama.275.3.194 · Cited by 222 · see citing works
Wellinghausen, N., Kirchner, H., & Rink, L. (1997) · Immunology Today · doi:10.1016/s0167-5699(97)01146-8 · Cited by 221 · see citing works
Self-citationGestational Zinc Deprivation in Mice: Persistence of Immunodeficiency for Three Generations
Beach, R. S., Gershwin, M. E., & Hurley, L. S. (1982) · Science · doi:10.1126/science.7123244 · Cited by 219 · see citing works
Modulating the immune response by oral zinc supplementation: a single approach for multiple diseases
Overbeck, S., Rink, L., & Haase, H. (2008) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-008-0003-8 · Cited by 211 · see citing works
Self-citationThe Effect of Age on the B-Cell Repertoire
Weksler, M. E., & Szabo, P. (2000) · Journal of Clinical Immunology · doi:10.1023/a:1006659401385 · Cited by 205 · see citing works
Zinc nutriture in the elderly in relation to taste acuity, immune response, and wound healing
Sandstead, H., Henriksen, L. K., Greger, J., PRASAD, A. S., & Ra, G. (1982) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/36.5.1046 · Cited by 198 · see citing works
Zinc modulates mRNA levels of cytokines
Bao, B., Prasad, A. S., Beck, F. W. J., & Godmere, M. (2003) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00545.2002 · Cited by 194 · see citing works
Ravaglia, G., Forti, P., Maioli, F., Bastagli, L., Facchini, A., Mariani, E., Savarino, L., Sassi, S., Cucinotta, D., & Lenaz, G. (2000) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/71.2.590 · Cited by 189 · see citing works
Dysregulation between TH1 and TH2 T cell subpopulations in the elderly
Cakman, I., Rohwer, J., Schütz, R.-M., Kirchner, H., & Rink, L. (1996) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(96)01708-3 · Cited by 184 · see citing works
Self-citationCousins, R. J., Blanchard, R. K., Popp, M. P., Liu, L., Cao, J., Moore, J. B., & Green, C. L. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0732111100 · Cited by 182 · see citing works
Facchini, A., Mariani, E., Mariani, A. R., Papa, S., Vitale, M., & Manzoli, F. A. (1987) · PubMed Central · Cited by 170 · see citing works
The Effect of Zinc and Vitamin A Supplementation on Immune Response in an Older Population
Fortes, C., Forastiere, F., Agabiti, N., Fano, V., Pacifici, R., Virgili, F., Piras, G., Guidi, L., Bartoloni, C., Tricerri, A., et al. (1998) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1998.tb01008.x · Cited by 164 · see citing works
Correlation between zinc status and immune function in the elderly
Haase, H., Mocchegiani, E., & Rink, L. (2006) · Biogerontology · doi:10.1007/s10522-006-9057-3 · Cited by 162 · see citing works
Self-citationFlow cytometric measurement of labile zinc in peripheral blood mononuclear cells
Haase, H., Hebel, S., Engelhardt, G., & Rink, L. (2006) · Analytical Biochemistry · doi:10.1016/j.ab.2006.02.009 · Cited by 158 · see citing works
Self-citationAllen, J. I., Perri, R. T., McClain, C. J., & Kay, N. E. (1983) · PubMed · Cited by 156 · see citing works
von Bülow, V., Dubben, S., Engelhardt, G., Hebel, S., Plümäkers, B., Heine, H., Rink, L., & Haase, H. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.6.4180 · Cited by 156 · see citing works
Self-citationBogden, J. D., Oleske, J. M., Lavenhar, M. A., Munves, E. M., Kemp, F. W., Bruening, K. S., Holding, K. J., Denny, T. N., Guarino, M. A., & Holland, B. K. (1990) · Journal of the American College of Nutrition · doi:10.1080/07315724.1990.10720372 · Cited by 156 · see citing works
Fabris, Ν., Amadio, L., Licastro, F., Mocchegiani, E., Zannotti, M., & Franceschi, C. (1984) · The Lancet · doi:10.1016/s0140-6736(84)92325-0 · Cited by 156 · see citing works
Paganelli, R., Quinti, I., Fagiolo, U., Cossarizza, A., ORTOLANI, C., GUERRA, E., Sansoni, P., Pucillo, L. P., Scala, E., Cozzi, E., et al. (1992) · Clinical & Experimental Immunology · doi:10.1111/j.1365-2249.1992.tb07954.x · Cited by 156 · see citing works
Serum zinc and pneumonia in nursing home elderly
Meydani, S. N., Barnett, J. B., Dallal, G. E., Fine, B. C., Jacques, P. F., Leka, L. S., & Hamer, D. H. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.4.1167 · Cited by 155 · see citing works
von Bülow, V., Rink, L., & Haase, H. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.175.7.4697 · Cited by 154 · see citing works
Self-citationCirculating thymic hormone levels in zinc deficiency
Iwata, T., Incefy, G. S., Tanaka, T., Fernandes, G., Menendez-Botet, C., Pih, K., & Good, R. A. (1979) · Cellular Immunology · doi:10.1016/0008-8749(79)90318-6 · Cited by 145 · see citing works
Aydemir, T. B., Blanchard, R. K., & Cousins, R. J. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0510407103 · Cited by 144 · see citing works
The incidence of herpes zoster
Donahue, J. G. (1995) · Archives of Internal Medicine · doi:10.1001/archinte.155.15.1605 · Cited by 139 · see citing works
Boukaïba, N., Flament, C., Acher, S., Chappuis, P., Piau, A., Fusselier, M., Dardenne, M., & Lemonnier, D. (1993) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/57.4.566 · Cited by 137 · see citing works
Oxidative Stress and Inflammation in Brain Aging: Nutritional Considerations
Joseph, J. A., Shukitt‐Hale, B., Casadesús, G., & Fisher, D. (2005) · Neurochemical Research · doi:10.1007/s11064-005-6967-4 · Cited by 137 · see citing works
Influence of Age and Sex on Plasma and Red-Cell Zinc Concentrations
Lindeman, R. D., Clark, M. L., & Colmore, J. P. (1971) · Journal of Gerontology · doi:10.1093/geronj/26.3.358 · Cited by 130 · see citing works
Driessen, C., Hirv, K., Rink, L., & Kirchner, H. (1994) · PubMed · Cited by 129 · see citing works
Self-citationKahmann, L., Uciechowski, P., Warmuth, S., Plümäkers, B., Gressner, A. M., Malavolta, M., Mocchegiani, E., & Rink, L. (2008) · Rejuvenation Research · doi:10.1089/rej.2007.0613 · Cited by 124 · see citing works
Self-citationGirodon, F., Blache, D., Monget, A. L., Lombart, M., Brunet-Lecompte, P., Arnaud, J., Richard, M., & Galan, P. (1997) · Journal of the American College of Nutrition · doi:10.1080/07315724.1997.10718698 · Cited by 122 · see citing works
Zinc supplementation reconstitutes the production of interferon-α by leukocytes from elderly persons
CAKMAN, I., KIRCHNER, H., & RINK, L. (1997) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.1997.17.469 · Cited by 121 · see citing works
Self-citationNatural killer cells in healthy aging
Solana, R., Alonso, M. C., & Peña, J. (1999) · Experimental Gerontology · doi:10.1016/s0531-5565(99)00008-x · Cited by 116 · see citing works
Zinc inhibits interleukin‐1‐dependent T cell stimulation
Wellinghausen, N., Martin, M. U., & Rink, L. (1997) · European Journal of Immunology · doi:10.1002/eji.1830271010 · Cited by 115 · see citing works
Self-citationPrasad, A. S., Beck, F. W., Grabowski, S. M., Kaplan, J., & Mathog, R. H. (1997) · PubMed · Cited by 112 · see citing works
Mocchegiani, E., Muzzioli, M., Giacconi, R., Cipriano, C., Gasparini, N., Franceschi, C., Gaetti, R., Cavalieri, E., & Suzuki, H. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(03)00023-x · Cited by 112 · see citing works
Zinc intake and status in middle-aged and older European subjects: the ZENITH study
Andriollo-Sanchez, M., Hininger‐Favier, I., Meunier, N., Toti, E., Zaccaria, M., Brandolini-Bunlon, M., Polito, A., O’Connor, J. M., Ferry, M., Coudray, C., et al. (2005) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602296 · Cited by 109 · see citing works
Zinc and immunocompetence in elderly people: effects of zinc supplementation for 3 months
Bogden, J. D., Oleske, J. M., Lavenhar, M., Munves, E. M., Kemp, F., Bruening, K. S., Holding, K. J., Denny, T. N., Guarino, M. A., & Krieger, L. (1988) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/48.3.655 · Cited by 106 · see citing works
A Zn2+ Ion Links the Cytoplasmic Tail of CD4 and the N-terminal Region of Lck
Huse, M., Eck, M. J., & Harrison, S. C. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.30.18729 · Cited by 105 · see citing works
Paganelli, R., Scala, E., Quinti, I., & Ansotegui, I. J. (1994) · Aging Clinical and Experimental Research · doi:10.1007/bf03324229 · Cited by 103 · see citing works
Bogden, J. D., Oleske, J. M., Munves, E. M., Lavenhar, M. A., Bruening, K. S., Kemp, F. W., Holding, K. J., Denny, T. N., & Louria, D. B. (1987) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/46.1.101 · Cited by 102 · see citing works
Zinc Is Essential for Binding of p56 to CD4 and CD8α
Lin, R. S.-Y., Rodríguez, C., Veillette, A., & Lodish, H. F. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.49.32878 · Cited by 100 · see citing works
Wirth, J. J., Fraker, P. J., & KIERSZENBAUM, F. (1989) · PubMed · Cited by 99 · see citing works
TH1 and TH2 cell polarization increases with aging and is modulated by zinc supplementation
Uciechowski, P., Kahmann, L., Plümäkers, B., Malavolta, M., Mocchegiani, E., Dedoussis, G., Herbein, G., Jajte, J., Fulop, T., & Rink, L. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2007.11.006 · Cited by 97 · see citing works
Self-citationOverproduction of monokines by leukocytes after stimulation with lipopolysaccharide in the elderly
Gabriel, P., Cakman, I., & Rink, L. (2002) · Experimental Gerontology · doi:10.1016/s0531-5565(01)00189-9 · Cited by 96 · see citing works
Self-citationNeutrophil immunity of the elderly
Schröder, A., & Rink, L. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(03)00017-4 · Cited by 96 · see citing works
Self-citationBlood Micronutrient and Thyroid Hormone Concentrations in the Oldest-Old
Ravaglia, G., Forti, P., Maioli, F., Nesi, B., Pratelli, L., Savarino, L., Cucinotta, D., & Cavalli, G. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.6.6627 · Cited by 95 · see citing works
Rajagopalan, S., Winter, C. C., Wagtmann, N. R., & Long, E. O. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.9.4143 · Cited by 93 · see citing works
Mariani, E., Cattini, L., Neri, S., Malavolta, M., Mocchegiani, E., Ravaglia, G., & Facchini, A. (2006) · Biogerontology · doi:10.1007/s10522-006-9060-8 · Cited by 92 · see citing works
Chavakis, T., May, A. E., Preissner, K. T., & Kanse, S. M. (1999) · Blood · doi:10.1182/blood.v93.9.2976 · Cited by 91 · see citing works
The ligand environment of zinc stored in vesicles
Wellenreuther, G., Cianci, M., Tucoulou, R., Meyer‐Klaucke, W., & Haase, H. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.01.074 · Cited by 90 · see citing works
Self-citationZhou, Z., Wang, L., Song, Z., Saari, J. T., McClain, C. J., & Kang, Y. J. (2004) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63713-3 · Cited by 87 · see citing works
Prevalence of zinc deficiency and its clinical relevance among hospitalised elderly
Pepersack, T., Rotsaert, P., Benoit, F., Willems, D., Fuss, M., Bourdoux, P., & Duchateau, J. (2001) · Archives of Gerontology and Geriatrics · doi:10.1016/s0167-4943(01)00186-8 · Cited by 84 · see citing works
Provinciali, M., MONTENOVO, A., Stefano, G. D., Colombo, M. M., Daghetta, L., Cairati, M., VERONI, C., Cassino, R., TORRE, F. D., & Fabris, N. (1998) · Age and Ageing · doi:10.1093/ageing/27.6.715 · Cited by 81 · see citing works
Restoration of the Thymus in Aging Mice by in Vivo Zinc Supplementation
Dardenne, M., Boukaïba, N., Gagnerault, M. C., Homo‐Delarche, F., Chappuis, P., Lemonnier, D., & Savino, W. (1993) · Clinical Immunology and Immunopathology · doi:10.1006/clin.1993.1016 · Cited by 78 · see citing works
Sandstead, H. H., Prasad, A. S., Penland, J. G., Beck, F. W. J., Kaplan, J., Egger, N. G., Alcock, N. W., Carroll, R., Ramanujam, V., Dayal, H. H., et al. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/88.4.1067 · Cited by 73 · see citing works
Bunker, V. W., Hinks, L. J., Lawson, M. S., & Clayton, B. E. (1984) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/40.5.1096 · Cited by 73 · see citing works
Zinc Potentiates the Antiviral Action of Human IFN- α Tenfold
Berg, K., Bolt, G. R., Andersen, H., & Owen, T. C. (2001) · Journal of Interferon & Cytokine Research · doi:10.1089/10799900152434330 · Cited by 68 · see citing works
Surface markers and transendothelial migration of dendritic cells from elderly subjects
Pietschmann, P., Hahn, P., Kudlacek, S., Thomas, R., & Peterlik, M. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(99)00089-3 · Cited by 68 · see citing works
Polymorphonuclear leukocyte chemotaxis induced by zinc, copper and nickel in vitro
Hujanen, E., Seppä, S., & Virtanen, K. K. (1995) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/0304-4165(95)00082-m · Cited by 64 · see citing works
In vivo and in vitro studies of thymulin in marginally zinc‐deficient mice
Dardenne, M., Savino, W., Wade, S., Kaiserlian, D., Lemonnier, D., & Bach, J. (1984) · European Journal of Immunology · doi:10.1002/eji.1830140513 · Cited by 63 · see citing works
Zinc nutriture and cell-mediated immunity in the aged.
Wagner, P. A., Ja, J., Lb, B., Nickens, C., & Ga, B. (1983) · PubMed · Cited by 62 · see citing works
Faber, C., Gabriel, P., Ibs, K.-H., & Rink, L. (2004) · Bone Marrow Transplantation · doi:10.1038/sj.bmt.1704509 · Cited by 60 · see citing works
Self-citationHodkinson, C., Kelly, M. T., Alexander, H. D., Bradbury, I., Robson, P. J., Bonham, M. P., O’Connor, J. M., Coudray, C., Strain, J. J., & Wallace, J. M. W. (2007) · The Journals of Gerontology Series A · doi:10.1093/gerona/62.6.598 · Cited by 55 · see citing works
Zinc Inhibits the Mixed Lymphocyte Culture
Rink, L., Campo, C. A., Wellinghausen, N., Faber, C., & Fischer, A. (2001) · Biological Trace Element Research · doi:10.1385/bter:79:1:15 · Cited by 54 · see citing works
Self-citationRomir, J., Lilie, H., Egerer-Sieber, C., Bauer, F., Sticht, H., & Muller, Y. A. (2006) · Journal of Molecular Biology · doi:10.1016/j.jmb.2006.10.058 · Cited by 54 · see citing works
Zinc status of healthy elderly adults: response to supplementation
Swanson, A., Mansourian, R., Dirren, H., & Rapin, C. H. (1988) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/48.2.343 · Cited by 52 · see citing works
Control of in Vitro Lymphocyte Proliferation by Copper, Magnesium and Zinc Deficiency
Flynn, A. (1984) · Journal of Nutrition · doi:10.1093/jn/114.11.2034 · Cited by 52 · see citing works
Cossack, Z. T. (1989) · European Journal of Cancer and Clinical Oncology · doi:10.1016/0277-5379(89)90156-9 · Cited by 52 · see citing works
Kreft, B., Fischer, A., Krüger, S., Sack, K., Kirchner, H., & Rink, L. (2000) · Biogerontology · doi:10.1023/a:1010077622172 · Cited by 51 · see citing works
Self-citationKahmann, L., Uciechowski, P., Warmuth, S., Malavolta, M., Mocchegiani, E., & Rink, L. (2006) · Biogerontology · doi:10.1007/s10522-006-9058-2 · Cited by 51 · see citing works
Self-citationRich, E. A., Mincek, M., Armitage, K. B., Duffy, E. G., Owen, D. C., Fayen, J. D., Hom, D. L., & Ellner, J. J. (2009) · Gerontology · doi:10.1159/000213519 · Cited by 50 · see citing works
McClain, C., McClain, M., Barve, S., & Boosalis, M. (2002) · Clinics in Geriatric Medicine · doi:10.1016/s0749-0690(02)00040-x · Cited by 50 · see citing works
Hypocupremia induced by zinc therapy in adults
Prasad, A. S. (1978) · JAMA · doi:10.1001/jama.240.20.2166 · Cited by 50 · see citing works
Monocyte function in ageing humans
Gardner, I., Lim, S. T. K., & Lawton, J. W. M. (1981) · Mechanisms of Ageing and Development · doi:10.1016/0047-6374(81)90099-3 · Cited by 49 · see citing works
Fabian, E., & Elmadfa, I. (2008) · Annals of Nutrition and Metabolism · doi:10.1159/000115352 · Cited by 49 · see citing works
Ratio of low serum zinc levels in elderly Japanese people living in the central part of Japan
Kogirima, M., Kurasawa, R., Kubori, S., Sarukura, N., Nakamori, M., Okada, S., Kamioka, H., & Yamamoto, S. (2006) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602520 · Cited by 48 · see citing works
Prasad, A. S., Bao, B., Beck, F. W. J., & Sarkar, F. H. (2006) · Translational research · doi:10.1016/j.trsl.2006.07.008 · Cited by 48 · see citing works
Serum Zinc and Copper Status in Hospitalized vs. Healthy Elderly Subjects
Belbraouet, S., Biaudet, H., Tébi, A., Chau, N., Gray‐Donald, K., & Debry, G. (2007) · Journal of the American College of Nutrition · doi:10.1080/07315724.2007.10719643 · Cited by 47 · see citing works
Thymic output, ageing and zinc
Mitchell, W. A., Meng, I., Nicholson, S. A., & Aspinall, R. (2006) · Biogerontology · doi:10.1007/s10522-006-9061-7 · Cited by 47 · see citing works
Differential Gene Expression after Zinc Supplementation and Deprivation in Human Leukocyte Subsets
Haase, H., Mazzatti, D. J., White, A., Ibs, K.-H., Engelhardt, G., Hebel, S., Powell, J. R., & Rink, L. (2007) · Molecular Medicine · doi:10.2119/2007-00049.haase · Cited by 46 · see citing works
Self-citationThe differential sensitivity of T-Cell and B-Cell mitogenesis to in vitro zinc deficiency
ZANZONICO, P. B., Fernandes, G., & Good, R. A. (1981) · Cellular Immunology · doi:10.1016/0008-8749(81)90260-4 · Cited by 44 · see citing works
Apoptotic capability in ageing T cells
McLeod, J. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00206-2 · Cited by 44 · see citing works
Zinc as a possible mediator of signal transduction in T lymphocytes.
Csermely, P. ́., & Somogyi, J. (1989) · PubMed · Cited by 43 · see citing works
Zinc and copper status of the elderly
Vir, S., & Love, A. H. G. (1979) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/32.7.1472 · Cited by 42 · see citing works
Bunker, V. W., Hinks, L. J., Stansfield, M. F., Lawson, M. S., & Clayton, B. E. (1987) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/46.2.353 · Cited by 42 · see citing works
Metz, C. H. D., Schröder, A., Overbeck, S., Kahmann, L., Plümäkers, B., & Rink, L. (2006) · Nutrition · doi:10.1016/j.nut.2006.10.007 · Cited by 42 · see citing works
Self-citation[Characteristics of immunologic test values in the elderly].
Rink, L., & Seyfarth, M. (1997) · PubMed · Cited by 41 · see citing works
Self-citationErshler, W. B., & Longo, D. L. (1997) · Cancer · doi:10.1002/(sici)1097-0142(19971001)80:7 · Cited by 41 · see citing works
Diet and Human Immune Function
(2004) · doi:10.1007/978-1-59259-652-2 · Cited by 36 · see citing works
Mı́nguez, F., Chiu, M. L., Lima, J. E., et al. (1994) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/34.1.93 · Cited by 33 · see citing works
Prevalence of magnesium and zinc deficiencies in nursing home residents in Germany.
Wörwag, M., Classen, H. G., & Schumacher, E. (1999) · PubMed · Cited by 30 · see citing works
Skin reactivity, basophil degranulation and IgE levels in ageing
Schwarzenbach, H., Nakagawa, T., Conroy, M. C., & WECK, A. L. D. (1982) · Clinical & Experimental Allergy · doi:10.1111/j.1365-2222.1982.tb01645.x · Cited by 29 · see citing works
Zinc deficiency among the elderly attending a care centre in Sharpeville, South Africa
Oldewage-Theron, W. H., Samuel, F. O., & Venter, C. S. (2008) · Journal of Human Nutrition and Dietetics · doi:10.1111/j.1365-277x.2008.00914.x · Cited by 27 · see citing works
Zinc, oxidative stress, genetic background and immunosenescence: implications for healthy ageing
Mocchegiani, E., Malavolta, M., Marcellini, F., & Pawelec, G. (2006) · Immunity & Ageing · doi:10.1186/1742-4933-3-6 · Cited by 27 · see citing works
Davies, P. D. O. (1994) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/34.suppl_a.93 · Cited by 24 · see citing works
Influence of Aging and Sex on Specific IgE Antibody Production.
Nakazawa, T., Houjou, S., Dobashi, K., & Sato, K. (1994) · Internal Medicine · doi:10.2169/internalmedicine.33.396 · Cited by 22 · see citing works
Evidence of Cellular Zinc Depletion in Hospitalized but not in Healthy Elderly Subjects
Goode, H. F., PENN, N. D., Kelleher, J., & WALKER, B. E. (1991) · Age and Ageing · doi:10.1093/ageing/20.5.345 · Cited by 21 · see citing works
Ibs, K.-H., & Rink, L. (2001) · Zeitschrift für Gerontologie und Geriatrie · doi:10.1007/s003910170023 · Cited by 20 · see citing works
Self-citationA STUDY OF ZINC STATUS OF ELDERLY INSTITUTIONALIZED PATIENTS
STAFFORD, W., Smith, R. G., LEWIS, S. J., HENERY, E., STEPHEN, P. J., RAFFERTY, J., SIMPSON, G. K., BELLS, P. C., & ORORKE, K. (1988) · Age and Ageing · doi:10.1093/ageing/17.1.42 · Cited by 19 · see citing works
Finamore, A., Devirgiliis, C., Panno, D., D'Aquino, M., Polito, A., Venneria, E., Raguzzini, A., Coudray, C., & Mengheri, E. (2005) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602302 · Cited by 16 · see citing works
Sbarbati, A., Mocchegiani, E., Marzola, P., Tibaldi, A., Mannucci, R., Nicolato, E., & Osculati, F. (1998) · Biomedicine & Pharmacotherapy · doi:10.1016/s0753-3322(99)80024-9 · Cited by 16 · see citing works
Steinmann, G. G., & Hartwig, M. (1995) · Immunology Today · doi:10.1016/0167-5699(95)80053-0 · Cited by 15 · see citing works
Hodkinson, C., Kelly, M. T., Coudray, C., Gilmore, W., HANNIGAN, B. M., O’Connor, J. M., Strain, J., & Wallace, J. M. W. (2005) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602301 · Cited by 15 · see citing works
Senapati, A., Gillian, J., & Thompson, R. P. H. (1989) · QJM · doi:10.1093/oxfordjournals.qjmed.a068304 · Cited by 14 · see citing works
Marcellini, F., Giuli, C., Papa, R., Gagliardi, C., Dedoussis, G. V., Monti, D., Jajte, J., Giacconi, R., Malavolta, M., & Mocchegiani, E. (2008) · Rejuvenation Research · doi:10.1089/rej.2008.0680 · Cited by 11 · see citing works
Nutrition and Immunity in the Elderly
Bogden, J. D., & Louria, D. B. (2004) · Humana Press eBooks · doi:10.1007/978-1-59259-652-2_5 · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Zinc and human health: an update
Chasapis, C. T., Loutsidou, A. K., Spiliopoulou, C., & Stefanidou, M. E. (2011) · Archives of Toxicology · doi:10.1007/s00204-011-0775-1 · Cited by 1,072 · see citing works
Aiello, A., Farzaneh, F., Candore, G., Caruso, C., Davinelli, S., Gambino, C. M., Ligotti, M. E., Zareian, N., & Accardi, G. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02247 · Cited by 693 · see citing works
Heavy metal toxicity: An update of chelating therapeutic strategies
Kim, J.-J., Kim, Y.-S., & Kumar, V. (2019) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2019.05.003 · Cited by 648 · see citing works
COVID-19: The Inflammation Link and the Role of Nutrition in Potential Mitigation
Zabetakis, I., Lordan, R., Norton, C., & Τσούπρας, Α. (2020) · Nutrients · doi:10.3390/nu12051466 · Cited by 535 · see citing works
Nutritional Modulation of Immune Function: Analysis of Evidence, Mechanisms, and Clinical Relevance
Wu, D., Lewis, E. D., Pae, M., & Meydani, S. N. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2018.03160 · Cited by 494 · see citing works
Metal Ions, Metal Chelators and Metal Chelating Assay as Antioxidant Method
Gülçın, İ., & Alwasel, S. H. (2022) · Processes · doi:10.3390/pr10010132 · Cited by 448 · see citing works
Zinc and respiratory tract infections: Perspectives for COVID‑19 (Review)
Skalny, A. V., Rink, L., Ajsuvakova, O. P., Aschner, M., Гриценко, В. А., Alekseenko, S. I., Svistunov, A. А., Petrakis, D., Spandidos, D. A., Aaseth, J., et al. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4575 · Cited by 435 · see citing works
Self-citationZinc signals and immune function
Haase, H., & Rink, L. (2013) · BioFactors · doi:10.1002/biof.1114 · Cited by 305 · see citing works
Self-citationThe relationship between nutrition and the immune system
Munteanu, C., & Schwartz, B. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1082500 · Cited by 315 · see citing works
Taylor, K. M., Hiscox, S., Nicholson, R. I., Högstrand, C., & Kille, P. (2012) · Science Signaling · doi:10.1126/scisignal.2002585 · Cited by 266 · see citing works
Fallah, A., Mohammad‐Hasani, A., & Colagar, A. H. (2018) · Europe PMC (PubMed Central) · Cited by 248 · see citing works
The influence of diet on anti-cancer immune responsiveness
Soldati, L., Renzo, L. D., Jirillo, E., Ascierto, P. A., Marincola, F. M., & LORENZO, A. D. (2018) · Journal of Translational Medicine · doi:10.1186/s12967-018-1448-0 · Cited by 247 · see citing works
Natural Compounds and Products from an Anti-Aging Perspective
Bjørklund, G., Shanaida, M., Lysiuk, R., Butnariu, M., Peana, M., Sărac, I., Strus, O., Smetanina, K., & Chirumbolo, S. (2022) · Molecules · doi:10.3390/molecules27207084 · Cited by 231 · see citing works
Zinc: Dietary intake and impact of supplementation on immune function in elderly
Mocchegiani, E., Romeo, J., Malavolta, M., Costarelli, L., Giacconi, R., Diaz, L.-E., & Marcos, A. (2013) · AGE · doi:10.1007/s11357-011-9377-3 · Cited by 198 · see citing works
Kaur, K., Gupta, R., Saraf, S. A., & Saraf, S. K. (2014) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12067 · Cited by 199 · see citing works
Barrea, L., Muscogiuri, G., Frías-Toral, E., Laudisio, D., Pugliese, G., Castellucci, B., Garcia-Velasquez, E., Savastano, S., & Colao, A. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1792826 · Cited by 200 · see citing works
Zinc in innate and adaptive tumor immunity
John, E. B., Laskow, T. C., Buchser, W., Pitt, B. R., Basse, P. H., Butterfield, L. H., Kaliński, P., & Lotze, M. T. (2010) · Journal of Translational Medicine · doi:10.1186/1479-5876-8-118 · Cited by 188 · see citing works
Interactions of zinc- and redox-signaling pathways
Hübner, C., & Haase, H. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101916 · Cited by 183 · see citing works
Self-citationQueen, B., & Tollefsbol, T. O. (2010) · Current Aging Science · doi:10.2174/1874609811003010034 · Cited by 178 · see citing works
The role of nutrition in enhancing immunity in aging.
Pae, M., Meydani, S. N., & Wu, D. (2012) · Europe PMC (PubMed Central) · Cited by 173 · see citing works
Wong, C. P., Rinaldi, N. A., & Ho, E. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400761 · Cited by 174 · see citing works
The Role of Zinc and Zinc Homeostasis in Macrophage Function
Gao, H., Dai, W., Zhao, L., Min, J.-X., & Wang, F.-D. (2018) · Journal of Immunological Research · doi:10.1155/2018/6872621 · Cited by 159 · see citing works
The enormity of the zinc deficiency problem and available solutions; an overview
Khan, S. T., Malik, A., Al‐Warthan, A., & Shaik, M. R. (2021) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2021.103668 · Cited by 169 · see citing works
Cerullo, G., Negro, M., Parimbelli, M., Pecoraro, M., Perna, S., Liguori, G., Rondanelli, M., Cena, H., & D’Antona, G. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.574029 · Cited by 171 · see citing works
Iron, zinc, and copper in retinal physiology and disease.
Ugarte, M., Osborne, N., Brown, L., & Bishop, P. (2013) · Survey of ophthalmology · doi:10.1016/j.survophthal.2012.12.002 · Cited by 158 · see citing works
Weßels, I., Haase, H., Engelhardt, G., Rink, L., & Uciechowski, P. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.06.007 · Cited by 147 · see citing works
Self-citationGuo, C.-H., Chen, P., Yeh, M.-S., Hsiung, D.-Y., & Wang, C.-L. (2011) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2010.12.017 · Cited by 146 · see citing works
Differential Regulation of TLR-Dependent MyD88 and TRIF Signaling Pathways by Free Zinc Ions
Brieger, A., Rink, L., & Haase, H. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1301261 · Cited by 139 · see citing works
Self-citationBlood Metals Concentration in Type 1 and Type 2 Diabetics
Forte, G., Bocca, B., Peruzzu, A., Tolu, F., Asara, Y., Farace, C., Oggiano, R., & Madeddu, R. (2013) · Biological Trace Element Research · doi:10.1007/s12011-013-9858-6 · Cited by 131 · see citing works
Calder, P. C., Ortega, E. F., Meydani, S. N., Adkins, Y. C., Stephensen, C. B., Thompson, B., & Zwickey, H. L. (2022) · Advances in Nutrition · doi:10.1093/advances/nmac052 · Cited by 136 · see citing works
Guo, C.-H., & Wang, C. (2013) · International Journal of Medical Sciences · doi:10.7150/ijms.5291 · Cited by 121 · see citing works
Regulatory Role of Zinc in Immune Cell Signaling
Kim, B., & Lee, W. (2021) · Molecules and Cells · doi:10.14348/molcells.2021.0061 · Cited by 121 · see citing works
Turpin, W., Dong, M., Sasson, G., Garay, J. A. R., Espin‐Garcia, O., Lee, S.-H., Neustaeter, A., Smith, M. I., Leibovitzh, H., Guttman, D. S., et al. (2022) · Gastroenterology · doi:10.1053/j.gastro.2022.05.037 · Cited by 121 · see citing works
Assessment of reference ranges for blood Cu, Mn, Se and Zn in a selected Italian population
Bocca, B., Madeddu, R., Asara, Y., Tolu, P., Marchal, J. A., & Forte, G. (2011) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2010.12.004 · Cited by 114 · see citing works
Zinc and Cancer: Implications for LIV-1 in Breast Cancer
Grattan, B. J., & Freake, H. C. (2012) · Nutrients · doi:10.3390/nu4070648 · Cited by 114 · see citing works
Zinc and its role in age‐related inflammation and immune dysfunction
Wong, C. P., & Ho, E. (2011) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201100511 · Cited by 113 · see citing works
Zinc biofortification of maize ( Zea mays L.): Status and challenges
Maqbool, M. A., & Beshir, A. (2018) · Plant Breeding · doi:10.1111/pbr.12658 · Cited by 106 · see citing works
Name, J. J., Souza, A. C. R., Vasconcelos, A. R., Prado, P. S., & Pereira, C. P. M. (2020) · Frontiers in Nutrition · doi:10.3389/fnut.2020.606398 · Cited by 112 · see citing works
Abnormal Epigenetic Regulation of Immune System during Aging
Jasiulionis, M. G. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00197 · Cited by 99 · see citing works
Wong, C. P., Magnusson, K. R., & Ho, E. (2012) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2012.07.005 · Cited by 98 · see citing works
Zinc, aging, and immunosenescence: an overview
Cabrera, Á. (2015) · Pathobiology of Aging & Age-related Diseases · doi:10.3402/pba.v5.25592 · Cited by 100 · see citing works
Inadequacy of Immune Health Nutrients: Intakes in US Adults, the 2005–2016 NHANES
Reider, C. A., Chung, R.-Y., Devarshi, P. P., Grant, R. W., & Mitmesser, S. H. (2020) · Nutrients · doi:10.3390/nu12061735 · Cited by 98 · see citing works
Gupta, C., & Prakash, D. (2014) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2014.10.004 · Cited by 95 · see citing works
Relation of Serum Copper Status to Survival in COVID-19
Hackler, J., Heller, R. A., Sun, Q., Schwarzer, M., Diegmann, J., Bachmann, M., Moghaddam, A., & Schomburg, L. (2021) · Nutrients · doi:10.3390/nu13061898 · Cited by 90 · see citing works
Immunosenescence of Polymorphonuclear Neutrophils
Weßels, I., Jansen, J., Rink, L., & Uciechowski, P. (2010) · The Scientific World JOURNAL · doi:10.1100/tsw.2010.14 · Cited by 89 · see citing works
Self-citationVegetarian Diets Across the Lifecycle
Foster, M. J., & Samman, S. (2015) · Advances in food and nutrition research · doi:10.1016/bs.afnr.2014.11.003 · Cited by 86 · see citing works
Mocchegiani, E., Costarelli, L., Giacconi, R., Malavolta, M., Basso, A., Piacenza, F., Ostan, R., Cevenini, E., Gonos, E. S., & Monti, D. (2014) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2013.12.007 · Cited by 85 · see citing works
Mocchegiani, E., Costarelli, L., Giacconi, R., Piacenza, F., Basso, A., & Malavolta, M. (2012) · Ageing Research Reviews · doi:10.1016/j.arr.2012.01.004 · Cited by 81 · see citing works
Rosenkranz, E., Maywald, M., Hilgers, R., Brieger, A., Clarner, T., Kipp, M., Plümäkers, B., Meyer, S., Schwerdtle, T., & Rink, L. (2016) · Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.11.010 · Cited by 80 · see citing works
Self-citationMetallothionein: a Potential Link in the Regulation of Zinc in Nutritional Immunity
Rahman, M. T., & Karim, M. M. (2018) · Biological Trace Element Research · doi:10.1007/s12011-017-1061-8 · Cited by 77 · see citing works
Nutritional modulation of age-related changes in the immune system and risk of infection
Pae, M., & Wu, D. (2017) · Nutrition Research · doi:10.1016/j.nutres.2017.02.001 · Cited by 80 · see citing works
Socha, K., Klimiuk, K., Naliwajko, S. K., Soroczyńska, J., Puścion‐Jakubik, A., Markiewicz‐Żukowska, R., & Kochanowicz, J. (2021) · Nutrients · doi:10.3390/nu13020287 · Cited by 72 · see citing works
Vignesh, K. S., & Deepe, G. S. (2016) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2016.02.020 · Cited by 72 · see citing works
The Implications of Zinc Therapy in Combating the COVID-19 Global Pandemic
Samad, N., Sodunke, T. E., Abubakar, A. R., Jahan, I., Sharma, P., Islam, S., Dutta, S., & Haque, M. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s295377 · Cited by 68 · see citing works
The interplay of obesity, gut microbiome and diet in the immune check point inhibitors therapy era
Spyrou, N., Vallianou, N. G., Kadillari, J., & Dalamaga, Μ. (2021) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2021.05.008 · Cited by 65 · see citing works
Metal Ion Signaling in Biomedicine
Rodriguez, R., Müller, S., Colombeau, L., Solier, S., Sindikubwabo, F., & Cañeque, T. (2025) · Chemical Reviews · doi:10.1021/acs.chemrev.4c00577 · Cited by 66 · see citing works
Roles of zinc in cancers: From altered metabolism to therapeutic applications
Bendellaa, M., Lelièvre, P., Coll, J., Sancey, L., Deniaud, A., & Busser, B. (2023) · International Journal of Cancer · doi:10.1002/ijc.34679 · Cited by 60 · see citing works
Zinc as nutritional intervention and prevention measure for COVID–19 disease
Mossink, J. P. (2020) · BMJ Nutrition Prevention & Health · doi:10.1136/bmjnph-2020-000095 · Cited by 60 · see citing works
Thingholm, T. E., Rönnstrand, L., & Rosenberg, P. A. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03473-3 · Cited by 63 · see citing works
Pisano, A., Santolla, M. F., Francesco, E. M. D., Marco, P. D., Rigiracciolo, D. C., Perri, M. G., Vivacqua, A., Abonante, S., Cappello, A. R., Dolce, V., et al. (2016) · Molecular Carcinogenesis · doi:10.1002/mc.22518 · Cited by 57 · see citing works
Barchitta, M., Maugeri, A., Mastra, C. L., Rosa, M. C. L., Favara, G., Lio, R. M. S., & Agodi, A. (2020) · Nutrients · doi:10.3390/nu12051384 · Cited by 57 · see citing works
Frydrych, A., Krośniak, M., & Jurowski, K. (2023) · Nutrients · doi:10.3390/nu15041012 · Cited by 56 · see citing works
Zinc Deficiency in Human Health
Nriagu, J. O. (2011) · Elsevier eBooks · doi:10.1016/b978-0-444-52272-6.00674-7 · Cited by 56 · see citing works
COVID-19 Outbreak: Pathogenesis, Current Therapies, and Potentials for Future Management
Hossain, M. F., Hasana, S., Mamun, A. A., Uddin, M. S., Wahed, M. I. I., Sarker, S., Behl, T., Ullah, I., Begum, Y., Bulbul, I. J., et al. (2020) · Frontiers in Pharmacology · doi:10.3389/fphar.2020.563478 · Cited by 55 · see citing works
Kim, B., Kim, H. Y., Yoon, B. R., Yeo, J., Jung, J. I., Yu, K., Kim, H. C., Yoo, S., Park, J. K., Kang, S. W., et al. (2022) · Science Signaling · doi:10.1126/scisignal.abi7400 · Cited by 55 · see citing works
Risk of malnutrition and zinc deficiency in community-living elderly men and women: the Tromsø Study
Kvamme, J., Grønli, O., Jacobsen, B. K., & Florholmen, J. (2014) · Public Health Nutrition · doi:10.1017/s1368980014002420 · Cited by 53 · see citing works
Reversing the immune ageing clock: lifestyle modifications and pharmacological interventions
Duggal, N. A. (2018) · Biogerontology · doi:10.1007/s10522-018-9771-7 · Cited by 53 · see citing works
Hosseini, R., Ferns, G. A., Sahebkar, A., Mirshekar, M. A., & Jalali, M. (2020) · Cytokine · doi:10.1016/j.cyto.2020.155396 · Cited by 51 · see citing works
Zinc, metallothioneins and immunosenescence: effect of zinc supply as nutrigenomic approach
Mocchegiani, E., Costarelli, L., Giacconi, R., Piacenza, F., Basso, A., & Malavolta, M. (2011) · Biogerontology · doi:10.1007/s10522-011-9337-4 · Cited by 51 · see citing works
Devarshi, P. P., Mao, Q., Grant, R. W., & Mitmesser, S. H. (2024) · Nutrients · doi:10.3390/nu16244269 · Cited by 50 · see citing works
Manipulating the immune system for pigs to optimise performance
Pluske, J. R., Kim, J.-C., & Black, J. L. (2018) · Animal Production Science · doi:10.1071/an17598 · Cited by 50 · see citing works
Effects of aluminum trichloride on the trace elements and cytokines in the spleen of rats
Zhu, Y., Li, X., Chen, C., Wang, F., Li, J., Hu, C., Li, Y., & Miao, L. (2012) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.05.041 · Cited by 48 · see citing works
Molecular and pathophysiological aspects of metal ion uptake by the zinc transporter ZIP8 (SLC39A8)
Zang, Z., Xu, Y., & Lau, A. T. Y. (2016) · Toxicology Research · doi:10.1039/c5tx00424a · Cited by 48 · see citing works
Effects of zinc status on age-related T cell dysfunction and chronic inflammation
Wong, C. P., Magnusson, K. R., Sharpton, T. J., & Ho, E. (2021) · BioMetals · doi:10.1007/s10534-020-00279-5 · Cited by 46 · see citing works
The nutritional roles of zinc for immune system and COVID-19 patients
Jin, D., Wei, X., He, Y., Zhong, L., Lü, H., Lan, J., Wei, Y., Liu, Z., & Liu, H. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1385591 · Cited by 46 · see citing works
Laine, J. T., Tuomainen, T., Salonen, J. T., & Virtanen, J. K. (2020) · European Journal of Epidemiology · doi:10.1007/s10654-020-00644-1 · Cited by 44 · see citing works
Zinc supplementation reduces diet-induced obesity and improves insulin sensitivity in rats
Thoen, R. U., Barther, N. N., Schemitt, E., Bona, S., Fernandes, S., Coral, G., Marroni, N. P., Tovo, C., Guedes, R. P., & Porawski, M. (2019) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2018-0519 · Cited by 43 · see citing works
Zinc deficiency as possible link between immunosenescence and age-related diseases
Schulz, M., & Rink, L. (2025) · Immunity & Ageing · doi:10.1186/s12979-025-00511-1 · Cited by 42 · see citing works
Self-citationCalvo, I., Olivar, J. E. R., Martínez, E., Rico, A., Diaz, J. M. Q., & Gimena, M. (2012) · PubMed · doi:10.3305/nh.2012.27.5.5888 · Cited by 43 · see citing works
Lead and zinc interactions – An influence of zinc over lead related toxic manifestations
Wani, A. L., Shadab, G. G. H. A., & Afzal, M. (2020) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2020.126702 · Cited by 43 · see citing works
Zinc toxicity and ATP production inPseudomonas fluorescens
Alhasawi, A. A., Auger, C., Appanna, V. D., Chahma, M., & Appanna, V. D. (2014) · Journal of Applied Microbiology · doi:10.1111/jam.12497 · Cited by 42 · see citing works
Glia and zinc in ageing and Alzheimer’s disease: a mechanism for cognitive decline?
Hancock, S. M., Finkelstein, D. I., & Adlard, P. A. (2014) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2014.00137 · Cited by 34 · see citing works
Nutrition and nonmelanoma skin cancers
Payette, M. J., Whalen, J. D., & Grant-Kels, J. M. (2010) · Clinics in Dermatology · doi:10.1016/j.clindermatol.2010.03.033 · Cited by 38 · see citing works
Li, X., Shenashen, M. A., Wang, X., Ito, A., Taniguchi, A., & El‐Safty, S. A. (2017) · Scientific Reports · doi:10.1038/s41598-017-12446-9 · Cited by 38 · see citing works
Arnaud, J., Touvier, M., Galan, P., Andriollo-Sanchez, M., Ruffieux, D., Roussel, A. M., Herçberg, S., & Favier, A. E. (2010) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2010.118 · Cited by 37 · see citing works
Sickle cell disease as an accelerated aging syndrome
Idris, I. M., Botchwey, E. A., & Hyacinth, H. I. (2022) · Experimental Biology and Medicine · doi:10.1177/15353702211068522 · Cited by 37 · see citing works
Obesity and dysregulated innate immune responses: impact of micronutrient deficiencies
Vrieling, F., & Stienstra, R. (2023) · Trends in Immunology · doi:10.1016/j.it.2023.01.003 · Cited by 36 · see citing works
The role of DNA methylation and hydroxymethylation in immunosenescence
Johnson, N. D., & Conneely, K. N. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.01.011 · Cited by 35 · see citing works
Diwan, B., & Sharma, R. (2022) · Food Science and Biotechnology · doi:10.1007/s10068-022-01114-y · Cited by 36 · see citing works
The role of micronutrients in the diet of HIV-1-infected individuals
Nunnari, G. (2012) · Frontiers in Bioscience-Elite · doi:10.2741/e556 · Cited by 34 · see citing works
Influence of d-Electron Divalent Metal Ions in Complex Formation with L-Tartaric and L-Malic Acids
Zabiszak, M., Frymark, J., Nowak, M., Grajewski, J., Stachowiak, K., Kaczmarek, M. T., & Jastrząb, R. (2021) · Molecules · doi:10.3390/molecules26175290 · Cited by 34 · see citing works
Sheikh, A. A., Aggarwal, A., Indu, B., & Aarif, O. (2017) · Theriogenology · doi:10.1016/j.theriogenology.2017.02.024 · Cited by 34 · see citing works
Trace Element Zinc, a Nature’s Gift to Fight Unprecedented Global Pandemic COVID-19
Sharma, P., Reddy, P. K., & Kumar, B. (2020) · Biological Trace Element Research · doi:10.1007/s12011-020-02462-8 · Cited by 33 · see citing works
Zinc: Roles in pancreatic physiology and disease
Wang, M., Phadke, M., Packard, D. G., Yadav, D. K., & Gorelick, F. S. (2020) · Pancreatology · doi:10.1016/j.pan.2020.08.016 · Cited by 32 · see citing works
Olafisoye, O. B., Fatoki, O. S., Oguntibeju, O. O., & Osibote, O. A. (2020) · Toxicology Reports · doi:10.1016/j.toxrep.2020.01.016 · Cited by 32 · see citing works
Metals on the Menu—Analyzing the Presence, Importance, and Consequences
Milanković, V., Tasić, T., Leskovac, A. R., Petrović, S. Ž., Mitić, M., Pašti, T. D. L., Novković, M., & Potkonjak, N. (2024) · Foods · doi:10.3390/foods13121890 · Cited by 36 · see citing works
Immunopharmacological perspective on zinc in SARS-CoV-2 infection
Asl, S. H., Nikfarjam, S., Zolbanin, N. M., Nassiri, R., & Jafari, R. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107630 · Cited by 32 · see citing works
Eggersdorfer, M. L., Berger, M. M., Calder, P. C., Gombart, A. F., Ho, E., Laviano, A., & Meydani, S. N. (2022) · Advances in Nutrition · doi:10.1093/advances/nmac058 · Cited by 31 · see citing works
Systemic zinc redistribution and dyshomeostasis in cancer cachexia
Siren, P. M. A., & Siren, M. J. (2010) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1007/s13539-010-0009-z · Cited by 31 · see citing works
- Authors
- Haase, H., & Rink, L.
- Affiliations
- RWTH Aachen University (DE)
- Corresponding author
- Rink, Lothar
- Venue
- Immunity & Ageing
- Published
- 2009-06-12
- Volume
- 6
- Issue
- 1
- Pages
- 9-9
- ISSN
- 1742-4933 (ISSN-L)
- PMC
- PMC2702361
- OpenAlex
- W2124890716
- Cited by
- 334
- References
- 157
- Citations by year
- 2026: 14 · 2025: 20 · 2024: 18 · 2023: 14 · 2022: 30 · 2021: 38 · 2020: 31 · 2019: 18 · 2018: 13 · 2017: 17 · 2016: 16 · 2015: 13 · 2014: 17 · 2013: 16 · 2012: 28
- FWCI
- 19.04
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Immunity & Ageing (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- RWTH Publications (RWTH Aachen) (submittedVersion, cc-by)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- zinc, zinc deficiency, immunosenescence, aging, innate immunity, adaptive immunity, thymus, T helper cells, Th2 shift, vaccine response, oral zinc supplementation, chronic inflammation, older adults
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review