Cited by 186Ovarian function and disordersHypothalamic control of reproductive hormonesReproductive Biology and Fertility

New Perspectives on the Pathogenesis of PCOS: Neuroendocrine Origins

Walters, Kirsty A., Gilchrist, Robert B., Ledger, William L., Teede, Helena J., Handelsman, David J., Campbell, Rebecca E.·2018·Trends in Endocrinology & Metabolism

Abstract

Polycystic ovary syndrome (PCOS) is the most common endocrine condition in reproductive-aged women. It is characterized by reproductive, endocrine, metabolic, and psychological features. The cause of PCOS is unknown, thus there is no cure and its management remains suboptimal because it relies on the ad hoc empirical management of symptoms only. We review here the strong support for PCOS having a neuroendocrine origin. In particular, we focus on the role of aberrant hypothalamic-pituitary function and associated hyperandrogenism, and their role as major drivers of the mechanisms underpinning the development of PCOS. This important information now provides a target site and a potential mechanism for the future development of novel, targeted, and mechanism-based effective therapies for the treatment of PCOS.

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Crossref · 10.1016/j.tem.2018.08.005

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  • Fetal exposure to high levels of testosterone during an early, critical window of embryological development biases the HPG axis toward increased testosterone production that continues throughout postnatal life.

    “Fetal exposure to high levels of testosterone during an early, critical window of embryological development biases the HPG axis toward increased testosterone production that continues throughout postnatal life (Abbott et al., 2002, 2019; Filippou & Homburg, 2017; Walters et al., 2018).”

    From Endometriosis and polycystic ovary syndrome are diametric disorders (2021) · cites this paper as Walters et al., 2018

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Authors
Walters, K. A., Gilchrist, R. B., Ledger, W. L., Teede, H. J., Handelsman, D. J., & Campbell, R. E.
Affiliations
  • UNSW Sydney (AU)
  • Monash University (AU)
  • The University of Sydney (AU)
  • University of Otago (NZ)
Corresponding author
Walters, Kirsty A.
Venue
Trends in Endocrinology & Metabolism
Publisher
Elsevier BV
Published
2018-12
Volume
29
Issue
12
Pages
841-852
ISSN
1043-2760 (ISSN-L)
OpenAlex
W2890654310
Cited by
186
References
89
Citations by year
2026: 14 · 2025: 23 · 2024: 28 · 2023: 45 · 2022: 23 · 2021: 20 · 2020: 18 · 2019: 15
FWCI
2.00
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Endocrinology and Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Keywords
polycystic ovary syndrome, pathogenesis, hypothalamic-pituitary dysfunction, hyperandrogenism, women of reproductive age
MeSH terms
Animals, Brain, Female, Humans, Neurosecretory Systems, Polycystic Ovary Syndrome, Hyperandrogenism

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