Cited by 492Metal-Catalyzed Oxygenation MechanismsBiochemical Acid Research StudiesMicrobial metabolism and enzyme function

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2-Oxoglutarate-Dependent Oxygenases

Islam, Md. Saiful, Leissing, Thomas M., Chowdhury, Rasheduzzaman, Hopkinson, Richard J., Schofield, Christopher J.·2018·Annual Review of Biochemistry

DOI 10.1146/annurev-biochem-061516-044724

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Abstract

2-Oxoglutarate (2OG)-dependent oxygenases (2OGXs) catalyze a remarkably diverse range of oxidative reactions. In animals, these comprise hydroxylations and N-demethylations proceeding via hydroxylation; in plants and microbes, they catalyze a wider range including ring formations, rearrangements, desaturations, and halogenations. The catalytic flexibility of 2OGXs is reflected in their biological functions. After pioneering work identified the roles of 2OGXs in collagen biosynthesis, research revealed they also function in plant and animal development, transcriptional regulation, nucleic acid modification/repair, fatty acid metabolism, and secondary metabolite biosynthesis, including of medicinally important antibiotics. In plants, 2OGXs are important agrochemical targets and catalyze herbicide degradation. Human 2OGXs, particularly those regulating transcription, are current therapeutic targets for anemia and cancer. Here, we give an overview of the biochemistry of 2OGXs, providing examples linking to biological function, and outline how knowledge of their enzymology is being exploited in medicine, agrochemistry, and biocatalysis.

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Authors: Islam, M. S., Leissing, T. M., Chowdhury, R., Hopkinson, R. J., & Schofield, C. J.
Affiliations: University of Oxford (GB)
University of Leicester (GB)
Corresponding author: Islam, Md. Saiful
Leissing, Thomas M.
Chowdhury, Rasheduzzaman
Hopkinson, Richard J.
Schofield, Christopher J.
ORCID: Islam, Md. Saiful
Chowdhury, Rasheduzzaman
Hopkinson, Richard J.
Schofield, Christopher J.
Venue: Annual Review of Biochemistry
Publisher: Annual Reviews
Published: 2018-06-20
Volume: 87
Issue: 1
Pages: 585-620
ISSN: 0066-4154 (ISSN-L)
1545-4509
DOI: 10.1146/annurev-biochem-061516-044724
OpenAlex: W2483061037
Semantic Scholar: 1f082a9f33c479e0e3ec9bbbf5edfe3f16c04e9d
Cited by: 472
References: 168
Citations by year: 2026: 39 · 2025: 58 · 2024: 76 · 2023: 54 · 2022: 57 · 2021: 70 · 2020: 53 · 2019: 38 · 2018: 18
FWCI: 1.57
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Biochemistry (publishedVersion)
PubMed (publishedVersion)
Funders: Wellcome Trust
Cancer Research UK
Biotechnology and Biological Sciences Research Council (BB/L009846/1)
Topics: Physical Sciences › Chemistry › Inorganic Chemistry › Metal-Catalyzed Oxygenation Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Biochemical Acid Research Studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial metabolism and enzyme function
Keywords: 2-oxoglutarate-dependent dioxygenase, hydroxylation, N-demethylation, cyclization, desaturation, halogenation, collagen synthesis, transcriptional regulation, nucleic acid modification, fatty acid metabolism, secondary metabolite biosynthesis, antibiotic biosynthesis, herbicide degradation, anemia, cancer, biocatalysis, enzyme biochemistry
MeSH terms: Animals, Collagen, Humans, Hydroxylation, Ketoglutaric Acids, Models, Biological, Models, Molecular, Oxidation-Reduction, Oxygenases, Protein Conformation, Substrate Specificity, Biocatalysis

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