The DOI matches its Crossref record; 135 of the 135 references it cites were found in a registry or an index.
Structural Perspective of Peptidoglycan Biosynthesis and Assembly
Abstract
The peptidoglycan biosynthetic pathway is a critical process in the bacterial cell and is exploited as a target for the design of antibiotics. This pathway culminates in the production of the peptidoglycan layer, which is composed of polymerized glycan chains with cross-linked peptide substituents. This layer forms the major structural component of the protective barrier known as the cell wall. Disruption in the assembly of the peptidoglycan layer causes a weakened cell wall and subsequent bacterial lysis. With bacteria responsible for both properly functioning human health (probiotic strains) and potentially serious illness (pathogenic strains), a delicate balance is necessary during clinical intervention. Recent research has furthered our understanding of the precise molecular structures, mechanisms of action, and functional interactions involved in peptidoglycan biosynthesis. This research is helping guide our understanding of how to capitalize on peptidoglycan-based therapeutics and, at a more fundamental level, of the complex machinery that creates this critical barrier for bacterial survival.
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Cites
Construction of Escherichia coli K‐12 in‐frame, single‐gene knockout mutants: the Keio collection
Baba, T., Ara, T., Hasegawa, M., Takai, Y., Okumura, Y., Baba, M., Datsenko, K. A., Tomita, M., Wanner, B. L., & Mori, H. (2006) · Molecular Systems Biology · doi:10.1038/msb4100050 · Cited by 7,858
Peptidoglycan structure and architecture
Vollmer, W., Blanot, D., & De Pedro, M. A. (2008) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2007.00094.x · Cited by 2,340
The penicillin-binding proteins: structure and role in peptidoglycan biosynthesis
Sauvage, E., Kerff, F., Terrak, M., Ayala, J. A., & Charlier, P. (2008) · FEMS Microbiology Reviews · doi:10.1111/j.1574-6976.2008.00105.x · Cited by 1,317
Growth of the Stress-Bearing and Shape-Maintaining Murein Sacculus of Escherichia coli
Höltje, J.-V. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.1.181-203.1998 · Cited by 1,129
Tipper, D. J., & Strominger, J. L. (1965) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.54.4.1133 · Cited by 1,008
THE MECHANISM OF ACTION OF FOSFOMYCIN (PHOSPHONOMYCIN)
Kahan, F. M., Kahan, J. S., Cassidy, P. J., & Kropp, H. (1974) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1974.tb43277.x · Cited by 777
Multimodular Penicillin-Binding Proteins: An Enigmatic Family of Orthologs and Paralogs
Goffin, C., & Ghuysen, J.-M. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.4.1079-1093.1998 · Cited by 636
D-Amino Acids Govern Stationary Phase Cell Wall Remodeling in Bacteria
Lam, H., Oh, D.-C., Cava, F., Takacs, C. N., Clardy, J., de Pedro, M. A., & Waldor, M. K. (2009) · Science · doi:10.1126/science.1178123 · Cited by 618
Plectasin, a Fungal Defensin, Targets the Bacterial Cell Wall Precursor Lipid II
Schneider, T., Kruse, T., Wimmer, R., Wiedemann, I., Sass, V., Pag, U., Jansen, A., Nielsen, A. K., Mygind, P. H., Raventós, D. S., et al. (2010) · Science · doi:10.1126/science.1185723 · Cited by 550
Processive Movement of MreB-Associated Cell Wall Biosynthetic Complexes in Bacteria
Domínguez-Escobar, J., Chastanet, A., Crevenna, A. H., Fromion, V., Wedlich-Söldner, R., & Carballido-López, R. (2011) · Science · doi:10.1126/science.1203466 · Cited by 538
Cited by
Nonribosomal Peptide Synthesis—Principles and Prospects
Süssmuth, R. D., & Mainz, A. (2017) · Angewandte Chemie International Edition · doi:10.1002/anie.201609079 · Cited by 958
Antimicrobial peptides for combating drug-resistant bacterial infections
Xuan, J., Feng, W., Wang, J., Wang, R., Zhang, B., Bo, L., Chen, Z.-S., Yang, H., & Sun, L. (2023) · Drug Resistance Updates · doi:10.1016/j.drup.2023.100954 · Cited by 665
Mechanisms of Methicillin Resistance in Staphylococcus aureus
Peacock, S. J., & Paterson, G. K. (2015) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060614-034516 · Cited by 656
On the maverick Planctomycetes
Wiegand, S., Jogler, M., & Jogler, C. (2018) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuy029 · Cited by 319
Staying in Shape: the Impact of Cell Shape on Bacterial Survival in Diverse Environments
Yang, D. C., Blair, K. M., & Salama, N. R. (2016) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00031-15 · Cited by 295
Metadata
- Authors
- Lovering, A. L., Safadi, S. S., & Strynadka, N. C. J.
- Venue
- Annual Review of Biochemistry
- Publisher
- Annual Reviews
- Published
- 2012-07-07
- Volume
- 81
- Issue
- 1
- Pages
- 451-478
- ISSN
- 0066-4154 (ISSN-L)
- 1545-4509
- OpenAlex
- W2148325233
- Cited by
- 329
- References
- 135
- FWCI
- 3.58
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lovering, A. L., Safadi, S. S., & Strynadka, N. C. J. (2012). Structural Perspective of Peptidoglycan Biosynthesis and Assembly. Annual Review of Biochemistry. https://doi.org/10.1146/annurev-biochem-061809-112742
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