Repair of DNA Double-Strand Breaks by the Nonhomologous End Joining Pathway

The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway

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Homologous recombination and non‐homologous end‐joining pathways of DNA double‐strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells

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Increasing the efficiency of precise genome editing with CRISPR-Cas9 by inhibition of nonhomologous end joining

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Repair of Strand Breaks by Homologous RecombinationPreprint

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A Pathway of Double-Strand Break Rejoining Dependent upon ATM, Artemis, and Proteins Locating to γ-H2AX Foci

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Shelterin-Mediated Telomere Protection

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XLF Interacts with the XRCC4-DNA Ligase IV Complex to Promote DNA Nonhomologous End-Joining

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Cernunnos, a Novel Nonhomologous End-Joining Factor, Is Mutated in Human Immunodeficiency with Microcephaly

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Endogenous DNA double-strand breaks: production, fidelity of repair, and induction of cancer

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Activity of DNA ligase IV stimulated by complex formation with XRCC4 protein in mammalian cells

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A critical role for DNA end-joining proteins in both lymphogenesis and neurogenesis

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Microhomology-Mediated End Joining: A Back-up Survival Mechanism or Dedicated Pathway?

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V(D)J Recombination: Mechanisms of Initiation

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DNA processing is not required for ATM-mediated telomere damage response after TRF2 deletion

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IgH class switching and translocations use a robust non-classical end-joining pathway

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Late embryonic lethality and impaired V (D)J recombination in mice lacking DNA ligase IV

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Changes in chromatin structure and mobility in living cells at sites of DNA double-strand breaks

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Regulation of Single-Strand Annealing and its Role in Genome Maintenance

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Positional stability of single double-strand breaks in mammalian cells

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Mechanisms of Programmed DNA Lesions and Genomic Instability in the Immune System

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Nonhomologous recombination in mammalian cells: role for short sequence homologies in the joining reaction.

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The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination

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Preclinical Evaluation of a Potent Novel DNA-Dependent Protein Kinase Inhibitor NU7441

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Targeted disruption of the gene encoding DNA ligase IV leads to lethality in embryonic mice

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Quantitative Live Cell Imaging Reveals a Gradual Shift between DNA Repair Mechanisms and a Maximal Use of HR in Mid S Phase

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Is Non-Homologous End-Joining Really an Inherently Error-Prone Process?

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A human 5′-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage

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Autophosphorylation of DNA-PKCS regulates its dynamics at DNA double-strand breaks

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A eukaryotic enzyme that can disjoin dead-end covalent complexes between DNA and type I topoisomerases.

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Ku Recruits the XRCC4-Ligase IV Complex to DNA Ends

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The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates

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A Biochemically Defined System for Mammalian Nonhomologous DNA End Joining

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End-joining, translocations and cancer

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Conversion of Topoisomerase I Cleavage Complexes on the Leading Strand of Ribosomal DNA into 5′-Phosphorylated DNA Double-Strand Breaks by Replication Runoff

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Synapsis of DNA ends by DNA‐dependent protein kinase

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PAXX, a paralog of XRCC4 and XLF, interacts with Ku to promote DNA double-strand break repair

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Eukaryotic DNA Ligases: Structural and Functional Insights

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AZD7648 is a potent and selective DNA-PK inhibitor that enhances radiation, chemotherapy and olaparib activity

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Chromosomal Translocations in Human Cells Are Generated by Canonical Nonhomologous End-Joining

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Long noncoding RNA LINP1 regulates repair of DNA double-strand breaks in triple-negative breast cancer

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IgH Chain Class Switch Recombination: Mechanism and Regulation

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A Gradient of Template Dependence Defines Distinct Biological Roles for Family X Polymerases in Nonhomologous End Joining

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Autophosphorylation of the Catalytic Subunit of the DNA-Dependent Protein Kinase Is Required for Efficient End Processing during DNA Double-Strand Break Repair

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Ku complex interacts with and stimulates the Werner proteinPreprint

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Regulation of DNA repair pathway choice in S and G2 phases by the NHEJ inhibitor CYREN

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DNA end-joining catalyzed by human cell-free extracts

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The DNA-dependent Protein Kinase Is Inactivated by Autophosphorylation of the Catalytic Subunit

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Chapter 2 DNA-PK

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The DNA-dependent protein kinase: A multifunctional protein kinase with roles in DNA double strand break repair and mitosis

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Autophosphorylation of DNA-Dependent Protein Kinase Regulates DNA End Processing and May Also Alter Double-Strand Break Repair Pathway Choice

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Activation of the ATR kinase by the RPA-binding protein ETAA1

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Three-Dimensional Structure of the Human DNA-PKcs/Ku70/Ku80 Complex Assembled on DNA and Its Implications for DNA DSB Repair

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Pharmacological inhibition of DNA-PK stimulates Cas9-mediated genome editing

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The AID enzyme induces class switch recombination in fibroblasts

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Ku Regulates the Non-Homologous End Joining Pathway Choice of DNA Double-Strand Break Repair in Human Somatic Cells

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Mapping of protein-protein interactions within the DNA-dependent protein kinase complex

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Two-Stage Synapsis of DNA Ends during Non-homologous End Joining

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The E3 ligase RNF8 regulates KU80 removal and NHEJ repair

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Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV

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DNA double-strand break repair in cell-free extracts from Ku80-deficient cells: implications for Ku serving as an alignment factor in non-homologous DNA end joining

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Differential Phosphorylation of DNA-PKcs Regulates the Interplay between End-Processing and End-Ligation during Nonhomologous End-Joining

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Human Tdp1 Cleaves a Broad Spectrum of Substrates, Including Phosphoamide Linkages

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Implication of DNA Polymerase λ in Alignment-based Gap Filling for Nonhomologous DNA End Joining in Human Nuclear Extracts

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The ataxia–oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4

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Conversion of Phosphoglycolate to Phosphate Termini on 3′ Overhangs of DNA Double Strand Breaks by the Human Tyrosyl-DNA Phosphodiesterase hTdp1

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Nonoverlapping Functions of DNA Polymerases Mu, Lambda, and Terminal Deoxynucleotidyltransferase during Immunoglobulin V(D)J Recombination In Vivo

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The clinical impact of deficiency in DNA non-homologous end-joining

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Ku is a 5′-dRP/AP lyase that excises nucleotide damage near broken ends

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ATM orchestrates the DNA-damage response to counter toxic non-homologous end-joining at broken replication forks

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Cernunnos/XLF promotes the ligation of mismatched and noncohesive DNA ends

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The X family portrait: Structural insights into biological functions of X family polymerases

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trans Autophosphorylation at DNA-Dependent Protein Kinase's Two Major Autophosphorylation Site Clusters Facilitates End Processing but Not End Joining

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The Artemis:DNA-PKcs endonuclease cleaves DNA loops, flaps, and gaps

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DNA-PK as an Emerging Therapeutic Target in Cancer

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Interactome analysis identifies a new paralogue of XRCC4 in non-homologous end joining DNA repair pathway

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XRCC4 protein interactions with XRCC4-like factor (XLF) create an extended grooved scaffold for DNA ligation and double strand break repair

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Organization and dynamics of the nonhomologous end-joining machinery during DNA double-strand break repair

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The Role of the Core Non-Homologous End Joining Factors in Carcinogenesis and Cancer

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