The DOI matches its Crossref record; 150 of the 151 references it cites were found in a registry or an index.
Epigenetic Regulation: A New Frontier for Biomedical Engineers
Abstract
Gene expression in mammalian cells depends on the epigenetic status of the chromatin, including DNA methylation, histone modifications, promoter-enhancer interactions, and noncoding RNA-mediated regulation. The coordinated actions of these multifaceted regulations determine cell development, cell cycle regulation, cell state and fate, and the ultimate responses in health and disease. Therefore, studies of epigenetic modulations are critical for our understanding of gene regulation mechanisms at the molecular, cellular, tissue, and organ levels. The aim of this review is to provide biomedical engineers with an overview of the principles of epigenetics, methods of study, recent findings in epigenetic regulation in health and disease, and computational and sequencing tools for epigenetics analysis, with an emphasis on the cardiovascular system. This review concludes with the perspectives of the application of bioengineering to advance epigenetics and the utilization of epigenetics to translate bioengineering research into clinical medicine.
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In the citing paper
“On the other hand, the deacetylases remove acetyl groups of acetylated lysine.”
From Revisiting Epigenetics Fundamentals and Its Biomedical Implications (2024) · cites this paper as [58]
In the citing paper
“This modification in tail histones plays a very important role during transcription regulation through two mechanisms.”
From Revisiting Epigenetics Fundamentals and Its Biomedical Implications (2024) · cites this paper as [58]
In the citing paper
“The main mechanism by which the structure and the function of chromatin are regulated is through post-translational modifications in the amino acids of histone proteins, such as methylation, acetylation, ubiquitination, phosphorylation, SUMOylation, ribosylation, propionylation, butyrylation, crotonylation, and citrullination [58].”
From Revisiting Epigenetics Fundamentals and Its Biomedical Implications (2024) · cites this paper as [58]
In the citing paper
“Firstly, it refers to the ability to neutralize the positive charge of the lysine by adding the acetyl group to histones, thus forming an affinity between DNA (negatively charged) and histones less tightly arranged, and consequently, greater accessibility of DNA to transcription factors is observed, for example.”
From Revisiting Epigenetics Fundamentals and Its Biomedical Implications (2024) · cites this paper as [58]
In the citing paper
“Acetylation occurs in the N-terminal lysine residues of histones, and this mechanism is mediated by acetyltransferases (HATs) that are responsible for adding acetyl groups to the tails of histones.”
From Revisiting Epigenetics Fundamentals and Its Biomedical Implications (2024) · cites this paper as [58]
In the citing paper
“And secondly, it is involved in the recognition of acetylation marks on histones by different proteins which can recruit different classes of chromatin structures, regulating proteins to promote or inhibit gene transcription [55,58].”
From Revisiting Epigenetics Fundamentals and Its Biomedical Implications (2024) · cites this paper as [58]
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Metadata
- Authors
- Chen, Z., Li, S., Subramaniam, S., Shyy, J. Y.-J., & Chien, S.
- Affiliations
- City Of Hope National Medical Center (US)
- University of California San Diego (US)
- Venue
- Annual Review of Biomedical Engineering
- Publisher
- Annual Reviews
- Published
- 2017-06-21
- Volume
- 19
- Issue
- 1
- Pages
- 195-219
- ISSN
- 1523-9829 (ISSN-L)
- 1545-4274
- OpenAlex
- W2509725501
- Cited by
- 163
- References
- 151
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 12 · 2023: 19 · 2022: 12 · 2021: 29 · 2020: 33 · 2019: 28 · 2018: 12 · 2017: 9
- FWCI
- 2.10
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Biomedical Engineering (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Heart, Lung, and Blood Institute (R00HL122368)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Keywords
- epigenetic regulation, chromatin, DNA methylation, histone modifications, enhancer-promoter interactions, non-coding RNA, gene expression regulation, cardiovascular system, bioengineering applications, clinical translation
- MeSH terms
- Animals, Biomedical Engineering, Chromatin, Forecasting, Gene Expression Regulation, Humans, Models, Genetic, Protein Processing, Post-Translational, DNA Methylation, RNA, Untranslated, Epigenesis, Genetic
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