Cited by 165Epigenetics and DNA MethylationGenomics and Chromatin DynamicsCancer-related molecular mechanisms research

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Epigenetic Regulation: A New Frontier for Biomedical Engineers

Chen, Zhen, Li, Shuai, Subramaniam, Shankar, Shyy, John Y.-J., Chien, Shu·2017·Annual Review of Biomedical Engineering

DOI 10.1146/annurev-bioeng-071516-044720

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Abstract

Gene expression in mammalian cells depends on the epigenetic status of the chromatin, including DNA methylation, histone modifications, promoter-enhancer interactions, and noncoding RNA-mediated regulation. The coordinated actions of these multifaceted regulations determine cell development, cell cycle regulation, cell state and fate, and the ultimate responses in health and disease. Therefore, studies of epigenetic modulations are critical for our understanding of gene regulation mechanisms at the molecular, cellular, tissue, and organ levels. The aim of this review is to provide biomedical engineers with an overview of the principles of epigenetics, methods of study, recent findings in epigenetic regulation in health and disease, and computational and sequencing tools for epigenetics analysis, with an emphasis on the cardiovascular system. This review concludes with the perspectives of the application of bioengineering to advance epigenetics and the utilization of epigenetics to translate bioengineering research into clinical medicine.

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Self-citation

Authors: Chen, Z., Li, S., Subramaniam, S., Shyy, J. Y.-J., & Chien, S.
Affiliations: City Of Hope National Medical Center (US)
University of California San Diego (US)
ORCID: Chen, Zhen
Li, Shuai
Subramaniam, Shankar
Chien, Shu
Venue: Annual Review of Biomedical Engineering
Publisher: Annual Reviews
Published: 2017-06-21
Volume: 19
Issue: 1
Pages: 195-219
ISSN: 1523-9829 (ISSN-L)
1545-4274
DOI: 10.1146/annurev-bioeng-071516-044720
OpenAlex: W2509725501
Cited by: 163
References: 151
Citations by year: 2026: 2 · 2025: 5 · 2024: 12 · 2023: 19 · 2022: 12 · 2021: 29 · 2020: 33 · 2019: 28 · 2018: 12 · 2017: 9
FWCI: 2.10
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Biomedical Engineering (publishedVersion)
PubMed (publishedVersion)
Funders: National Heart, Lung, and Blood Institute (R00HL122368)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Epigenetics and DNA Methylation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
Keywords: epigenetic regulation, chromatin, DNA methylation, histone modifications, enhancer-promoter interactions, non-coding RNA, gene expression regulation, cardiovascular system, bioengineering applications, clinical translation
MeSH terms: Animals, Biomedical Engineering, Chromatin, Forecasting, Gene Expression Regulation, Humans, Models, Genetic, Protein Processing, Post-Translational, DNA Methylation, RNA, Untranslated, Epigenesis, Genetic

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Epigenetic Regulation: A New Frontier for Biomedical Engineers

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