The DOI matches its Crossref record; 144 of the 144 references it cites were found in a registry or an index.
Forcing Stem Cells to Behave: A Biophysical Perspective of the Cellular Microenvironment
Open accessAbstract
Physical factors in the local cellular microenvironment, including cell shape and geometry, matrix mechanics, external mechanical forces, and nanotopographical features of the extracellular matrix, can all have strong influences on regulating stem cell fate. Stem cells sense and respond to these insoluble biophysical signals through integrin-mediated adhesions and the force balance between intracellular cytoskeletal contractility and the resistant forces originated from the extracellular matrix. Importantly, these mechanotransduction processes can couple with many other potent growth-factor-mediated signaling pathways to regulate stem cell fate. Different bioengineering tools and microscale/nanoscale devices have been successfully developed to engineer the physical aspects of the cellular microenvironment for stem cells, and these tools and devices have proven extremely powerful for identifying the extrinsic physical factors and their downstream intracellular signaling pathways that control stem cell functions.
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Cites
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Cited by
Extracellular matrix: A dynamic microenvironment for stem cell niche
Gattazzo, F., Urciuolo, A., & Bonaldo, P. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.01.010 · Cited by 1,294
Functional and Biomimetic Materials for Engineering of the Three-Dimensional Cell Microenvironment
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Stretch-activated ion channel Piezo1 directs lineage choice in human neural stem cells
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Metadata
- Authors
- Sun, Y., Chen, C. S., & Fu, J.
- Venue
- Annual Review of Biophysics
- Publisher
- Annual Reviews
- Published
- 2012-06-09
- Volume
- 41
- Issue
- 1
- Pages
- 519-542
- ISSN
- 1936-122X (ISSN-L)
- 1936-1238
- OpenAlex
- W2122033285
- Cited by
- 425
- References
- 144
- FWCI
- 2.62
- Type
- journal article
- Language
- en
- Open access
- green
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- Sun, Y., Chen, C. S., & Fu, J. (2012). Forcing Stem Cells to Behave: A Biophysical Perspective of the Cellular Microenvironment. Annual Review of Biophysics. https://doi.org/10.1146/annurev-biophys-042910-155306
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
