Cited by 592Pregnancy and preeclampsia studiesReproductive System and PregnancyBirth, Development, and Health

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Placenta: The Forgotten Organ

Maltepe, Emin, Fisher, Susan J.·2015·Annual Review of Cell and Developmental Biology

DOI 10.1146/annurev-cellbio-100814-125620

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Abstract

The placenta sits at the interface between the maternal and fetal vascular beds where it mediates nutrient and waste exchange to enable in utero existence. Placental cells (trophoblasts) accomplish this via invading and remodeling the uterine vasculature. Amazingly, despite being of fetal origin, trophoblasts do not trigger a significant maternal immune response. Additionally, they maintain a highly reliable hemostasis in this extremely vascular interface. Decades of research into how the placenta differentiates itself from embryonic tissues to accomplish these and other feats have revealed a previously unappreciated level of complexity with respect to the placenta's cellular composition. Additionally, novel insights with respect to roles played by the placenta in guiding fetal development and metabolism have sparked a renewed interest in understanding the interrelationship between fetal and placental well-being. Here, we present an overview of emerging research in placental biology that highlights these themes and the importance of the placenta to fetal and adult health.

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See all 592

Authors: Maltepe, E., & Fisher, S. J.
Affiliations: University of California, San Francisco (US)
ORCID: Maltepe, Emin
Fisher, Susan J.
Venue: Annual Review of Cell and Developmental Biology
Publisher: Annual Reviews
Published: 2015-11-13
Volume: 31
Issue: 1
Pages: 523-552
ISSN: 1081-0706 (ISSN-L)
1530-8995
DOI: 10.1146/annurev-cellbio-100814-125620
OpenAlex: W2101822059
Semantic Scholar: 4e22a122e4d9dbec6ecc8419350745b2d4db94da
Cited by: 592
References: 257
Citations by year: 2026: 82 · 2025: 87 · 2024: 76 · 2023: 90 · 2022: 80 · 2021: 66 · 2020: 37 · 2019: 23 · 2018: 21 · 2017: 22 · 2016: 7 · 2015: 1
FWCI: 2.49
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Cell and Developmental Biology (publishedVersion)
PubMed (publishedVersion)
Funders: Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD055764, R01HD072455)
Topics: Health Sciences › Medicine › Obstetrics and Gynecology › Pregnancy and preeclampsia studies
Life Sciences › Immunology and Microbiology › Immunology › Reproductive System and Pregnancy
Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Birth, Development, and Health
Keywords: placenta, trophoblast, maternal-fetal interface, maternal-fetal immune tolerance, hemostasis, placental differentiation, fetal development, fetal metabolism, placental biology
MeSH terms: Animals, Biological Transport, Female, Humans, Placenta, Pregnancy, Trophoblasts, Fetal Development

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Placenta: The Forgotten Organ

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