The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Mitogen-Activated Protein Kinase Pathways in Osteoblasts
Abstract
Mitogen-activated protein kinases (MAPKs) are ancient signal transducers well characterized as mediators of inflammation and neoplastic transformation. Recent work has expanded our understanding of their developmental functions, particularly in the regulation of bone mass via control of osteoblast differentiation. Here, we review the functions of MAPK pathways in osteoblasts, including a consideration of MAPK substrates. In particular, MAPKs function to regulate the key transcriptional mediators of osteoblast differentiation, with ERK and p38 MAPKs phosphorylating RUNX2, the master regulator of osteoblast differentiation. ERK also activates RSK2, which in turn phosphorylates ATF4, a transcriptional regulator of late-stage osteoblast synthetic functions. The MAP3Ks and MAP2Ks upstream of MAPKs have also been investigated, and significant differences have been found in the wiring of MAPK pathways in osteoblasts relative to other tissues. Thus, the investigation of MAPKs in osteoblasts has both revealed critical mechanisms for the maintenance of bone mass and added to our understanding of how the individual components of MAPK pathways function in concert in a complex in vivo system.
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Cites
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Cited by
p38 MAPK Signaling in Osteoblast Differentiation
Rodríguez-Carballo, E., Gámez, B., & Ventura, F. (2016) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2016.00040 · Cited by 316
Interplay between Cartilage and Subchondral Bone Contributing to Pathogenesis of Osteoarthritis
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Wu, X., Li, S., Xue, P., & Li, Y. (2017) · Experimental Cell Research · doi:10.1016/j.yexcr.2017.09.018 · Cited by 92
Metadata
- Authors
- Greenblatt, M. B., Shim, J.-H., & Glimcher, L. H.
- Venue
- Annual Review of Cell and Developmental Biology
- Publisher
- Annual Reviews
- Published
- 2013-10-06
- Volume
- 29
- Issue
- 1
- Pages
- 63-79
- ISSN
- 1081-0706 (ISSN-L)
- 1530-8995
- OpenAlex
- W2158186990
- Cited by
- 253
- References
- 13
- FWCI
- 1.33
- Type
- journal article
- Language
- en
- Open access
- closed
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- Greenblatt, M. B., Shim, J.-H., & Glimcher, L. H. (2013). Mitogen-Activated Protein Kinase Pathways in Osteoblasts. Annual Review of Cell and Developmental Biology. https://doi.org/10.1146/annurev-cellbio-101512-122347
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
