The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Engineering Microneedle Patches for Vaccination and Drug Delivery to Skin
Open accessAbstract
Microneedle patches (MNPs) contain arrays of solid needles measuring hundreds of microns in length that deliver drugs and vaccines into skin in a painless, easy-to-use manner. Optimal MNP design balances multiple interdependent parameters that determine mechanical strength, skin-insertion reliability, drug delivery efficiency, painlessness, manufacturability, and other features of MNPs that affect their performance. MNPs can be made by adapting various microfabrication technologies for delivery of small-molecule drugs, biologics, and vaccines targeted to the skin, which can have pharmacokinetic and immunologic advantages. A small number of human clinical trials, as well as a large and growing market for MNP products for cosmetics, indicate that MNPs can be used safely, efficaciously, and with strong patient acceptance. More advanced clinical trials and commercial-scale manufacturing will facilitate development of MNPs to realize their potential to dramatically increase patient access to otherwise-injectable drugs and to improve drug performance via skin delivery.
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Cites
McAllister, D. V., Wang, P. M., Davis, S. P., Park, J.-H., Canatella, P. J., Allen, M. G., & Prausnitz, M. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2331316100 · Cited by 859
Self-citationGill, H. S., & Prausnitz, M. R. (2007) · Journal of Diabetes Science and Technology · doi:10.1177/193229680700100517 · Cited by 164
Self-citation
Cited by
Dissolving microneedles: Applications and growing therapeutic potential
Sartawi, Z., Blackshields, C., & Faisal, W. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.05.045 · Cited by 503
Kim, E., Erdos, G., Huang, S., Kenniston, T. W., Balmert, S. C., Carey, C. D., Raj, V. S., Epperly, M. W., Klimstra, W. B., Haagmans, B. L., et al. (2020) · eBioMedicine · doi:10.1016/j.ebiom.2020.102743 · Cited by 404
Mechanisms of sampling interstitial fluid from skin using a microneedle patch
Samant, P. P., & Prausnitz, M. R. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1716772115 · Cited by 363
Self-citationAdvances in transdermal insulin delivery
Zhang, Y., Yu, J., Kahkoska, A. R., Wang, J., Buse, J. B., & Gu, Z. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.12.006 · Cited by 325
Designing spatial and temporal control of vaccine responses
Roth, G. A., Picece, V. C. T. M., Ou, B. S., Luo, W., Pulendran, B., & Appel, E. A. (2021) · Nature Reviews Materials · doi:10.1038/s41578-021-00372-2 · Cited by 316
Metadata
- Authors
- Prausnitz, M. R.
- Venue
- Annual Review of Chemical and Biomolecular Engineering
- Publisher
- Annual Reviews
- Published
- 2017-06-07
- Volume
- 8
- Issue
- 1
- Pages
- 177-200
- ISSN
- 1947-5438 (ISSN-L)
- 1947-5446
- OpenAlex
- W2605322593
- Cited by
- 439
- References
- 2
- FWCI
- 4.88
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Prausnitz, M. R. (2017). Engineering Microneedle Patches for Vaccination and Drug Delivery to Skin. Annual Review of Chemical and Biomolecular Engineering. https://doi.org/10.1146/annurev-chembioeng-060816-101514
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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