The DOI matches its Crossref record; 225 of the 225 references it cites were found in a registry or an index.
Omega-3 Polyunsaturated Fatty Acids and Their Health Benefits
Open accessAbstract
Omega-3 polyunsaturated fatty acids (PUFAs) include α-linolenic acid (ALA; 18:3 ω-3), stearidonic acid (SDA; 18:4 ω-3), eicosapentaenoic acid (EPA; 20:5 ω-3), docosapentaenoic acid (DPA; 22:5 ω-3), and docosahexaenoic acid (DHA; 22:6 ω-3). In the past few decades, many epidemiological studies have been conducted on the myriad health benefits of omega-3 PUFAs. In this review, we summarized the structural features, properties, dietary sources, metabolism, and bioavailability of omega-3 PUFAs and their effects on cardiovascular disease, diabetes, cancer, Alzheimer's disease, dementia, depression, visual and neurological development, and maternal and child health. Even though many health benefits of omega-3 PUFAs have been reported in the literature, there are also some controversies about their efficacy and certain benefits to human health.
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“Both species are rich sources of polyunsaturated fatty acids (PUFAs), including γ-linolenic acid (18:3 ω-6), arachidonic acid (ARA, 20:4 ω-6), eicosapentaenoic acid (EPA, 20:5 ω-3), and docosahexaenoic acid (DHA, 22:6 ω-3), and their protein content can reach 600–710 g/kg of dry biomass (Shahidi and Ambigaipalan, 2018; Sinetova et al., 2024).”
From Microalgae biotechnology and its role in sustainable and healthy food design (2025) · cites this paper as Shahidi and Ambigaipalan, 2018
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“Both species are rich sources of polyunsaturated fatty acids (PUFAs), including γ-linolenic acid (18:3 ω-6), arachidonic acid (ARA, 20:4 ω-6), eicosapentaenoic acid (EPA, 20:5 ω-3), and docosahexaenoic acid (DHA, 22:6 ω-3), and their protein content can reach 600–710 g/kg of dry biomass (Shahidi and Ambigaipalan, 2018; Sinetova et al., 2024).”
From Microalgae biotechnology and its role in sustainable and healthy food design (2025) · cites this paper as Shahidi and Ambigaipalan, 2018
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Cites
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Microalgae as Sources of Omega-3 Polyunsaturated Fatty Acids: Biotechnological Aspects
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Advances in bioconversion of spent tea leaves to value-added products
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Dihydroxy‐Metabolites of Dihomo‐γ‐linolenic acid drive ferroptosis‐mediated neurodegeneration
Sarparast, M., Pourmand, E., Hinman, J., Vonarx, D., Reason, T., Zhang, F., Paithankar, S., Chen, B., Borhan, B., Watts, J. L., et al. (2023) · ACS Central Science · doi:10.1021/acscentsci.3c00052 · Cited by 33
rs953413 Regulates Polyunsaturated Fatty Acid Metabolism by Modulating ELOVL2 Expression
Pan, G., Cavalli, M., Carlsson, B., Skrtic, S., Kumar, C., & Wadelius, C. (2020) · iScience · doi:10.1016/j.isci.2019.100808 · Cited by 26
Microalgae biotechnology and its role in sustainable and healthy food design
Schneider, A. T., Machado, R. L. S., Dutra, D. A., Machado, E. F., Dias, R. R., Deprá, M. C., Zepka, L. Q., & Jacob-Lopes, E. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1716473 · Cited by 15
Nikolova, K., Gentscheva, G., Gyurova, D., Pavlova, V., Dincheva, I., Velikova, M., Gerasimova, A., Makedonski, L., & Gergov, G. (2024) · Life · doi:10.3390/life14020174 · Cited by 7
Is There Something Fishy About Fish Oil?
Šunderić, M., Robajac, D., Gligorijević, N., Miljuš, G., Nedić, O., Smilkov, K., Ackova, D. G., Rudić-Grujić, V., & Penezić, A. (2019) · Current Pharmaceutical Design · doi:10.2174/1381612825666190705185800 · Cited by 5
Metadata
- Authors
- Shahidi, F., & Ambigaipalan, P.
- Affiliations
- Memorial University of Newfoundland (CA)
- Corresponding author
- Shahidi, Fereidoon
- Venue
- Annual Review of Food Science and Technology
- Publisher
- Annual Reviews
- Published
- 2018-03-25
- Volume
- 9
- Issue
- 1
- Pages
- 345-381
- ISSN
- 1941-1421 (ISSN-L)
- 1941-1413
- OpenAlex
- W2768855358
- Cited by
- 1,390
- References
- 225
- Citations by year
- 2026: 152 · 2025: 230 · 2024: 230 · 2023: 224 · 2022: 209 · 2021: 176 · 2020: 99 · 2019: 50 · 2018: 16
- FWCI
- 10.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annual Review of Food Science and Technology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Aquaculture Nutrition and Growth
- Keywords
- omega-3 polyunsaturated fatty acids, alpha-linolenic acid, stearidonic acid, eicosapentaenoic acid, docosahexaenoic acid, docosapentaenoic acid, food sources, fatty acid metabolism, bioavailability, cardiovascular disease, diabetes mellitus, cancer, Alzheimer's disease, dementia, depression, visual development, brain development, maternal and child health
- MeSH terms
- Biological Availability, Fish Oils, Food, Humans, Preventive Medicine, Molecular Structure, Fatty Acids, Omega-3, Functional Food, Aquatic Organisms
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