Uniting Germline and Stem Cells: The Function of Piwi Proteins and the piRNA Pathway in Diverse Organisms

Stem cells, cancer, and cancer stem cells

Reya, T., Morrison, S. J., Clarke, M. F., & Weissman, I. L. (2001) · Nature · doi:10.1038/35102167 · Cited by 9,738

Phylogeny.fr: robust phylogenetic analysis for the non-specialist

Dereeper, A., Guignon, V., Blanc, G., Audic, S., Buffet, S., Chevenet, F., Dufayard, J.-F., Guindon, S., Lefort, V., Lescot, M., et al. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn180 · Cited by 4,700

Biogenesis of small RNAs in animals

Kim, V. N., Han, J., & Siomi, M. C. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2632 · Cited by 2,814

Discrete Small RNA-Generating Loci as Master Regulators of Transposon Activity in Drosophila

Brennecke, J., Aravin, A. A., Stark, A., Dus, M., Kellis, M., Sachidanandam, R., & Hannon, G. J. (2007) · Cell · doi:10.1016/j.cell.2007.01.043 · Cited by 2,524

Regulation of Heterochromatic Silencing and Histone H3 Lysine-9 Methylation by RNAi

Volpe, T. A., Kidner, C. A., Hall, I. M., Teng, G., Grewal, S. I. S., & Martienssen, R. A. (2002) · Science · doi:10.1126/science.1074973 · Cited by 2,055

Broad phylogenomic sampling improves resolution of the animal tree of life

Dunn, C. W., Hejnol, A., Matus, D. Q., Pang, K., Browne, W. E., Smith, S. A., Seaver, E., Rouse, G. W., Obst, M., Edgecombe, G. D., et al. (2008) · Nature · doi:10.1038/nature06614 · Cited by 1,921

Tunicates and not cephalochordates are the closest living relatives of vertebrates

Delsuc, F., Brinkmann, H., Chourrout, D., & Philippe, H. (2006) · Nature · doi:10.1038/nature04336 · Cited by 1,651

Sea Anemone Genome Reveals Ancestral Eumetazoan Gene Repertoire and Genomic Organization

Putnam, N. H., Srivastava, M., Hellsten, U., Dirks, B., Chapman, J., Salamov, A., Terry, A., Shapiro, H., Lindquist, E., Kapitonov, V. V., et al. (2007) · Science · doi:10.1126/science.1139158 · Cited by 1,555

Crystal Structure of Argonaute and Its Implications for RISC Slicer Activity

Song, J., Smith, S. K., Hannon, G. J., & Joshua‐Tor, L. (2004) · Science · doi:10.1126/science.1102514 · Cited by 1,531

A novel class of small RNAs bind to MILI protein in mouse testes

Aravin, A., Gaidatzis, D., Pfeffer, S., Lagos-Quintana, M., Landgraf, P., Iovino, N., Morris, P., Brownstein, M. J., Kuramochi-Miyagawa, S., Nakano, T., et al. (2006) · Nature · doi:10.1038/nature04916 · Cited by 1,516

Small RNA regulation of reproductive function

Hale, B. J., Yang, C., & Ross, J. W. (2013) · Molecular Reproduction and Development · doi:10.1002/mrd.22272 · Cited by 53

Transcriptional evidence for small RNA regulation of pupal diapause in the flesh fly, Sarcophaga bullata

Reynolds, J. A., Clark, J., Diakoff, S. J., & Denlinger, D. L. (2013) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2013.07.005 · Cited by 52

A Sex Chromosome piRNA Promotes Robust Dosage Compensation and Sex Determination in C. elegans

Tang, W., Seth, M., Tu, S., Shen, E.-Z., Li, Q., Shirayama, M., Weng, Z., & Mello, C. C. (2018) · Developmental Cell · doi:10.1016/j.devcel.2018.01.025 · Cited by 49

Distinct and Collaborative Functions of Yb and Armitage in Transposon-Targeting piRNA Biogenesis

Ishizu, H., Kinoshita, T., Hirakata, S., Komatsuzaki, C., & Siomi, M. C. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.04.029 · Cited by 51

Silencing of Transposable Elements by piRNAs in Drosophila : An Evolutionary Perspective

Luo, S., & Lü, J. (2017) · Genomics Proteomics & Bioinformatics · doi:10.1016/j.gpb.2017.01.006 · Cited by 51

Per- and polyfluoroalkyl substances impact human spermatogenesis in a stem-cell-derived model

Steves, A. N., Turry, A., Gill, B., Clarkson-Townsend, D. A., Bradner, J. M., Bachli, I., Caudle, W. M., Miller, G. W., Chan, A. W. S., & Easley, C. A. (2018) · Systems Biology in Reproductive Medicine · doi:10.1080/19396368.2018.1481465 · Cited by 50

The Tudor domain protein Tapas, a homolog of the vertebrate Tdrd7, functions in piRNA pathway to regulate retrotransposons in germline of Drosophila melanogaster

Patil, V. S., Anand, A., Chakrabarti, A., & Kai, T. (2014) · BMC Biology · doi:10.1186/s12915-014-0061-9 · Cited by 56

Gonad establishment during asexual reproduction in the annelid Pristina leidyi

Özpolat, B. D., & Bely, A. E. (2015) · Developmental Biology · doi:10.1016/j.ydbio.2015.06.001 · Cited by 47

A prescription for ‘stress’ – the role of Hsp90 in genome stability and cellular adaptation

Kaplan, K. B., & Li, R. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.08.006 · Cited by 47

The meaning of PIWI proteins in cancer development

Litwin, M., Szczepańska-Buda, A., Piotrowska, A., Dzięgiel, P., & Witkiewicz, W. (2017) · Oncology Letters · doi:10.3892/ol.2017.5932 · Cited by 49

Modulation of miRISC-Mediated Gene Silencing in Eukaryotes

Jungers, C. F., & Djuranović, S. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.832916 · Cited by 46

Regulation of apomixis: learning from sexual experience

Rodríguez-Leal, D., & Vielle‐Calzada, J. (2012) · Current Opinion in Plant Biology · doi:10.1016/j.pbi.2012.09.005 · Cited by 46

Retrotransposon long interspersed nucleotide element‐1 (LINE‐1) is activated during salamander limb regeneration

Zhu, W. Z., Kuo, D., Nathanson, J. L., Satoh, A., Pao, G. M., Yeo, G. W.-M., Bryant, S. V., Voss, S. R., Gardiner, D. M., & Hunter, T. R. (2012) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2012.01368.x · Cited by 45

Analysis of piRNA-Like Small Non-coding RNAs Present in Axons of Adult Sensory Neurons

Phay, M., Kim, H. H., & Yoo, S. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0340-2 · Cited by 45

Localization in Oogenesis of Maternal Regulators of Embryonic Development

Escobar-Aguirre, M., Elkouby, Y. M., & Mullins, M. C. (2016) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-46095-6_5 · Cited by 46

Evolutionary dynamics of transposable elements in bdelloid rotifers

Nowell, R. W., Wilson, C. G., Almeida, P., Schiffer, P. H., Fontaneto, D., Becks, L., Rodríguez, F., Arkhipova, I. R., & Barraclough, T. G. (2021) · eLife · doi:10.7554/elife.63194 · Cited by 48

Apomixis in flowering plants: Developmental and evolutionary considerations

León-Martínez, G., & Vielle‐Calzada, J. (2018) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2018.11.014 · Cited by 45

Structure and function of eTudor domain containing TDRD proteins

Gan, B. S., Chen, S., Liu, H., Min, J., & Liu, K. (2019) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2019.1603199 · Cited by 43

piRNA-1742 promotes renal cell carcinoma malignancy by regulating USP8 stability through binding to hnRNPU and thereby inhibiting MUC12 ubiquitination

Zhang, W., Zheng, Z., Wang, K., Mao, W., Li, X., Wang, G., Zhang, Y., Huang, J., Zhang, N., Wu, P., et al. (2023) · Experimental & Molecular Medicine · doi:10.1038/s12276-023-01010-3 · Cited by 44

TFIIS-Dependent Non-coding Transcription Regulates Developmental Genome Rearrangements

Maliszewska‐Olejniczak, K., Gruchota, J., Gromadka, R., Wilkes, C. D., Arnaiz, O., Mathy, N., Duharcourt, S., Bétermier, M., & Nowak, J. (2015) · PLoS Genetics · doi:10.1371/journal.pgen.1005383 · Cited by 43

Planarian flatworms as a new model system for understanding the epigenetic regulation of stem cell pluripotency and differentiation

Dattani, A., Sridhar, D., & Aboobaker, A. A. (2018) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2018.04.007 · Cited by 42

PIWI homologs mediate Histone H4 mRNA localization to planarian chromatoid bodies

Rouhana, L., Weiss, J. A., King, R. S., & Newmark, P. A. (2014) · Development · doi:10.1242/dev.101618 · Cited by 42

Comparative proteome analysis of Milnesium tardigradum in early embryonic state versus adults in active and anhydrobiotic state

Schokraie, E., Warnken, U. H., Hotz‐Wagenblatt, A., Grohme, M. A., Hengherr, S., Förster, F., Schill, R. O., Frohme, M., Dandekar, T., & Schnölzer, M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0045682 · Cited by 42

Noncoding RNA Regulation of Dormant States in Evolutionarily Diverse Animals

Reynolds, J. A. (2019) · Biological Bulletin · doi:10.1086/705484 · Cited by 40

Co-chaperone Hsp70/Hsp90-organizing protein (Hop) is required for transposon silencing and Piwi-interacting RNA (piRNA) biogenesis

Karam, J. A. Q., Parikh, R. Y., Nayak, D., Rosenkranz, D., & Gangaraju, V. K. (2017) · Journal of Biological Chemistry · doi:10.1074/jbc.c117.777730 · Cited by 41

PIWI-piRNA pathway: Setting the pace of aging by reducing DNA damage

Lenárt, P., Novák, J., & Vašků, J. B. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.03.009 · Cited by 42

Comparative profiling of ovarian and testicular piRNAs in the mud crab Scylla paramamosain

Waiho, K., Fazhan, H., Zhang, Y., Li, S., Zhang, Y., Zheng, H., Ikhwanuddin, M., & Ma, H. (2019) · Genomics · doi:10.1016/j.ygeno.2019.02.012 · Cited by 40

Loss of l(3)mbt leads to acquisition of the ping-pong cycle in Drosophila ovarian somatic cellsPreprint

Sumiyoshi, T., Sato, K., Yamamoto, H., Iwasaki, Y. W., Siomi, H., & Siomi, M. C. (2016) · Genes & Development · doi:10.1101/gad.283929.116 · Cited by 40

Integrin-alpha-6+ Candidate stem cells are responsible for whole body regeneration in the invertebrate chordate Botrylloides diegensis

Kassmer, S. H., Langenbacher, A. D., & Tomaso, A. W. D. (2020) · Nature Communications · doi:10.1038/s41467-020-18288-w · Cited by 39

Small Non-Coding-RNA in Gynecological Malignancies

Dwivedi, S. K. D., Rao, G., Dey, A., Mukherjee, P., Wren, J. D., & Bhattacharya, R. (2021) · Cancers · doi:10.3390/cancers13051085 · Cited by 40

Requirements for multivalent Yb body assembly in transposon silencing in Drosophila

Hirakata, S., Ishizu, H., Fujita, A., Tomoe, Y., & Siomi, M. C. (2019) · EMBO Reports · doi:10.15252/embr.201947708 · Cited by 36

Arthropod viruses and small RNAs

Vijayendran, D., Airs, P. M., Dolezal, K., & Bonning, B. C. (2013) · Journal of Invertebrate Pathology · doi:10.1016/j.jip.2013.07.006 · Cited by 37

Pivots of pluripotency: The roles of non-coding RNA in regulating embryonic and induced pluripotent stem cells

Huo, J. S., & Zambidis, E. T. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.10.014 · Cited by 37

Germ granule dysfunction is a hallmark and mirror of Piwi mutant sterility

Spichal, M., Heestand, B., Billmyre, K. K., Frenk, S., Mello, C. C., & Ahmed, S. C. (2021) · Nature Communications · doi:10.1038/s41467-021-21635-0 · Cited by 33

The diverse functions of germline P‐granules in Caenorhabditis elegans

Voronina, E. (2012) · Molecular Reproduction and Development · doi:10.1002/mrd.22136 · Cited by 35

Lessons for inductive germline determination

Seervai, R. N. H., & Wessel, G. M. (2013) · Molecular Reproduction and Development · doi:10.1002/mrd.22151 · Cited by 34

Therapeutic targeting of noncoding RNAs in hepatocellular carcinoma: Recent progress and future prospects (Review)

Xiao, Z., Shen, J., Zhang, L., Li, M., Hu, W., & Cho, C. H. (2018) · Oncology Letters · doi:10.3892/ol.2018.7758 · Cited by 35

Ubiquitous Flame-Retardant Toxicants Impair Spermatogenesis in a Human Stem Cell Model

Steves, A. N., Bradner, J. M., Fowler, K. L., Clarkson-Townsend, D. A., Gill, B., Turry, A., Caudle, W. M., Miller, G. W., Chan, A. W. S., & Easley, C. A. (2018) · iScience · doi:10.1016/j.isci.2018.04.014 · Cited by 34

Piwi Genes Are Dispensable for Normal Hematopoiesis in Mice

Nolde, M. J., Cheng, E.-C., Guo, S., & Lin, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0071950 · Cited by 36

Immuno-Electron Microscopy and Electron Microscopic In Situ Hybridization for Visualizing piRNA Biogenesis Bodies in Drosophila Ovaries

Shibata, S., Murota, Y., Nishimoto, Y., Yoshimura, M., Nagai, T., Okano, H., & Siomi, M. C. (2015) · Methods in molecular biology · doi:10.1007/978-1-4939-2851-4_12 · Cited by 32

PiRNA pathway in the cardiovascular system: a novel regulator of cardiac differentiation, repair and regeneration

Zhou, Y., Fang, Y., Dai, C., & Wang, Y. (2021) · Journal of Molecular Medicine · doi:10.1007/s00109-021-02132-9 · Cited by 34

Coordination of transposon expression with DNA replication in the targeting of telomeric retrotransposons in Drosophila

Zhang, L., Beaucher, M., Cheng, Y., & Rong, Y. S. (2014) · The EMBO Journal · doi:10.1002/embj.201386940 · Cited by 32

Long non-coding RNA LINC-PINT attenuates paclitaxel resistance in triple-negative breast cancer cells via targeting the RNA-binding protein NONO

Chen, J., Zhu, M.-Q., Liqiu, Z., Xia, J., Huang, J., Deng, Q., & Xu, R. (2020) · Acta Biochimica et Biophysica Sinica · doi:10.1093/abbs/gmaa072 · Cited by 32

Conserved functional characteristics of the PIWI family members in chicken germ cell lineage

Kim, T. H., Yun, T. W., Rengaraj, D., Lee, S. I., Lim, S., Seo, H. W., Park, T. S., & Han, J. Y. (2012) · Theriogenology · doi:10.1016/j.theriogenology.2012.07.019 · Cited by 33

Localization of early germ cells in a stony coral, Euphyllia ancora: potential implications for a germline stem cell system in coral gametogenesis

Shikina, S., Chung, Y.-J., Wang, H.-M., Chiu, Y., Shao, Z., Lee, Y., & Chang, C. (2015) · Coral Reefs · doi:10.1007/s00338-015-1270-6 · Cited by 32

The non-redundant functions of PIWI family proteins in gametogenesis in golden hamsters

Lv, X., Xiao, W., Lai, Y., Zhang, Z., Zhang, H., Qiu, C., Hou, L., Chen, Q., Wang, D., Gao, Y. J., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40650-x · Cited by 29

Signaling pathways that control mRNA turnover

Thapar, R., & Denmon, A. P. (2013) · Cellular Signalling · doi:10.1016/j.cellsig.2013.03.026 · Cited by 32

Piwi Proteins and piRNAs Step onto the Systems Biology Stage

Clark, J. P., & Lau, N. C. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-1-4939-1221-6_5 · Cited by 33

Expression Dynamics of Core RNAi Machinery Genes in Pea Aphids Upon Exposure to Artificially Synthesized dsRNA and miRNAs

Yang, L. C., Tian, Y., Peng, Y., Niu, J., & Wang, J. (2020) · Insects · doi:10.3390/insects11020070 · Cited by 28

piRNA biogenesis and its functions

Huang, Y., Bai, J. Y., & Ren, H. (2014) · Russian Journal of Bioorganic Chemistry · doi:10.1134/s1068162014030169 · Cited by 30

Mammalian PNLDC1 is a novel poly(A) specific exonuclease with discrete expression during early development

Anastasakis, D. G., Skeparnias, I., Shaukat, A., Grafanaki, K., Κανέλλου, Α., Taraviras, S. L., Papachristou, D. J., Papakyriakou, A., & Stathopoulos, C. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw709 · Cited by 30

Twin Promotes the Maintenance and Differentiation of Germline Stem Cell Lineage through Modulation of Multiple Pathways

Fu, Z., Geng, C., Wang, H., Yang, Z., Weng, C., Li, H., Deng, L., Liu, L., Liu, N., Ni, J., et al. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.10.017 · Cited by 28

Genetic and Epigenetic Changes Involving (Retro)transposons in Animal Hybrids and Polyploids

Arkhipova, I. R., & Rodríguez, F. (2013) · Cytogenetic and Genome Research · doi:10.1159/000352069 · Cited by 32

The epigenetic regulation of transposable elements by PIWI-interacting RNAs in Drosophila

Saito, K. (2013) · Genes & Genetic Systems · doi:10.1266/ggs.88.9 · Cited by 30

Investigation of piwi-interacting RNA pathway genes role in idiopathic non-obstructive azoospermia

Kamaliyan, Z., Pouriamanesh, S., Soosanabadi, M., Gholami, M., & Mirfakhraie, R. (2018) · Scientific Reports · doi:10.1038/s41598-017-17518-4 · Cited by 29

PIWI Proteins Are Dispensable for Mouse Somatic Development and Reprogramming of Fibroblasts into Pluripotent Stem Cells

Cheng, E.-C., Kang, D., Wang, Z., & Lin, H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097821 · Cited by 26

Dual functions of Macpiwi1 in transposon silencing and stem cell maintenance in the flatworm Macrostomum lignano

Zhou, X., Battistoni, G., Demerdash, O. E., Gurtowski, J., Wunderer, J., Falciatori, I., Ladurner, P., Schatz, M. C., Hannon, G. J., & Wasik, K. A. (2015) · RNA · doi:10.1261/rna.052456.115 · Cited by 28

Non-Coding RNAs Set a New Phenotypic Frontier in Prostate Cancer Metastasis and Resistance

Altschuler, J., Stockert, J. A., & Kyprianou, N. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042100 · Cited by 29

The active stem cell specific expression of sponge Musashi homolog EflMsiA suggests its involvement in maintaining the stem cell state

Okamoto, K., Nakatsukasa, M., Alié, A., Masuda, Y., Agata, K., & Funayama, N. (2012) · Mechanisms of Development · doi:10.1016/j.mod.2012.03.001 · Cited by 28

The PIWI‐Interacting RNA Molecular Pathway: Insights From Cultured Silkworm Germline Cells

Sakakibara, K., & Siomi, M. C. (2017) · BioEssays · doi:10.1002/bies.201700068 · Cited by 26

Transcriptomic and functional analyses of the piRNA pathway in the Chagas disease vector Rhodnius prolixus

de Brito, T. F., Julio, A. H. F., Berni, M. A., Poncio, L. D. C., Bernardes, E. S., Araujo, H. M., Sammeth, M., & Pane, A. (2018) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0006760 · Cited by 27

piRNAQuest V.2: an updated resource for searching through the piRNAome of multiple species

Ghosh, B., Sarkar, A., Mondal, S., Bhattacharya, N., Khatua, S., & Ghosh, Z. (2021) · RNA Biology · doi:10.1080/15476286.2021.2010960 · Cited by 27

Altered Expression of Porcine Piwi Genes and piRNA during Development

Kowalczykiewicz, D., Pawlak, P., Lechniak, D., & Wrzesiński, J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043816 · Cited by 28

Tudor-SN Interacts with Piwi Antagonistically in Regulating Spermatogenesis but Synergistically in Silencing Transposons in Drosophila

Ku, H.-Y., Gangaraju, V. K., Qi, H., Liu, N., & Lin, H. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1005813 · Cited by 27

Small extracellular vesicles in follicular fluids for predicting reproductive outcomes in assisted reproductive technology

Muraoka, A., Yokoi, A., Yoshida, K., Kitagawa, M., Asano‐Inami, E., Murakami, M., Bayasula, Miyake, N., Nakanishi, N., Nakamura, T., et al. (2024) · Communications Medicine · doi:10.1038/s43856-024-00460-8 · Cited by 26

BmHen1 is essential for eupyrene sperm development in Bombyx mori but PIWI proteins are not

Xu, Y., Chen, D., Zheng, S., Yi, M., Liu, Z., Liu, Y., Yang, D., Liu, Y., Tang, L., Zhu, C., et al. (2022) · Insect Biochemistry and Molecular Biology · doi:10.1016/j.ibmb.2022.103874 · Cited by 25

Invertebrate Immunity, Natural Transplantation Immunity, Somatic and Germ Cell Parasitism, and Transposon Defense

Kloc, M., Hałasa, M., Kubiak, J. Z., & Ghobrial, R. M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25021072 · Cited by 25

Biogenesis and Mechanism of Action of Small Non-Coding RNAs: Insights from the Point of View of Structural Biology

Costa, M. C., Leitão, A. L., & Enguita, F. J. (2012) · International Journal of Molecular Sciences · doi:10.3390/ijms130810268 · Cited by 28

A Novel Terminal-Repeat Retrotransposon in Miniature (TRIM) Is Massively Expressed inEchinococcus multilocularisStem Cells

Koziol, U., Radío, S., Smircich, P., Zarowiecki, M., Fernández, C., & Brehm, K. (2015) · Genome Biology and Evolution · doi:10.1093/gbe/evv126 · Cited by 26

The Immunocytochemical Identification of PIWI-Positive Cells during the Recovery of a Coelomocyte Population after Evisceration in the Holothurian Eupentacta fraudatrix (Djakonov et Baranova, 1958) (Holothuroidea: Dendrochirota)

Zavalnaya, E. G., Shamshurina, E. V., & Елисейкина, М. Г. (2020) · Russian Journal of Marine Biology · doi:10.1134/s106307402002011x · Cited by 24

HITS-CLIP (CLIP-Seq) for Mouse Piwi Proteins

Vourekas, A., & Mourelatos, Z. (2013) · Methods in molecular biology · doi:10.1007/978-1-62703-694-8_7 · Cited by 24

Gonad specific genes in Atlantic salmon (Salmon salar L.): Characterization of tdrd7-2, dazl-2, piwil1 and tdrd1 genes

Kleppe, L., Wargelius, A., Johnsen, H., Andersson, E., & Edvardsen, R. B. (2015) · Gene · doi:10.1016/j.gene.2015.02.008 · Cited by 24

Discovery of microRNAs during early spermatogenesis in chicken

Xu, L., Guo, Q., Chang, G., Qiu, L., Liu, X., Bi, Y., Zhang, Y., Wang, H., Lu, W., Ren, L., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0177098 · Cited by 24

Heat shock protein DNAJA1 stabilizes PIWI proteins to support regeneration and homeostasis of planarian Schmidtea mediterranea

Wang, C., Yang, Z., Guo, F., Shi, S., Han, X.-S., Zeng, A., Lin, H., & Jing, Q. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra118.004445 · Cited by 23

miRNA Signature in Mouse Spermatogonial Stem Cells Revealed by High-Throughput Sequencing

Tan, T., Zhang, Y., Ji, W., & Zheng, P. (2014) · BioMed Research International · doi:10.1155/2014/154251 · Cited by 22

Single nucleotide polymorphisms in piRNA-pathway genes: an insight into genetic determinants of human diseases

Roy, J., Anand, K., Mohapatra, S., Nayak, R., Chattopadhyay, T., & Mallick, B. (2019) · Molecular Genetics and Genomics · doi:10.1007/s00438-019-01612-5 · Cited by 24

Expression Profiles of PIWIL2 Short Isoforms Differ in Testicular Germ Cell Tumors of Various Differentiation Subtypes

Gainetdinov, I. V., Skvortsova, Y. V., Stukacheva, E. A., Bychenko, O. S., Kondratieva, S. A., Zinovieva, M. V., & Azhikina, T. L. (2014) · PLoS ONE · doi:10.1371/journal.pone.0112528 · Cited by 23

Transcriptome Analysis Identifies Piwi-Interacting RNAs as Prognostic Markers for Recurrence of Prostate Cancer

Zuo, Y., Liang, Y., Zhang, J., Hao, Y., Li, M., Wen, Z., & Zhao, Y. F. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.01018 · Cited by 23

The DExH Box Helicase Domain of Spindle-E Is Necessary for Retrotransposon Silencing and Axial Patterning DuringDrosophilaOogenesis

Ott, K., Nguyen, T. T. N., & Navarro, C. (2014) · G3 Genes Genomes Genetics · doi:10.1534/g3.114.014332 · Cited by 22

Sexual Reproduction in Stony Corals and Insight into the Evolution of Oogenesis in Cnidaria

Shikina, S., & Chang, C. (2016) · Springer eBooks · doi:10.1007/978-3-319-31305-4_16 · Cited by 22

PIWI-like protein, HIWI2 is aberrantly expressed in retinoblastoma cells and affects cell-cycle potentially through OTX2

Sivagurunathan, S., Arunachalam, J. P., & Chidambaram, S. (2017) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-017-0048-y · Cited by 22

Molecular approaches underlying the oogenic cycle of the scleractinian coral, Acropora tenuis

Tan, E. S., Izumi, R., Takeuchi, Y., Isomura, N., & Takemura, A. (2020) · Scientific Reports · doi:10.1038/s41598-020-66020-x · Cited by 21

Zfrp8/PDCD2is required in ovarian stem cells and interacts with the piRNA pathway machinery

Minakhina, S., Changela, N., & Steward, R. (2013) · Development · doi:10.1242/dev.101410 · Cited by 21

Hili inhibits HIV replication in activated T cells

Peterlin, B. M., Liu, P., Wang, X., Cary, D., Shao, W., Leoz, M., Hong, T., Pan, T., & Fujinaga, K. (2017) · Journal of Virology · doi:10.1128/jvi.00237-17 · Cited by 21

Identification and expression pattern analysis of Piwi genes during the spermiogenesis of Portunus trituberculatus

Xiang, D.-F., Zhu, J., Hou, C.-C., & Yang, W. (2013) · Gene · doi:10.1016/j.gene.2013.10.050 · Cited by 21

Defining the expression of piRNA and transposable elements inDrosophilaovarian germline stem cells and somatic support cells

Story, B. A., Ma, X., Ishihara, K., Li, H., Hall, K., Peak, A., Perera, A. G., Park, J., Haug, J., Blanchette, M., et al. (2019) · Life Science Alliance · doi:10.26508/lsa.201800211 · Cited by 19

Identification and verification of potential piRNAs from domesticated yak testis

Gong, J., Zhang, Q., Wang, Q., Ma, Y., Du, J., Zhang, Y., & Zhao, X. (2017) · Reproduction · doi:10.1530/rep-17-0592 · Cited by 20

Senescence and Longevity of Sea Urchins

Amir, Y., Insler, M., Giller, A., Gutman, D., & Atzmon, G. (2020) · Genes · doi:10.3390/genes11050573 · Cited by 22

Endogenous Retroviruses Walk a Fine Line between Priming and Silencing

Cullen, H. B., & Schorn, A. J. (2020) · Viruses · doi:10.3390/v12080792 · Cited by 20

Butter: High-precision genomic alignment of small RNA-seq dataPreprint

Axtell, M. J. (2014) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/007427 · Cited by 20

Characterization of a piRNA binding protein Miwi in mouse oocytes

Ding, X., Guan, H.-T., & Li, H. (2012) · Theriogenology · doi:10.1016/j.theriogenology.2012.11.013 · Cited by 21

Analysis of hairpin RNA transgene-induced gene silencing in Fusarium oxysporum

Schümann, U., Smith, N. A., Kazan, K., Ayliffe, M., & Wang, M. (2013) · Silence · doi:10.1186/1758-907x-4-3 · Cited by 19

A microRNA-mRNA expression network during oral siphon regeneration in Ciona

Spina, E. J., Guzman, E., Zhou, H., Kosik, K. S., & Smith, W. C. (2017) · Development · doi:10.1242/dev.144097 · Cited by 19

Leaf wax trait in crops for drought and biotic stress tolerance: regulators of epicuticular wax synthesis and role of small RNAs

Sajeevan, R. S., Parvathi, M. S., & Nataraja, K. N. (2017) · Indian Journal of Plant Physiology · doi:10.1007/s40502-017-0333-9 · Cited by 19

Expression of Piwi, MMP, TIMP, and Sox during Gut Regeneration in Holothurian Eupentacta fraudatrix (Holothuroidea, Dendrochirotida)

Dolmatov, I. Y., Kalacheva, N. V., Tkacheva, E. S., Shulga, A. P., Zavalnaya, E. G., Shamshurina, E. V., Girich, A. S., Boyko, A. V., & Елисейкина, М. Г. (2021) · Genes · doi:10.3390/genes12081292 · Cited by 20

Expression of Piwi protein MIWI2 defines a distinct population of multiciliated cells

Wasserman, G. A., Szymaniak, A. D., Hinds, A., Yamamoto, K., Kamata, H., Smith, N. M. S., Hilliard, K. L., Carrieri, C., Labadorf, A. T., Quinton, L. J., et al. (2017) · Journal of Clinical Investigation · doi:10.1172/jci94639 · Cited by 19

A critical role for nucleoporin 358 (Nup358) in transposon silencing and piRNA biogenesis in Drosophila

Parikh, R. Y., Lin, H., & Gangaraju, V. K. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.ac118.003264 · Cited by 18

Evolutionary conservation of the mature oocyte proteome

Lotan, T., Caspi, V. C., Ziv, T., Brekhman, V., Gordon, M. M., Admon, A., & Lubzens, E. (2014) · EuPA Open Proteomics · doi:10.1016/j.euprot.2014.01.003 · Cited by 17

Stem cells: A view from the roots

Somorjai, I., Lohmann, J. U., Holstein, T. W., & Zhao, Z. (2012) · Biotechnology Journal · doi:10.1002/biot.201100349 · Cited by 16

Glycolytic enzymes localize to ribonucleoprotein granules in Drosophila germ cells, bind Tudor and protect from transposable elements

Gao, M., Thomson, T., Creed, T. M., Tu, S., Loganathan, S. N., Jackson, C. A., McCluskey, P., Lin, Y., Collier, S. E., Weng, Z., et al. (2015) · EMBO Reports · doi:10.15252/embr.201439694 · Cited by 17

Editorial: Functional implications of Piwi proteins and piRNAs in stem cell maintenance and development

de Almeida, F. L., Das, A. V., & Rojas‐Ríos, P. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1583955 · Cited by 2

PIWI proteins and piRNAs: key regulators of stem cell biology

Claro-Linares, F., & Rojas‐Ríos, P. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1540313 · Cited by 25

The Role of piRNAs in Germline Stem Cell Division and Spermatogenesis.

Lin, H. (2008) · Biology of Reproduction · doi:10.1093/biolreprod/78.s1.281a

piRNA and PIWI in animal germ cells

Liu, M. (2010) · Shengming kexue

piRNAs and PIWI proteins: regulators of gene expression in development and stem cells

Rojas‐Ríos, P., & Simonelig, M. (2018) · Development · doi:10.1242/dev.161786 · Cited by 173