The DOI matches its Crossref record; 195 of the 196 references it cites were found in a registry or an index.
The Genomic and Cellular Foundations of Animal Origins
Abstract
The first animals arose more than six hundred million years ago, yet they left little impression in the fossil record. Nonetheless, the cell biology and genome composition of the first animal, the Urmetazoan, can be reconstructed through the study of phylogenetically relevant living organisms. Comparisons among animals and their unicellular and colonial relatives reveal that the Urmetazoan likely possessed a layer of epithelium-like collar cells, preyed on bacteria, reproduced by sperm and egg, and developed through cell division, cell differentiation, and invagination. Although many genes involved in development, body patterning, immunity, and cell-type specification evolved in the animal stem lineage or after animal origins, several gene families critical for cell adhesion, signaling, and gene regulation predate the origin of animals. The ancestral functions of these and other genes may eventually be revealed through studies of gene and genome function in early-branching animals and their closest non-animal relatives.
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“While sequencing projects have produced an abundance of information about the genomic foundations of animal evolution 32 , emerging genetic tools of the kind described herein now permit functional interrogation of the ancestral molecular toolkit employed in the diversification of early animal body plans.”
From TALEN and CRISPR/Cas9-mediated genome editing in the early-branching metazoan Nematostella vectensis (2014) · cites this paper as [32]
Citations
Cites
Hynes (2002) · doi:10.1016/s0092-8674(02)00971-6 · Cited by 8,606
An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System
Mazmanian, S. K., Liu, C. H., Tzianabos, A. O., & Kasper, D. L. (2005) · Cell · doi:10.1016/j.cell.2005.05.007 · Cited by 2,910
Animals in a bacterial world, a new imperative for the life sciences
McFall‐Ngai, M., Hadfield, M. G., Bosch, T. C. G., Carey, H. V., Domazet‐Lošo, T., Douglas, A. E., Dubilier, N., Eberl, G., Fukami, T., Gilbert, S. F., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1218525110 · Cited by 2,879
Self-citationSNAREs — engines for membrane fusion
Jahn, R., & Scheller, R. H. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2002 · Cited by 2,635
Broad phylogenomic sampling improves resolution of the animal tree of life
Dunn, C. W., Hejnol, A., Matus, D. Q., Pang, K., Browne, W. E., Smith, S. A., Seaver, E., Rouse, G. W., Obst, M., Edgecombe, G. D., et al. (2008) · Nature · doi:10.1038/nature06614 · Cited by 1,921
Comparative Genomics of the Eukaryotes
Rubin, G. M., Yandell, M. D., Wortman, J. R., Gabor, G. L., Miklos, Nelson, C. R., Hariharan, I. K., Fortini, M. E., Li, P. W., Apweiler, R., et al. (2000) · Science · doi:10.1126/science.287.5461.2204 · Cited by 1,698
Shiu, S., & Bleecker, A. B. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.181141598 · Cited by 1,472
The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans
King, N., Westbrook, M. J., Young, S. L., Kuo, A., Abedin, M., Chapman, J., Fairclough, S., Hellsten, U., Isogai, Y., Letunic, I., et al. (2008) · Nature · doi:10.1038/nature06617 · Cited by 1,139
Self-citationResolving difficult phylogenetic questions: Why more sequences are not enough
Philippe, H., Brinkmann, H., Lavrov, D. V., Littlewood, D. T. J., Manuel, M., Wörheide, G., & Baurain, D. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1000602 · Cited by 1,129
Cadherins in development: cell adhesion, sorting, and tissue morphogenesisPreprint
Halbleib, J. M., & Nelson, W. J. (2006) · Genes & Development · doi:10.1101/gad.1486806 · Cited by 1,101
Research works printed but not linked: 9
- Broad Inst, 2013, Origins of Multicellularity Database.
- Frame MC., 2002, Biochim. Biophys. Acta, 1602, 114
- 10.5962/bhl.title.49539 · DOI
- Haeckel E., 1874, Q. J. Microscop. Sci., 14, 142
- Haeckel E., 1869, Jenaische Z., 5, 207
- Karpov SA, 1998, Acta Protozool., 37, 23
- Price AL, 2004, Gastrulation: From Cells to Embryo, 695
- Saville-Kent W., 1880, A Manual of the Infusoria
- Traut W, 2007, Chromosome Res., 15, 371
Cited by
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Suga, H., & Miller, W. T. (2018) · Scientific Reports · doi:10.1038/s41598-018-23721-8 · Cited by 11
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Yuan, X., Pang, K., Tang, Q., Li, G., Xiao, S., Zhou, C., Chen, Z., Chen, L., Wan, B., Wang, W., et al. (2022) · Chinese Science Bulletin (Chinese Version) · doi:10.1360/tb-2022-0804 · Cited by 11
Lozada-Chávez, I., Stadler, P. F., & Prohaska, S. J. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/283549 · Cited by 11
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Nunez-Castilla, J., & Siltberg-Liberles, J. (2020) · Methods in molecular biology · doi:10.1007/978-1-0716-0524-0_7 · Cited by 10
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Tong, K., Wang, Y., & Su, Z. (2017) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2017.0681 · Cited by 10
Reproduction and early life stages of the poecilosclerid sponge Crella incrustans
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Richter, D. J., & Nitsche, F. (2017) · Springer eBooks · doi:10.1007/978-3-319-28149-0_5 · Cited by 11
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Kenny, N. J., Francis, W. R., Rivera-Vicéns, R. E., Juravel, K., de Mendoza, A., Díez-Vives, C., Lister, R., Bezares-Calderon, L., Grombacher, L., Roller, M., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.02.18.954784 · Cited by 6
Chin, N. E., Wu, T. C., O'Toole, J. M., Xu, K., Hata, T., & Koehl, M. A. R. (2022) · Journal of Eukaryotic Microbiology · doi:10.1111/jeu.12961 · Cited by 5
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Self-citationWalters, B. M., Guttieres, L., Goëb, M., Marjenberg, S. J., Martindale, M. Q., & Wikramanayake, A. H. (2025) · Developmental Dynamics · doi:10.1002/dvdy.70004 · Cited by 4
Richter, D. J., & Nitsche, F. (2016) · Springer eBooks · doi:10.1007/978-3-319-32669-6_5-1 · Cited by 3
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Harold, F. M. (2021) · doi:10.1093/oso/9780197604540.001.0001 · Cited by 2
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Alaminos, M., & Campos, A. (2023) · PubMed · doi:10.14670/hh-18-485 · Cited by 2
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Cofré, J. (2024) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2023.1260930 · Cited by 2
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Li, F., Aeran, R., Pone, E. J., Kang, D., Liu, L., Le, X. C., & Zhao, W. (2014) · Elsevier eBooks · doi:10.1016/b978-1-4557-3146-6.00015-5
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Harold, F. M. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780197604540.003.0008
Harold, F. M. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780197604540.003.0009
Harold, F. M. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780197604540.003.0003
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Harold, F. M. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780197604540.003.0001
Harold, F. M. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780197604540.003.0006
Harold, F. M. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780197604540.003.0005
Harold, F. M. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780197604540.003.0011
Harold, F. M. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780197604540.003.0010
Harold, F. M. (2021) · Oxford University Press eBooks · doi:10.1093/oso/9780197604540.003.0004
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Strano, F. (2023) · Open Access Victoria University of Wellington | Te Herenga Waka (Figshare) · doi:10.26686/wgtn.24057300
Harold, F. M. (2022) · Oxford University Press eBooks · doi:10.1093/oso/9780197604540.002.0009
Harold, F. M. (2022) · Oxford University Press eBooks · doi:10.1093/oso/9780197604540.002.0008
Harold, F. M. (2022) · Oxford University Press eBooks · doi:10.1093/oso/9780197604540.002.0006
Harold, F. M. (2022) · Oxford University Press eBooks · doi:10.1093/oso/9780197604540.002.0010
Harold, F. M. (2022) · Oxford University Press eBooks · doi:10.1093/oso/9780197604540.002.0012
Harold, F. M. (2022) · Oxford University Press eBooks · doi:10.1093/oso/9780197604540.002.0003
Harold, F. M. (2022) · Oxford University Press eBooks · doi:10.1093/oso/9780197604540.002.0004
Blachier, F. (2025) · Fascinating life sciences · doi:10.1007/978-3-031-93393-6_6
Seixas, V. C., Russo, C., & Klautau., M. R. L. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-15750-9.00167-1
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Piccinini, G., & Milani, L. (2023) · Figshare · doi:10.6084/m9.figshare.22617092
Cellular predation and motility as drivers of animal origins and the Cambrian radiation
Zhang, L. (2026) · Frontiers in Ecology and Evolution · doi:10.3389/fevo.2025.1736160
Study of modularity in molecular, morphological and linguistic evolution using networks methods
Pathmanathan, J. S. (2017) · theses.fr (ABES) · doi:10.70675/6a1ec9a8zac37z4fb1z9567zf643a8aacc0f
Pathophysiological role of Pyk2 in the nervous system
de Pins, B. (2019) · theses.fr (ABES) · doi:10.70675/e9fd4e35z9e7ez42d4za65cz5d999e5b2d5e
A unicellular relative links aggregative multicellularity to animal origins
Li, R., Dharamshi, J. E., Kwok, K., Ruiz‐Trillo, I., & Gerdt, J. P. (2026) · Nature · doi:10.1038/s41586-026-10748-5 · Cited by 3
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Sun, H., Walters, B. M., Žídek, R., Martindale, M. Q., & Wikramanayake, A. H. (2026) · Molecular Biology and Evolution · doi:10.1093/molbev/msag185 · Cited by 5
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Baselga‐Cervera, B., Gettle, N., & Travisano, M. (2026) · The American Naturalist · doi:10.1086/744242
Metadata
- Authors
- Richter, D. J., & King, N.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Annual Review of Genetics
- Publisher
- Annual Reviews
- Published
- 2013-11-23
- Volume
- 47
- Issue
- 1
- Pages
- 509-537
- ISSN
- 0066-4197 (ISSN-L)
- 1545-2948
- OpenAlex
- W2160011794
- Semantic Scholar
- 8a5bdc2bd381b3ef4062f08647a6c2f2c8906886
- Cited by
- 196
- References
- 196
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 6 · 2023: 13 · 2022: 15 · 2021: 23 · 2020: 12 · 2019: 15 · 2018: 22 · 2017: 25 · 2016: 22 · 2015: 15 · 2014: 16
- FWCI
- 2.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute of General Medical Sciences (R01GM099533, R01GM089977)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Marine Invertebrate Physiology and Ecology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Protist diversity and phylogeny
- Keywords
- origin of animals, cell adhesion genes, signaling genes, gene expression regulation, cell differentiation, invagination, gene family evolution, body patterning, immunity genes
- MeSH terms
- Animals, Cell Adhesion, Cnidaria, Biological Evolution, Fossils, Genes, Phylogeny, Porifera, Protein-Tyrosine Kinases, Structure-Activity Relationship, Cell Adhesion Molecules, Genome, Protein Structure, Tertiary, Ctenophora, Eukaryota, Choanoflagellata, Gene-Environment Interaction
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