The Genomic and Cellular Foundations of Animal Origins

Untitled work

Hynes (2002) · doi:10.1016/s0092-8674(02)00971-6 · Cited by 8,606

An Immunomodulatory Molecule of Symbiotic Bacteria Directs Maturation of the Host Immune System

Mazmanian, S. K., Liu, C. H., Tzianabos, A. O., & Kasper, D. L. (2005) · Cell · doi:10.1016/j.cell.2005.05.007 · Cited by 2,910

Animals in a bacterial world, a new imperative for the life sciences

McFall‐Ngai, M., Hadfield, M. G., Bosch, T. C. G., Carey, H. V., Domazet‐Lošo, T., Douglas, A. E., Dubilier, N., Eberl, G., Fukami, T., Gilbert, S. F., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1218525110 · Cited by 2,879

SNAREs — engines for membrane fusion

Jahn, R., & Scheller, R. H. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2002 · Cited by 2,635

Broad phylogenomic sampling improves resolution of the animal tree of life

Dunn, C. W., Hejnol, A., Matus, D. Q., Pang, K., Browne, W. E., Smith, S. A., Seaver, E., Rouse, G. W., Obst, M., Edgecombe, G. D., et al. (2008) · Nature · doi:10.1038/nature06614 · Cited by 1,921

Comparative Genomics of the Eukaryotes

Rubin, G. M., Yandell, M. D., Wortman, J. R., Gabor, G. L., Miklos, Nelson, C. R., Hariharan, I. K., Fortini, M. E., Li, P. W., Apweiler, R., et al. (2000) · Science · doi:10.1126/science.287.5461.2204 · Cited by 1,698

Receptor-like kinases from Arabidopsis form a monophyletic gene family related to animal receptor kinases

Shiu, S., & Bleecker, A. B. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.181141598 · Cited by 1,472

The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans

King, N., Westbrook, M. J., Young, S. L., Kuo, A., Abedin, M., Chapman, J., Fairclough, S., Hellsten, U., Isogai, Y., Letunic, I., et al. (2008) · Nature · doi:10.1038/nature06617 · Cited by 1,139

Resolving difficult phylogenetic questions: Why more sequences are not enough

Philippe, H., Brinkmann, H., Lavrov, D. V., Littlewood, D. T. J., Manuel, M., Wörheide, G., & Baurain, D. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1000602 · Cited by 1,129

Cadherins in development: cell adhesion, sorting, and tissue morphogenesisPreprint

Halbleib, J. M., & Nelson, W. J. (2006) · Genes & Development · doi:10.1101/gad.1486806 · Cited by 1,101

The Amphimedon queenslandica genome and the evolution of animal complexity

Srivastava, M., Simakov, O., Chapman, J., Fahey, B., Gauthier, M. E. A., Mitros, T., Richards, G. S., Conaco, C., Dacre, M., Hellsten, U., et al. (2010) · Nature · doi:10.1038/nature09201 · Cited by 1,049

Late-Neoproterozoic Deep-Ocean Oxygenation and the Rise of Animal Life

Canfield, D. E., Poulton, S. W., & Narbonne, G. M. (2007) · Science · doi:10.1126/science.1135013 · Cited by 1,000

Integrin signalling at a glance

Harburger, D. S., & Calderwood, D. (2008) · Journal of Cell Science · doi:10.1242/jcs.018093 · Cited by 956

The Ectocarpus genome and the independent evolution of multicellularity in brown algae

Cock, J. M., Sterck, L., Rouzé, P., Scornet, D., Allen, A. E., Amoutzias, G. D., Anthouard, V., Artiguenave, F., Aury, J., Badger, J. H., et al. (2010) · Nature · doi:10.1038/nature09016 · Cited by 944

Src family kinases, key regulators of signal transduction

Parsons, S. J., & Parsons, J. T. (2004) · Oncogene · doi:10.1038/sj.onc.1208160 · Cited by 942

Estimating the timing of early eukaryotic diversification with multigene molecular clocks

Parfrey, L. W., Lahr, D. J. G., Knoll, A. H., & Katz, L. A. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110633108 · Cited by 899

The Trichoplax genome and the nature of placozoans

Srivastava, M., Begovic, E., Chapman, J., Putnam, N. H., Hellsten, U., Kawashima, T., Kuo, A., Mitros, T., Salamov, A., Carpenter, M. L., et al. (2008) · Nature · doi:10.1038/nature07191 · Cited by 889

Role of Src expression and activation in human cancer

Irby, R., & Yeatman, T. J. (2000) · Oncogene · doi:10.1038/sj.onc.1203912 · Cited by 878

Early animal evolution: emerging views from comparative biology and geology

Knoll, A. H., & Carroll, S. B. (1999) · Science · doi:10.1126/science.284.5423.2129 · Cited by 821

Ferruginous Conditions Dominated Later Neoproterozoic Deep-Water Chemistry

Canfield, D. E., Poulton, S. W., Knoll, A. H., Narbonne, G. M., Ross, G., Goldberg, T., & Strauss, H. (2008) · Science · doi:10.1126/science.1154499 · Cited by 789

Early origins and evolution of microRNAs and Piwi-interacting RNAs in animals

Grimson, A., Srivastava, M., Fahey, B., Woodcroft, B. J., Chiang, H. R., King, N., Degnan, B. M., Rokhsar, D. S., & Bartel, D. P. (2008) · Nature · doi:10.1038/nature07415 · Cited by 756

Fossil steroids record the appearance of Demospongiae during the Cryogenian period

Love, G. D., Grosjean, E., Stalvies, C., Fike, D. A., Grotzinger, J. P., Bradley, A. S., Kelly, A. E., Bhatia, M., Meredith, W., Snape, C. E., et al. (2009) · Nature · doi:10.1038/nature07673 · Cited by 731

The Ediacara biota: Neoproterozoic origin of animals and their ecosystems

Narbonne, G. M. (2005) · Annual Review of Earth and Planetary Sciences · doi:10.1146/annurev.earth.33.092203.122519 · Cited by 714

Src in cancer: deregulation and consequences for cell behaviour

Frame, M. C. (2002) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(02)00040-9 · Cited by 696

Phylogenomics Revives Traditional Views on Deep Animal Relationships

Philippe, H., Derelle, R., Lopez, P., Pick, K., Borchiellini, C., Boury-Esnault, N., Vacelet, J., Renard, E., Houliston, E., Quéinnec, E., et al. (2009) · Current Biology · doi:10.1016/j.cub.2009.02.052 · Cited by 695

Tyrosine phosphorylation: thirty years and counting

Hunter, T. R. (2009) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2009.01.028 · Cited by 664

Monophyletic Origins of the Metazoa: an Evolutionary Link with Fungi

Wainright, P. O., Hinkle, G., Sogin, M. L., & Stickel, S. K. (1993) · Science · doi:10.1126/science.8469985 · Cited by 656

The timing of eukaryotic evolution: Does a relaxed molecular clock reconcile proteins and fossils?

Douzery, E. J. P., Snell, E. A., Bapteste, E., Delsuc, F., & Philippe, H. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403984101 · Cited by 638

The cadherin superfamily: diversity in form and function

Angst, B. D., Marcozzi, C., & Magee, A. I. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.4.629 · Cited by 619

Planar Cell Polarity Signaling: From Fly Development to Human Disease

Simons, M., & Mlodzik, M. (2008) · Annual Review of Genetics · doi:10.1146/annurev.genet.42.110807.091432 · Cited by 600

WNT signalling molecules act in axis formation in the diploblastic metazoan Hydra

Hobmayer, B., Rentzsch, F., Kuhn, K., Happel, C. M., von Laue, C. C., Snyder, P., Rothbächer, U., & Holstein, T. W. (2000) · Nature · doi:10.1038/35025063 · Cited by 599

Untitled work

(1940) · Andalas University Repository (Andalas University) · Cited by 591

A molecular timescale of eukaryote evolution and the rise of complex multicellular life

Hedges, S. B., Blair, J. E., Venturi, M. L., & Shoe, J. L. (2004) · BMC Evolutionary Biology · doi:10.1186/1471-2148-4-2 · Cited by 578

The Multiple Origins of Complex Multicellularity

Knoll, A. H. (2011) · Annual Review of Earth and Planetary Sciences · doi:10.1146/annurev.earth.031208.100209 · Cited by 562

Multigene Analyses of Bilaterian Animals Corroborate the Monophyly of Ecdysozoa, Lophotrochozoa, and Protostomia

Philippe, H., Lartillot, N., & Brinkmann, H. (2005) · Molecular Biology and Evolution · doi:10.1093/molbev/msi111 · Cited by 551

The deep evolution of metazoan microRNAs

Wheeler, B. M., Heimberg, A. M., Moy, V. N., Sperling, E. A., Holstein, T. W., Heber, S., & Peterson, K. J. (2009) · Evolution & Development · doi:10.1111/j.1525-142x.2008.00302.x · Cited by 534

The Unicellular Ancestry of Animal Development

King, N. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.08.010 · Cited by 489

Estimating metazoan divergence times with a molecular clock

Peterson, K. J., Lyons, J. B., Nowak, K. S., Takacs, C. M., Wargo, M. J., & McPeek, M. A. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401670101 · Cited by 461

Evolution of Key Cell Signaling and Adhesion Protein Families Predates Animal Origins

King, N., Hittinger, C. T., & Carroll, S. B. (2003) · Science · doi:10.1126/science.1083853 · Cited by 424

Gastrulation: from cells to embryo

(2005) · Choice Reviews Online · doi:10.5860/choice.42-4013 · Cited by 414

Solution Structure of the Epithelial Cadherin Domain Responsible for Selective Cell Adhesion

Overduin, M., Harvey, T. S., Bagby, S., Tong, K. I., Yau, P., Takeichi, M., & Ikura, M. (1995) · Science · doi:10.1126/science.7824937 · Cited by 414

Structure and Mechanism of Cadherins and Catenins in Cell-Cell Contacts

Pokutta, S., & Weis, W. I. (2007) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev.cellbio.22.010305.104241 · Cited by 390

The fossil record and the early evolution of the Metazoa

Morris, S. C. (1993) · Nature · doi:10.1038/361219a0 · Cited by 389

Origin of Bilaterian Body Plans: Evolution of Developmental Regulatory Mechanisms

Davidson, E. H., Peterson, K. J., & Cameron, R. A. (1995) · Science · doi:10.1126/science.270.5240.1319 · Cited by 381

Microbial Factor-Mediated Development in a Host-Bacterial Mutualism

Koropatnick, T. A., Engle, J. T., Apicella, M. A., Stabb, E. V., Goldman, W. E., & McFall‐Ngai, M. (2004) · Science · doi:10.1126/science.1102218 · Cited by 379

Animal Evolution and the Molecular Signature of Radiations Compressed in Time

Rokas, A., Krüger, D., & Carroll, S. B. (2005) · Science · doi:10.1126/science.1116759 · Cited by 374

Uniting Germline and Stem Cells: The Function of Piwi Proteins and the piRNA Pathway in Diverse Organisms

Juliano, C., Wang, J., & Lin, H. (2011) · Annual Review of Genetics · doi:10.1146/annurev-genet-110410-132541 · Cited by 374

Phosphotyrosine Signaling: Evolving a New Cellular Communication System

Lim, W. A., & Pawson, T. J. (2010) · Cell · doi:10.1016/j.cell.2010.08.023 · Cited by 346

Six major steps in animal evolution: Are we derived sponge larvae?

Nielsen, C. (2008) · Evolution & Development · doi:10.1111/j.1525-142x.2008.00231.x · Cited by 343

Genome of Acanthamoeba castellanii highlights extensive lateral gene transfer and early evolution of tyrosine kinase signaling

Clarke, M., Lohan, A. J., Liu, B. A., Lagkouvardos, I., Roy, S. W., Zafar, N., Bertelli, C., Schilde, C., Kianianmomeni, A., Bürglin, T. R., et al. (2013) · Genome biology · doi:10.1186/gb-2013-14-2-r11 · Cited by 337

Early evolution of animal cell signaling and adhesion genes

Nichols, S., Dirks, W., Pearse, J. S., & King, N. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604065103 · Cited by 330

The Closest Unicellular Relatives of Animals

Lang, B. F., O'Kelly, C., Nerad, T., Gray, M. W., & Burger, G. (2002) · Current Biology · doi:10.1016/s0960-9822(02)01187-9 · Cited by 326

The Origins of Multicellularity and the Early History of the Genetic Toolkit For Animal Development

Rokas, A. (2008) · Annual Review of Genetics · doi:10.1146/annurev.genet.42.110807.091513 · Cited by 312

The Protistan Origins of Animals and Fungi

Steenkamp, E. T., Wright, J., & Baldauf, S. L. (2005) · Molecular Biology and Evolution · doi:10.1093/molbev/msj011 · Cited by 311

Receptor-like kinases shape the plant

Smet, I. D., Voß, U., Jürgens, G., & Beeckman, T. (2009) · Nature Cell Biology · doi:10.1038/ncb1009-1166 · Cited by 301

Origin and diversification of the basic helix-loop-helix gene family in metazoans: insights from comparative genomics

Simionato, E., Ledent, V., Richards, G. S., Thomas‐Chollier, M., Kerner, P., Coornaert, D., Degnan, B. M., & Vervoort, M. (2007) · BMC Evolutionary Biology · doi:10.1186/1471-2148-7-33 · Cited by 292

Premetazoan genome evolution and the regulation of cell differentiation in the choanoflagellate Salpingoeca rosetta

Fairclough, S. R., Chen, Z., Kramer, E., Zeng, Q., Young, S., Robertson, H. M., Begović, E., Richter, D. J., Russ, C., Westbrook, M. J., et al. (2013) · Genome biology · doi:10.1186/gb-2013-14-2-r15 · Cited by 292

A Post-Synaptic Scaffold at the Origin of the Animal Kingdom

Sakarya, O., Armstrong, K. A., Adamska, M., Adamski, M., Wang, I.-F., Tidor, B., Degnan, B. M., Oakley, T. H., & Kosik, K. S. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000506 · Cited by 291

An overview of the genome of Nostoc punctiforme, a multicellular, symbiotic cyanobacterium

Meeks, J. C., Elhai, J., Thiel, T., Potts, M., Larimer, F. W., Lamerdin, J. E., Predki, P. F., & Atlas, R. (2001) · Photosynthesis Research · doi:10.1023/a:1013840025518 · Cited by 285

Kunstformen der Natur

Haeckel, E., & Bibliographisches Institut (Leipzig, G. (1899) · doi:10.5962/bhl.title.102214 · Cited by 283

Genesis and Expansion of Metazoan Transcription Factor Gene Classes

Larroux, C., Luke, G. N., Koopman, P. A., Rokhsar, D. S., Shimeld, S. M., & Degnan, B. M. (2008) · Molecular Biology and Evolution · doi:10.1093/molbev/msn047 · Cited by 280

Cell differentiation and morphogenesis in the colony-forming choanoflagellate Salpingoeca rosetta

Dayel, M. J., Alegado, R. A., Fairclough, S. R., Levin, T. C., Nichols, S. A., McDonald, K., & King, N. (2011) · Developmental Biology · doi:10.1016/j.ydbio.2011.06.003 · Cited by 277

Sponge paraphyly and the origin of Metazoa

Borchiellini, C., Manuel, M., Alivon, E., Boury-Esnault, N., Vacelet, J., & Le Parco, Y. (2001) · Journal of Evolutionary Biology · doi:10.1046/j.1420-9101.2001.00244.x · Cited by 275

A Phylogenomic Investigation into the Origin of Metazoa

Ruiz‐Trillo, I., Roger, A. J., Burger, G., Gray, M. W., & Lang, B. F. (2008) · Molecular Biology and Evolution · doi:10.1093/molbev/msn006 · Cited by 270

Multigene Phylogeny of Choanozoa and the Origin of Animals

Shalchian‐Tabrizi, K., Minge, M. A., Espelund, M., Orr, R. J. S., Ruden, T. A., Jakobsen, K. S., & Cavalier‐Smith, T. (2008) · PLoS ONE · doi:10.1371/journal.pone.0002098 · Cited by 269

Concatenated Analysis Sheds Light on Early Metazoan Evolution and Fuels a Modern “Urmetazoon” Hypothesis

Schierwater, B., Eitel, M., Jakob, W., Osigus, H.-J., Hadrys, H., Dellaporta, S. L., Kolokotronis, S.-O., & DeSalle, R. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000020 · Cited by 260

Wnt and TGF-β Expression in the Sponge Amphimedon queenslandica and the Origin of Metazoan Embryonic Patterning

Adamska, M., Degnan, S. M., Green, K. M., Adamski, M., Craigie, A., Larroux, C., & Degnan, B. M. (2007) · PLoS ONE · doi:10.1371/journal.pone.0001031 · Cited by 257

Ancient origin of the integrin-mediated adhesion and signaling machinery

Sebé-Pedrós, A., Roger, A. J., Lang, B. F., King, N., & Ruiz‐Trillo, I. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002257107 · Cited by 256

A bacterial sulfonolipid triggers multicellular development in the closest living relatives of animals

Alegado, R. A., Brown, L. W., Cao, S., Dermenjian, R. K., Zuzow, R., Fairclough, S. R., Clardy, J., & King, N. (2012) · eLife · doi:10.7554/elife.00013 · Cited by 249

Increases in the Number of SNARE Genes Parallels the Rise of Multicellularity among the Green Plants

Sanderfoot, A. A. (2007) · PLANT PHYSIOLOGY · doi:10.1104/pp.106.092973 · Cited by 247

An Ecological Theory for the Sudden Origin of Multicellular Life in the Late Precambrian

Stanley, S. M. (1973) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.70.5.1486 · Cited by 246

Diverse evolutionary paths to cell adhesion

Sigg, M. A., & King, N. (2010) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.08.002 · Cited by 244

The Premetazoan Ancestry of Cadherins

Sigg, M. A., & King, N. (2008) · Science · doi:10.1126/science.1151084 · Cited by 240

A receptor tyrosine kinase from choanoflagellates: Molecular insights into early animal evolution

King, N., & Carroll, S. B. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.261477698 · Cited by 234

Type IV collagen in sponges, the missing link in basement membrane ubiquity*

Boute, N., Exposito, J., Boury‐Esnault, N., Vacelet, J., Noro, N., Miyazaki, K., Yoshizato, K., & Garrone, R. (1996) · Biology of the Cell · doi:10.1016/s0248-4900(97)86829-3 · Cited by 223

The protist, Monosiga brevicollis , has a tyrosine kinase signaling network more elaborate and diverse than found in any known metazoan

Manning, G., Young, S. L., Miller, W. T., & Zhai, Y. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801314105 · Cited by 216

Possible animal-body fossils in pre-Marinoan limestones from South Australia

Maloof, A. C., Rose, C. V., Beach, R., Samuels, B. M., Calmet, C. C., Erwin, D. H., Poirier, G. R., Yao, N., & Simons, F. J. (2010) · Nature Geoscience · doi:10.1038/ngeo934 · Cited by 213

The origins of multicellularity: a multi-taxon genome initiative

Ruiz‐Trillo, I., Burger, G., Holland, P. W. H., King, N., Lang, B. F., Roger, A. J., & Gray, M. W. (2007) · Trends in Genetics · doi:10.1016/j.tig.2007.01.005 · Cited by 208

Choanoflagellates, choanocytes, and animal multicellularity

Maldonado, M. (2004) · Invertebrate Biology · doi:10.1111/j.1744-7410.2004.tb00138.x · Cited by 207

Molecular phylogeny of choanoflagellates, the sister group to Metazoa

Carr, M., Leadbeater, B. S. C., Hassan, R., Nelson, M., & Baldauf, S. L. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801667105 · Cited by 205

A potential catalytic site revealed by the 1.7-Å crystal structure of the amino-terminal signalling domain of Sonic hedgehog

Hall, T. M. T., Porter, J. A., Beachy, P. A., & Leahy, D. J. (1995) · Nature · doi:10.1038/378212a0 · Cited by 199

Origin of metazoan cadherin diversity and the antiquity of the classical cadherin/β-catenin complex

Nichols, S., Roberts, B., Richter, D. J., Fairclough, S. R., & King, N. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1120685109 · Cited by 195

Unexpected repertoire of metazoan transcription factors in the unicellular holozoan Capsaspora owczarzaki

Sebe-Pedros, A., de Mendoza, A., Lang, B. F., Degnan, B. M., & Ruiz-Trillo, I. (2011) · Molecular Biology and Evolution · doi:10.1093/molbev/msq309 · Cited by 195

Thousands of Rab GTPases for the Cell Biologist

Diekmann, Y., Seixas, E., Gouw, M., Tavares-Cadete, F., Seabra, M. C., & Pereira‐Leal, J. B. (2011) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1002217 · Cited by 193

Epithelium--The Primary Building Block for Metazoan Complexity

Tyler, S. (2003) · Integrative and Comparative Biology · doi:10.1093/icb/43.1.55 · Cited by 187

Innate Immune Defense of the Sponge Suberites domuncula against Bacteria Involves a MyD88-dependent Signaling Pathway

Wiens, M., Korzhev, M., Krasko, A., Thakur, N. L., Perović‐Ottstadt, S., Breter, H. J., Ushijima, H., Diehl‐Seifert, B., Müller, I. M., & Müller, W. E. G. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504049200 · Cited by 182

Sponge phylogeny, animal monophyly, and the origin of the nervous system: 18S rRNA evidence

Cavalier-Smith, T., Allsopp, M. T. E. P., Chao, E. E., Boury-Esnault, N., & Vacelet, J. (1996) · Canadian Journal of Zoology · doi:10.1139/z96-231 · Cited by 180

The NK homeobox gene cluster predates the origin of Hox genes.

Larroux, C., Fahey, B., Degnan, S. M., Adamski, M., Rokhsar, D. S., & Degnan, B. M. (2007) · Current Biology · doi:10.1016/j.cub.2007.03.008 · Cited by 173

Developmental expression of transcription factor genes in a demosponge: insights into the origin of metazoan multicellularity

Larroux, C., Fahey, B., Liubicich, D., Hinman, V. F., Gauthier, M., Gongora, M., Green, K., Wörheide, G., Leys, S. P., & Degnan, B. M. (2006) · Evolution & Development · doi:10.1111/j.1525-142x.2006.00086.x · Cited by 173

Phylogenetic-signal dissection of nuclear housekeeping genes supports the paraphyly of sponges and the monophyly of Eumetazoa

Sperling, E. A., Peterson, K. J., & Pisani, D. (2009) · Molecular Biology and Evolution · doi:10.1093/molbev/msp148 · Cited by 172

Evolution of the phospho-tyrosine signaling machinery in premetazoan lineages

Pincus, D., Letunić, I., Peer Bork, B., & Lim, W. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803161105 · Cited by 165

Sponge Genes Provide New Insight into the Evolutionary Origin of the Neurogenic Circuit

Richards, G. S., Simionato, E., Perron, M., Adamska, M., Vervoort, M., & Degnan, B. M. (2008) · Current Biology · doi:10.1016/j.cub.2008.06.074 · Cited by 165

Multicellular development in a choanoflagellate

Fairclough, S. R., Dayel, M. J., & King, N. (2010) · Current Biology · doi:10.1016/j.cub.2010.09.014 · Cited by 163

The Cambrian explosion: Animals or fossils?

Runnegar, B. (1982) · Journal of the Geological Society of Australia · doi:10.1080/00167618208729222 · Cited by 151

Evolution of sodium channels predates the origin of nervous systems in animals

Liebeskind, B. J., Hillis, D. M., & Zakon, H. H. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106363108 · Cited by 149

Non-Lithistid Fossil Demospongiae — Origins of their Palaeobiodiversity and Highlights in History of Preservation

Reitner, J., & Wörheide, G. (2002) · Systema Porifera · doi:10.1007/978-1-4615-0747-5_4 · Cited by 140

Structure and expression of conserved Wnt pathway components in the demosponge Amphimedon queenslandica

Adamska, M., Larroux, C., Adamski, M., Green, K., Lovas, E., Koop, D., Richards, G. S., Zwafink, C., & Degnan, B. M. (2010) · Evolution & Development · doi:10.1111/j.1525-142x.2010.00435.x · Cited by 139

Embryogenesis and metamorphosis in a haplosclerid demosponge: Gastrulation and transdifferentiation of larval ciliated cells to choanocytes.

Leys, S. P., & Degnan, B. M. (2002) · Invertebrate Biology · doi:10.1111/j.1744-7410.2002.tb00058.x · Cited by 138

The evolutionary origin of hedgehog proteins

Adamska, M., Matus, D. Q., Adamski, M., Green, K., Rokhsar, D. S., Martindale, M. Q., & Degnan, B. M. (2007) · Current Biology · doi:10.1016/j.cub.2007.08.010 · Cited by 137

Premetazoan Origin of the Hippo Signaling Pathway

Sebé-Pedrós, A., Zheng, Y., Ruiz‐Trillo, I., & Pan, D. (2012) · Cell Reports · doi:10.1016/j.celrep.2011.11.004 · Cited by 137

Genomic Survey of Premetazoans Shows Deep Conservation of Cytoplasmic Tyrosine Kinases and Multiple Radiations of Receptor Tyrosine Kinases

Suga, H., Dacre, M., de Mendoza, A., Shalchian‐Tabrizi, K., Manning, G., & Ruiz‐Trillo, I. (2012) · Science Signaling · doi:10.1126/scisignal.2002733 · Cited by 126

Observations on the ultrastructure of the choanoflagellate Codosiga botrytis (Ehr.) saville-kent with special reference to the flagellar apparatus

Hibberd, D. J. (1975) · Journal of Cell Science · doi:10.1242/jcs.17.1.191 · Cited by 125

Flagellates

Leadbeater, B. S. C., & Green, J. C. (2000) · doi:10.1201/9781482268225 · Cited by 121

Androglobin: A Chimeric Globin in Metazoans That Is Preferentially Expressed in Mammalian Testes

Hoogewijs, D., Ebner, B., Germani, F., Hoffmann, F. G., Fabrizius, A., Moens, L. J., Burmester, T., Dewilde, S., Storz, J. F., Vinogradov, S. N., et al. (2011) · Molecular Biology and Evolution · doi:10.1093/molbev/msr246 · Cited by 121

Epithelia and integration in sponges

Leys, S. P., Nichols, S., & ADAMS, E. D. M. (2009) · Integrative and Comparative Biology · doi:10.1093/icb/icp038 · Cited by 120

Die Kalkschwämme. Eine Monographie ...

Haeckel, E. (1872) · G. Reimer eBooks · doi:10.5962/bhl.title.11323 · Cited by 119

Life-history and ultrastructure of a new marine species of Proterospongia (Choanoflagellida)

Leadbeater, B. S. C. (1983) · Journal of the Marine Biological Association of the United Kingdom · doi:10.1017/s0025315400049857 · Cited by 118

Genomic insights into Wnt signaling in an early diverging metazoan, the ctenophore Mnemiopsis leidyi

Pang, K., Ryan, J. F., Program, N. C. S., Mullikin, J. C., Baxevanis, A. D., & Martindale, M. Q. (2010) · EvoDevo · doi:10.1186/2041-9139-1-10 · Cited by 115

A Search for the Origins of Animals and Fungi: Comparing and Combining Molecular Data

Baldauf, S. L. (1999) · The American Naturalist · doi:10.1086/303292 · Cited by 114

Phylogenetic analysis of the Hsp70 sequences reveals the monophyly of Metazoa and specific phylogenetic relationships between animals and fungi

Borchiellini, C., Boury‐Esnault, N., Vacelet, J., & Parco, Y. L. (1998) · Molecular Biology and Evolution · doi:10.1093/oxfordjournals.molbev.a025968 · Cited by 113

Rangeomorphs, Thectardis (Porifera?) and dissolved organic carbon in the Ediacaran oceans: Rangeomorphs, Thectardis and DOC

SPERLING, E. A., PETERSON, K. J., & LAFLAMME, M. (2011) · Geobiology · doi:10.1111/j.1472-4669.2010.00259.x · Cited by 112

Regulatory Factor X (RFX)-mediated transcriptional rewiring of ciliary genes in animals

Piasecki, B. P., Burghoorn, J., & Swoboda, P. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914241107 · Cited by 110

Origin of animal epithelia: insights from the sponge genome

Fahey, B., & Degnan, B. M. (2010) · Evolution & Development · doi:10.1111/j.1525-142x.2010.00445.x · Cited by 109

Epithelia, an Evolutionary Novelty of Metazoans

Leys, S. P., & Riesgo, A. (2011) · Journal of Experimental Zoology Part B Molecular and Developmental Evolution · doi:10.1002/jez.b.21442 · Cited by 107

The telomere repeat motif of basal Metazoa

Traut, W., Szczepanowski, M., Zrzavá, M., Opitz, C., Marec, F., & Zrzavý, J. (2007) · Chromosome Research · doi:10.1007/s10577-007-1132-3 · Cited by 107

Functional development of Src tyrosine kinases during evolution from a unicellular ancestor to multicellular animals

Segawa, Y., Suga, H., Iwabe, N., Oneyama, C., Akagi, T., Miyata, T., & Okada, M. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600021103 · Cited by 107

Origin of metazoan adhesion molecules and adhesion receptors as deduced from cDNA analyses in the marine sponge Geodia cydonium : a review

Müller, W. E. G. (1997) · Cell and Tissue Research · doi:10.1007/s004410050885 · Cited by 104

Development of ichthyosporeans sheds light on the origin of metazoan multicellularity

Suga, H., & Ruiz‐Trillo, I. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.01.009 · Cited by 101

Evolution of the MAGUK protein gene family in premetazoan lineages

de Mendoza, A., Suga, H., & Ruiz‐Trillo, I. (2010) · BMC Evolutionary Biology · doi:10.1186/1471-2148-10-93 · Cited by 100

Embryogenesis and larval differentiation in sponges

Leys, S. P., & Ereskovsky, A. V. (2006) · Canadian Journal of Zoology · doi:10.1139/z05-170 · Cited by 100

The SH2 Domain–Containing Proteins in 21 Species Establish the Provenance and Scope of Phosphotyrosine Signaling in Eukaryotes

Liu, B. A., Shah, E. E., Jablonowski, K. D., Stergachis, A. B., Engelmann, B. W., & Nash, P. (2011) · Science Signaling · doi:10.1126/scisignal.2002105 · Cited by 99

THE CAMBRIAN EXPLOSION: ANIMALS OR FOSSILS?

Peterson, K. J. (2012) · 2012 GSA Annual Meeting in Charlotte · Cited by 98

A talin homologue of Dictyostelium rapidly assembles at the leading edge of cells in response to chemoattractant.

Kreitmeier, M., Gerisch, G., Heizer, C., & Müller‐Taubenberger, A. (1995) · The Journal of Cell Biology · doi:10.1083/jcb.129.1.179 · Cited by 97

The genome of the sponge Amphimedon queenslandica provides new perspectives into the origin of Toll‐like and interleukin 1 receptor pathways

Gauthier, M. E. A., Pasquier, L. D., & Degnan, B. M. (2010) · Evolution & Development · doi:10.1111/j.1525-142x.2010.00436.x · Cited by 96

Unicellular Ca2+ Signaling 'Toolkit' at the Origin of Metazoa

Cai, X. (2008) · Molecular Biology and Evolution · doi:10.1093/molbev/msn077 · Cited by 96

The first animals: ca. 760-million-year-old sponge-like fossils from Namibia

Brain, C. K. ‘., Prave, A. R., Hoffmann, K.-H., Fallick, A. E., Botha, A., Herd, D. A., Sturrock, C. J., Young, I. M., Condon, D. J., & Allison, S. G. (2012) · South African Journal of Science · doi:10.4102/sajs.v108i1/2.658 · Cited by 96

Molecular evolution of Phox-related regulatory subunits for NADPH oxidase enzymes

Kawahara, T., & Lambeth, J. D. (2007) · BMC Evolutionary Biology · doi:10.1186/1471-2148-7-178 · Cited by 95

The stem cell system in demosponges: Insights into the origin of somatic stem cells

Funayama, N. (2010) · Development, Growth & Differentiation · doi:10.1111/j.1440-169x.2009.01162.x · Cited by 95

The Dispanins: A Novel Gene Family of Ancient Origin That Contains 14 Human Members

Almén, M. S., Bringeland, N., Fredriksson, R., & Schiöth, H. B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0031961 · Cited by 92

WNT/β-Catenin Signalling and Epithelial Patterning in the Homoscleromorph Sponge Oscarella

Lapébie, P., Gazave, E., Ereskovsky, A. V., Derelle, R., Bézac, C., Renard, E., Houliston, E., & Borchiellini, C. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005823 · Cited by 91

Phylogenetic Analysis of the Teneurins: Conserved Features and Premetazoan Ancestry

Tucker, R. P., Beckmann, J., Leachman, N. T., Schöler, J., & Chiquet‐Ehrismann, R. (2011) · Molecular Biology and Evolution · doi:10.1093/molbev/msr271 · Cited by 91

Evolutionary relationships of Metazoa within the eukaryotes based on molecular data from Porifera

Schütze, J., Krasko, A., Custódio, M. R., Efremova, S. M., Müller, I. M., & Müller, W. E. G. (1999) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.1999.0605 · Cited by 86

Receptor kinase signalling in plants and animals: distinct molecular systems with mechanistic similarities

Cock, J. M., Vanoosthuyse, V., & Gaude, T. (2002) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(02)00305-8 · Cited by 85

Signaling Properties of a Non-metazoan Src Kinase and the Evolutionary History of Src Negative Regulation

Li, W., Young, S. L., King, N., & Miller, W. T. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m800002200 · Cited by 79

The backbone of the post-synaptic density originated in a unicellular ancestor of choanoflagellates and metazoans

Alié, A., & Manuel, M. (2010) · BMC Evolutionary Biology · doi:10.1186/1471-2148-10-34 · Cited by 79

Primordial neurosecretory apparatus identified in the choanoflagellate Monosiga brevicollis

Burkhardt, P., Stegmann, C. M., Cooper, B. H., Kloepper, T. H., Imig, C., Varoqueaux, F., Wahl, M. C., & Fasshauer, D. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106189108 · Cited by 77

Organising cells into tissues: new roles for cell adhesion molecules in planar cell polarity

Saburi, S., & McNeill, H. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.08.011 · Cited by 76

Evolution of the holozoan ribosome biogenesis regulon

Brown, S. J., Cole, M. D., & Erives, A. J. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-442 · Cited by 74

Hsp70 sequences indicate that choanoflagellates are closely related to animals

Snell, E. A., Furlong, R. F., & Holland, P. W. H. (2001) · Current Biology · doi:10.1016/s0960-9822(01)00275-5 · Cited by 73

Demosponge and Sea Anemone Fibrillar Collagen Diversity Reveals the Early Emergence of A/C Clades and the Maintenance of the Modular Structure of Type V/XI Collagens from Sponge to Human

Exposito, J., Larroux, C., Cluzel, C., Valcourt, U., Lethias, C., & Degnan, B. M. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804573200 · Cited by 73

Memoirs: The Gastraea-Theory, the Phylogenetic Classification of the Animal Kingdom and the Homology of the Germ-Lamellæ

Haeckel, E. (1874) · Journal of Cell Science · doi:10.1242/jcs.s2-14.54.142 · Cited by 70

Multicellularity arose several times in the evolution of eukaryotes (Response to DOI 10.1002/bies.201100187)

Parfrey, L. W., & Lahr, D. J. G. (2013) · BioEssays · doi:10.1002/bies.201200143 · Cited by 69

Tyrosine kinase signaling and the emergence of multicellularity

Miller, W. T. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.03.009 · Cited by 69

A holistic phylogeny of the coronin gene family reveals an ancient origin of the tandem-coronin, defines a new subfamily, and predicts protein function

Eckert, C., Hammesfahr, B., & Kollmar, M. (2011) · BMC Evolutionary Biology · doi:10.1186/1471-2148-11-268 · Cited by 68

Premetazoan Ancestry of the Myc–Max Network

Young, S. L., Diolaiti, D., Conacci‐Sorrell, M., Ruiz‐Trillo, I., Eisenman, R. N., & King, N. (2011) · Molecular Biology and Evolution · doi:10.1093/molbev/msr132 · Cited by 65

Convergent evolution of RFX transcription factors and ciliary genes predated the origin of metazoans

Chu, J. S., Baillie, D. L., & Chen, N. (2010) · BMC Evolutionary Biology · doi:10.1186/1471-2148-10-130 · Cited by 63

Early diversification and complex evolutionary history of the p53 tumor suppressor gene family

Nedelcu, A. M., & Tan, C. A. (2007) · Development Genes and Evolution · doi:10.1007/s00427-007-0185-9 · Cited by 63

An unusual choanoflagellate protein released by Hedgehog autocatalytic processing

Snell, E. A., Brooke, N. M., Taylor, W. R., Casañe, D., Philippe, H., & Holland, P. W. H. (2005) · Proceedings of the Royal Society B Biological Sciences · doi:10.1098/rspb.2005.3263 · Cited by 63

An epithelial tissue in Dictyostelium challenges the traditional origin of metazoan multicellularity

Dickinson, D. J., Nelson, W. J., & Weis, W. I. (2012) · BioEssays · doi:10.1002/bies.201100187 · Cited by 62

Origin and Evolution of Laminin Gene Family Diversity

Fahey, B., & Degnan, B. M. (2012) · Molecular Biology and Evolution · doi:10.1093/molbev/mss060 · Cited by 61

Gastrulation in Calcareous Sponges: In Search of Haeckel's Gastraea

Leys, S. P. (2005) · Integrative and Comparative Biology · doi:10.1093/icb/45.2.342 · Cited by 57

Sponge Development and Antiquity of Animal Pattern Formation

Degnan, B. M. (2005) · Integrative and Comparative Biology · doi:10.1093/icb/45.2.335 · Cited by 54

XXXIII.—On the Spongiæ ciliatæ as Infusoria flagellata; or observations on the structure, animality, and relationship of Leucosolenia botryoides, bowerbank

James‐Clark, H. (1868) · Annals and Magazine of Natural History · doi:10.1080/00222936808695688 · Cited by 53

The kinome of Phytophthora infestans reveals oomycete-specific innovations and links to other taxonomic groups

Judelson, H. S., & Ah‐Fong, A. M. V. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-700 · Cited by 53

A cooperative model for receptor recognition and cell adhesion: evidence from the molecular packing in the 1.6-A crystal structure of the pheromone Er-1 from the ciliated protozoan Euplotes raikovi.

Weiss, M. S., Anderson, D. H., Raffioni, S., Bradshaw, R. A., Ortenzi, C., Luporini, P., & Eisenberg, D. S. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.22.10172 · Cited by 52

Evolution of the 2′-5′-Oligoadenylate Synthetase Family in Eukaryotes and Bacteria

Kjær, K. H., Poulsen, J. B., Reintamm, T., Saby, E., Martensen, P. M., Kelve, M., & Justesen, J. (2009) · Journal of Molecular Evolution · doi:10.1007/s00239-009-9299-1 · Cited by 52

Comparative Genomics of Phylogenetically Diverse Unicellular Eukaryotes Provide New Insights into the Genetic Basis for the Evolution of the Programmed Cell Death Machinery

Nedelcu, A. M. (2009) · Journal of Molecular Evolution · doi:10.1007/s00239-009-9201-1 · Cited by 51

Sponge homologs of vertebrate protein tyrosine kinases and frequent domain shufflings in the early evolution of animals before the parazoan–eumetazoan split

Suga, H., Katoh, K., & Miyata, T. (2001) · Gene · doi:10.1016/s0378-1119(01)00784-3 · Cited by 49

Mitochondrial carrier homolog 2 (MTCH2): The recruitment and evolution of a mitochondrial carrier protein to a critical player in apoptosis

Robinson, A. J., Kunji, E. R. S., & Gross, A. (2012) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.01.026 · Cited by 44

XXII.—On the Spongiæ ciliatæ as Infusoria flagellata; or observations on the structure, animality, and relationship of Leucosolenia botryoides, Bowerbank

James‐Clark, H. (1868) · Annals and Magazine of Natural History · doi:10.1080/00222936808695657 · Cited by 42

NK homeobox genes with choanocyte-specific expression in homoscleromorph sponges

Gazave, E., Lapébie, P., Renard, E., Bézac, C., Boury-Esnault, N., Vacelet, J., Pérez, T., Manuel, M., & Borchiellini, C. (2008) · Development Genes and Evolution · doi:10.1007/s00427-008-0242-z · Cited by 42

Molecular-phylogenetic, structural and biochemical features of a cold-adapted, marine ichthyosporean near the animal-fungal divergence, described from in vitro cultures

Jøstensen, J.-P., Sperstad, S. V., Johansen, S., & Landfald, B. (2002) · European Journal of Protistology · doi:10.1078/0932-4739-00855 · Cited by 38

Involvement of a 40-kDa Glycoprotein in Food Recognition, Prey Capture, and Induction of Phagocytosis in the Protozoon Actinophrys sol

Sakaguchi, M., Murakami, H., & Suzaki, T. (2001) · Protist · doi:10.1078/1434-4610-00041 · Cited by 37

Ultrastructure of the collar of the choanoflagellate Codonosiga botrytis (Ehrenb.)

Fjerdingstad, E. J. (1961) · Cell and Tissue Research · doi:10.1007/bf00340451 · Cited by 36

Developmental expression of COE across the Metazoa supports a conserved role in neuronal cell-type specification and mesodermal development

Jackson, D. J., Meyer, N. P., Seaver, E. C., Pang, K., McDougall, C., Moy, V. N., Gordon, K. L., Degnan, B. M., Martindale, M. Q., Burke, R. D., et al. (2010) · Development Genes and Evolution · doi:10.1007/s00427-010-0343-3 · Cited by 36

Neuroglobins, Pivotal Proteins Associated with Emerging Neural Systems and Precursors of Metazoan Globin Diversity

Lechauve, C., Jager, M., Laguerre, L., Kiger, L., Correc, G., Leroux, C., Vinogradov, S. N., Czjzek, M., Marden, M. C., & Bailly, X. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.407601 · Cited by 36

Nme Gene Family Evolutionary History Reveals Pre-Metazoan Origins and High Conservation between Humans and the Sea Anemone, Nematostella vectensis

Desvignes, T., Pontarotti, P., & Bobe, J. (2010) · PLoS ONE · doi:10.1371/journal.pone.0015506 · Cited by 35

Phylogeny of Tec Family Kinases: Identification of a Premetazoan Origin of Btk, Bmx, Itk, Tec, Txk, and the Btk Regulator SH3BP5

Ortutay, C., Nore, B. F., Vihinen, M., & Smith, C. I. E. (2008) · Advances in genetics · doi:10.1016/s0065-2660(08)00803-1 · Cited by 34

Early Neoproterozoic origin of the metazoan clade recorded in carbonate rock texture

Neuweiler, F., Turner, E. C., & Burdige, D. J. (2009) · Geology · doi:10.1130/g25621a.1 · Cited by 34

Multiple Independent Fusions of Glucose-6-Phosphate Dehydrogenase with Enzymes in the Pentose Phosphate Pathway

Stover, N. A., Dixon, T. A., & Cavalcanti, A. R. O. (2011) · PLoS ONE · doi:10.1371/journal.pone.0022269 · Cited by 31

Ancient origin of animal U-box ubiquitin ligases

Marı́n, I. (2010) · BMC Evolutionary Biology · doi:10.1186/1471-2148-10-331 · Cited by 31

Phylogeny and evolution of Rab7 and Rab9 proteins

Mackiewicz, P., & Wyroba, E. (2009) · BMC Evolutionary Biology · doi:10.1186/1471-2148-9-101 · Cited by 31

SELF-RECOGNITION AS THE ORIGINAL FUNCTION OF AN AMOEBAN DEFENSE-INDUCING KAIROMONE

Kusch, J. (1999) · Ecology · doi:10.1890/0012-9658(1999)080[0715:sratof]2.0.co;2 · Cited by 30

Cysteine Proteases and Cell Differentiation: Excystment of the Ciliated Protist Sterkiella histriomuscorum

Villalobo, E., Moch, C., Fryd-Versavel, G., Fleury‐Aubusson, A., & Morin, L. (2003) · Eukaryotic Cell · doi:10.1128/ec.2.6.1234-1245.2003 · Cited by 30

Ancient divergence of animal protein tyrosine kinase genes demonstrated by a gene family tree including choanoflagellate genes

Suga, H., Sasaki, G., Kuma, K.-I., Nishiyori, H., Hirose, N., Su, Z.-H., Iwabe, N., & Miyata, T. (2008) · FEBS Letters · doi:10.1016/j.febslet.2008.02.002 · Cited by 29

Early Neoproterozoic origin of the metazoan clade recorded in carbonate rock texture: REPLY

Neuweiler, F., Turner, E. C., & Burdige, D. J. (2009) · Geology · doi:10.1130/g30484y.1 · Cited by 29

The RJL family of small GTPases is an ancient eukaryotic invention probably functionally associated with the flagellar apparatus

Eliáš, M., & Archibald, J. M. (2009) · Gene · doi:10.1016/j.gene.2009.04.011 · Cited by 28

Evolution of the spectrin-based membrane skeleton

Baines, A. J. (2010) · Transfusion Clinique et Biologique · doi:10.1016/j.tracli.2010.06.008 · Cited by 26

Genomic, phylogenetic, and cell biological insights into metazoan origins

Nichols, S. A., Dayel, M. J., & King, N. (2009) · Animal Evolution · doi:10.1093/acprof:oso/9780199549429.003.0003 · Cited by 24

Cyst Formation in a Freshwater Strain of the Choanoflagellate Desmarella moniliformis Kent

Leadbeater, B. S. C., & Karpov, S. A. (2000) · Journal of Eukaryotic Microbiology · doi:10.1111/j.1550-7408.2000.tb00071.x · Cited by 22

Functional prediction and physiological characterization of a novel short trans-membrane protein 1 as a subunit of mitochondrial respiratory complexes

Zhang, D., Xi, Y., Coccimiglio, M. L., Mennigen, J. A., Jonz, M. G., Ekker, M., & Trudeau, V. L. (2012) · Physiological Genomics · doi:10.1152/physiolgenomics.00079.2012 · Cited by 22

Evolutionary genomics reveals the premetazoan origin of opposite gating polarity in animal-type voltage-gated ion channels

Cai, X. (2012) · Genomics · doi:10.1016/j.ygeno.2012.01.007 · Cited by 21

Citric acid cycle and the origin of MARS

Eswarappa, S. M., & Fox, P. L. (2013) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2013.01.005 · Cited by 21

Lack of Csk-Mediated Negative Regulation in a Unicellular Src Kinase

Schultheiss, K. P., Suga, H., Ruiz‐Trillo, I., & Miller, W. T. (2012) · Biochemistry · doi:10.1021/bi300965h · Cited by 20

The Cell Type-Specific Signal Proteins (Pheromones) of Protozoan Ciliates

Luporini, P., Vallesi, A., Alimenti, C., & Ortenzi, C. (2006) · Current Pharmaceutical Design · doi:10.2174/138161206777947452 · Cited by 20

Evolutionary Conservation of the Ribosomal Biogenesis Factor Rbm19/Mrd1: Implications for Function

Kallberg, Y., Segerstolpe, Å., Lackmann, F., Persson, B., & Wieslander, L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0043786 · Cited by 14

Evolution of sodium channels and the new view of early nervous system evolution

Liebeskind, B. J. (2011) · Communicative & Integrative Biology · doi:10.4161/cib.17069 · Cited by 12

Evidence for Convergent Evolution in the Signaling Properties of a Choanoflagellate Tyrosine Kinase

Li, W., Scarlata, S., & Miller, W. T. (2009) · Biochemistry · doi:10.1021/bi9000672 · Cited by 12

PTB Domain-Directed Substrate Targeting in a Tyrosine Kinase from the Unicellular Choanoflagellate Monosiga brevicollis

Prieto-Echagüe, V., Chan, P. M., Craddock, B. P., Manser, E. J., & Miller, W. T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019296 · Cited by 10

Functional transition of Pak proto-oncogene during early evolution of metazoans

Watari, A., Iwabe, N., Masuda, H., & Okada, M. (2010) · Oncogene · doi:10.1038/onc.2010.148 · Cited by 9

Arginine kinase isoforms in the closest protozoan relative of metazoans

Hoffman, G. G., & Ellington, W. R. (2011) · Comparative Biochemistry and Physiology Part D Genomics and Proteomics · doi:10.1016/j.cbd.2011.02.004 · Cited by 7

Metazoan-like signaling in a unicellular receptor tyrosine kinase

Schultheiss, K. P., Craddock, B. P., Tong, M., Seeliger, M. A., & Miller, W. T. (2013) · BMC Biochemistry · doi:10.1186/1471-2091-14-4 · Cited by 6

I.—A description of two new Calcispongiæ, to which is added confirmation of Prof. James-Clark's discovery of the true form of the sponge-cell (animal), and an account of the polype-like pore-area of Cliona corallinoides contrasted with Prof. E. Häckel's view on the relationship of the sponges to the corals

Carter, H. J. (1871) · Annals and Magazine of Natural History · doi:10.1080/00222937108696422 · Cited by 6

XXVII.—On the Calcispongiæ, their position in the animal kingdom, and their relation to the theory of descendence

Häckel, E. (1873) · Annals and Magazine of Natural History · doi:10.1080/00222937308696810 · Cited by 5

Nature of Cancer Explored from the Perspective of the Functional Evolution of Proto-oncogenes

Watari, A. (2012) · YAKUGAKU ZASSHI · doi:10.1248/yakushi.12-00204 · Cited by 3

The Origin of Animal Multicellularity and Cell Differentiation

(2017) · doi:10.1016/j.devcel.2017.09.016 · Cited by 419

A Structural Perspective on the Regulation of the Epidermal Growth Factor Receptor

Kovács, E., Zorn, J. A., Huang, Y., Barros, T. F., & Kuriyan, J. (2015) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060614-034402 · Cited by 371

The origin of Metazoa: a unicellular perspective

Sebé-Pedrós, A., Degnan, B. M., & Ruiz-Trillo, I. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.21 · Cited by 332

Gene family innovation, conservation and loss on the animal stem lineage

(2018) · doi:10.7554/elife.34226 · Cited by 226

The triple helix of collagens – an ancient protein structure that enabled animal multicellularity and tissue evolution

Fidler, A. L., Boudko, S. P., Rokas, A., & Hudson, B. G. (2018) · Journal of Cell Science · doi:10.1242/jcs.203950 · Cited by 238

A Comparative Genomics Perspective on the Origin of Multicellularity and Early Animal Evolution

Srivastava, M. (2015) · Advances in marine genomics · doi:10.1007/978-94-017-9642-2_14 · Cited by 10

The origin of Metazoa: a unicellular perspective

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Genomic, phylogenetic, and cell biological insights into metazoan origins

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The Protistan Cellular and Genomic Roots of Animal Multicellularity

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Dynamics of genomic innovation in the unicellular ancestry of animals

Grau‐Bové, X., Torruella, G., Donachie, S. P., Suga, H., Leonard, G., Richards, T. A., & Ruiz‐Trillo, I. (2017) · eLife · doi:10.7554/elife.26036 · Cited by 171