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The Genomic and Cellular Foundations of Animal Origins
Abstract
The first animals arose more than six hundred million years ago, yet they left little impression in the fossil record. Nonetheless, the cell biology and genome composition of the first animal, the Urmetazoan, can be reconstructed through the study of phylogenetically relevant living organisms. Comparisons among animals and their unicellular and colonial relatives reveal that the Urmetazoan likely possessed a layer of epithelium-like collar cells, preyed on bacteria, reproduced by sperm and egg, and developed through cell division, cell differentiation, and invagination. Although many genes involved in development, body patterning, immunity, and cell-type specification evolved in the animal stem lineage or after animal origins, several gene families critical for cell adhesion, signaling, and gene regulation predate the origin of animals. The ancestral functions of these and other genes may eventually be revealed through studies of gene and genome function in early-branching animals and their closest non-animal relatives.
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“While sequencing projects have produced an abundance of information about the genomic foundations of animal evolution 32 , emerging genetic tools of the kind described herein now permit functional interrogation of the ancestral molecular toolkit employed in the diversification of early animal body plans.”
From TALEN and CRISPR/Cas9-mediated genome editing in the early-branching metazoan Nematostella vectensis (2014) · cites this paper as [32]
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Metadata
- Authors
- Richter, D. J., & King, N.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Annual Review of Genetics
- Publisher
- Annual Reviews
- Published
- 2013-11-23
- Volume
- 47
- Issue
- 1
- Pages
- 509-537
- ISSN
- 0066-4197 (ISSN-L)
- 1545-2948
- OpenAlex
- W2160011794
- Semantic Scholar
- 8a5bdc2bd381b3ef4062f08647a6c2f2c8906886
- Cited by
- 196
- References
- 196
- Citations by year
- 2026: 5 · 2025: 7 · 2024: 6 · 2023: 13 · 2022: 15 · 2021: 23 · 2020: 12 · 2019: 15 · 2018: 22 · 2017: 25 · 2016: 22 · 2015: 15 · 2014: 16
- FWCI
- 2.05
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institute of General Medical Sciences (R01GM099533, R01GM089977)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Marine Invertebrate Physiology and Ecology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Agricultural and Biological Sciences › Ecology, Evolution, Behavior and Systematics › Protist diversity and phylogeny
- Keywords
- origin of animals, cell adhesion genes, signaling genes, gene expression regulation, cell differentiation, invagination, gene family evolution, body patterning, immunity genes
- MeSH terms
- Animals, Cell Adhesion, Cnidaria, Biological Evolution, Fossils, Genes, Phylogeny, Porifera, Protein-Tyrosine Kinases, Structure-Activity Relationship, Cell Adhesion Molecules, Genome, Protein Structure, Tertiary, Ctenophora, Eukaryota, Choanoflagellata, Gene-Environment Interaction
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