Germinal Centers

CD45 links the B cell receptor with cell survival and is required for the persistence of germinal centers

Huntington, N. D., Xu, Y., Puthalakath, H., Light, A., Willis, S. N., Strasser, A., & Tarlinton, D. M. (2005) · Nature Immunology · doi:10.1038/ni1292 · Cited by 85

Germinal centers in human lymph nodes contain reactivated memory B cells

Bende, R. J., van Maldegem, F., Triesscheijn, M., Wormhoudt, T. A. M., Guijt, R., & van Noesel, C. J. M. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20071006 · Cited by 81

In vivo imaging studies shed light on germinal-centre development

Hauser, A. E., Shlomchik, M. J., & Haberman, A. M. (2007) · Nature reviews. Immunology · doi:10.1038/nri2120 · Cited by 79

Single-round of antigen receptor signaling programs naïve B cells to receive T cell help

Damdinsuren, B., Zhang, Y.-Q., Khalil, A., Wood, W., Becker, K., Shlomchik, M., & Sen, R. (2010) · Immunity · doi:10.1016/j.immuni.2010.02.013 · Cited by 73

Differential expression of GL7 activation antigen on bone marrow B cell subpopulations and peripheral B cells

Cervenak, L., Magyar, A., Fajka‐Boja, R., & László, G. (2001) · Immunology Letters · doi:10.1016/s0165-2478(01)00239-5 · Cited by 70

Isolation and characteristics of tonsil centroblasts with reference to Ig class switching

Feuillard, J., Taylor, D. R., Casamayor‐Palleja, M., Johnson, G. D., & MacLennan, I. C. M. (1995) · International Immunology · doi:10.1093/intimm/7.1.121 · Cited by 70

T regulatory cells participate in the control of germinal centre reactions

Alexander, C., Tygrett, L. T., Boyden, A. W., Wolniak, K. L., Legge, K. L., & Waldschmidt, T. J. (2011) · Immunology · doi:10.1111/j.1365-2567.2011.03456.x · Cited by 69

Antiviral Protection and Germinal Center Formation, But Impaired B Cell Memory in the Absence of CD19

Fehr, T. H., Rickert, R. C., Odermatt, B. F., Roes, J., Rajewsky, K., Hengartner, H., & Zinkernagel, R. M. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.188.1.145 · Cited by 69

B cells within germinal centers migrate preferentially from dark to light zone

Beltman, J. B., Allen, C. D. C., Cyster, J. G., & de Boer, R. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1101554108 · Cited by 52

The Role Of Somatic Mutation Of Immunoglobulin Genes In Autoimmunity

Davidson, A., Shefner, R., Livneh, A., & Diamond, B. (1987) · Annual Review of Immunology · doi:10.1146/annurev.iy.05.040187.000505 · Cited by 51

Changes in CD44 Expression during B Cell Differentiation in the Human Tonsil

Kremmidiotis, G., & Zola, H. (1995) · Cellular Immunology · doi:10.1006/cimm.1995.1021 · Cited by 50

ANTIHAPTEN ANTIBODY SPECIFICITY AND L CHAIN TYPE

Nussenzweig, V., & Benacerraf, B. (1967) · The Journal of Experimental Medicine · doi:10.1084/jem.126.4.727 · Cited by 50

Dominant, Hierarchical Induction of Peripheral Tolerance during Foreign Antigen-Driven B Cell Development

Notidis, E., Heltemes-Harris, L. M., & Manser, T. (2002) · Immunity · doi:10.1016/s1074-7613(02)00392-8 · Cited by 49

Constitutive CD40L Expression on B Cells Prematurely Terminates Germinal Center Response and Leads to Augmented Plasma Cell Production in T Cell Areas

Bolduc, A., Long, E., Stapler, D., Cascalho, M., Tsubata, T., Koni, P. A., & Shimoda, M. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0901689 · Cited by 46

Subpopulations of B lymphocytes in germinal centers.

Fyfe, G., Cebra‐Thomas, J. A., Mustain, E., Davie, J. M., Alley, C. D., & Nahm, M. H. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.139.7.2187 · Cited by 44

Visualizing the effects of antigen affinity on T‐dependent B‐cell differentiation

Brink, R. A., Phan, T. G., Paus, D., & Chan, T. D. (2007) · Immunology and Cell Biology · doi:10.1038/sj.icb.7100143 · Cited by 44

H2-O, a MHC class II-like protein, sets a threshold for B-cell entry into germinal centers

Draghi, N. A., & Denzin, L. K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1004664107 · Cited by 41

Prevention of Autoimmunity and Control of Recall Response to Exogenous Antigen by Fas Death Receptor Ligand Expression on T Cells

Mabrouk, I., Buart, S., Hasmim, M., Michiels, C., Connault, E., Opolon, P., Chiocchia, G., Lévi‐Strauss, M., Chouaı̈b, S., & Karray, S. (2008) · Immunity · doi:10.1016/j.immuni.2008.10.007 · Cited by 39

Germinal center structure and function: Lessons from CD19

Carter, R. H., & Myers, R. C. (2008) · Seminars in Immunology · doi:10.1016/j.smim.2007.12.007 · Cited by 38

The Human CD77− B Cell Population Represents a Heterogeneous Subset of Cells Comprising Centroblasts, Centrocytes, and Plasmablasts, Prompting Phenotypical Revision

Högerkorp, C., & Borrebaeck, C. A. K. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.7.4341 · Cited by 37

Augmented Antibody Response with Premature Germinal Center Regression in CD40L Transgenic Mice

Kishi, Y., Aiba, Y., Higuchi, T., Furukawa, K., Tokuhisa, T., Takemori, T., & Tsubata, T. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0901694 · Cited by 36

The role of integrins and coreceptors in refining thresholds for B‐cell responses

Batista, F. D., Arana, E., Barral, P., Carrasco, Y. R., Depoil, D., Eckl‐Dorna, J., Fleire, S. J., Howe, K., Vehlow, A., Weber, M., et al. (2007) · Immunological Reviews · doi:10.1111/j.1600-065x.2007.00540.x · Cited by 36

Follicular Dendritic Cells: Antigen Retention, B Cell Activation, and Cytokine Production

Kosco‐Vilbois, M. H., & Scheidegger, D. (1995) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-79603-6_4 · Cited by 33

On the Origin of Tingible Bodies in Germinal Centers

Fliedner, T. M. (1967) · Springer eBooks · doi:10.1007/978-3-642-86837-5_27 · Cited by 27

Establishment of Lymphotoxin β Receptor Signaling-Dependent Cell Lines with Follicular Dendritic Cell Phenotypes from Mouse Lymph Nodes

Nishikawa, Y., Hikida, M., Magari, M., Kanayama, N., Mori, M., Kitamura, H., Kurosaki, T., & Ohmori, H. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.8.5204 · Cited by 27

Immunologic memory to phosphocholine keyhole limpet hemocyanin. Recurrent mutations in the lambda 1 light chain increase affinity for antigen

Brown, M. A., Stenzel‐Poore, M. P., Stevens, S. L., Kondoleon, S. K., Ng, J., Bächinger, H. P., & Rittenberg, M. B. (1992) · The Journal of Immunology · doi:10.4049/jimmunol.148.2.339 · Cited by 24

A limited number of genes are involved in the differentiation of germinal center B cells

Nakayama, Y., Stabach, P. R., Maher, S. E., Mahajan, M. C., Masiar, P., Liao, C. L., Zhang, X., Ye, Z., Tuck, D. P., Bothwell, A. L. M., et al. (2006) · Journal of Cellular Biochemistry · doi:10.1002/jcb.20952 · Cited by 23

Shining a Light on Germinal Center B Cells

Cyster, J. G. (2010) · Cell · doi:10.1016/j.cell.2010.10.036 · Cited by 22

Antibody Diversification and Selection in the Mature B-cell CompartmentPreprint

NEUBERGER, M. S., LANOUE, A., EHRENSTEIN, M. R., Batista, F., Sale, J., & WILLIAMS, G. T. (1999) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.1999.64.211 · Cited by 14

Aborted Germinal Center Reactions and B Cell Memory by Follicular T Cells Specific for a B Cell Receptor V Region Peptide

Heiser, R. A., Snyder, C. M., Clair, J. S., & Wysocki, L. J. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002328 · Cited by 12

Mitochondrial hyperpolarization and ATP depletion in patients with systemic lupus erythematosus

Gergely, P., Grossman, C., Niland, B., Puskas, F., Neupane, H., Allam, F., Banki, K., Phillips, P. E., & Perl, A. (2002) · Arthritis & Rheumatism · doi:10.1002/1529-0131(200201)46:1 · Cited by 5

The discovery of T cell help for B cell antibody formation: A perspective from the 30th anniversary of this discovery

Janeway, C. A. (1999) · Immunology and Cell Biology · doi:10.1046/j.1440-1711.1999.00814.x · Cited by 4

Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity

Griffith, J. W., Sokol, C. L., & Luster, A. D. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120145 · Cited by 2,119

T follicular helper cell differentiation, function, and roles in disease

Crotty, S. (2014) · Immunity · doi:10.1016/j.immuni.2014.10.004 · Cited by 1,847

Evolution of antibody immunity to SARS-CoV-2

Gaebler, C., Wang, Z., Lorenzi, J. C. C., Muecksch, F., Finkin, S., Tokuyama, M., Cho, A., Jankovic, M., Schaefer-Babajew, D., Oliveira, T. Y., et al. (2021) · Nature · doi:10.1038/s41586-021-03207-w · Cited by 1,674

T follicular helper cell biology: a decade of discovery and diseases

Crotty, S. (2019) · Immunity · doi:10.1016/j.immuni.2019.04.011 · Cited by 1,591

The generation of antibody-secreting plasma cells

Nutt, S. L., Hodgkin, P. D., Tarlinton, D. M., & Corcoran, L. M. (2015) · Nature reviews. Immunology · doi:10.1038/nri3795 · Cited by 1,565

Clonal and cellular dynamics in germinal centers

Victora, G. D., & Mesin, L. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.02.010 · Cited by 89

Germinal Center Biology

Sprumont, A., & Bannard, O. (2025) · Elsevier eBooks · doi:10.1016/b978-0-12-824465-4.00232-5

Selection Dynamics in the Germinal Center During Antibody Affinity Maturation

Gitlin, A. D. (2025) · Digital Commons - RU (Rockefeller University) · doi:10.48496/w8c5-tx93

Germinal Center B Cell Dynamics

Mesin, L., Ersching, J., & Victora, G. D. (2016) · Immunity · doi:10.1016/j.immuni.2016.09.001 · Cited by 1,028

Dynamics of B cells in germinal centres

De Silva, N. S., & Klein, U. (2015) · Nature Reviews Immunology · doi:10.1038/nri3804 · Cited by 1,084