Germinal Centers

Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme

Muramatsu, M., Kinoshita, K., Fagarasan, S., Yamada, S., Shinkai, Y., & Honjo, T. (2000) · Cell · doi:10.1016/s0092-8674(00)00078-7 · Cited by 3,475

Follicular Helper CD4 T Cells (T FH )

Crotty, S. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101400 · Cited by 2,738

Social controls on cell survival and cell death

RAFF, M. C. (1992) · Nature · doi:10.1038/356397a0 · Cited by 2,591

Predominant Autoantibody Production by Early Human B Cell Precursors

Wardemann, H., Yurasov, S., Schaefer, A., Young, J. W., Meffre, E., & Nussenzweig, M. C. (2003) · Science · doi:10.1126/science.1086907 · Cited by 2,088

Autoimmune Dilated Cardiomyopathy in PD-1 Receptor-Deficient Mice

Nishimura, H., Okazaki, T., Tanaka, Y., Nakatani, K., Hara, M., Matsumori, A., Sasayama, S., Mizoguchi, A., Hiai, H., Minato, N., et al. (2001) · Science · doi:10.1126/science.291.5502.319 · Cited by 1,868

Germinal Centers

MacLennan, I. C. M. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.001001 · Cited by 1,795

Clonal selection and learning in the antibody system

Rajewsky, K. (1996) · Nature · doi:10.1038/381751a0 · Cited by 1,701

IgG Fc Receptors

Ravetch, J. V., & Bolland, S. M. (2001) · Annual Review of Immunology · doi:10.1146/annurev.immunol.19.1.275 · Cited by 1,686

Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation

Johnston, R. J., Poholek, A. C., DiToro, D., Yusuf, I., Eto, D., Barnett, B., Dent, A. L., Craft, J., & Crotty, S. (2009) · Science · doi:10.1126/science.1175870 · Cited by 1,626

Bcl6 mediates the development of T follicular helper cells

Nurieva, R. I., Chung, Y., Martinez, G. J., Yang, X. O., Tanaka, S., Matskevitch, T. D., Wang, Y.-H., & Dong, C. (2009) · Science · doi:10.1126/science.1176676 · Cited by 1,506

Chemokines and Chemokine Receptors: Positioning Cells for Host Defense and Immunity

Griffith, J. W., Sokol, C. L., & Luster, A. D. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120145 · Cited by 2,119

T follicular helper cell differentiation, function, and roles in disease

Crotty, S. (2014) · Immunity · doi:10.1016/j.immuni.2014.10.004 · Cited by 1,847

Evolution of antibody immunity to SARS-CoV-2

Gaebler, C., Wang, Z., Lorenzi, J. C. C., Muecksch, F., Finkin, S., Tokuyama, M., Cho, A., Jankovic, M., Schaefer-Babajew, D., Oliveira, T. Y., et al. (2021) · Nature · doi:10.1038/s41586-021-03207-w · Cited by 1,674

T follicular helper cell biology: a decade of discovery and diseases

Crotty, S. (2019) · Immunity · doi:10.1016/j.immuni.2019.04.011 · Cited by 1,591

The generation of antibody-secreting plasma cells

Nutt, S. L., Hodgkin, P. D., Tarlinton, D. M., & Corcoran, L. M. (2015) · Nature reviews. Immunology · doi:10.1038/nri3795 · Cited by 1,565

Dynamics of B cells in germinal centres

De Silva, N. S., & Klein, U. (2015) · Nature Reviews Immunology · doi:10.1038/nri3804 · Cited by 1,084

Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)

Cossarizza, A., Chang, H., Radbruch, A., Acs, A., Adam, D., Adam‐Klages, S., Agace, W. W., Aghaeepour, N., Akdiş, M., Allez, M., et al. (2019) · European Journal of Immunology · doi:10.1002/eji.201970107 · Cited by 1,007

Germinal Center B Cell Dynamics

Mesin, L., Ersching, J., & Victora, G. D. (2016) · Immunity · doi:10.1016/j.immuni.2016.09.001 · Cited by 1,028

B Cell Responses: Cell Interaction Dynamics and Decisions

Cyster, J. G., & Allen, C. D. C. (2019) · Cell · doi:10.1016/j.cell.2019.03.016 · Cited by 1,025

The Phagocytic Function of Macrophage-Enforcing Innate Immunity and Tissue Homeostasis

Hirayama, D., Iida, T., & Nakase, H. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms19010092 · Cited by 927

Human Circulating PD-1+CXCR3−CXCR5+ Memory Tfh Cells Are Highly Functional and Correlate with Broadly Neutralizing HIV Antibody Responses

Locci, M., Havenar‐Daughton, C., Landais, E., Wu, J. E., Kroenke, M. A., Arlehamn, C. S. L., Su, L. F., Cubas, R. A., Davis, M. M., Sette, A., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.031 · Cited by 885

Germinal Centers

Victora, G. D., & Nussenzweig, M. C. (2022) · Annual Review of Immunology · doi:10.1146/annurev-immunol-120419-022408 · Cited by 893

Lipid nanoparticles enhance the efficacy of mRNA and protein subunit vaccines by inducing robust T follicular helper cell and humoral responses

Alameh, M.-G., Tombácz, I., Bettini, E., Lederer, K., Ndeupen, S., Sittplangkoon, C., Wilmore, J. R., Gaudette, B. T., Soliman, O. Y., Pine, M., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.11.001 · Cited by 775

Loss of Bcl-6-Expressing T Follicular Helper Cells and Germinal Centers in COVID-19

Kaneko, N., Kuo, H.-H., Boucau, J., Farmer, J. R., Allard-Chamard, H., Mahajan, V. S., Piechocka-Trocha, A., Lefteri, K., Osborn, M., Bals, J., et al. (2020) · Cell · doi:10.1016/j.cell.2020.08.025 · Cited by 734

Naturally enhanced neutralizing breadth against SARS-CoV-2 one year after infection

Wang, Z., Muecksch, F., Schaefer-Babajew, D., Finkin, S., Viant, C., Gaebler, C., Hoffmann, H. H., Barnes, C. O., Cipolla, M., Ramos, V., et al. (2021) · Nature · doi:10.1038/s41586-021-03696-9 · Cited by 721

The promise and challenge of high-throughput sequencing of the antibody repertoire

Georgiou, G., Ippolito, G. C., Beausang, J., Busse, C. E., Wardemann, H., & Quake, S. R. (2014) · Nature Biotechnology · doi:10.1038/nbt.2782 · Cited by 652

Induction of ICOS + CXCR3 + CXCR5 + T H Cells Correlates with Antibody Responses to Influenza Vaccination

Bentebibel, S.-E., Lopez, S. M. C., Obermoser, G., Schmitt, N., Mueller, C., Harrod, C., Flaño, E., Mejías, A., Albrecht, R. A., Blankenship, D., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3005191 · Cited by 607

Clonal selection in the germinal centre by regulated proliferation and hypermutation

Gitlin, A. D., Shulman, Z., & Nussenzweig, M. C. (2014) · Nature · doi:10.1038/nature13300 · Cited by 577

The tumour microenvironment in B cell lymphomas

Scott, D. W., & Gascoyne, R. D. (2014) · Nature reviews. Cancer · doi:10.1038/nrc3774 · Cited by 582

A brief history of T cell help to B cells

Crotty, S. (2015) · Nature reviews. Immunology · doi:10.1038/nri3803 · Cited by 584

In Vivo CD4 + T Cell Differentiation and Function: Revisiting the Th1/Th2 Paradigm

Ruterbusch, M., Pruner, K. B., Shehata, L., & Pepper, M. (2020) · Annual Review of Immunology · doi:10.1146/annurev-immunol-103019-085803 · Cited by 550

PI3K signalling in inflammation

Hawkins, P. T., & Stephens, L. R. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.12.006 · Cited by 541

Injectable, spontaneously assembling, inorganic scaffolds modulate immune cells in vivo and increase vaccine efficacy

Kim, J., Li, A. W., Choi, Y., Lewin, S. A., Verbeke, C. S., Dranoff, G., & Mooney, D. J. (2014) · Nature Biotechnology · doi:10.1038/nbt.3071 · Cited by 546

Nucleoside-modified mRNA vaccines induce potent T follicular helper and germinal center B cell responses

Pardi, N., Hogan, M. J., Naradikian, M. S., Parkhouse, K., Cain, D. W., Jones, L., Moody, M. A., Verkerke, H. P., Myles, A., Willis, E., et al. (2018) · Journal of Experimental Medicine · doi:10.1084/jem.20171450 · Cited by 530

The good, the bad and the ugly — TFH cells in human health and disease

Tangye, S. G., Ma, C. S., Brink, R. A., & Deenick, E. K. (2013) · Nature reviews. Immunology · doi:10.1038/nri3447 · Cited by 548

A Temporal Switch in the Germinal Center Determines Differential Output of Memory B and Plasma Cells

Weisel, F. J., Zuccarino-Catania, G. V., Chikina, M., & Shlomchik, M. J. (2016) · Immunity · doi:10.1016/j.immuni.2015.12.004 · Cited by 524

Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization

Klein, F., Diskin, R., Scheid, J. F., Gaebler, C., Mouquet, H., Georgiev, I. S., Pancera, M., Zhou, T., Incesu, R., Fu, B. Z., et al. (2013) · Cell · doi:10.1016/j.cell.2013.03.018 · Cited by 538

Germinal centres and B cell lymphomagenesis

Basso, K., & Dalla-Favera, R. (2015) · Nature Reviews Immunology · doi:10.1038/nri3814 · Cited by 510

B Cells, Antibodies, and More

Hoffman, W., Lakkis, F. G., & Chalasani, G. (2015) · Clinical Journal of the American Society of Nephrology · doi:10.2215/cjn.09430915 · Cited by 543

IgA and the intestinal microbiota: the importance of being specific

Pabst, O., & Slack, E. M. C. (2019) · Mucosal Immunology · doi:10.1038/s41385-019-0227-4 · Cited by 490

CD4+ T cells in cancer

Speiser, D. E., Chijioke, O., Schaeuble, K., & Münz, C. (2023) · Nature Cancer · doi:10.1038/s43018-023-00521-2 · Cited by 514

The proto-oncogene MYC is required for selection in the germinal center and cyclic reentry

Dominguez-Sola, D., Victora, G. D., Ying, C. Y., Phan, R. T., Saito, M., Nussenzweig, M. C., & Dalla‐Favera, R. (2012) · Nature Immunology · doi:10.1038/ni.2428 · Cited by 485

Persistent Antigen and Germinal Center B Cells Sustain T Follicular Helper Cell Responses and Phenotype

Baumjohann, D., Preite, S., Reboldi, A., Ronchi, F., Ansel, K. M., Lanzavecchia, A., & Sallusto, F. (2013) · Immunity · doi:10.1016/j.immuni.2012.11.020 · Cited by 502

Mechanisms of Programmed DNA Lesions and Genomic Instability in the Immune System

Alt, F. W., Zhang, Y., Meng, F., Guo, C., & Schwer, B. (2013) · Cell · doi:10.1016/j.cell.2013.01.007 · Cited by 477

Enhanced SARS-CoV-2 neutralization by dimeric IgA

Wang, Z., Lorenzi, J. C. C., Muecksch, F., Finkin, S., Viant, C., Gaebler, C., Cipolla, M., Hoffmann, H.-H., Oliveira, T. Y., Oren, D. A., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abf1555 · Cited by 475

Visualizing antibody affinity maturation in germinal centers

Tas, J. M. J., Mesin, L., Pasqual, G., Targ, S., Jacobsen, J. T., Mano, Y. M., Chen, C. S., Weill, J., Reynaud, C., Browne, E. P., et al. (2016) · Science · doi:10.1126/science.aad3439 · Cited by 464

Antibodies in HIV-1 Vaccine Development and Therapy

Klein, F., Mouquet, H., Dosenovic, P., Scheid, J. F., Scharf, L., & Nussenzweig, M. C. (2013) · Science · doi:10.1126/science.1241144 · Cited by 452

Efficient evolution of human antibodies from general protein language models

Hie, B., Shanker, V. R., Xu, D., Bruun, T. U. J., Weidenbacher, P. A. B., Tang, S., Wu, W. C. H., Pak, J. E., & Kim, P. S. (2023) · Nature Biotechnology · doi:10.1038/s41587-023-01763-2 · Cited by 472

Pathophysiology of T follicular helper cells in humans and mice

Ueno, H., Banchereau, J., & Vinuesa, C. G. (2015) · Nature Immunology · doi:10.1038/ni.3054 · Cited by 455

Mechanical forces in the immune system

Huse, M. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.74 · Cited by 452

Targeting B cell receptor signalling in cancer: preclinical and clinical advances

Burger, J. A., & Wiestner, A. (2018) · Nature Reviews Cancer · doi:10.1038/nrc.2017.121 · Cited by 431

T–B-cell entanglement and ICOSL-driven feed-forward regulation of germinal centre reaction

Liu, D., Xu, H., Shih, C., Wan, Z., Ma, X., Ma, W., Luo, D., & Qi, H. (2014) · Nature · doi:10.1038/nature13803 · Cited by 444

Alarmins and immunity

Yang, D., Han, Z., & Oppenheim, J. J. (2017) · Immunological Reviews · doi:10.1111/imr.12577 · Cited by 424

Phenotype and functions of memory Tfh cells in human blood

Schmitt, N., Bentebibel, S.-E., & Ueno, H. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.06.002 · Cited by 423

Identification of human germinal center light and dark zone cells and their relationship to human B-cell lymphomas

Victora, G. D., Dominguez-Sola, D., Holmes, A. B., Deroubaix, S., Dalla‐Favera, R., & Nussenzweig, M. C. (2012) · Blood · doi:10.1182/blood-2012-03-415380 · Cited by 436

Regulated selection of germinal-center cells into the memory B cell compartment

Shinnakasu, R., Inoue, T., Kometani, K., Moriyama, S., Adachi, Y., Nakayama, M., Takahashi, Y., Fukuyama, H., Okada, T., & Kurosaki, T. (2016) · Nature Immunology · doi:10.1038/ni.3460 · Cited by 425

Targeting pathological B cell receptor signalling in lymphoid malignancies

Young, R. M., & Staudt, L. M. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd3937 · Cited by 421

Follicular T-helper cell recruitment governed by bystander B cells and ICOS-driven motility

Xu, H., Li, X., Liu, D., Li, J., Zhang, X., Chen, X., Hou, S., Peng, L., Xu, C., Liu, W., et al. (2013) · Nature · doi:10.1038/nature12058 · Cited by 408

Dynamic signaling by T follicular helper cells during germinal center B cell selection

Shulman, Z., Gitlin, A. D., Weinstein, J. S., Lainez, B., Esplugues, E., Flavell, R. A., Craft, J. E., & Nussenzweig, M. C. (2014) · Science · doi:10.1126/science.1257861 · Cited by 406

IgA Responses to Microbiota

Bunker, J. J., & Bendelac, A. S. (2018) · Immunity · doi:10.1016/j.immuni.2018.08.011 · Cited by 402

Selenium–GPX4 axis protects follicular helper T cells from ferroptosis

Yao, Y., Chen, Z., Zhang, H., Chen, C., Zeng, M., Yunis, J., Wei, Y., Wan, Y., Wang, N., Zhou, M., et al. (2021) · Nature Immunology · doi:10.1038/s41590-021-00996-0 · Cited by 387

The cytokine TGF-β co-opts signaling via STAT3-STAT4 to promote the differentiation of human TFH cells

Schmitt, N., Liu, Y., Bentebibel, S.-E., Munagala, I. D., Bourdery, L., Venuprasad, K., Banchereau, J., & Ueno, H. (2014) · Nature Immunology · doi:10.1038/ni.2947 · Cited by 382

T Follicular Helper Cell Dynamics in Germinal Centers

Shulman, Z., Gitlin, A. D., Targ, S., Janković, M., Pasqual, G., Nussenzweig, M. C., & Victora, G. D. (2013) · Science · doi:10.1126/science.1241680 · Cited by 363

Amino acid metabolism in immune cells: essential regulators of the effector functions, and promising opportunities to enhance cancer immunotherapy

Yang, L., Chu, Z., Liu, M., Zou, Q., Li, J., Liu, Q., Wang, Y., Wang, T., Xiang, J., & Wang, B. (2023) · Journal of Hematology & Oncology · doi:10.1186/s13045-023-01453-1 · Cited by 383

Germinal centre-driven maturation of B cell response to mRNA vaccination

Kim, W., Zhou, J. Q., Horvath, S. C., Schmitz, A. J., Sturtz, A. J., Lei, T., Liu, Z., Kalaidina, E., Thapa, M., Alsoussi, W. B., et al. (2022) · Nature · doi:10.1038/s41586-022-04527-1 · Cited by 362

CXCL13 is a plasma biomarker of germinal center activity

Havenar‐Daughton, C., Lindqvist, M., Heit, A., Wu, J. E., Reiss, S. M., Kendric, K. J., Bélanger, S., Kasturi, S. P., Landais, E., Akondy, R. S., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1520112113 · Cited by 343

PI3Kδ and primary immunodeficiencies

Lucas, C. L., Chandra, A., Nejentsev, S., Condliffe, A. M., & Okkenhaug, K. (2016) · Nature Reviews Immunology · doi:10.1038/nri.2016.93 · Cited by 342

Modeling human adaptive immune responses with tonsil organoids

Wagar, L. E., Salahudeen, A. A., Constantz, C. M., Wendel, B. S., Lyons, M. M., Mallajosyula, V. V. A., Jatt, L. P., Adamska, J. Z., Blum, L. K., Gupta, N., et al. (2021) · Nature Medicine · doi:10.1038/s41591-020-01145-0 · Cited by 334

EBV Persistence—Introducing the Virus

Thorley‐Lawson, D. A. (2015) · Current topics in microbiology and immunology · doi:10.1007/978-3-319-22822-8_8 · Cited by 333

Intestinal IgA production and its role in host-microbe interaction

Gutzeit, C., Magri, G., & Cerutti, A. (2014) · Immunological Reviews · doi:10.1111/imr.12189 · Cited by 332

LEF-1 and TCF-1 orchestrate TFH differentiation by regulating differentiation circuits upstream of the transcriptional repressor Bcl6

Choi, Y. S., Gullicksrud, J. A., Xing, S., Zeng, Z., Shan, Q., Li, F., Love, P. E., Peng, W., Xue, H., & Crotty, S. (2015) · Nature Immunology · doi:10.1038/ni.3226 · Cited by 337

T follicular regulatory cells

Sage, P. T., & Sharpe, A. H. (2016) · Immunological Reviews · doi:10.1111/imr.12411 · Cited by 327

T Follicular Helper Cell-Germinal Center B Cell Interaction Strength Regulates Entry into Plasma Cell or Recycling Germinal Center Cell Fate

Ise, W., Fujii, K., Shiroguchi, K., Ito, A., Kometani, K., Takeda, K., Kawakami, E., Yamashita, K., Suzuki, K., Okada, T., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.03.027 · Cited by 337

Metabolic regulation of inflammation

Gaber, T., Strehl, C., & Buttgereit, F. (2017) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2017.37 · Cited by 320

Structural Insights on the Role of Antibodies in HIV-1 Vaccine and Therapy

West, A. P., Scharf, L., Scheid, J. F., Klein, F., Björkman, P. J., & Nussenzweig, M. C. (2014) · Cell · doi:10.1016/j.cell.2014.01.052 · Cited by 324

T follicular regulatory cells in the regulation of B cell responses

Sage, P. T., & Sharpe, A. H. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.05.005 · Cited by 318

Peyer's patches: organizing B‐cell responses at the intestinal frontier

Reboldi, A., & Cyster, J. G. (2016) · Immunological Reviews · doi:10.1111/imr.12400 · Cited by 327

Sequential Immunization Elicits Broadly Neutralizing Anti-HIV-1 Antibodies in Ig Knockin Mice

Escolano, A., Steichen, J. M., Dosenovic, P., Kulp, D. W., Golijanin, J., Sok, D., Freund, N. T., Gitlin, A. D., Oliveira, T. Y., Araki, T., et al. (2016) · Cell · doi:10.1016/j.cell.2016.07.030 · Cited by 309

How B cells capture, process and present antigens: a crucial role for cell polarity

Yuseff, M.-I., Pierobon, P., Reversat, A., & Lennon‐Duménil, A. (2013) · Nature reviews. Immunology · doi:10.1038/nri3469 · Cited by 327

Germinal centre hypoxia and regulation of antibody qualities by a hypoxia response system

Cho, S. H., Raybuck, A. L., Stengel, K. R., Wei, M., Beck, T. C., Volanakis, E. J., Thomas, J. W., Hiebert, S. W., Haase, V. H., & Boothby, M. R. (2016) · Nature · doi:10.1038/nature19334 · Cited by 326

Human germinal centres engage memory and naive B cells after influenza vaccination

Turner, J. S., Zhou, J. Q., Han, J., Schmitz, A. J., Rizk, A. A., Alsoussi, W. B., Lei, T., Amor, M., McIntire, K. M., Meade, P., et al. (2020) · Nature · doi:10.1038/s41586-020-2711-0 · Cited by 304

Germinal Center Selection and Affinity Maturation Require Dynamic Regulation of mTORC1 Kinase

Ersching, J., Efeyan, A., Mesin, L., Jacobsen, J. T., Pasqual, G., Grabiner, B. C., Dominguez-Sola, D., Sabatini, D. M., & Victora, G. D. (2017) · Immunity · doi:10.1016/j.immuni.2017.06.005 · Cited by 322

SARS-CoV-2 mRNA vaccination elicits a robust and persistent T follicular helper cell response in humans

Mudd, P. A., Minervina, A. A., Pogorelyy, M. V., Turner, J. S., Kim, W., Kalaidina, E., Petersen, J., Schmitz, A. J., Lei, T., Haile, A., et al. (2021) · Cell · doi:10.1016/j.cell.2021.12.026 · Cited by 306

Melanomacrophage Centers As a Histological Indicator of Immune Function in Fish and Other Poikilotherms

Steinel, N. C., & Bolnick, D. I. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00827 · Cited by 316

Elicitation of Robust Tier 2 Neutralizing Antibody Responses in Nonhuman Primates by HIV Envelope Trimer Immunization Using Optimized Approaches

Pauthner, M. G., Havenar‐Daughton, C., Sok, D., Nkolola, J. P., Bastidas, R. B., Boopathy, A. V., Carnathan, D. G., Chandrashekar, A., Cirelli, K. M., Cottrell, C. A., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.05.007 · Cited by 296

The production and regulation of IgE by the immune system

Wu, L. C., & Zarrin, A. A. (2014) · Nature reviews. Immunology · doi:10.1038/nri3632 · Cited by 295

Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses

Kanekiyo, M., Joyce, M. G., Gillespie, R. A., Gallagher, J. R., Andrews, S. F., Yassine, H. M., Wheatley, A. K., Fisher, B. E., Ambrozak, D. R., Creanga, A., et al. (2019) · Nature Immunology · doi:10.1038/s41590-018-0305-x · Cited by 297

Rapid development of broadly influenza neutralizing antibodies through redundant mutations

Pappas, L., Foglierini, M., Piccoli, L., Kallewaard, N. L., Turrini, F., Silacci, C., Fernandez-Rodriguez, B. M., Agatic, G., Giacchetto-Sasselli, I., Pellicciotta, G., et al. (2014) · Nature · doi:10.1038/nature13764 · Cited by 290

Differentiation of germinal center B cells into plasma cells is initiated by high-affinity antigen and completed by Tfh cells

Kräutler, N. J., Suan, D., Butt, D., Bourne, K., Hermes, J. R., Chan, T. D., Sundling, C., Kaplan, W. H., Schofield, P., Jackson, J., et al. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20161533 · Cited by 287

ICOS Co-Stimulation: Friend or Foe?

Wikenheiser, D. J., & Stumhofer, J. S. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00304 · Cited by 298

Remembrance of Things Past: Long-Term B Cell Memory After Infection and Vaccination

Palm, A.-K. E., & Henry, C. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01787 · Cited by 297

T follicular helper cells in space-time

Qi, H. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.94 · Cited by 281

TLR signaling in B-cell development and activation

Hua, Z., & Hou, B. (2012) · Cellular and Molecular Immunology · doi:10.1038/cmi.2012.61 · Cited by 267

Affinity maturation of SARS-CoV-2 neutralizing antibodies confers potency, breadth, and resilience to viral escape mutations

Muecksch, F., Weisblum, Y., Barnes, C. O., Schmidt, F., Schaefer-Babajew, D. J., Wang, Z., Lorenzi, J. C. C., Flyak, A. I., DeLaitsch, A. T., Huey‐Tubman, K. E., et al. (2021) · Immunity · doi:10.1016/j.immuni.2021.07.008 · Cited by 279

Germinal Center Centroblasts Transition to a Centrocyte Phenotype According to a Timed Program and Depend on the Dark Zone for Effective Selection

Bannard, O., Horton, R. M., Allen, C. D. C., An, J., Nagasawa, T., & Cyster, J. G. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.038 · Cited by 262

Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction

Yamano, T., Nedjic, J., Hinterberger, M., Steinert, M., Koser, S. D., Pinto, S., Gerdes, N., Lutgens, E., Ishimaru, N., Busslinger, M., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.05.013 · Cited by 260

Germinal center dysregulation by histone methyltransferase EZH2 promotes lymphomagenesis

Cagánová, M., Carrisi, C., Varano, G., Mainoldi, F., Zanardi, F., Germain, P., George, L. A., Alberghini, F., Ferrarini, L., Talukder, A. K., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci70626 · Cited by 271

Anti-SARS-CoV-2 receptor-binding domain antibody evolution after mRNA vaccination

Cho, A., Muecksch, F., Schaefer-Babajew, D. J., Wang, Z., Finkin, S., Gaebler, C., Ramos, V., Cipolla, M., Mendoza, P., Agudelo, M., et al. (2021) · Nature · doi:10.1038/s41586-021-04060-7 · Cited by 263

Regulation of immunity during visceral Leishmania infection

Rodrigues, V., Cordeiro‐da‐Silva, A., Laforge, M., Silvestre, R., & Estaquier, J. (2016) · Parasites & Vectors · doi:10.1186/s13071-016-1412-x · Cited by 253

Convergent Transcription at Intragenic Super-Enhancers Targets AID-Initiated Genomic Instability

Meng, F., Du, Z., Alexander Joel Federation, Hu, J., Wang, Q., Kieffer-Kwon, K.-R., Meyers, R. M., Amor, C., Wasserman, C. R., Neuberg, D. S., et al. (2014) · Cell · doi:10.1016/j.cell.2014.11.014 · Cited by 252

Follicular regulatory T cells control humoral and allergic immunity by restraining early B cell responses

Clement, R. L., Daccache, J., Mohammed, M. T., Diallo, A., Blazar, B. R., Kuchroo, V. K., Lovitch, S. B., Sharpe, A. H., & Sage, P. T. (2019) · Nature Immunology · doi:10.1038/s41590-019-0472-4 · Cited by 261

Low CD21 expression defines a population of recent germinal center graduates primed for plasma cell differentiation

Lau, D., Lan, L. Y.-L., Andrews, S. F., Henry, C., Rojas, K. T., Neu, K. E., Huang, M., Huang, Y., DeKosky, B. J., Palm, A.-K. E., et al. (2017) · Science Immunology · doi:10.1126/sciimmunol.aai8153 · Cited by 251

Human memory B cells

Seifert, M., & Küppers, R. (2016) · Leukemia · doi:10.1038/leu.2016.226 · Cited by 267

Whole-genome sequencing reveals activation-induced cytidine deaminase signatures during indolent chronic lymphocytic leukaemia evolution

Kasar, S. N., Kim, J., Improgo, R., Tiao, G., Polak, P. P., Haradhvala, N. J., Lawrence, M. S., Kieżun, A., Fernandes, S. M., Bahl, S., et al. (2015) · Nature Communications · doi:10.1038/ncomms9866 · Cited by 257

A Cytokine-Independent Approach To Identify Antigen-Specific Human Germinal Center T Follicular Helper Cells and Rare Antigen-Specific CD4+ T Cells in Blood

Dan, J. M., Arlehamn, C. S. L., Weiskopf, D., Antunes, R. D. S., Havenar‐Daughton, C., Reiss, S. M., Brigger, M., Bothwell, M., Sette, A., & Crotty, S. (2016) · The Journal of Immunology · doi:10.4049/jimmunol.1600318 · Cited by 248

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Dominguez-Sola, D., Kung, J., Holmes, A. B., Wells, V. A., Mo, T., Basso, K., & Dalla‐Favera, R. (2015) · Immunity · doi:10.1016/j.immuni.2015.10.015 · Cited by 255

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Sander, S., Chu, V. T., Yasuda, T., Franklin, A., Graf, R., Calado, D. P., Li, S., Imami, K., Selbach, M., Virgilio, M. D., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.10.021 · Cited by 254

Metabolic Regulation of the Immune Humoral Response

Boothby, M. R., & Rickert, R. C. (2017) · Immunity · doi:10.1016/j.immuni.2017.04.009 · Cited by 252

Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody

Schmidt, A. G., Xu, H., Khan, A. R., O’Donnell, T. J., Khurana, S., King, L. R., Manischewitz, J. F., Golding, H., Suphaphiphat, P., Carfí, A., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1218256109 · Cited by 247

The CREBBP Acetyltransferase Is a Haploinsufficient Tumor Suppressor in B-cell Lymphoma

Zhang, J., Vlasevska, S., Wells, V. A., Nataraj, S. E., Holmes, A. B., Duval, R., Meyer, S. N., Mo, T., Basso, K., Brindle, P. K., et al. (2017) · Cancer Discovery · doi:10.1158/2159-8290.cd-16-1417 · Cited by 261

Clonal and cellular dynamics in germinal centers

Victora, G. D., & Mesin, L. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.02.010 · Cited by 89

Germinal Center Biology

Sprumont, A., & Bannard, O. (2025) · Elsevier eBooks · doi:10.1016/b978-0-12-824465-4.00232-5

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Gitlin, A. D. (2025) · Digital Commons - RU (Rockefeller University) · doi:10.48496/w8c5-tx93

Germinal Center B Cell Dynamics

Mesin, L., Ersching, J., & Victora, G. D. (2016) · Immunity · doi:10.1016/j.immuni.2016.09.001 · Cited by 1,028

Dynamics of B cells in germinal centres

De Silva, N. S., & Klein, U. (2015) · Nature Reviews Immunology · doi:10.1038/nri3804 · Cited by 1,084