The DOI matches its Crossref record; 133 of the 133 references it cites were found in a registry or an index.
An Integrated View of Humoral Innate Immunity: Pentraxins as a Paradigm
Abstract
The innate immune system consists of a cellular and a humoral arm. Pentraxins (e.g., the short pentraxin C reactive protein and the long pentraxin PTX3) are key components of the humoral arm of innate immunity which also includes complement components, collectins, and ficolins. In response to microorganisms and tissue damage, neutrophils, macrophages, and dendritic cells are major sources of fluid-phase pattern-recognition molecules (PRMs) belonging to different molecular classes. Humoral PRMs in turn interact with and regulate cellular effectors. Effector mechanisms of the humoral innate immune system include activation and regulation of the complement cascade; agglutination and neutralization; facilitation of recognition via cellular receptors (opsonization); and regulation of inflammation. Thus, the humoral arm of innate immunity is an integrated system consisting of different molecules and sharing functional outputs with antibodies.
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“CRP, SAP and PTX3 participate in innate immune responses against extracellular and intracellular pathogens through activation and regulation of the complement cascade, microorganism opsonisation and agglutination. Moreover, they take part in inflammation and clearance of apoptotic cells (Bottazzi et al. 2010).”
From Neuronal pentraxins as biomarkers of synaptic activity: from physiological functions to pathological changes in neurodegeneration (2022) · cites this paper as Bottazzi et al. 2010
Citations
Cites
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Self-citationGenetically elevated C-reactive protein and ischemic vascular disease
Zacho, J., Tybjærg-Hansen, A., Jensen, J. S., Grande, P., Sillesen, H., & Nordestgaard, B. G. (2008) · New England Journal of Medicine · doi:10.1056/nejmoa0707402 · Cited by 839
Collectins and Ficolins: Humoral Lectins of the Innate Immune Defense
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Complement evasion by human pathogens
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Biswas, S. K., & Mantovani, A. (2010) · Nature Immunology · doi:10.1038/ni.1937 · Cited by 3,840
Self-citationNeutrophils in the activation and regulation of innate and adaptive immunity
Mantovani, A., Cassatella, M. A., Costantini, C., & Jaillon, S. (2011) · Nature reviews. Immunology · doi:10.1038/nri3024 · Cited by 3,159
Self-citationMacrophage plasticity and polarization in tissue repair and remodelling
Mantovani, A., Biswas, S. K., Galdiero, M. R., Sica, A., & Locati, M. (2013) · The Journal of Pathology · doi:10.1002/path.4133 · Cited by 2,384
Self-citationAdverse childhood experiences, allostasis, allostatic load and age-related disease
Danese, A., & McEwen, B. S. (2012) · Physiology & Behavior · doi:10.1016/j.physbeh.2011.08.019 · Cited by 2,140
Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns
Bachmann, M. F., & Jennings, G. T. (2010) · Nature reviews. Immunology · doi:10.1038/nri2868 · Cited by 2,120
Metadata
- Authors
- Bottazzi, B., Doni, A., Garlanda, C., & Mantovani, A.
- Affiliations
- IRCCS Humanitas Research Hospital (IT)
- Laboratory for Immunology and Inflammation, IRCCS Istituto Clinico Humanitas, Rozzano (Milano) 20089, Italy;, ,
- University of Milan (IT)
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2010-03-01
- Volume
- 28
- Issue
- 1
- Pages
- 157-183
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2160125610
- Cited by
- 592
- References
- 133
- Citations by year
- 2026: 11 · 2025: 27 · 2024: 34 · 2023: 32 · 2022: 44 · 2021: 42 · 2020: 40 · 2019: 35 · 2018: 28 · 2017: 36 · 2016: 48 · 2015: 38 · 2014: 45 · 2013: 45 · 2012: 30
- FWCI
- 2.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Annual Review of Immunology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
- Keywords
- pentraxins, C-reactive protein, pentraxin 3, pattern recognition molecules, complement system, collectins, ficolins, opsonization, agglutination, neutralization, inflammation regulation, immunoglobulins, neutrophils, macrophages, dendritic cells
- MeSH terms
- Animals, Antibodies, C-Reactive Protein, Humans, Immunity, Innate, Ligands, Immunity, Humoral
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