An Integrated View of Humoral Innate Immunity: Pentraxins as a Paradigm

C-reactive protein: a critical update

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C-reactive protein: a critical update

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C1q and Mannose Binding Lectin Engagement of Cell Surface Calreticulin and Cd91 Initiates Macropinocytosis and Uptake of Apoptotic Cells

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Immunoregulatory functions of surfactant proteins

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PENTRAXINS AT THE CROSSROADS BETWEEN INNATE IMMUNITY, INFLAMMATION, MATRIX DEPOSITION, AND FEMALE FERTILITY

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Genetically elevated C-reactive protein and ischemic vascular disease

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Collectins and Ficolins: Humoral Lectins of the Innate Immune Defense

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Complement evasion by human pathogens

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Evolution of the lectin–complement pathway and its role in innate immunity

Fujita, T. (2002) · Nature reviews. Immunology · doi:10.1038/nri800 · Cited by 697

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

Biswas, S. K., & Mantovani, A. (2010) · Nature Immunology · doi:10.1038/ni.1937 · Cited by 3,840

Neutrophils in the activation and regulation of innate and adaptive immunity

Mantovani, A., Cassatella, M. A., Costantini, C., & Jaillon, S. (2011) · Nature reviews. Immunology · doi:10.1038/nri3024 · Cited by 3,159

Macrophage plasticity and polarization in tissue repair and remodelling

Mantovani, A., Biswas, S. K., Galdiero, M. R., Sica, A., & Locati, M. (2013) · The Journal of Pathology · doi:10.1002/path.4133 · Cited by 2,384

Adverse childhood experiences, allostasis, allostatic load and age-related disease

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Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns

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Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation

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The complement system

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Sexual Dimorphism in Innate Immunity

Jaillon, S., Berthenet, K., & Garlanda, C. (2017) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-017-8648-x · Cited by 670

Characterization of the nature of granulocytic myeloid-derived suppressor cells in tumor-bearing mice

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PTX3 Is an Extrinsic Oncosuppressor Regulating Complement-Dependent Inflammation in Cancer

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Macrophage Activation and Polarization as an Adaptive Component of Innate Immunity

Locati, M., Mantovani, A., & Sica, A. (2013) · Advances in immunology · doi:10.1016/b978-0-12-417028-5.00006-5 · Cited by 418

The macrophage response towards LPS and its control through the p38MAPK–STAT3 axis

Bode, J. G., Ehlting, C., & Häussinger, D. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.01.018 · Cited by 397

Pattern recognition receptors: function, regulation and therapeutic potential

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Humoral Innate Immunity and Acute-Phase Proteins

Mantovani, A., & Garlanda, C. (2023) · New England Journal of Medicine · doi:10.1056/nejmra2206346 · Cited by 349

Neutrophils in innate and adaptive immunity

Jaillon, S., Galdiero, M. R., Prete, D. D., Cassatella, M. A., Garlanda, C., & Mantovani, A. (2013) · Seminars in Immunopathology · doi:10.1007/s00281-013-0374-8 · Cited by 295

Current Concept and Update of the Macrophage Plasticity Concept: Intracellular Mechanisms of Reprogramming and M3 Macrophage “Switch” Phenotype

Malyshev, I. Y., & Malyshev, Y. (2015) · BioMed Research International · doi:10.1155/2015/341308 · Cited by 293

Mesenteric fat as a source of C reactive protein and as a target for bacterial translocation in Crohn's disease

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Letter to the Glyco-Forum: Since there are PAMPs and DAMPs, there must be SAMPs? Glycan "self-associated molecular patterns" dampen innate immunity, but pathogens can mimic them

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Immunomodulatory Effects of Dietary Polyphenols

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Evolution of C-Reactive Protein

Pathak, A., & Agrawal, A. C. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00943 · Cited by 250

Inflammation in sleep apnea: An update

Unnikrishnan, D. C., Jun, J. C., & Polotsky, V. Y. (2014) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-014-9304-x · Cited by 235

Apolipoprotein A-I (ApoA-I), Immunity, Inflammation and Cancer

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PTX3, a Humoral Pattern Recognition Molecule, in Innate Immunity, Tissue Repair, and Cancer

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Urinary phthalate metabolites in relation to biomarkers of inflammation and oxidative stress: NHANES 1999–2006

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Complement factor H in host defense and immune evasion

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Emerging role of high density lipoproteins as a player in the immune system

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The pentraxins PTX3 and SAP in innate immunity, regulation of inflammation and tissue remodelling

Bottazzi, B., Inforzato, A., Messa, M., Barbagallo, M., Magrini, E. I., Garlanda, C., & Mantovani, A. (2016) · Journal of Hepatology · doi:10.1016/j.jhep.2016.02.029 · Cited by 192

Structural and functional diversity of the lectin repertoire in teleost fish: Relevance to innate and adaptive immunity

Vasta, G. R., Lazar, M. N., Giomarelli, B., Ahmed, H., Du, S., Cammarata, M., Parrinello, N., Bianchet, M. A., & Amzel, L. M. (2011) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2011.08.011 · Cited by 183

Future perspectives in melanoma research

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Porphyromonas gingivalis disturbs host–commensal homeostasis by changing complement function

Olsen, I., Lambris, J. D., & Hajishengallis, G. (2017) · Journal of Oral Microbiology · doi:10.1080/20002297.2017.1340085 · Cited by 175

Pentraxin 3 in Cardiovascular Disease

Ristagno, G., Fumagalli, F., Bottazzi, B., Mantovani, A., Olivari, D., Novelli, D., & Latini, R. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00823 · Cited by 170

Nanoparticle Vaccines Adopting Virus-like Features for Enhanced Immune Potentiation

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Systematic review of herbals as potential anti-inflammatory agents: Recent advances, current clinical status and future perspectives

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Role of neoplastic monocyte-derived fibrocytes in primary myelofibrosis

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Pentraxins in innate immunity: lessons from PTX3

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The immunoglobulin, IgG Fc receptor and complement triangle in autoimmune diseases

Karsten, C. M., & Köhl, J. (2012) · Immunobiology · doi:10.1016/j.imbio.2012.07.015 · Cited by 164

Factor H: A Complement Regulator in Health and Disease, and a Mediator of Cellular Interactions

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Recognition and inhibition of SARS-CoV-2 by humoral innate immunity pattern recognition molecules

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Competition between histone and transcription factor binding regulates the onset of transcription in zebrafish embryos

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Macrophage expression and prognostic significance of the long pentraxin PTX3 in COVID-19

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More than complementing Tolls: complement–Toll‐like receptor synergy and crosstalk in innate immunity and inflammation

Hajishengallis, G., & Lambris, J. D. (2016) · Immunological Reviews · doi:10.1111/imr.12467 · Cited by 153

An acidic microenvironment sets the humoral pattern recognition molecule PTX3 in a tissue repair mode

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The Long Pentraxin PTX3 as a Link Between Innate Immunity, Tissue Remodeling, and Cancer

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Leptospirosis: Aspects of Innate Immunity, Immunopathogenesis and Immune Evasion From the Complement System

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Macrophage Differentiation and Polarization via Phosphatidylinositol 3-Kinase/Akt–ERK Signaling Pathway Conferred by Serum Amyloid P Component

Zhang, W., Xu, W., & Xiong, S. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002315 · Cited by 145

Population genetic tools for dissecting innate immunity in humans

Quintana‐Murci, L., & Clark, A. G. (2013) · Nature reviews. Immunology · doi:10.1038/nri3421 · Cited by 160

Bitter-sweet symphony: glycan–lectin interactions in virus biology

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Immune response in COVID-19: what is next?

Li, Q., Wang, Y., Sun, Q., Knopf, J., i, M. H., Lin, L., Jiang, J., Shao, C., Li, P., He, X., et al. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-01015-x · Cited by 150

The Long Pentraxin PTX3 as a Humoral Innate Immunity Functional Player and Biomarker of Infections and Sepsis

Porte, R., Davoudian, S., Asgari, F., Parente, R., Mantovani, A., Garlanda, C., & Bottazzi, B. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00794 · Cited by 139

C-reactive protein as a biomarker for urological cancers

Saito, K., & Kihara, K. (2011) · Nature Reviews Urology · doi:10.1038/nrurol.2011.145 · Cited by 135

Circulating microparticles generate and transport monomeric C-reactive protein in patients with myocardial infarction

Habersberger, J., Strang, F., Scheichl, A., Htun, N., Bassler, N., Merivirta, R., Diehl, P., Krippner, G. Y., Meikle, P. J., Eisenhardt, S. U., et al. (2012) · Cardiovascular Research · doi:10.1093/cvr/cvs237 · Cited by 134

The Humoral Pattern Recognition Molecule PTX3 Is a Key Component of Innate Immunity against Urinary Tract Infection

Jaillon, S., Moalli, F., Ragnarsdottir, B., Bonavita, E., Puthia, M., Riva, F., Barbati, E., Nebuloni, M., Cvetko Krajinovic, L., Markotic, A., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.02.015 · Cited by 132

Vitellogenin Recognizes Cell Damage through Membrane Binding and Shields Living Cells from Reactive Oxygen Species

Salmela, H., Münch, D., Baumann, A., Zhong, S., Halskau, Ø., Krogsgaard, M., & Amdam, G. V. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.465021 · Cited by 131

The innate immune response to Aspergillus fumigatus at the alveolar surface

Margalit, A., & Kavanagh, K. A. (2015) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuv018 · Cited by 137

Pentraxin 3(PTX 3): An Endogenous Modulator of the Inflammatory Response

Kunes, P., Holubcová, Z., Koláčková, M., & Krejsek, J. (2012) · Mediators of Inflammation · doi:10.1155/2012/920517 · Cited by 128

Heterocomplexes of Mannose-binding Lectin and the Pentraxins PTX3 or Serum Amyloid P Component Trigger Cross-activation of the Complement System

Ma, Y. J., Doni, A., Skjoedt, M., Honoré, C., Arendrup, M. C., Mantovani, A., & Garred, P. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.190637 · Cited by 117

Astrocyte-derived pentraxin 3 supports blood-brain barrier integrity under acute phase of stroke

Shindo, A., Maki, T., Mandeville, E., Liang, A. C., Egawa, N., Itoh, K., Itoh, N., Borlongan, M., Holder, J., Chuang, T. T., et al. (2016) · Stroke · doi:10.1161/strokeaha.115.012133 · Cited by 103

Pentraxins in the activation and regulation of innate immunity

Daigo, K., Inforzato, A., Barajon, I., Garlanda, C., Bottazzi, B., Meri, S., & Mantovani, A. (2016) · Immunological Reviews · doi:10.1111/imr.12476 · Cited by 123

An Update on Sepsis Biomarkers

Kim, M.-H., & Choi, J. (2020) · Infection and Chemotherapy · doi:10.3947/ic.2020.52.1.1 · Cited by 117

Virus-induced humoral immunity: on how B cell responses are initiated

Zabel, F., Kündig, T. M., & Bachmann, M. F. (2013) · Current Opinion in Virology · doi:10.1016/j.coviro.2013.05.004 · Cited by 113

Neuronal pentraxins as biomarkers of synaptic activity: from physiological functions to pathological changes in neurodegeneration

Gómez de San José, N., Massa, F., Halbgebauer, S., Oeckl, P., Steinacker, P., & Otto, M. (2022) · Journal of Neural Transmission · doi:10.1007/s00702-021-02411-2 · Cited by 112

Neutrophils in respiratory syncytial virus infection: A target for asthma prevention

Geerdink, R. J., Pillay, J., Meyaard, L., & Bont, L. (2015) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.06.034 · Cited by 109

Innate immunesenescence: underlying mechanisms and clinical relevance

Hazeldine, J., & Lord, J. M. (2015) · Biogerontology · doi:10.1007/s10522-014-9514-3 · Cited by 104

Pentraxins in Complement Activation and Regulation

Ma, Y. J., & Garred, P. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.03046 · Cited by 103

Regulation of the Complement System by Pentraxins

Haapasalo, K., & Meri, S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01750 · Cited by 106

The long pentraxin PTX3 as a correlate of cancer-related inflammation and prognosis of malignancy in gliomas

Locatelli, M., Ferrero, S., Boneschi, F. M., Boiocchi, L., Zavanone, M. L., Gaini, S. M., Bello, L., Valentino, S., Barbati, E., Nebuloni, M., et al. (2013) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2013.04.009 · Cited by 101

Pentraxin-3 in Chronic Heart Failure: The CORONA and GISSI-HF Trials

Latini, R., Gullestad, L. L., Masson, S., Nymo, S. H., Ueland, T., Cuccovillo, I., Vårdal, M., Bottazzi, B., Mantovani, A., Lucci, D., et al. (2012) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfs092 · Cited by 100

Selective up‐regulation of the soluble pattern‐recognition receptor pentraxin 3 and of vascular endothelial growth factor in giant cell arteritis: Relevance for recent optic nerve ischemia

Baldini, M., Maugeri, N., Ramirez, G. A., Giacomassi, C., Castiglioni, A., Prieto‐González, S., Corbera‐Bellalta, M., Comite, G. D., Papa, I., DellʼAntonio, G., et al. (2011) · Arthritis & Rheumatism · doi:10.1002/art.33411 · Cited by 98

The Development of Serum Amyloid P as a Possible Therapeutic

Pilling, D., & Gomer, R. H. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02328 · Cited by 92

PTX3 as a paradigm for the interaction of pentraxins with the Complement system

Inforzato, A., Doni, A., Barajon, I., Leone, R., Garlanda, C., Bottazzi, B., & Mantovani, A. (2013) · Seminars in Immunology · doi:10.1016/j.smim.2013.05.002 · Cited by 91

Recognition of microbial glycans by soluble human lectins

Wesener, D. A., Dugan, A. E., & Kiessling, L. L. (2017) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2017.04.002 · Cited by 88

Mesenchymal Stromal Cell-Derived PTX3 Promotes Wound Healing via Fibrin Remodeling

Cappuzzello, C., Doni, A., Dander, E., Pasqualini, F., Nebuloni, M., Bottazzi, B., Mantovani, A., Biondi, A., Garlanda, C., & D’Amico, G. (2015) · Journal of Investigative Dermatology · doi:10.1038/jid.2015.346 · Cited by 89

The Dual Complexity of PTX3 in Health and Disease: A Balancing Act?

Magrini, E. I., Mantovani, A., & Garlanda, C. (2016) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2016.04.007 · Cited by 91

Endogenous and exogenous pentraxin-3 limits postischemic acute and chronic kidney injury

Lech, M., Römmele, C., Gröbmayr, R., Susanti, H. E., Kulkarni, O. P., Wang, S., Gröne, H., Uhl, B., Reichel, C. A., Krombach, F., et al. (2013) · Kidney International · doi:10.1038/ki.2012.463 · Cited by 89

The yin-yang of long pentraxin PTX3 in inflammation and immunity

Daigo, K., Mantovani, A., & Bottazzi, B. (2014) · Immunology Letters · doi:10.1016/j.imlet.2014.04.012 · Cited by 89

Humoral innate immune response and disease

Shishido, S. N., Varahan, S., Yuan, K., Li, X., & Fleming, S. D. (2012) · Clinical Immunology · doi:10.1016/j.clim.2012.06.002 · Cited by 88

The long pentraxin PTX3: a paradigm for humoral pattern recognition molecules

Mantovani, A., Valentino, S., Gentile, S., Inforzato, A., Bottazzi, B., & Garlanda, C. (2013) · Annals of the New York Academy of Sciences · doi:10.1111/nyas.12043 · Cited by 87

Factor H–Related Protein 5 Interacts with Pentraxin 3 and the Extracellular Matrix and Modulates Complement Activation

Csincsi, Á. I., Kopp, A., Zöldi, M., Bánlaki, Z., Uzonyi, B., Hebecker, M., Caesar, J. J. E., Pickering, M. C., Daigo, K., Hamakubo, T., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1403121 · Cited by 87

Acute phase protein response to viral infection and vaccination

Pérez, L. (2019) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2019.07.013 · Cited by 86

Long pentraxin 3: A novel multifaceted player in cancer

Giacomini, A., Ghedini, G. C., Presta, M., & Ronca, R. (2017) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2017.11.004 · Cited by 85

Rutin prevents cardiac oxidative stress and inflammation induced by bisphenol A and dibutyl phthalate exposure via NRF-2/NF-κB pathway

Oluranti, O. I., Alabi, B. A., Michael, O. S., Ojo, A. O., & Fatokun, B. P. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119878 · Cited by 85

Pentraxin 3 as a Prognostic Biomarker in Patients with Systemic Inflammation or Infection

Liu, S., Qu, X., Liu, F., & Wang, C. (2014) · Mediators of Inflammation · doi:10.1155/2014/421429 · Cited by 84

Pathogen Recognition by the Long Pentraxin PTX3

Moalli, F., Jaillon, S., Inforzato, A., Sironi, M., Bottazzi, B., Mantovani, A., & Garlanda, C. (2011) · BioMed Research International · doi:10.1155/2011/830421 · Cited by 83

Systemic pentraxin-3 levels reflect vascular enhancement and progression in Takayasu arteritis

Tombetti, E., Chio, M. C. D., Sartorelli, S., Papa, M., Salerno, A., Bottazzi, B., Bozzolo, E. P., Greco, M., Rovere, P. Q., Baldissera, E. M., et al. (2014) · Arthritis Research & Therapy · doi:10.1186/s13075-014-0479-z · Cited by 82

Ficolin-1–PTX3 Complex Formation Promotes Clearance of Altered Self-Cells and Modulates IL-8 Production

Ma, Y. J., Doni, A., Romani, L. R., Jürgensen, H. J., Behrendt, N., Mantovani, A., & Garred, P. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300382 · Cited by 82

M-Ficolin Interacts with the Long Pentraxin PTX3: A Novel Case of Cross-Talk between Soluble Pattern-Recognition Molecules

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