HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

Scaffidi, P., Misteli, T., & Bianchi, M. E. (2002) · Nature · doi:10.1038/nature00858 · Cited by 4,221

HMG-1 as a Late Mediator of Endotoxin Lethality in Mice

Wang, H., Bloom, O., Zhang, M., Vishnubhakat, J. M., Ombrellino, M., Che, J., Frazier, A., Yang, H., Ivanova, S., Borovikova, L. V., et al. (1999) · Science · doi:10.1126/science.285.5425.248 · Cited by 3,386

Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

Apetoh, L., Ghiringhelli, F., Tesniere, A., Obeid, M., Ortiz, C., Criollo, A., Mignot, G., Maiuri, M. C., Ullrich, E., Saulnier, P., et al. (2007) · Nature Medicine · doi:10.1038/nm1622 · Cited by 3,056

Involvement of Toll-like Receptors 2 and 4 in Cellular Activation by High Mobility Group Box 1 Protein

Park, J. S., Svetkauskaite, D., He, Q., Kim, J., Strassheim, D., Ishizaka, A., & Abraham, E. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m306793200 · Cited by 1,582

High Mobility Group 1 Protein (Hmg-1) Stimulates Proinflammatory Cytokine Synthesis in Human Monocytes

Andersson, U., Wang, H., Palmblad, K., Aveberger, A.-C., Bloom, O., Erlandsson-Harris, H., Janson, A., Kokkola, R., Zhang, M., Yang, H., et al. (2000) · The Journal of Experimental Medicine · doi:10.1084/jem.192.4.565 · Cited by 1,401

Toll-like receptor 9–dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE

Tian, J., Avalos, A. M., Mao, S.-Y., Chen, B., Senthil, K., Wu, H., Parroche, P., Drabic, S., Golenbock, D., Sirois, C., et al. (2007) · Nature Immunology · doi:10.1038/ni1457 · Cited by 1,372

Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases

Taguchi, A., Blood, D. C., del Toro, G., Canet, A., Lee, D. C., Qu, W., Tanji, N., Lu, Y., Lalla, E., Fu, C., et al. (2000) · Nature · doi:10.1038/35012626 · Cited by 1,217

Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis

Wang, H., Liao, H., Ochani, M., Justiniani, M., Lin, X., Yang, L., Al-Abed, Y., Wang, H., Metz, C., Miller, E. J., et al. (2004) · Nature Medicine · doi:10.1038/nm1124 · Cited by 1,170

Reflex control of immunity

Tracey, K. J. (2009) · Nature Reviews Immunology · doi:10.1038/nri2566 · Cited by 1,154

The Receptor for Advanced Glycation End Products (RAGE) Is a Cellular Binding Site for Amphoterin

Hori, O., Brett, J., Slattery, T., Cao, R., Zhang, J., Chen, J. X., Nagashima, M., Lundh, E. R., Vijay, S., Nitecki, D., et al. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.43.25752 · Cited by 1,151

Mechanisms of Chromatin Remodeling and Repurposing During Extracellular Translocation

Pisetsky, D. S. (2016) · Advances in protein chemistry and structural biology · doi:10.1016/bs.apcsb.2016.08.003 · Cited by 15

Inhibitory effects of lupane-type triterpenoid saponins from the leaves of Acanthopanax gracilistylus on lipopolysaccharide-induced TNF-α, IL-1β and high-mobility group box 1 release in macrophages

Zou, Q.-P., Liu, X., Huang, J., Yook, C., Whang, W. K., Lee, H., & Kwon, O. (2017) · Molecular Medicine Reports · doi:10.3892/mmr.2017.7767 · Cited by 14

The Pharmacological Targets and Clinical Evidence of Natural Products With Anti-hepatic Inflammatory Properties

Peng, J. (2018) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.00455 · Cited by 14

HMGB1 from Lampetra japonica promotes inflammatory activation in supraneural body cells

Li, C., Wang, D., Guan, X., Liu, S., Su, P., Li, Q., & Pang, Y. (2018) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2018.11.008 · Cited by 14

An identified PfHMGB1 promotes microcystin-LR-induced liver injury of yellow catfish (Pelteobagrus fulvidraco)

Wang, Y., Xiao, X., Feijie, W., Yang, Z., Yue, J., Shi, J., Ke, F., Xie, Z., & Fan, Y. (2020) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2020.111266 · Cited by 14

The role of high mobility group box 1 protein in acute cerebrovascular diseases (Review)

Mu, S., Dang, Y., Wang, S., & Gu, J. (2018) · Biomedical Reports · doi:10.3892/br.2018.1127 · Cited by 14

Effects of mimicked acetylated HMGB1 on macrophages and dendritic cells

Chen, X., Xu, Y. X., Xiong, P., Tan, Z., Gong, F., Hou, X., & Zheng, F. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9584 · Cited by 14

Physiopathology of High-Altitude Pulmonary Edema

Miserocchi, G. (2024) · High Altitude Medicine & Biology · doi:10.1089/ham.2024.0037 · Cited by 13

High-mobility group box 1 in acute kidney injury

Li, X., Jing, G., Guo, Z., & Guo, Z. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1618971 · Cited by 13

Establishment of a schizophrenia classifier based on peripheral blood signatures and investigation of pathogenic miRNA-mRNA regulation

Jin, M., Liu, Y., Hu, G., Li, X., Jia, N., Cui, X., Li, Z., Ai, L., Xie, M., Xue, F., et al. (2023) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2023.01.035 · Cited by 13

Impact of microglia isolation and culture methodology on transcriptional profile and function

Mizrachi, M., & Diamond, B. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03076-w · Cited by 13

Ecliptasaponin A protects heart against acute ischemia-induced myocardial injury by inhibition of the HMGB1/TLR4/NF-κB pathway

Ge, S., Wu, S., Yin, Q., Tan, M., Wang, S., Yang, Y., Chen, Z., Xu, L., Zhang, H., Meng, C., et al. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118612 · Cited by 13

Elevated HMGB1-related interleukin-6 is associated with dynamic responses of monocytes in patients with active pulmonary tuberculosis.

Zeng, J., Xiang, W., Lin, D., Zhang, J., Liu, G.-B., Kong, B., Gao, Y., Lu, Y.-B., Wu, X.-J., Lailong, Y., et al. (2015) · Europe PMC (PubMed Central) · Cited by 13

MicroRNA-421 improves ischemia/reperfusion injury via regulation toll-like receptor 4 pathway

Guo, L., Guo, M., Yao, J. Q., Weng, Y., & Zhang, X. (2019) · Journal of International Medical Research · doi:10.1177/0300060519871863 · Cited by 13

IRF3 Signaling within the Mouse Stroma Influences Sepsis Pathogenesis

Heipertz, E. L., Harper, J., Goswami, D. G., Lopez, C. A., Nellikappallil, J., Zamora, R., Yoram Vodovotz, B., & Walker, W. E. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1900217 · Cited by 13

Deficiency of the novel high mobility group protein HMGXB4 protects against systemic inflammation-induced endotoxemia in mice

He, X., Dong, K., Shen, J., Hu, G., Liu, J., Kang, X., Wang, L., Atawia, R. T., Osman, I., Caldwell, R. W., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2021862118 · Cited by 13

Prednisolone Suppresses the Extracellular Release of HMGB-1 and Associated Inflammatory Pathways in Kawasaki Disease

Ueno, K., Nomura, Y., Morita, Y., & Kawano, Y. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.640315 · Cited by 13

High mobility group box-1 (HMGB-1) and its receptors in the pathogenesis of malaria-associated acute lung injury/acute respiratory distress syndrome in a mouse model

Techarang, T., Jariyapong, P., Viriyavejakul, P., & Punsawad, C. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e08589 · Cited by 13

Dangshen Erling Decoction Ameliorates Myocardial Hypertrophy via Inhibiting Myocardial Inflammation

Zhong, Y., Chen, L., Li, M., Chen, L., Qian, Y., Chen, C.-F., Wáng, Y., & Xu, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.725186 · Cited by 13

Efficacy and safety of glycyrrhizic acid preparation treating comorbid liver injury in COVID-19: A systematic review

Liu, X., Tian, X., Ma, Z., Chen, J., Huang, Q., Gao, P., & Zhang, C. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1003697 · Cited by 13

Downregulation of miR-26b attenuates early brain injury induced by subarachnoid hemorrhage via mediating the KLF4/STAT3/HMGB1 axis

Huang, Z., Liu, J., Xu, J., Dai, L., & Wang, H. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114270 · Cited by 13

Autoimmune diseases

Harsini, S., & Rezaei, N. (2023) · Elsevier eBooks · doi:10.1016/b978-0-12-818006-8.00001-3 · Cited by 13

Olmesartan alleviates SARS-CoV-2 envelope protein induced renal fibrosis by regulating HMGB1 release and autophagic degradation of TGF-β1

Zhou, S., Yu, Z., Chen, Z., Ning, F., Hu, X., Wu, T., Li, M., Xin, H., Reilly, S. N., & Zhang, X. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1187818 · Cited by 13

The activation of SIRT1 ameliorates BPDE‐induced inflammatory damage in BEAS‐2B cells via HMGB1 / TLR4 / NF‐κB pathway

Lei, Y., Zhu, Y., Mallah, M. A., Lu, P., Yang, L., He, X., Shang, P., Chen, Y., Zhou, X., Feng, F., et al. (2023) · Environmental Toxicology · doi:10.1002/tox.23878 · Cited by 13

HMGB1 is a therapeutic target for leukemia.

Yu, Y., Xie, M., Kang, R., Livesey, K. M., Cao, L., & Tang, D. (2012) · PubMed Central · Cited by 13

Quinic acid derivatives from Salicornia herbacea alleviate HMGB1-mediated endothelial dysfunction

Tuấn, N. Q., Lee, W., Oh, J., Kwak, S., Lee, H. G., Ferreira, D., Bae, J., & Na, M. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.03.044 · Cited by 13

PKR stirs up inflammasomes

Stunden, H. J., & Latz, E. (2012) · Cell Research · doi:10.1038/cr.2012.125 · Cited by 13

Inhibition of High Mobility Group Box 1–Toll-Like Receptor-4 Signaling by Glycyrrhizin Contributes to the Attenuation of Cold Ischemic Injury of Liver in a Rat Model

Su, S., Wu, J., Gong, T.-L., He, K., Feng, C., Zhang, M., Li, B., & Xia, X. (2016) · Transplantation Proceedings · doi:10.1016/j.transproceed.2015.12.014 · Cited by 13

Increased HMGB1 levels in lesional skin and sera in patients with cutaneous T-cell lymphoma

Senda, N., Miyagaki, T., Kamijo, H., Nakajima, R., Oka, T., Takahashi, N., Suga, H., Yoshizaki, A., Asano, Y., Sugaya, M., et al. (2018) · European Journal of Dermatology · doi:10.1684/ejd.2018.3400 · Cited by 13

Macrophage‐derived HMGB1 is dispensable for tissue fibrogenesis

Personnaz, J., Piccolo, E. B., Branchereau, M., Filliol, A. A., Paccoud, R., Moreau, E., Calise, D., Riant, É., Gourdy, P., Heymes, C., et al. (2019) · FASEB BioAdvances · doi:10.1096/fba.2018-00035 · Cited by 13

Relevance of Receptor for Advanced Glycation end Products (RAGE) in Murine Antibody-Mediated Autoimmune Diseases

Eichhorst, A., Daniel, C., Rzepka, R., Sehnert, B., Nimmerjahn, F., Voll, R. E., & Chevalier, N. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133234 · Cited by 13

NLRP3 as a sensor of metabolism gone awry

Neuwirt, E., Gorka, O., Saller, B. S., Groß, C. J., Madl, T., & Groß, O. (2021) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2021.03.009 · Cited by 13

Hyperbaric oxygen via mediating SIRT1‐induced deacetylation of HMGB1 improved cReperfusion inj/reperfusion injury

Zhao, P., Xu, S., Huang, Z., Jiang, G., Deng, P., & Zhang, Y. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15458 · Cited by 13

Central high mobility group box-1 induces mechanical hypersensitivity with spinal microglial activation in a mouse model of hemi-Parkinson’s disease

Sato, F., Nakamura, Y., Ma, S., Kochi, T., Hisaoka‐Nakashima, K., Wang, D., Liu, K., Wake, H., Nishibori, M., & Morioka, N. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112479 · Cited by 13

Role of cell–cell interactions in high mobility group box 1 cytokine activity in human peripheral blood mononuclear cells and mouse splenocytes

Takahashi, H. K., Sadamori, H., Liu, K., Wake, H., Mori, S., Yoshino, T., Yamamoto, Y., Yamamoto, H., & Nishibori, M. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.11.058 · Cited by 13

CgHMGB1 functions as a broad-spectrum recognition molecule to induce the expressions of CgIL17-5 and Cgdefh2 via MAPK or NF-κB signaling pathway in Crassostrea gigas

Lv, X., Yang, W., Guo, Z., Wu, W., Li, Y., Yan, X., Wang, W., Zhang, T., Sun, J., Wang, L., et al. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.04.166 · Cited by 12

Ameliorative Effect of D-Carvone against Hepatic Ischemia-Reperfusion-Induced Injury in Rats

Mohamed, M. E., & Younis, N. S. (2022) · Life · doi:10.3390/life12101502 · Cited by 12

Inhibition of BRD4 expression attenuates the inflammatory response and apoptosis by downregulating the HMGB-1/NF-κB signaling pathway following traumatic brain injury in rats

Zhu, Y., Ni, H., Chen, Q., Qian, H., Fang, Y., Gao, R., & Liu, B. (2023) · Neuroscience Letters · doi:10.1016/j.neulet.2023.137385 · Cited by 12

Matrine: A Promising Treatment for Ulcerative Colitis by Targeting the HMGB1/NLRP3/Caspase-1 Pathway

Sun, K., Lin, W., Hong, Q., Chen, S., Li, J., & Qiu, S. (2024) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/0113862073292384240209095838 · Cited by 12

Coronary Microvascular Dysfunction Is Associated With Augmented Lysosomal Signaling in Hypercholesterolemic Mice

Wang, Y., Moura, A. K., Zuo, R. M., Zhou, W., Wang, Z., Roudbari, K., Hu, J. Z., Li, P., Zhang, Y., & Li, X. (2024) · Journal of the American Heart Association · doi:10.1161/jaha.124.037460 · Cited by 12

Impact of uric acid on liver injury and intestinal permeability following resuscitated hemorrhagic shock in rats

Khazoom, F., L’Écuyer, S., Kim, G., Gagné, M.-A., Bouchard, C., Rose, C. F., Rousseau, G., & Charbonney, E. (2020) · The Journal of Trauma: Injury, Infection, and Critical Care · doi:10.1097/ta.0000000000002868 · Cited by 12

In schizophrenia, non-remitters and partial remitters to treatment with antipsychotics are qualitatively distinct classes with respect to neurocognitive deficits and neuro-immune biomarkers: results of soft independent modeling of class analogy

Al‐Hakeim, H. K., Mousa, R. F., Al-Dujaili, A. H., & Maes, M. H. J. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-021-00685-9 · Cited by 12

CRISPLD2 attenuates pro-inflammatory cytokines production in HMGB1-stimulated monocytes and septic mice.

Zhang, S., Pei, L., Qu, J., Sun, L., Jiang, W., Li, W., Lin, Z., & Chen, D. (2021) · PubMed Central · Cited by 12

Bicyclol Alleviates Signs of BDL-Induced Cholestasis by Regulating Bile Acids and Autophagy-Mediated HMGB1/p62/Nrf2 Pathway

Zhao, J., Ran, M., Yang, T., Chen, L., Ji, P., Xu, X., Zhang, L., Sun, S., Liu, X., Zhou, S., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.686502 · Cited by 12

Jing Si Herbal Drink as a prospective adjunctive therapy for COVID-19 treatment: Molecular evidence and mechanisms

Lu, P., Tseng, C.-W., Lee, J.-L., Lee, E.-Y., Lin, Y., Lin, I., Yu, M., Lu, K., & Kuo, K. (2021) · Pharmacological Research - Modern Chinese Medicine · doi:10.1016/j.prmcm.2021.100024 · Cited by 12

The Comprehensive Role of High Mobility Group Box 1 (HMGB1) Protein in Different Tumors: A Pan-Cancer Analysis

Guan, H., Zhong, M., Ma, K., Tang, C., Wang, X., Ouyang, M., Qin, R., Chen, J., Zhu, E., Zhu, T., et al. (2023) · Journal of Inflammation Research · doi:10.2147/jir.s386898 · Cited by 14

Hemorrhage-Induced Interleukin-1 Receptor Pathway in Lung Is Suppressed by 3,5-Bis(2-Fluorobenzylidene)-4-Piperidone in a Rat Model of Hypovolemic Shock

Yadav, V. R., Vilekar, P., Awasthi, S., & Awasthi, V. (2014) · Artificial Organs · doi:10.1111/aor.12305 · Cited by 12

Temporal and spatial expression of high‐mobility group box 1 in surgically injured rat vocal folds

Li‐Jessen, N. Y. K., Lee, B., & Thibeault, S. L. (2011) · The Laryngoscope · doi:10.1002/lary.22435 · Cited by 12

Interplay between trauma and Pseudomonas entomophila infection in flies: a central role of the JNK pathway and of CrebA

Ragheb, R., Chuyen, A., Torres, M., Defaye, A., Seyres, D., Kremmer, L., Fernandez, N., Tricoire, H., Rihet, P., Nguyen, C., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-14969-7 · Cited by 13

Pathogenicity Induced by Invasive Infection of Streptococcus dysgalactiae subsp. equisimilis in a Mouse Model of Diabetes

Ogura, K., Okumura, K., Shimizu, Y., Kirikae, T., & Miyoshi‐Akiyama, T. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.02128 · Cited by 12

Cytosolic HMGB1 Mediates Autophagy Activation in an Emulsified Isoflurane Anesthesia Cell Model

Liu, R., Li, T., & Zhao, G.-Q. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02740-5 · Cited by 12

Extracellular HMGB-1 activates inflammatory signaling in tendon cells and tissues

Zhang, C., Gu, X.-F., Zhao, G., Wang, W., Shao, J., Zhu, J., Yuan, T., Sun, J., Nie, D., & Zhou, Y. (2020) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622320956429 · Cited by 12

Transient Global Ischemia-Induced Brain Inflammatory Cascades Attenuated by Targeted Temperature Management

Hong, D. K., Park, Y. S., Woo, J. S., Kim, J. H., Beom, J. H., Chung, S. P., You, J. S., & Suh, S. W. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105114 · Cited by 12

Exendin-4 Inhibits HMGB1-Induced Inflammatory Responses in HUVECs and in Murine Polymicrobial Sepsis

Lee, W., Ku, S., Park, E. J., Na, D. H., Kim, K., & Bae, J. (2014) · Inflammation · doi:10.1007/s10753-014-9919-9 · Cited by 12

Abnormal Expression of Toll-Like Receptor 4 Is Associated with Susceptibility to Ethanol-Induced Gastric Mucosal Injury in Mice

Ye, H.-H., Hua, R., Yu, L., Wu, K., Fei, S., Qin, X., Song, Y., Cao, J., & Zhang, Y. (2013) · Digestive Diseases and Sciences · doi:10.1007/s10620-013-2727-5 · Cited by 12

Cerebral Concussion Primes the Lungs for Subsequent Neutrophil-Mediated Injury

Humphries, D. C., O’Neill, S., Scholefield, E., Dorward, D. A., MacKinnon, A. C., Rossi, A. G., Haslett, C., Andrews, P., Rhodes, J. K. J., & Dhaliwal, K. (2018) · Critical Care Medicine · doi:10.1097/ccm.0000000000003270 · Cited by 12

Anti-HMGB1 auto-Abs influence fatigue in patients with Crohn’s disease

Kvivik, I., Grimstad, T. B., Jonsson, G., Kvaløy, J. T., & Omdal, R. (2021) · Innate Immunity · doi:10.1177/17534259211014252 · Cited by 11

A Protein Complex of Liver Origin Activates a Pro-inflammatory Program That Drives Hepatic and Intestinal Injury in Alcohol-Associated Liver Disease

Ge, X., Han, H., Désert, R., Das, S., Song, Z., Komakula, S. S. B., Chen, W., Athavale, D., Lantvit, D. D., & Nieto, N. (2024) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2024.05.010 · Cited by 11

The Immunohistochemical and Bioinformatics Analysis of the Placental Expressions of Vascular Cell Adhesion Protein 1 (VCAM-1) and High Mobility Group Box 1 (HMGB1) Proteins in Gestational Diabetic Mothers

Oğlak, S. C., Aşir, F., Yılmaz, E. Z., Bolluk, G., Korak, T., & Ağaçayak, E. (2024) · Zeitschrift für Geburtshilfe und Neonatologie · doi:10.1055/a-2451-2223 · Cited by 11

Melatonin Reduces Mito‐Inflammation in Ischaemic Hippocampal HT22 Cells and Modulates the cGAS – STING Cytosolic DNA Sensing Pathway and FGF21 Release

Carloni, S., Nasoni, M. G., Casabianca, A., Orlandi, C., Capobianco, L., Iaconisi, G. N., Cerioni, L., Burattini, S., Benedetti, S., Reiter, R. J., et al. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70285 · Cited by 13

HMGB1 in Septic Muscle Atrophy: Roles and Therapeutic Potential for Muscle Atrophy and Regeneration

Qi, S., Wu, Q., Xiang, P., Hou, C., Kang, Z., Chen, M., Yi, C., Bai, X., Li, T., Li, Z., et al. (2025) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.13711 · Cited by 11

Epigenetic Modulation by Lactylation in Sepsis: Linking Metabolism to Immune Dysfunction

Chen, Y., Hu, H., Wang, C., Wu, J., Zan, J., & Liu, Y. (2025) · Journal of Inflammation Research · doi:10.2147/jir.s522081 · Cited by 11

Intrinsic disorder and fuzzy interactions drive multiple functions of HMGB1

Ghitti, M., Colley, L. S., Mantonico, M. V., Musco, G., & Bianchi, M. E. (2025) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2025.08.001 · Cited by 12

An ongoing search for potential targets and therapies for lethal sepsis

Bao, G., He, L., Lee, D., D’Angelo, J. K., & Wang, H. (2015) · Military Medical Research · doi:10.1186/s40779-015-0047-0 · Cited by 11

Role of the high mobility group box 1 signalling axes via the receptor for advanced glycation end‐products and toll‐like receptor‐4 in the immunopathology of oral lichen planus: a potential drug target?

Salem, A., Almahmoudi, R., Vehviläinen, M., & Salo, T. A. (2018) · European Journal Of Oral Sciences · doi:10.1111/eos.12416 · Cited by 12

Glycyrrhizin ameliorating sterile inflammation induced by low-dose radiation exposure

Kim, H. C., Oh, H.-W., You, J. S., & Chung, Y. E. (2021) · Scientific Reports · doi:10.1038/s41598-021-97800-8 · Cited by 11

miR-505 inhibits replication of Borna disease virus 1 via inhibition of HMGB1-mediated autophagy

Guo, Y., Xu, X., Tang, T., Sun, L., Zhang, X., Shen, X., Li, D., Wang, L., Zhao, L., & Xie, P. (2022) · Journal of General Virology · doi:10.1099/jgv.0.001713 · Cited by 11

Targeting high-mobility-group-box-1-mediated inflammation: a promising therapeutic approach for myocardial infarction

Date, S., & Bhatt, L. K. (2024) · Inflammopharmacology · doi:10.1007/s10787-024-01586-w · Cited by 11

Repeated inhalation of sevoflurane inhibits airway inflammation in an OVA ‐induced mouse model of allergic airway inflammation

Shen, Q., Fang, L., Wu, H., He, F., Ding, P., & Liu, R. (2014) · Respirology · doi:10.1111/resp.12439 · Cited by 11

Secreted HMGB1 from Wnt activated intestinal cells is required to maintain a crypt progenitor phenotype

Reed, K. R., Song, F., Young, M. A., Hassan, N., Antoine, D. J., Gemici, N.-P. B., Clarke, A. R., & Jenkins, J. R. (2016) · Oncotarget · doi:10.18632/oncotarget.10076 · Cited by 11

A novel synthetic derivative of squamosamide FLZ inhibits the high mobility group box 1 protein-mediated neuroinflammatory responses in murine BV2 microglial cells

Li, D., Bao, X.-Q., Wang, X., Sun, H., & Zhang, D. (2017) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-017-1363-6 · Cited by 11

Papaverine Has Therapeutic Potential for Sepsis-Induced Neuropathy in Rats, Possibly via the Modulation of HMGB1-RAGE Axis and Its Antioxidant Prosperities

Solmaz, V., Kaya, M., Uslu, F. B., Atasoy, Ö., & Erbaş, O. (2020) · Journal of Investigative Surgery · doi:10.1080/08941939.2020.1809751 · Cited by 11

Discovery of 5,5′-Methylenedi-2,3-Cresotic Acid as a Potent Inhibitor of the Chemotactic Activity of the HMGB1·CXCL12 Heterocomplex Using Virtual Screening and NMR Validation

Leo, F. D., Quilici, G., Marchis, F. D., Mantonico, M. V., Bianchi, M. E., & Musco, G. (2020) · Frontiers in Chemistry · doi:10.3389/fchem.2020.598710 · Cited by 11

Inflammation related to high-mobility group box-1 in endometrial ovarian cyst

Ikeda, M., Negishi, Y., Akira, S., Morita, R., & Takeshita, T. (2021) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2021.103292 · Cited by 12

PRRSV Induces HMGB1 Phosphorylation at Threonine-51 Residue to Enhance Its Secretion

Wang, R., Zhang, J., Fu, Y., Jia, L., Zhang, Y., Bai, L., Wang, W., Cheng, D., & Liu, E. (2022) · Viruses · doi:10.3390/v14051002 · Cited by 11

Identification of a Candidate Proteomic Signature to Discriminate Multipotent and Non-Multipotent Stromal Cells

Rosu‐Myles, M., She, Y., Fair, J., Muradia, G., Mehic, J., Menéndez, P. R., Prasad, S. S., & Cyr, T. D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038954 · Cited by 11

Epilepsy and the inflammasome: Targeting inflammation as a novel therapeutic strategy for seizure disorders

Edye, M. E., Walker, L. E., Sills, G. J., Allan, S. M., & Brough, D. (2014) · Inflammasome · doi:10.2478/infl-2014-0004 · Cited by 11

High levels of HMGB1 in plasma may be due to ex vivo cell necrosis.

Nowak, P., Nyström, J., & Trøseid, M. (2012) · PubMed · Cited by 11

Cerebral Edema and Neurological Recovery after Traumatic Brain Injury Are Worsened if Accompanied by a Concomitant Long Bone Fracture

Suto, Y., Nagata, K., Ahmed, S. M., Jacovides, C. L., Browne, K. D., Cognetti, J. S., Johnson, V. E., Leone, R., Kaplan, L. J., Smith, D. H., et al. (2018) · Journal of Neurotrauma · doi:10.1089/neu.2018.5812 · Cited by 11

The impact of damage‐associated molecular patterns on the neurotransmitter release and gene expression in the ex vivo rat carotid body

Mkrtchian, S., Kåhlin, J., Gómez‐Galán, M., Ebberyd, A., Yoshitake, T., Schmidt, S., Kehr, J., Hildenborg, M., Fagerlund, M. J., Harris, H. E., et al. (2020) · Experimental Physiology · doi:10.1113/ep088705 · Cited by 11

Combination therapy with hydrogen peroxide and irradiation promotes an abscopal effect in mouse models

Kemmotsu, N., Zhu, L., Nagasaki, J., Otani, Y., Ueda, Y., Dansako, H., Fang, Y., Date, I., & Togashi, Y. (2023) · Cancer Science · doi:10.1111/cas.15911 · Cited by 10

Role of SIRT1 in sepsis‐induced encephalopathy: Molecular targets for future therapies

Shehata, A. H., Anter, A. F., & Ahmed, A. F. (2023) · European Journal of Neuroscience · doi:10.1111/ejn.16167 · Cited by 10

The role of high mobility group box-1 on the development of diabetes complications: A plausible pharmacological target

Ngcobo, N. N., & Sibiya, N. H. (2024) · Diabetes and Vascular Disease Research · doi:10.1177/14791641241271949 · Cited by 10

Impact of Tobacco Smoking and Type-2 Diabetes Mellitus on Public Health: A Cerebrovascular Perspective

Prasad, S., & Cucullo, L. (2015) · Journal of Pharmacovigilance · doi:10.4172/2329-6887.s2-e003 · Cited by 10

Different concentration of human cord blood HMGB1 according to delivery and labour: A pilot study

D’Angelo, G., Marseglia, L. M., Granese, R., Benedetto, A. D., Giacobbe, A., Impellizzeri, P., Alibrandi, A., Ferro, E., Palmara, A., Manti, S., et al. (2018) · Cytokine · doi:10.1016/j.cyto.2018.03.019 · Cited by 10

Trimebutine suppresses Toll-like receptor 2/4/7/8/9 signaling pathways in macrophages

Ogawa, N., Nakajima, S., Tamada, K., Yokoue, N., Tachibana, H., Okazawa, M., Oyama, T., Abe, H., Yamazaki, H., Yoshimori, A., et al. (2021) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2021.109029 · Cited by 10

MicroRNA‑23a‑3p targeting of HMGB1 inhibits LPS‑induced inflammation in murine macrophages in vitro

Sun, Q., Wang, B., & Li, M. (2022) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2022.11251 · Cited by 10

α-Iso-cubebene attenuates neointima formation by inhibiting HMGB1-induced monocyte to macrophage differentiation via suppressing ROS production

Baek, S. E., Jang, E. J., Choi, J. M., Choi, Y. W., & Kim, C. D. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109121 · Cited by 10

Plakoglobin and High-Mobility Group Box 1 Mediate Intestinal Epithelial Cell Apoptosis Induced by Clostridioides difficile TcdB

Li, Y., Xu, W., Ren, Y., Cheung, H., Huang, P., Kaur, G., Kuo, C., McDonough, S. P., Fubini, S. L., Lipkin, S. M., et al. (2022) · mBio · doi:10.1128/mbio.01849-22 · Cited by 10

HMGB1 Is a Prognostic Factor for Mortality in Acute Kidney Injury Requiring Renal Replacement Therapy

Matsuura, R., Komaru, Y., Miyamoto, Y., Yoshida, T., Yoshimoto, K., Yamashita, T., Hamasaki, Y., Noiri, E., Nangaku, M., & Doi, K. (2023) · Blood Purification · doi:10.1159/000530774 · Cited by 12

Vagus nerve SARS‐CoV‐2 infection and inflammatory reflex dysfunction: Is there a causal relationship?

Andersson, J., & Tracey, K. J. (2023) · Journal of Internal Medicine · doi:10.1111/joim.13746 · Cited by 10

Unraveling the interplay of neuroinflammatory signaling between parenchymal and meningeal cells in migraine headache

Dalkara, T., Kaya, Ζ., & Erdener, Ş. E. (2024) · The Journal of Headache and Pain · doi:10.1186/s10194-024-01827-x · Cited by 10

Chicken IgY facilitates allergic airway inflammation in a chemical-induced murine asthma model by potentiating IL-4 release

Yao, L., Zhao, H., Tang, H., Song, J., Dong, H., Zou, F., & Cai, S. (2015) · Toxicology Letters · doi:10.1016/j.toxlet.2015.08.1108 · Cited by 10

The Condition of Neuropathic Pain

Toth, C. C., & Moulin, D. E. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139152211.005 · Cited by 10

The salutary effects of diphenyldifluoroketone EF24 in liver of a rat hemorrhagic shock model

Yadav, V. R., Hussain, A., Xie, J., Kosanke, S. D., & Awasthi, V. (2015) · Scandinavian Journal of Trauma Resuscitation and Emergency Medicine · doi:10.1186/s13049-015-0098-y · Cited by 10

Distinct Inflammatory Mediator Patterns Characterize Infectious and Sterile Systemic Inflammation in Febrile Neutropenic Hematology Patients

Wennerås, C., Hagberg, L., Andersson, R., Hynsjö, L., Lindahl, A. H., Okrój, M., Blom, A. M., Johansson, P., Andréasson, B., Gottfries, J., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092319 · Cited by 10

Effects of bone marrow MSCs transfected with sRAGE on the intervention of HMGB1 induced immuno-inflammatory reaction.

Wang, J., Wang, H., Shi, J., & Ding, Y. (2015) · PubMed Central · Cited by 10

Assessment of HMGB-1 concentration in tick-borne encephalitis and neuroborreliosis

Moniuszko-Malinowska, A. M., Penza, P., Czupryna, P., Zajkowska, O., Pancewicz, S. A., Świerzbińska, R., Dunaj, J., & Zajkowska, J. M. (2018) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2018.03.013 · Cited by 10

Reduced-HMGB1 suppresses poly(I:C)-induced inflammation in keratinocytes

Mori, H., Murakami, M., Tsuda, T., Kameda, K., Utsunomiya, R., Masuda, K., Shiraishi, K., Dai, X., Tohyama, M., Nakaoka, H., et al. (2018) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2018.01.007 · Cited by 10

Targeted temperature management at 33°C or 36℃ induces equivalent myocardial protection by inhibiting HMGB1 release in myocardial ischemia/reperfusion injury

Beom, J. H., Kim, J. H., Seo, J., Lee, J. H., Chung, Y. E., Chung, H. S., Chung, S. P., Kim, C. H., & You, J. S. (2021) · PLoS ONE · doi:10.1371/journal.pone.0246066 · Cited by 10

High‐mobility group box‐1 in sterile inflammation

Tsung, A., Tohme, S., & Billiar, T. R. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12276 · Cited by 187

A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release

Yang, H., Hreggvidsdottir, H. S., Palmblad, K., Wang, H., Ochani, M., Li, J., Lü, B., Chavan, S. S., Rosas‐Ballina, M., Al‐Abed, Y., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003893107 · Cited by 812

Targeting Inflammation Driven by HMGB1

Yang, H., Wang, H., & Andersson, U. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00484 · Cited by 662

Targeting HMGB1 in inflammation

Yang, H., & Tracey, K. J. (2010) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2009.11.019 · Cited by 351

High Mobility Group Box 1 Protein as a Potential Drug Target for Infection- and Injury-Elicited Inflammation

Zhu, S., Li, W., Ward, M. F., Sama, A. E., & Wang, H. (2010) · Inflammation & Allergy - Drug Targets · doi:10.2174/187152810791292872 · Cited by 57