HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

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HMG-1 as a Late Mediator of Endotoxin Lethality in Mice

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Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

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Involvement of Toll-like Receptors 2 and 4 in Cellular Activation by High Mobility Group Box 1 Protein

Park, J. S., Svetkauskaite, D., He, Q., Kim, J., Strassheim, D., Ishizaka, A., & Abraham, E. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m306793200 · Cited by 1,582

High Mobility Group 1 Protein (Hmg-1) Stimulates Proinflammatory Cytokine Synthesis in Human Monocytes

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Toll-like receptor 9–dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE

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Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases

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Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis

Wang, H., Liao, H., Ochani, M., Justiniani, M., Lin, X., Yang, L., Al-Abed, Y., Wang, H., Metz, C., Miller, E. J., et al. (2004) · Nature Medicine · doi:10.1038/nm1124 · Cited by 1,170

Reflex control of immunity

Tracey, K. J. (2009) · Nature Reviews Immunology · doi:10.1038/nri2566 · Cited by 1,154

The Receptor for Advanced Glycation End Products (RAGE) Is a Cellular Binding Site for Amphoterin

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Antitumor Immunity Induced after α Irradiation

Gorin, J., Ménager, J., Gouard, S., Maurel, C., Guilloux, Y., Faivre-Chauvet, A., Morgenstern, A., Bruchertseifer, F., Chérel, M., Davodeau, F., et al. (2014) · Neoplasia · doi:10.1016/j.neo.2014.04.002 · Cited by 111

Systemic inflammation in early neonatal mice induces transient and lasting neurodegenerative effects

Cardoso, F. L., Herz, J., Fernandes, A., Rocha, J., Sepodes, B., Brito, M. A., McGavern, D. B., & Brites, D. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0299-3 · Cited by 103

The role of damage- and pathogen-associated molecular patterns in inflammation-mediated vulnerability of atherosclerotic plaques

Rai, V., & Agrawal, D. K. (2017) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2016-0664 · Cited by 103

HMGB1 downregulation in retinal pigment epithelial cells protects against diabetic retinopathy through the autophagy-lysosome pathway

Feng, L., Liang, L., Zhang, S., Yang, J., Yue, Y., & Zhang, X. (2021) · Autophagy · doi:10.1080/15548627.2021.1926655 · Cited by 105

PKR-Dependent Inflammatory Signals

Kang, R., & Tang, D. (2012) · Science Signaling · doi:10.1126/scisignal.2003511 · Cited by 103

Novel Role of Resveratrol

Xu, W. L., Lü, Y., Yao, J., Li, Z., Chen, Z., Wang, G., Jing, H., Zhang, X., Li, M., Peng, J., et al. (2014) · Shock · doi:10.1097/shk.0000000000000225 · Cited by 102

Neuroinflammation, Pain and Depression: An Overview of the Main Findings

Campos, A. C. P., Antunes, G. F., Matsumoto, M., Pagano, R. L., & Martinez, R. C. R. (2020) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.01825 · Cited by 107

High-mobility group box-1 and its role in angiogenesis

Yang, S., Xu, L., Yang, T., & Wang, F. (2014) · Journal of Leukocyte Biology · doi:10.1189/jlb.0713412 · Cited by 104

Exploring the biological functional mechanism of the HMGB1/TLR4/MD-2 complex by surface plasmon resonance

He, M., Bianchi, M. E., Coleman, T. R., Tracey, K. J., & Al‐Abed, Y. (2018) · Molecular Medicine · doi:10.1186/s10020-018-0023-8 · Cited by 101

Anti-Inflammatory Effects of Hyperoside in Human Endothelial Cells and in Mice

Ku, S., Zhou, W. P., Lee, W., Han, M. S., Na, M., & Bae, J. (2014) · Inflammation · doi:10.1007/s10753-014-9989-8 · Cited by 101

The vascular biology of macrophage migration inhibitory factor (MIF)

Asare, Y., Schmitt, M. M. N., & Bernhagen, J. (2013) · Thrombosis and Haemostasis · doi:10.1160/th12-11-0831 · Cited by 100

Salidroside ameliorates sepsis-induced acute lung injury and mortality via downregulating NF-κB and HMGB1 pathways through the upregulation of SIRT1

Lan, K., Chao, S., Wu, H.-Y., Chiang, C.-L., Wang, C., Liu, S., & Weng, T. (2017) · Scientific Reports · doi:10.1038/s41598-017-12285-8 · Cited by 99

The platelet NLRP3 inflammasome is upregulated in sickle cell disease via HMGB1/TLR4 and Bruton tyrosine kinase

Vogel, S., Arora, T. K., Wang, X., Mendelsohn, L. G., Nichols, J., Allen, D. T., Shet, A. S., Combs, C. A., Quezado, Z., & Thein, S. L. (2018) · Blood Advances · doi:10.1182/bloodadvances.2018021709 · Cited by 103

Interplay between RAGE and TLR4 Regulates HMGB1-Induced Inflammation by Promoting Cell Surface Expression of RAGE and TLR4

Zhong, H., Li, X., Zhou, S.-N., Jiang, P., Liu, X., Ouyang, M.-W., Nie, Y., Chen, X., Zhang, L., Liu, Y., et al. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.1900860 · Cited by 102

HMGB1 released from nociceptors mediates inflammation

Yang, H., Zeng, Q., Silverman, H. A., Gunasekaran, M., George, S. J., Devarajan, A., Addorisio, M. E., Li, J., Tsaava, T., Shah, V. D., et al. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2102034118 · Cited by 101

Exosome‐Based Mitochondrial Delivery of circRNA mSCAR Alleviates Sepsis by Orchestrating Macrophage Activation

Fan, L., Li, Y., Li, Z., Wan, Z., Sun, W., Qiu, S., Zhang, W., Xiao, D., Song, L., Yang, G., et al. (2023) · Advanced Science · doi:10.1002/advs.202205692 · Cited by 99

Oxidative Stress Elicits Platelet/Leukocyte Inflammatory Interactions via HMGB1: A Candidate for Microvessel Injury in Sytemic Sclerosis

Maugeri, N., Rovere, P. Q., Baldini, M., Baldissera, E. M., Sabbadini, M. G., Bianchi, M. E., & Manfredi, A. A. (2013) · Antioxidants and Redox Signaling · doi:10.1089/ars.2013.5298 · Cited by 97

Extracellular High-Mobility Group Box 1 Protein (HMGB1) as a Mediator of Persistent Pain

Agalave, N. M., & Svensson, C. I. (2014) · Molecular Medicine · doi:10.2119/molmed.2014.00176 · Cited by 99

Tissue damage negatively regulates LPS-induced macrophage necroptosis

Li, Z. A., Scott, M. J., Fan, E., Li, Y., Liu, J., Xiao, G., Li, S., Billiar, T. R., Wilson, M. A., Jiang, Y., et al. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.21 · Cited by 98

Toll-Like Receptor 4 (TLR4) Expression and Stimulation in a Model of Intervertebral Disc Inflammation and Degeneration

Rajan, N., Bloom, O., Maidhof, R., Stetson, N., Sherry, B. A., Levine, M. E., & Chahine, N. O. (2012) · Spine · doi:10.1097/brs.0b013e31826b71f4 · Cited by 97

Emerging role of HMGB1 in lung diseases: friend or foe

Ding, J., Cui, X., & Liu, Q. (2016) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.13048 · Cited by 95

The Role of HMGB1, a Nuclear Damage-Associated Molecular Pattern Molecule, in the Pathogenesis of Lung Diseases

Wang, M., Gauthier, A. G., Daley, L.-A., Dial, K., Wu, J., Woo, J., Lin, M., Ashby, C. R., & Mantell, L. L. (2019) · Antioxidants and Redox Signaling · doi:10.1089/ars.2019.7818 · Cited by 95

Immunomodulating effects of epigallocatechin-3-gallate from green tea: mechanisms and applications

Pae, M., & Wu, D. (2013) · Food & Function · doi:10.1039/c3fo60076a · Cited by 95

Oleanolic acid enhances tight junctions and ameliorates inflammation in Salmonella typhimurium -induced diarrhea in mice via the TLR4/NF-κB and MAPK pathway

Dong, N., Xue, C., Zhang, L., Zhang, T., Wang, C., Bi, C., & Shan, A. (2019) · Food & Function · doi:10.1039/c9fo01718f · Cited by 95

Glycyrrhizin protects brain against ischemia–reperfusion injury in mice through HMGB1-TLR4-IL-17A signaling pathway

Zhang, J., Wu, Y., Weng, Z., Zhou, T., Feng, T., & Lin, Y. (2014) · Brain Research · doi:10.1016/j.brainres.2014.07.002 · Cited by 94

HMGB1–C1q complexes regulate macrophage function by switching between leukotriene and specialized proresolving mediator biosynthesis

Liu, T., Xiang, A., Peng, T., Doran, A. C., Tracey, K. J., Barnes, B. J., Tabas, I. A., Son, M., & Diamond, B. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1907490116 · Cited by 93

Tubular Epithelial Cell HMGB1 Promotes AKI-CKD Transition by Sensitizing Cycling Tubular Cells to Oxidative Stress: A Rationale for Targeting HMGB1 during AKI Recovery

Zhao, Z., Marschner, J. A., Iwakura, T., Li, C., Motrapu, M., Kuang, M., Popper, B., Linkermann, A., Klocke, J., Enghard, P., et al. (2023) · Journal of the American Society of Nephrology · doi:10.1681/asn.0000000000000024 · Cited by 93

Emerging role of HMGB 1 in fibrotic diseases

Li, L., Gao, J., & Li, J. (2014) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12419 · Cited by 93

High mobility group box 1 ( HMGB 1) as a novel frontier in epileptogenesis: from pathogenesis to therapeutic approaches

Paudel, Y. N., Semple, B. D., Jones, N. C., Othman, I., & Shaikh, M. F. (2019) · Journal of Neurochemistry · doi:10.1111/jnc.14663 · Cited by 92

miR-181b increases drug sensitivity in acute myeloid leukemia via targeting HMGB1 and Mcl-1

Lu, F., Zhang, J., JI, M., Li, P., Du, Y., Wang, H., ZANG, S., Ma, D., Sun, X., & Ji, C. (2014) · International Journal of Oncology · doi:10.3892/ijo.2014.2390 · Cited by 91

TLR4 as receptor for HMGB1-mediated acute lung injury after liver ischemia/reperfusion injury

Yang, Z., Deng, Y., Su, D., Tian, J., Gao, Y., He, Z., & Wang, X. (2013) · Laboratory Investigation · doi:10.1038/labinvest.2013.66 · Cited by 91

CD52 glycan binds the proinflammatory B box of HMGB1 to engage the Siglec-10 receptor and suppress human T cell function

Bandala‐Sanchez, E., Bediaga, N. G., Goddard‐Borger, E. D., Ngui, K., Naselli, G., Stone, N. L., Neale, A. M., Pearce, L. A., Wardak, A. Z., Czabotar, P. E., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1722056115 · Cited by 91

Immunogenic Cell Death, DAMPs and Prothymosin α as a Putative Anticancer Immune Response Biomarker

Birmpilis, A. I., Paschalis, A., Mourkakis, A., Christodoulou, P., Kostopoulos, I. V., Antimissari, E., Terzoudi, G. I., Georgakilas, A. G., Armpilia, C., Papageorgis, P., et al. (2022) · Cells · doi:10.3390/cells11091415 · Cited by 91

WONOEP appraisal: Molecular and cellular biomarkers for epilepsy

Walker, L. E., Janigro, D., Heinemann, U., Riikonen, R., Bernard, C., & Patel, M. (2016) · Epilepsia · doi:10.1111/epi.13460 · Cited by 91

Activation of Plant Innate Immunity by Extracellular High Mobility Group Box 3 and Its Inhibition by Salicylic Acid

Choi, H. W., Manohar, M., Manosalva, P. M., Tian, M., Moreau, M., & Klessig, D. F. (2016) · PLoS Pathogens · doi:10.1371/journal.ppat.1005518 · Cited by 90

HMGB1 is a mediator of cuproptosis-related sterile inflammation

Liu, J., Liu, Y., Wang, Y., Kang, R., & Tang, D. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.996307 · Cited by 89

HMGB1, an innate alarmin, plays a critical role in chronic inflammation of adipose tissue in obesity

Zhang, J., Zhang, L., Zhang, S., Yu, Q., Xiong, F., Huang, K., Wang, C., & Yang, P. C. (2017) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2017.06.012 · Cited by 91

HuR and miR-1192 regulate myogenesis by modulating the translation of HMGB1 mRNA

Dormoy-Raclet, V., Cammas, A., Celona, B., Lian, X. J., van der Giessen, K., Zivojnovic, M., Brunelli, S., Riuzzi, F., Sorci, G., Wilhelm, B. T., et al. (2013) · Nature Communications · doi:10.1038/ncomms3388 · Cited by 89

HMGB1‐associated necroptosis and Kupffer cells M1 polarization underlies remote liver injury induced by intestinal ischemia/reperfusion in rats

Wen, S., Li, X., Ling, Y., Chen, S., Deng, Q., Yang, L., Li, Y., Shen, J., Qiu, Y., Zhan, Y., et al. (2020) · The FASEB Journal · doi:10.1096/fj.201900817r · Cited by 89

Anti-Inflammatory Effects of SGLT2 Inhibitors: Focus on Macrophages

RYKOVA, E. Y., Klimontov, V. V., Shmakova, E. O., Korbut, A. I., Merkulova, T. I., & Kzhyshkowska, J. G. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26041670 · Cited by 92

Inflammation-induced DNA damage and damage-induced inflammation: a vicious cycle

Palmai‐Pallag, T., & Bachrati, C. Z. (2014) · Microbes and Infection · doi:10.1016/j.micinf.2014.10.001 · Cited by 88

Identification of a functional interaction of HMGB1 with Receptor for Advanced Glycation End-products in a model of neuropathic pain

Allette, Y. M., Due, M. R., Wilson, S. M., Feldman, P., Ripsch, M. S., Khanna, R., & White, F. A. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.06.199 · Cited by 89

Blocking Cold-Inducible RNA-Binding Protein Protects Liver From Ischemia-Reperfusion Injury

Godwin, A. K., Yang, W.-L., Sharma, A., Khader, A., Wang, Z., Zhang, F., Nicastro, J. M., Coppa, G. F., & Wang, P. (2014) · Shock · doi:10.1097/shk.0000000000000251 · Cited by 87

Berberine protects against ischemia-reperfusion injury: A review of evidence from animal models and clinical studies

Liu, D.-Q., Chen, S., Sun, J., Wang, X., Chen, N., Zhou, Y., Tian, Y., & Ye, D. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.104385 · Cited by 86

The Role of Toll-Like Receptors in Diabetes-Induced Inflammation: Implications for Vascular Complications

Jialal, I., & Kaur, H. (2012) · Current Diabetes Reports · doi:10.1007/s11892-012-0258-7 · Cited by 86

The receptor for advanced glycation end-products: A complex signaling scenario for a promiscuous receptor

Armando Rojas, R., Delgado‐López, F., González, I., Pérez-Castro, R., Romero, J. A., & Rojas, I. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2012.11.022 · Cited by 86

Mitochondrial Transcription Factor A, an Endogenous Danger Signal, Promotes TNFα Release via RAGE- and TLR9-Responsive Plasmacytoid Dendritic Cells

Julian, M. W., Shao, G., VanGundy, Z. C., Papenfuss, T. L., & Crouser, E. D. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072354 · Cited by 85

Airway Epithelial Derived Cytokines and Chemokines and Their Role in the Immune Response to Respiratory Syncytial Virus Infection

Glaser, L., Coulter, P. J., Shields, M. D., Touzelet, O., Power, U. F., & Broadbent, L. (2019) · Pathogens · doi:10.3390/pathogens8030106 · Cited by 88

The amazing innate immune response to influenza A virus infection

Tripathi, S., White, M. R., & Hartshorn, K. L. (2013) · Innate Immunity · doi:10.1177/1753425913508992 · Cited by 88

Identification of Hemopexin as an Anti-Inflammatory Factor That Inhibits Synergy of Hemoglobin with HMGB1 in Sterile and Infectious Inflammation

Lin, T., Sammy, F., Yang, H., Thundivalappil, S. R., Hellman, J., Tracey, K. J., & Warren, H. S. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103623 · Cited by 85

The Multitasking Potential of Alarmins and Atypical Chemokines

Kapurniotu, A., Gökçe, Ö., & Bernhagen, J. (2019) · Frontiers in Medicine · doi:10.3389/fmed.2019.00003 · Cited by 85

The multifunctional alarmin HMGB1 with roles in the pathophysiology of sepsis and cancer

Diener, K. R., Al‐Dasooqi, N., Lousberg, E. L., & Hayball, J. D. (2013) · Immunology and Cell Biology · doi:10.1038/icb.2013.25 · Cited by 84

TLR4 as receptor for HMGB1 induced muscle dysfunction in myositis

Zong, M., Bruton, J. D., Grundtman, C., Yang, H., Li, J. H., Alexanderson, H., Palmblad, K., Andersson, U., Harris, H. E., Lundberg, I. E., et al. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2012-202207 · Cited by 84

Necroptosis is a key mediator of enterocytes loss in intestinal ischaemia/reperfusion injury

Wen, S., Ling, Y., Yang, W., Shen, J., Li, C., Deng, W., Liu, W., & Liu, K. (2016) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.12987 · Cited by 85

High mobility group box-1 (HMGB1) is increased in injured mouse spinal cord and can elicit neurotoxic inflammation

Kigerl, K. A., Lai, W., Wallace, L. M., Yang, H., & Popovich, P. G. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.11.018 · Cited by 83

The Effect and Regulatory Mechanism of High Mobility Group Box-1 Protein on Immune Cells in Inflammatory Diseases

Ge, Y., Huang, M., & Yao, Y.-M. (2021) · Cells · doi:10.3390/cells10051044 · Cited by 86

High-mobility group box 1 represents a potential marker of disease activity and novel therapeutic target in systemic lupus erythematosus

Urbonaviciute, V., & Voll, R. E. (2011) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2011.02432.x · Cited by 85

Mitochondrial Lysates Induce Inflammation and Alzheimer's Disease-Relevant Changes in Microglial and Neuronal Cells

Wilkins, H., Carl, S. M., Weber, S. G., Ramanujan, S., Festoff, B. W., Linseman, D. A., & Swerdlow, R. H. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-142334 · Cited by 83

Role of Extracellular Damage-Associated Molecular Pattern Molecules (DAMPs) as Mediators of Persistent Pain

Kato, J., & Svensson, C. I. (2015) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2014.11.014 · Cited by 85

Immune-mediated liver injury of the cancer therapeutic antibody catumaxomab targeting EpCAM, CD3 and Fcγ receptors

Borlak, J. T., Länger, F. P., Spanel, R., Schöndorfer, G., & Dittrich, C. (2016) · Oncotarget · doi:10.18632/oncotarget.8574 · Cited by 86

Soluble HMGB1 Is a Novel Adipokine Stimulating IL-6 Secretion through RAGE Receptor in SW872 Preadipocyte Cell Line: Contribution to Chronic Inflammation in Fat Tissue

Nativel, B., Marimoutou, M., Thon-Hon, V. G., Gunasekaran, M., Andries, J., Stanislas, G., Planesse, C., Silva, C. R. D., Césari, M., Iwema, T., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076039 · Cited by 81

Role of extracellular vesicles in the development of sepsis-induced coagulopathy

Iba, T., & Ogura, H. (2018) · Journal of Intensive Care · doi:10.1186/s40560-018-0340-6 · Cited by 82

Combination Cancer Immunotherapy of Nanoparticle-Based Immunogenic Cell Death Inducers and Immune Checkpoint Inhibitors

Qi, J., Jin, F., Xu, X., & Du, Y. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s285999 · Cited by 83

Toll-like Receptor 4 (TLR4) Antagonist Eritoran Tetrasodium Attenuates Liver Ischemia and Reperfusion Injury through Inhibition of High-Mobility Group Box Protein B1 (HMGB1) Signaling

McDonald, K.-A., Huang, H., Tohme, S. T., Loughran, P., Ferrero, K. M., Billiar, T. R., & Tsung, A. (2014) · Molecular Medicine · doi:10.2119/molmed.2014.00076 · Cited by 80

Intestinal epithelial HMGB1 inhibits bacterial infection via STAT3 regulation of autophagy

Zhang, Y., Zhu, X., Lu, R., Messer, J. S., Xia, Y., Chang, E. B., & Sun, J. (2019) · Autophagy · doi:10.1080/15548627.2019.1596485 · Cited by 81

Glycyrrhizin prevents SARS-CoV-2 S1 and Orf3a induced high mobility group box 1 (HMGB1) release and inhibits viral replication

Gowda, P., Patrick, S., Joshi, S. D., Kumawat, R. K., & Sen, E. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155496 · Cited by 79

Kaempferol: Unveiling its anti-inflammatory properties for therapeutic innovation

Herrera, T. E. S., Tello, I. P. S., Mustafa, M. A., Jamil, N. Y., Alaraj, M., Altameemi, K. K. A., Alasheqi, M. Q., Hamoody, A.-H. M., Alkhafaji, A. T., Shakir, M. N., et al. (2025) · Cytokine · doi:10.1016/j.cyto.2024.156846 · Cited by 83

The Cytokine mRNA Increase Induced by Withdrawal from Chronic Ethanol in the Sterile Environment of Brain is Mediated by CRF and HMGB1 Release

Whitman, B. A., Knapp, D. J., Werner, D. F., Crews, F. T., & Breese, G. R. (2013) · Alcoholism Clinical and Experimental Research · doi:10.1111/acer.12189 · Cited by 82

Autophagy induction contributes to the resistance to methotrexate treatment in rheumatoid arthritis fibroblast-like synovial cells through high mobility group box chromosomal protein 1

Xu, K., Cai, Y., Lu, S., Li, X.-L., Liu, L., Zhong, L., Liu, H., & Xu, P. (2015) · Arthritis Research & Therapy · doi:10.1186/s13075-015-0892-y · Cited by 79

Current insights in sepsis

Wiersinga, W. J. (2011) · Current Opinion in Critical Care · doi:10.1097/mcc.0b013e32834a4aeb · Cited by 81

Concise Review: Mesenchymal Stromal Cell-Based Approaches for the Treatment of Acute Respiratory Distress and Sepsis Syndromes

Johnson, C. L., Soeder, Y., & Dahlke, M. H. (2017) · Stem Cells Translational Medicine · doi:10.1002/sctm.16-0415 · Cited by 78

Targeting of GSDMD sensitizes HCC to anti-PD-1 by activating cGAS pathway and downregulating PD-L1 expression

Lv, T., Xiong, X., Yan, W., Liu, M., Xu, H., & He, Q. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-004763 · Cited by 79

Receptor for Advanced Glycation End Products (RAGE) on iNKT Cells Mediates Lung Ischemia–Reperfusion Injury

Sharma, A. K., LaPar, D. J., Stone, M. L., Zhao, Y., Kron, I. L., & Laubach, V. E. (2013) · American Journal of Transplantation · doi:10.1111/ajt.12368 · Cited by 79

Transcriptome Assessment Reveals a Dominant Role for TLR4 in the Activation of Human Monocytes by the Alarmin MRP8

Jorch, S. K., Austermann, J., Papantonopoulou, O., Riemenschneider, M., Xue, J., Bertheloot, D., Freise, N., Spiekermann, C., Witten, A., Viemann, D., et al. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1401085 · Cited by 80

Carbon monoxide–based therapy ameliorates acute pancreatitis via TLR4 inhibition

Xue, J., & Habtezion, A. (2013) · Journal of Clinical Investigation · doi:10.1172/jci71362 · Cited by 78

Anti-high mobility group box-1 (HMGB1) antibody attenuates delayed cerebral vasospasm and brain injury after subarachnoid hemorrhage in rats

Haruma, J., Teshigawara, K., Hishikawa, T., Wang, D., Liu, K., Wake, H., Mori, S., Takahashi, H. K., Sugiu, K., Date, I., et al. (2016) · Scientific Reports · doi:10.1038/srep37755 · Cited by 78

Poly(ADP-Ribosyl)ation of High Mobility Group Box 1 (HMGB1) Protein Enhances Inhibition of Efferocytosis

Davis, K. I., Banerjee, S., Friggeri, A., Bell, C. P., Abraham, E. H., & Zerfaoui, M. (2011) · Molecular Medicine · doi:10.2119/molmed.2011.00203 · Cited by 78

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HMGB1-Driven Inflammation and Intimal Hyperplasia After Arterial Injury Involves Cell-Specific Actions Mediated by TLR4

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Palmitoyl acyltransferase DHHC21 mediates endothelial dysfunction in systemic inflammatory response syndrome

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A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release

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