HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection

Release of chromatin protein HMGB1 by necrotic cells triggers inflammation

Scaffidi, P., Misteli, T., & Bianchi, M. E. (2002) · Nature · doi:10.1038/nature00858 · Cited by 4,221

HMG-1 as a Late Mediator of Endotoxin Lethality in Mice

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Toll-like receptor 4–dependent contribution of the immune system to anticancer chemotherapy and radiotherapy

Apetoh, L., Ghiringhelli, F., Tesniere, A., Obeid, M., Ortiz, C., Criollo, A., Mignot, G., Maiuri, M. C., Ullrich, E., Saulnier, P., et al. (2007) · Nature Medicine · doi:10.1038/nm1622 · Cited by 3,056

Involvement of Toll-like Receptors 2 and 4 in Cellular Activation by High Mobility Group Box 1 Protein

Park, J. S., Svetkauskaite, D., He, Q., Kim, J., Strassheim, D., Ishizaka, A., & Abraham, E. H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m306793200 · Cited by 1,582

High Mobility Group 1 Protein (Hmg-1) Stimulates Proinflammatory Cytokine Synthesis in Human Monocytes

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Toll-like receptor 9–dependent activation by DNA-containing immune complexes is mediated by HMGB1 and RAGE

Tian, J., Avalos, A. M., Mao, S.-Y., Chen, B., Senthil, K., Wu, H., Parroche, P., Drabic, S., Golenbock, D., Sirois, C., et al. (2007) · Nature Immunology · doi:10.1038/ni1457 · Cited by 1,372

Blockade of RAGE-amphoterin signalling suppresses tumour growth and metastases

Taguchi, A., Blood, D. C., del Toro, G., Canet, A., Lee, D. C., Qu, W., Tanji, N., Lu, Y., Lalla, E., Fu, C., et al. (2000) · Nature · doi:10.1038/35012626 · Cited by 1,217

Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis

Wang, H., Liao, H., Ochani, M., Justiniani, M., Lin, X., Yang, L., Al-Abed, Y., Wang, H., Metz, C., Miller, E. J., et al. (2004) · Nature Medicine · doi:10.1038/nm1124 · Cited by 1,170

Reflex control of immunity

Tracey, K. J. (2009) · Nature Reviews Immunology · doi:10.1038/nri2566 · Cited by 1,154

The Receptor for Advanced Glycation End Products (RAGE) Is a Cellular Binding Site for Amphoterin

Hori, O., Brett, J., Slattery, T., Cao, R., Zhang, J., Chen, J. X., Nagashima, M., Lundh, E. R., Vijay, S., Nitecki, D., et al. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.43.25752 · Cited by 1,151

Innate Immune System in the Pathogenesis of Non-Alcoholic Fatty Liver Disease

Ma, D. W., Ha, J., Yoon, K., Kang, I., Choi, T. G., & Kim, S. S. (2023) · Nutrients · doi:10.3390/nu15092068 · Cited by 26

Epithelial Cell Apoptosis in Recurrent Aphthous Ulcers

Al‐Samadi, A., Drozd, A., Salem, A., Hietanen, J. H., Häyrinen‐Immonen, R., & Konttinen, Y. T. (2015) · Journal of Dental Research · doi:10.1177/0022034515581012 · Cited by 24

Rituximab-induced HMGB1 release is associated with inhibition of STAT3 activity in human diffuse large B-cell lymphoma

Zhao, T., Ren, H., Wang, X., Liu, P., Fan, Y. L., Jiang, W., Li, Y., Li, J., Gribben, J. G., Jia, L., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.4816 · Cited by 24

Combined biomarkers discriminate a low likelihood of bacterial infection among surgical intensive care unit patients with suspected sepsis

Kelly, B. J., Lautenbach, E., Nachamkin, I., Coffin, S. E., Gerber, J. S., Fuchs, B. D., Garrigan, C., Han, X., Bilker, W. B., Wise, J. A., et al. (2016) · Diagnostic Microbiology and Infectious Disease · doi:10.1016/j.diagmicrobio.2016.01.003 · Cited by 24

Hypothermia inhibits the propagation of acute ischemic injury by inhibiting HMGB1

Lee, J. H., Yoon, E. J., Seo, J., Kavoussi, A., Chung, Y. E., Chung, S. P., Park, I., Kim, C. H., & You, J. S. (2016) · Molecular Brain · doi:10.1186/s13041-016-0260-0 · Cited by 24

Inhibition of DAMP signaling as an effective adjunctive treatment strategy in pneumococcal meningitis

Masouris, I., Klein, M., Dyckhoff-Shen, S., Angele, B., Pfister, H., & Koedel, U. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0989-0 · Cited by 24

Formononetin inhibits lipopolysaccharide-induced release of high mobility group box 1 by upregulating SIRT1 in a PPARδ-dependent manner

Hwang, J. S., Kang, E. S., Han, S. G., Lim, D., Paek, K. S., Lee, C.-H., & Seo, H. G. (2018) · PeerJ · doi:10.7717/peerj.4208 · Cited by 24

miR‑199a‑3p suppresses cervical epithelial cell inflammation by inhibiting the HMGB1/TLR4/NF‑κB pathway in preterm birth

Peng, J., Jiang, J., Wang, H., Feng, X., & Dong, X. (2020) · Molecular Medicine Reports · doi:10.3892/mmr.2020.11184 · Cited by 24

PTPN14 aggravates inflammation through promoting proteasomal degradation of SOCS7 in acute liver failure

Fu, B., Yin, S., Lin, X., Shi, L., Wang, Y., Zhang, S., Zhao, Q., Li, Z., Yang, Y., & Wu, H. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03014-7 · Cited by 24

Anti-septic Effects of Fisetin In Vitro and In Vivo

Yoo, H., Ku, S., Han, M. S., Kim, K., & Bae, J. (2014) · Inflammation · doi:10.1007/s10753-014-9883-4 · Cited by 24

Expression of the Receptor for Advanced Glycation End Products, a Target for High Mobility Group Box 1 Protein, and its Role in Chronic Recalcitrant Rhinosinusitis with Nasal Polyps

Dżaman, K., Szczepański, M. J., Molińska-Glura, M., Krzeski, A., & Zagor, M. (2014) · Archivum Immunologiae et Therapiae Experimentalis · doi:10.1007/s00005-014-0325-7 · Cited by 24

Inhibition of TLR4 signaling protects mice from sensory and motor dysfunction in an animal model of autoimmune peripheral neuropathy

Oladiran, O., Shi, X., Yang, M., Fournier, S., & Zhang, J. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02126-x · Cited by 23

Recombinant Klotho Protein Ameliorates Myocardial Ischemia/Reperfusion Injury by Attenuating Sterile Inflammation

Myung, J., Beom, J. H., Kim, J., Woo, J. S., Park, I., Chung, S. P., Chung, Y. E., & You, J. S. (2022) · Biomedicines · doi:10.3390/biomedicines10040894 · Cited by 23

A century of exercise physiology: lung fluid balance during and following exercise

Miserocchi, G., & Beretta, E. P. (2022) · European Journal of Applied Physiology · doi:10.1007/s00421-022-05066-3 · Cited by 23

An overview of hyperbaric oxygen preconditioning against ischemic stroke

Wu, X., You, J., Chen, X., Zhou, M., Ma, H., Zhang, T., & Huang, C. (2023) · Metabolic Brain Disease · doi:10.1007/s11011-023-01165-y · Cited by 25

Extracellular Vesicles in Sepsis: Pathogenic Roles, Organ Damage, and Therapeutic Implications

An, N., Chen, Z., Zhao, P., & Yin, W. (2023) · International Journal of Medical Sciences · doi:10.7150/ijms.86832 · Cited by 23

Role of Toll-like receptors and retinoic acid inducible gene I in endogenous production of type I interferon in dermatomyositis

Li, L., Dai, T., Lv, J., Ji, K., Liu, J., Zhang, B., & Yan, C. (2015) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2015.06.009 · Cited by 25

High-mobility group box 1 accelerates early acute allograft rejection via enhancing IL-17+γδ T-cell response

Xia, Q., Duan, L., Shi, L., Zheng, F., Gong, F., & Fang, M. (2014) · Transplant International · doi:10.1111/tri.12264 · Cited by 23

FIP200 is Involved in Murine Pseudomonas Infection by Regulating HMGB1 Intracellular Translocation

Li, Y., Gan, C., Zhang, S., Zhou, X., Li, X., Wei, Y., Yang, J., & Wu, M. (2014) · Cellular Physiology and Biochemistry · doi:10.1159/000362954 · Cited by 23

Inhibitory effects of epi-sesamin on HMGB1-induced vascular barrier disruptive responses in vitro and in vivo

Lee, W., Ku, S., Kim, J. A., Lee, T., & Bae, J. (2013) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2013.01.008 · Cited by 23

Novel insights for high mobility group box 1 protein-mediated cellular immune response in sepsis:A systemic review

Huang, L., Yao, Y.-M., & Sheng, Z.-Y. (2012) · World Journal of Emergency Medicine · doi:10.5847/wjem.j.issn.1920-8642.2012.03.001 · Cited by 23

Involvement of HMGB1 in Resistance to Tumor Vessel-Targeted, Monoclonal Antibody-Based Immunotherapy

Pistoia, V., & Pezzolo, A. (2016) · Journal of Immunology Research · doi:10.1155/2016/3142365 · Cited by 23

S100A10 Regulates ULK1 Localization to ER–Mitochondria Contact Sites in IFN-γ-Triggered Autophagy

Chen, Y.-D., Fang, Y.-T., Chang, C., Lin, C., Hsu, L., Wu, S.-R., Chiu, Y., Anderson, R., & Lin, Y.-S. (2016) · Journal of Molecular Biology · doi:10.1016/j.jmb.2016.11.009 · Cited by 23

Air blood barrier phenotype correlates with alveolo-capillary O2 equilibration in hypobaric hypoxia

Beretta, E. P., Lanfranconi, F., Grasso, G. S., Bartesaghi, M., Alemayehu, H. K., Pratali, L., Catuzzo, B., Giardini, G., & Miserocchi, G. (2017) · Respiratory Physiology & Neurobiology · doi:10.1016/j.resp.2017.08.006 · Cited by 23

The Role of High Mobility Group Box 1 Protein (HMGB1) in the Immunopathology of Experimental Pulmonary Tuberculosis

Hernández‐Pando, R., Barrios‐Payán, J., Mata‐Espinosa, D., Marquina‐Castillo, B., Hernández‐Ramírez, D. F., Botasso, O. A., & Bini, E. I. (2015) · PLoS ONE · doi:10.1371/journal.pone.0133200 · Cited by 23

Role of gut microbiota in neuroinflammation: a focus on perioperative neurocognitive disorders

Zhou, Q., Chen, T., Wang, X., Xu, Z., Song, Y., Liu, S., Ge, Y., & Gao, J. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1582909 · Cited by 24

The Potential Role of HMGB1 Release in Peritoneal Dialysis-Related Peritonitis

Cao, S., Li, S., Li, H., Xiong, L., Zhou, Y., Fan, J., Yu, X., & Mao, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054647 · Cited by 22

Microenvironmental Alterations in Carbon Nanotube-Induced Lung Inflammation and Fibrosis

Dong, J. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00126 · Cited by 22

Structure-based design of glycyrrhetinic acid derivatives as potent anti-sepsis agents targeting high-mobility group box-1

Wang, Y., Yu, Z., Yuan, H., Chen, H., Xie, N., Wang, Z., Sun, Q., & Zhang, W. (2020) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2020.104461 · Cited by 22

The cross‐talk between RAGE and DIAPH1 in neurological complications of diabetes: A review

Zglejc‐Waszak, K., Mukherjee, K., & Juranek, J. K. (2021) · European Journal of Neuroscience · doi:10.1111/ejn.15433 · Cited by 22

Systematic Development of Peptide Inhibitors Targeting the CXCL12/HMGB1 Interaction

Sgrignani, J., Cecchinato, V., Fassi, E. M. A., D’Agostino, G., Garofalo, M., Danelon, G., Pedotti, M., Simonelli, L., Varani, L., Grazioso, G., et al. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.1c00852 · Cited by 22

The role of HMGB1 in inflammatory skin diseases

Satoh, T. K. (2022) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2022.07.005 · Cited by 22

A multiscale inflammatory map: linking individual stress to societal dysfunction

Yoram Vodovotz, B., Arciero, J. C., Verschure, P. F. M. J., & Katz, D. L. (2024) · Frontiers in Science · doi:10.3389/fsci.2023.1239462 · Cited by 22

The Expression of HMGB 1 on Microparticles from Jurkat and HL ‐60 Cells Undergoing Apoptosisin vitro

Spencer, D. M., Mobarrez, F., Wallén, H., & Pisetsky, D. S. (2014) · Scandinavian Journal of Immunology · doi:10.1111/sji.12191 · Cited by 22

TNF and EPO: major players in the innate immune response: their discovery

Cerami, A. (2012) · Annals of the Rheumatic Diseases · doi:10.1136/annrheumdis-2011-200800 · Cited by 22

Traumatic Brain Injury: Lungs in a RAGE

Nicolls, M. R., & Laubach, V. E. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3010259 · Cited by 22

The in Vitro Immune-Modulating Properties of a Sweat Gland-Derived Antimicrobial Peptide Dermcidin

Wang, E., Qiang, X., Li, J., Zhu, S., & Wang, P. (2015) · Shock · doi:10.1097/shk.0000000000000488 · Cited by 22

Paeonol Inhibits Lipopolysaccharide-Induced HMGB1 Translocation from the Nucleus to the Cytoplasm in RAW264.7 Cells

Lei, H., Wen, Q., Li, H., Du, S., Wu, J., Chen, J., Huang, H., Chen, D., Li, Y., Zhang, S., et al. (2016) · Inflammation · doi:10.1007/s10753-016-0353-z · Cited by 22

HMGB1 May Be a Biomarker for Predicting the Outcome in Patients with Polymyositis /Dermatomyositis with Interstitial Lung Disease

Shu, X., Peng, Q., Lü, X., & Wang, G. (2016) · PLoS ONE · doi:10.1371/journal.pone.0161436 · Cited by 22

The Role of High-Mobility Group Box-1 and Its Crosstalk with Microbiome in Rheumatoid Arthritis

Biscetti, F., Flex, A., Alivernini, S., Tolusso, B., Gremese, E., & Ferraccioli, G. (2017) · Mediators of Inflammation · doi:10.1155/2017/5230374 · Cited by 23

Characterization of Three Ocular Clinical Isolates of P. aeruginosa: Viability, Biofilm Formation, Adherence, Infectivity, and Effects of Glycyrrhizin

Peng, X., Ekanayaka, S. A., McClellan, S. A., Barrett, R. P., Vistisen, K. S., & Hazlett, L. D. (2017) · Pathogens · doi:10.3390/pathogens6040052 · Cited by 22

Therapeutic time window of anti-high mobility group box-1 antibody administration in mouse model of spinal cord injury

Nakajo, M., Uezono, N., Nakashima, H., Wake, H., Komiya, S., Nishibori, M., & Nakashima, K. (2018) · Neuroscience Research · doi:10.1016/j.neures.2018.03.004 · Cited by 22

Porcine reproductive and respiratory syndrome virus induces concurrent elevation of High Mobility Group Box-1 protein and pro-inflammatory cytokines in experimentally infected piglets

Senthilkumar, D., Rajukumar, K., Kumar, M., Kalaiyarasu, S., Shrivastava, D., Katare, M., Kulkarni, D. D., & Singh, V. P. (2018) · Cytokine · doi:10.1016/j.cyto.2018.06.002 · Cited by 22

MicroRNA-193a Downregulates HMGB1 to Alleviate Diabetic Neuropathic Pain in a Mouse Model

Wu, B., Guo, Y., Chen, Q., Xiong, Q., & Min, S. (2019) · NeuroImmunoModulation · doi:10.1159/000503325 · Cited by 22

Novel Resolution Mediators of Severe Systemic Inflammation

Gudernatsch, V., Stefanczyk, S. A., & Mirakaj, V. (2020) · ImmunoTargets and Therapy · doi:10.2147/itt.s243238 · Cited by 24

Novel Synthetic and Natural Therapies for Traumatic Brain Injury

Battaglini, D., Siwicka-Gieroba, D., Rocco, P. R. M., Cruz, F. F., Silva, P. L., Dąbrowski, W., Brunetti, I., Patroniti, N. A., Pelosi, P. P., & Robba, C. (2021) · Current Neuropharmacology · doi:10.2174/1570159x19666210225145957 · Cited by 22

Effects and mechanisms of cavidine protecting mice against LPS-induced endotoxic shock

Li, W., Zhang, H., Niu, X., Wang, X., Wang, Y., He, Z., & Yao, H. (2016) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2016.05.021 · Cited by 22

Roles of High Mobility Group Box 1 in Cardiovascular Calcification

Chen, Q., Wang, Z., Chen, L., & Hu, H. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000477591 · Cited by 22

Involvement of role of HMGB1-NLRP3 pathway in systemic disorders

Yang, L., Li, X., Zhu, X., Ge, F., & Wang, Y. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1600596 · Cited by 21

Sterile inflammation in MASH: emerging role of extracellular RNA and therapeutic strategies

Raza, S., Mahamood, R., Medhe, P., Shahi, A., Yadav, A., Tewari, A., & Sinha, R. A. (2025) · npj Metabolic Health and Disease · doi:10.1038/s44324-025-00083-0 · Cited by 21

Nucleic acid sensing and beyond: virtues and vices of high‐mobility group box 1

Yanai, H., & Taniguchi, T. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12285 · Cited by 21

Sterile inflammation – do innate lymphoid cell subsets play a role?

Russell, S. E. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00246 · Cited by 21

Saquinavir plus methylprednisolone ameliorates experimental acute lung injury

Zhang, G., Zhang, X., Huang, H., Ji, Y., Li, D., & Jiang, W. (2018) · Brazilian Journal of Medical and Biological Research · doi:10.1590/1414-431x20187579 · Cited by 21

Inhibition of LOX-1 alleviates the proinflammatory effects of high-mobility group box 1 in Aspergillus fumigatus keratitis

Jiang, J.-Q., Li, C., Cui, C., Ma, Y.-N., Zhao, G., Peng, X.-D., Xu, Q., Wang, Q., Zhu, G.-Q., & Li, C. (2019) · International Journal of Ophthalmology · doi:10.18240/ijo.2019.06.03 · Cited by 21

LPS Primes Brain Responsiveness to High Mobility Group Box-1 Protein

Peek, V., Harden, L. M., Damm, J., Aslani, F., Leisengang, S., Roth, J., Gerstberger, R., Meurer, M., von Köckritz‐Blickwede, M., Schulz, S., et al. (2021) · Pharmaceuticals · doi:10.3390/ph14060558 · Cited by 21

Synthesis and anti-inflammatory activities of glycyrrhetinic acid derivatives containing disulfide bond

Zhang, Q., Wang, Y., Wang, Z., Mohammed, E. A. H., Zhao, Q., He, D., & Wang, Z. (2021) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2021.105542 · Cited by 21

Pevonedistat, a first-in-class NEDD8-activating enzyme inhibitor, sensitizes cancer cells to VSVΔ51 oncolytic virotherapy

Wong, B., Bergeron, A., Maznyi, G., Ng, K., Jirovec, A., Birdi, H. K., Serrano, D., Spinelli, M. M., Thomson, M., Taha, Z., et al. (2023) · Molecular Therapy · doi:10.1016/j.ymthe.2023.09.017 · Cited by 21

Sequestering HMGB1 via DNA-Conjugated Beads Ameliorates Murine Colitis

Ju, Z., Chavan, S. S., Antoine, D. J., Dancho, M. E., Tsaava, T., Li, J., Lü, B., Levine, Y. A., Stiegler, A., Tamari, Y., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103992 · Cited by 21

Inhibition of mTOR reduces lipotoxic cell death in primary macrophages through an autophagy-independent mechanism

He, L., Weber, K., Diwan, A., & Schilling, J. D. (2016) · Journal of Leukocyte Biology · doi:10.1189/jlb.3a1015-463r · Cited by 21

Gut-homing Δ42PD1+Vδ2 T cells promote innate mucosal damage via TLR4 during acute HIV type 1 infection

Cheung, A. K. L., Kwok, H., Huang, Y., Chen, M., Mo, Y., Wu, X., Lam, K. S., Kong, H.-K., Lau, T. C., Zhou, J., et al. (2017) · Nature Microbiology · doi:10.1038/s41564-017-0006-5 · Cited by 21

Activation of α7 Nicotinic Acetylcholine Receptor Ameliorates Zymosan-Induced Acute Kidney Injury in BALB/c Mice

Ibrahim, S. M., Al‐Shorbagy, M. Y., Abdallah, D. M., & El-Abhar, H. S. (2018) · Scientific Reports · doi:10.1038/s41598-018-35254-1 · Cited by 21

HMGB1 enhances mechanical stress-induced cardiomyocyte hypertrophy in�vitro via the RAGE/ERK1/2 signaling pathway

Zhang, L., Yang, X., Jiang, G., Yu, Y., Wu, J., Su, Y., Sun, A., Zou, Y., Jiang, H., & Ge, J. (2019) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2019.4276 · Cited by 21

Role of Atypical Chemokines and Chemokine Receptors Pathways in the Pathogenesis of COPD

Nucera, F., Bello, F. L., Shen, S., Ruggeri, P., Coppolino, I., Stefano, A. D., Stellato, C., Casolaro, V., Hansbro, P. M., Adcock, I. M., et al. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867327999200819145327 · Cited by 21

Nucleosome loss facilitates the chemotactic response of macrophages

Toma, I. D., Rossetti, G., Zambrano, S., Bianchi, M. E., & Agresti, A. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12286 · Cited by 21

Treatment with Anti-HMGB1 Monoclonal Antibody Does Not Affect Lupus Nephritis in MRL/lpr Mice

Schaper, F., van Timmeren, M. M., Petersen, A. H., Horst, G., Bijl, M., Limburg, P. C., Westra, J., & Heeringa, P. (2016) · Molecular Medicine · doi:10.2119/molmed.2015.00176 · Cited by 21

Intestinal preservation for transplantation

Oltean, M. (2015) · Current Opinion in Organ Transplantation · doi:10.1097/mot.0000000000000187 · Cited by 21

The HIV Protease Inhibitor Saquinavir Inhibits HMGBl-Driven Inflammation by Targeting the Interaction of Cathepsin V with TLR4/MyD88

Pribis, J. P., Al‐Abed, Y., Yang, H., Gerő, D., Xu, H., Montenegro, M. F., Bauer, E. M., Kim, S., Chavan, S. S., Cai, C., et al. (2015) · Molecular Medicine · doi:10.2119/molmed.2015.00197 · Cited by 20

Anti-septic effects of pelargonidin on HMGB1-induced responses in vitro and in vivo

Min, G., Ku, S., Park, M. S., Park, T. J., Lee, H., & Bae, J. (2016) · Archives of Pharmacal Research · doi:10.1007/s12272-016-0834-5 · Cited by 20

N-glycosylation of High Mobility Group Box 1 protein (HMGB1) modulates the interaction with glycyrrhizin: A molecular modeling study

Vergoten, G., & Bailly, C. (2020) · Computational Biology and Chemistry · doi:10.1016/j.compbiolchem.2020.107312 · Cited by 20

From Inflammation to Fibrosis: Novel Insights into the Roles of High Mobility Group Protein Box 1 in Schistosome-Induced Liver Damage

Zhong, H., Gui, X., Hou, L., Lv, R., & Jin, Y. (2022) · Pathogens · doi:10.3390/pathogens11030289 · Cited by 20

Sophoridine inhibits endotoxin-induced acute lung injury by enhancing autophagy of macrophage and reducing inflammation

Liang, J., Liu, J., Tang, Y., Peng, Q., Zhang, L., Ma, X., Xu, N., Wei, J., & Han, H. (2022) · Journal of Leukocyte Biology · doi:10.1002/jlb.3ma0322-428r · Cited by 20

HMGB1 increases RAGE expression in vascular smooth muscle cells via ERK and p-38 MAPK-dependent pathways

Jang, E. J., Kim, H., Baek, S. E., Jeon, E. Y., Kim, J. W., Kim, J. Y., & Kim, C. D. (2022) · Korean Journal of Physiology and Pharmacology · doi:10.4196/kjpp.2022.26.5.389 · Cited by 20

Oxidative Stress-Induced HMGB1 Translocation in Myenteric Neurons Contributes to Neuropathy in Colitis

Stavely, R. G., Sahakian, L., Filippone, R. T., Stojanovska, V., Bornstein, J. C., Sakkal, S., & Nurgali, K. (2022) · Biomolecules · doi:10.3390/biom12121831 · Cited by 20

Repetitive Transcranial Magnetic Stimulation (rTMS) Improves Cognitive Impairment and Intestinal Microecological Dysfunction Induced by High-Fat Diet in Rats

Jin, K., Chen, B., Han, S., Dong, J., Cheng, S., Qin, B. Y., & Lü, J. (2024) · Research · doi:10.34133/research.0384 · Cited by 21

Pharmacologic Suppression of Inflammation by a Diphenyldifluoroketone, EF24, in a Rat Model of Fixed-Volume Hemorrhage Improves Survival

Yadav, V. R., Sahoo, K. K., Roberts, P. R., & Awasthi, V. (2013) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.113.208009 · Cited by 22

Inhibition of CaMKIV relieves streptozotocin-induced diabetic neuropathic pain through regulation of HMGB1

Zhao, X., Shen, L., Xu, L., Wang, Z., Ma, C., & Huang, Y. (2015) · BMC Anesthesiology · doi:10.1186/s12871-016-0191-4 · Cited by 20

Properties of Human Embryonic Stem Cells and Their Differentiated Derivatives Depend on Nonhistone DNA-Binding HMGB1 and HMGB2 Proteins

Bagherpoor, A. J., Bohačiaková, D., Bárta, T., Kučírek, M., Sani, S. A., Ešner, M., Bosakova, M. K., Vinarský, V., Pešková, L., Hampl, A., et al. (2016) · Stem Cells and Development · doi:10.1089/scd.2016.0274 · Cited by 20

Porcine reproductive and respiratory syndrome virus induces HMGB1 secretion via activating PKC-delta to trigger inflammatory response

Wang, R., Yang, L., Zhang, Y., Li, J., Xu, L., Xiao, Y., Zhang, Q., Bai, L., Zhao, S., Liu, E., et al. (2018) · Virology · doi:10.1016/j.virol.2018.02.021 · Cited by 20

High mobility group box 1 as a biomarker in critically ill patients

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Role of toll-like receptor 4 in the regulation of the cell death pathway and neuroinflammation

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α7 Nicotinic Acetylcholine Receptor Signaling Modulates Ovine Fetal Brain Astrocytes Transcriptome in Response to Endotoxin

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Inhibition of HMGB1 Promotes Osseointegration under Hyperglycemic Condition through Improvement of BMSC Dysfunction

Liu, B., Gan, X., Zhao, Y., Yu, H., Gao, J., & Yu, H. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/1703709 · Cited by 20

The GSK‑3β/β‑catenin signaling pathway is involved in HMGB1‑induced chondrocyte apoptosis and cartilage matrix degradation

Shu, Z., Miao, X., Tang, T., Zhan, P., Zeng, L., & Jiang, Y. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4460 · Cited by 20

Cardiopulmonary Bypass Induces Acute Lung Injury via the High-Mobility Group Box 1/Toll-Like Receptor 4 Pathway

Deng, Y., Hou, L., Xu, Q., Liu, Q., Su, P., Gao, Y., Dixon, R. A. F., He, Z., & Wang, X. (2020) · Disease Markers · doi:10.1155/2020/8854700 · Cited by 20

Co-treatment with disulfiram and glycyrrhizic acid suppresses the inflammatory response of chondrocytes

Li, C., Li, L., & Lan, T. (2021) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-021-02262-3 · Cited by 20

Elevated high-mobility group B1 levels in active adult-onset Still’s disease associated with systemic score and skin rash

Jung, J., Suh, C., Sohn, S., Nam, J., & Kim, H. (2016) · Clinical Rheumatology · doi:10.1007/s10067-016-3314-x · Cited by 20

GTS-21, an α7nAChR agonist, increases pulmonary bacterial clearance in mice by restoring hyperoxia-compromised macrophage function

Sitapara, R. A., Gauthier, A. G., Patel, V., Lin, M., Zur, M., Ashby, C. R., & Mantell, L. L. (2020) · Molecular Medicine · doi:10.1186/s10020-020-00224-9 · Cited by 19

Harnessing the Immunogenic Potential of Gold Nanoparticle-Based Platforms as a Therapeutic Strategy in Breast Cancer Immunotherapy: A Mini Review

Chen, X., Yung, L. L., Tan, P. H., & Bay, B. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.865554 · Cited by 20

High Mobility Group Protein B1 Decreases Surface Localization of PD-1 to Augment T-cell Activation

Gao, Q., Wang, S., Li, F., Lian, J., Cheng, S., Yue, D., Zhang, Z., Liu, S., Ren, F., Zhang, D., et al. (2022) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-21-0652 · Cited by 19

DNA-mediated proteolysis by neutrophil elastase enhances binding activities of the HMGB1 protein

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Plasticity and crosstalk of mesenchymal stem cells and macrophages in immunomodulation in sepsis

Tao, X., Wang, J., Liu, B., Cheng, P.-F., Mu, D., Du, H., & Niu, B. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1338744 · Cited by 20

The Sterile Inflammation in the Exacerbation of HBV‐Associated Liver Injury

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The Emerging Role of the Receptor for Advanced Glycation End Products on Innate Immunity

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Sodium tanshinone IIA sulfonate prevents hypoxic trophoblast‐induced endothelial cell dysfunction via targeting HMGB1 release

Zhao, M., Feng, Y., Xiao, J., Liang, J., Yin, Y., & Chen, D. (2017) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.21903 · Cited by 19

Expression profiling and microbial ligand binding analysis of high-mobility group box-1 (HMGB1) in turbot (Scophthalmus maximus L.)

Cai, X. M., Gao, C., Su, B., Tan, F., Yang, N., & Wang, G. (2018) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2018.04.025 · Cited by 19

Licorice cream promotes full-thickness wound healing in Guinea pigs

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Systemic lidocaine inhibits high-mobility group box 1 messenger ribonucleic acid expression and protein in BALB/c mice after closed fracture musculoskeletal injury

Hatta, M., Sirait, R., Ramli, M., Islam, A., & Arief, S. K. (2018) · Saudi Journal of Anaesthesia · doi:10.4103/sja.sja_685_17 · Cited by 19

N-(2′-Hydroxyphenyl)-2-propylpentanamide (OH-VPA), a histone deacetylase inhibitor, induces the release of nuclear HMGB1 and modifies ROS levels in HeLa cells

de Oca, A. C.-M., Rodarte-Valle, E., Rosales‐Hernández, M. C., Abarca‐Rojano, E., Rojas-Hernández, S., Fragoso-Vázquez, M. J., Mendieta‐Wejebe, J. E., Correa-Basurto, A. M., Vásquez-Moctezuma, I., & Correa‐Basurto, J. (2018) · Oncotarget · doi:10.18632/oncotarget.26077 · Cited by 19

Chrysophanol alleviates myocardial injury in diabetic db/db mice by regulating the SIRT1/HMGB1/NF‑κB signaling pathway

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Correlation of host inflammatory cytokines and immune-related metabolites, but not viral NS1 protein, with disease severity of dengue virus infection

Soe, H. J., Manikam, R., Raju, C. S., Khan, M. A., & Sekaran, S. D. (2020) · PLoS ONE · doi:10.1371/journal.pone.0237141 · Cited by 19

High‐mobility group box‐1 in sterile inflammation

Tsung, A., Tohme, S., & Billiar, T. R. (2014) · Journal of Internal Medicine · doi:10.1111/joim.12276 · Cited by 187

A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release

Yang, H., Hreggvidsdottir, H. S., Palmblad, K., Wang, H., Ochani, M., Li, J., Lü, B., Chavan, S. S., Rosas‐Ballina, M., Al‐Abed, Y., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003893107 · Cited by 812

Targeting Inflammation Driven by HMGB1

Yang, H., Wang, H., & Andersson, U. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00484 · Cited by 662

Targeting HMGB1 in inflammation

Yang, H., & Tracey, K. J. (2010) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2009.11.019 · Cited by 351

High Mobility Group Box 1 Protein as a Potential Drug Target for Infection- and Injury-Elicited Inflammation

Zhu, S., Li, W., Ward, M. F., Sama, A. E., & Wang, H. (2010) · Inflammation & Allergy - Drug Targets · doi:10.2174/187152810791292872 · Cited by 57