Targeting HMGB1 in inflammation
Open accessAbstract
High mobility group box 1 (HMGB1), a highly conserved, ubiquitous protein present in the nuclei and cytoplasm of nearly all cell types, is a necessary and sufficient mediator of inflammation during sterile and infection-associated responses. Elevated levels of HMGB1 in serum and tissues occur during sterile tissue injury and during infection, and targeting HMGB1 with antibodies or specific antagonists is protective in established preclinical inflammatory disease models including lethal endotoxemia or sepsis, collagen-induced arthritis, and ischemia-reperfusion induced tissue injury. Future advances in this field will stem from understanding the biological basis for the success of targeting HMGB1 to therapeutic improvement in the treatment of inflammation, infection and ischemia-reperfusion induced injury.
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HMGB-1 is a potent proinflammatory signaling molecule that is released under inflammatory conditions, including sepsis and ischemia.
“Past research conducted on peripheral immune cells demonstrates that HMGB-1 is a potent proinflammatory signaling molecule that is released under inflammatory conditions, including sepsis and ischemia (Yang and Tracey, 2009).”
From Repeated Social Defeat, Neuroinflammation, and Behavior: Monocytes Carry the Signal (2017) · cites this paper as Yang and Tracey, 2009
Neuronal release of HMGB-1 typically occurs during necrotic conditions, such as ischemia and sepsis.
“Typically, neuronal release of HMGB-1 occurs during necrotic conditions, such as ischemia (Yang and Tracey, 2009) and sepsis (Yang et al, 2004).”
From Repeated Social Defeat, Neuroinflammation, and Behavior: Monocytes Carry the Signal (2017) · cites this paper as Yang and Tracey, 2009
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- Authors
- Yang, H., & Tracey, K. J.
- Affiliations
- Feinstein Institute for Medical Research (US)
- Corresponding author
- Yang, Huan
- Venue
- Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
- Publisher
- Elsevier BV
- Published
- 2010-01
- Volume
- 1799
- Issue
- 1-2
- Pages
- 149-156
- ISSN
- 1874-9399 (ISSN-L)
- PMC
- PMC4533842
- OpenAlex
- W1983348216
- Cited by
- 351
- References
- 113
- Citations by year
- 2026: 9 · 2025: 16 · 2024: 4 · 2023: 9 · 2022: 24 · 2021: 20 · 2020: 28 · 2019: 14 · 2018: 24 · 2017: 25 · 2016: 23 · 2015: 27 · 2014: 34 · 2013: 23 · 2012: 34
- FWCI
- 15.12
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (R01GM062508)
- National Center for Research Resources (MOL RR018535, M01RR018535)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Advanced Glycation End Products research
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › S100 Proteins and Annexins
- Keywords
- HMGB1, high mobility group box 1, inflammation, infection, endotoxemia, sepsis, collagen-induced arthritis, ischemia-reperfusion injury, inflammatory disease therapy
- MeSH terms
- Animals, Disease, Humans, Immunity, Inflammation, Receptors, Immunologic, Cytokines, HMGB1 Protein
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