The Interaction Between Signal Regulatory Protein Alpha (SIRPα) and CD47: Structure, Function, and Therapeutic Target

Role of CD47 as a Marker of Self on Red Blood Cells

Oldenborg, P., Zheleznyak, A., Fang, Y., Lagenaur, C. F., Gresham, H. D., & Lindberg, F. P. (2000) · Science · doi:10.1126/science.288.5473.2051 · Cited by 2,018

CD47 Is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells

Majeti, R., Chao, M. P., Alizadeh, A. A., Pang, W. W., Jaiswal, S., Gibbs, K. D., van Rooijen, N., & Weissman, I. L. (2009) · Cell · doi:10.1016/j.cell.2009.05.045 · Cited by 1,752

The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

Willingham, S. B., Volkmer, J.-P., Gentles, A. J., Sahoo, D., Dalerba, P. D., Mitra, S. S., Wang, J., Contreras-Trujillo, H., Martin, R. K., Cohen, J. D., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1121623109 · Cited by 1,706

CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis

Jaiswal, S., Jamieson, C. H. M., Pang, W. W., Park, C. Y., Chao, M. P., Majeti, R., Traver, D. J., van Rooijen, N., & Weissman, I. L. (2009) · Cell · doi:10.1016/j.cell.2009.05.046 · Cited by 1,578

Licensing of natural killer cells by host major histocompatibility complex class I molecules

Kim, S., Poursine‐Laurent, J., Truscott, S. M., Lybarger, L. P., Song, Y.-J., Yang, L., French, A. R., Sunwoo, J. B., Lemieux, S., Hansen, T. H., et al. (2005) · Nature · doi:10.1038/nature03847 · Cited by 1,328

Anti-CD47 Antibody Synergizes with Rituximab to Promote Phagocytosis and Eradicate Non-Hodgkin Lymphoma

Chao, M. P., Alizadeh, A. A., Tang, C. Z., Myklebust, J. H., Varghese, B., Gill, S. I., Jan, M., Cha, A. C., Chan, C. K. F., Tan, B. T., et al. (2010) · Cell · doi:10.1016/j.cell.2010.07.044 · Cited by 1,124

Minimal "Self" Peptides That Inhibit Phagocytic Clearance and Enhance Delivery of Nanoparticles

Rodriguez, P. L., Harada, T., Christian, D. A., Pantano, D. A., Tsai, R. K., & Discher, D. E. (2013) · Science · doi:10.1126/science.1229568 · Cited by 1,001

Integrin-associated protein (CD47) and its ligands

Brown, E. (2001) · Trends in Cell Biology · doi:10.1016/s0962-8924(00)01906-1 · Cited by 880

Transposition mediated by RAG1 and RAG2 and its implications for the evolution of the immune system

Agrawal, A., Eastman, Q. M., & Schatz, D. G. (1998) · Nature · doi:10.1038/29457 · Cited by 811

Calreticulin Is the Dominant Pro-Phagocytic Signal on Multiple Human Cancers and Is Counterbalanced by CD47

Chao, M. P., Jaiswal, S., Weissman-Tsukamoto, R., Alizadeh, A. A., Gentles, A. J., Volkmer, J., Weiskopf, K., Willingham, S. B., Raveh, T., Park, C. Y., et al. (2010) · Science Translational Medicine · doi:10.1126/scitranslmed.3001375 · Cited by 776

CD 47‐signal regulatory protein α signaling system and its application to cancer immunotherapy

Murata, Y., Saito, Y., Kotani, T., & Matozaki, T. (2018) · Cancer Science · doi:10.1111/cas.13663 · Cited by 110

Preclinical development of a novel CD47 nanobody with less toxicity and enhanced anti-cancer therapeutic potential

Ma, L., Zhu, M., Gai, J., Li, G., Chang, Q., Peng, Q., Cao, L., Chen, W., Zhang, S., & Wan, Y. (2020) · Journal of Nanobiotechnology · doi:10.1186/s12951-020-0571-2 · Cited by 111

Putting the brakes on phagocytosis: “don't-eat-me” signaling in physiology and disease

Kelley, S. M., & Ravichandran, K. S. (2021) · EMBO Reports · doi:10.15252/embr.202152564 · Cited by 117

Oncogenic KRAS signaling drives evasion of innate immune surveillance in lung adenocarcinoma by activating CD47

Hu, H., Cheng, R., Wang, Y., Wang, X., Wu, J., Kong, Y., Zhan, S., Zhou, Z., Zhu, H., Yu, R., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci153470 · Cited by 111

Nucleic acid drug vectors for diagnosis and treatment of brain diseases

Lü, Z., Shen, J., Yang, H. J., Wang, J., Zhao, R., Zhang, T.-L., Guo, J. R., & Zhang, X. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01298-z · Cited by 116

A bispecific antibody targeting GPC3 and CD47 induced enhanced antitumor efficacy against dual antigen-expressing HCC

Du, K., Li, Y., Liu, J., Chen, W., Wei, Z., Luo, Y., Liu, H., Qi, Y., Wang, F., & Sui, J. (2021) · Molecular Therapy · doi:10.1016/j.ymthe.2021.01.006 · Cited by 107

Molecular Mechanism of Tumor Cell Immune Escape Mediated by CD24/Siglec-10

Yin, S.-S., & Gao, F. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01324 · Cited by 107

Myeloid Cell Origins, Differentiation, and Clinical Implications

Weiskopf, K., Schnorr, P. J., Pang, W. W., Chao, M. P., Chhabra, A., Seita, J., Feng, M., & Weissman, I. L. (2016) · Microbiology Spectrum · doi:10.1128/microbiolspec.mchd-0031-2016 · Cited by 104

Mertk on tumor macrophages is a therapeutic target to prevent tumor recurrence following radiation therapy

Crittenden, M. R., Baird, J. R., Friedman, D. J., Savage, T., Uhde, L., Alice, A. F., Cottam, B., Young, K. H., Newell, P., Nguyen, C., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.11823 · Cited by 104

Critical role of integrin CD11c in splenic dendritic cell capture of missing-self CD47 cells to induce adaptive immunity

Wu, J., Wu, H., An, J., Ballantyne, C. M., & Cyster, J. G. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1805542115 · Cited by 106

Immunoreceptors on neutrophils

van Rees, D. J., Szilagyi, K., Kuijpers, T. W., Matlung, H. L., & van den Berg, T. K. (2016) · Seminars in Immunology · doi:10.1016/j.smim.2016.02.004 · Cited by 100

Prospects for chimeric antigen receptor-modified T cell therapy for solid tumors

Zhang, E., Gu, J., & Xu, H. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0759-3 · Cited by 103

Axl and Mertk Receptors Cooperate to Promote Breast Cancer Progression by Combined Oncogenic Signaling and Evasion of Host Antitumor Immunity

Davra, V., Kumar, S., Geng, K., Calianese, D. C., Mehta, D., Gadiyar, V., Kasikara, C., Lahey, K. C., Chang, Y., Wichroski, M. J., et al. (2020) · Cancer Research · doi:10.1158/0008-5472.can-20-2066 · Cited by 96

Signal‐regulatory protein α from the NOD mouse binds human CD 47 with an exceptionally high affinity – implications for engraftment of human cells

Kwong, L. S., Brown, M. H., Barclay, A. N., & Hatherley, D. (2014) · Immunology · doi:10.1111/imm.12290 · Cited by 96

The origins and formation of bone-resorbing osteoclasts

Elson, A., Anuj, A., Barnea-Zohar, M., & Reuven, N. (2022) · Bone · doi:10.1016/j.bone.2022.116538 · Cited by 95

Engineering macrophages to phagocytose cancer cells by blocking the CD47/SIRPɑ axis

Yang, H., Shao, R., Huang, H., Wang, X., Rong, Z., & Lin, Y. (2019) · Cancer Medicine · doi:10.1002/cam4.2332 · Cited by 97

Natural Killer Cell Recruitment and Activation Are Regulated by CD47 Expression in the Tumor Microenvironment

Nath, P. R., Pal-Nath, D., Mandal, A., Cam, M. C., Schwartz, A. L., & Roberts, D. D. (2019) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-18-0367 · Cited by 96

Efferocytosis of dying cells differentially modulate immunological outcomes in tumor microenvironment

Kumar, S., Calianese, D. C., & Birge, R. B. (2017) · Immunological Reviews · doi:10.1111/imr.12587 · Cited by 93

Functional categories of immune inhibitory receptors

Rumpret, M., Drylewicz, J., Ackermans, L. J. E., Borghans, J. A. M., Medzhitov, R. M., & Meyaard, L. (2020) · Nature reviews. Immunology · doi:10.1038/s41577-020-0352-z · Cited by 94

Cell Membrane-Coated Biomimetic Nanoparticles in Cancer Treatment

Zhang, S., Zhang, X., Gao, H., Zhang, X., Sun, L., Huang, Y., Zhang, J., & Ding, B. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16040531 · Cited by 92

Immune checkpoint molecules. Possible future therapeutic implications in autoimmune diseases

Huang, C., Zhu, H., Yao, Y., Bian, Z.-H., Zheng, Y.-J., Li, L., Moutsopoulos, H. Μ., Gershwin, M. E., & Lian, Z. (2019) · Journal of Autoimmunity · doi:10.1016/j.jaut.2019.102333 · Cited by 94

Just eat it: A review of CD47 and SIRP-α antagonism

Oronsky, B. T., Carter, C. A., Reid, T. R., Brinkhaus, F., & Knox, S. J. (2020) · Seminars in Oncology · doi:10.1053/j.seminoncol.2020.05.009 · Cited by 93

Tumor-Associated Macrophages in Gliomas—Basic Insights and Treatment Opportunities

Andersen, J. K., Miletić, H., & Hossain, J. A. (2022) · Cancers · doi:10.3390/cancers14051319 · Cited by 94

Targeting CD47/SIRPα as a therapeutic strategy, where we are and where we are headed

Qu, T., Li, B., & Wang, Y. (2022) · Biomarker Research · doi:10.1186/s40364-022-00373-5 · Cited by 98

“Velcro” Engineering of High Affinity CD47 Ectodomain as Signal Regulatory Protein α (SIRPα) Antagonists That Enhance Antibody-dependent Cellular Phagocytosis

Ho, C. C. M., Ring, N. G., Sockolosky, J. T., Ring, A. M., Weiskopf, K., Özkan, E., Mori, Y., Weissman, I. L., & García, K. C. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.648220 · Cited by 88

Transgenic Expression of Human CD47 Markedly Increases Engraftment in a Murine Model of Pig-to-Human Hematopoietic Cell Transplantation

Tena, A., Kurtz, J., Leonard, D. A., Dobrinsky, J. R., Terlouw, S. L., Mtango, N. R., Verstegen, J., Germana, S. K., Mallard, C. A., Arn, J. S., et al. (2014) · American Journal of Transplantation · doi:10.1111/ajt.12918 · Cited by 88

Emerging functional markers for cancer stem cell-based therapies: Understanding signaling networks for targeting metastasis

Marquardt, S., Solanki, M., Spitschak, A., Vera, J., & Pützer, B. M. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2018.06.006 · Cited by 87

CD47: the next checkpoint target for cancer immunotherapy

Feng, R., Hai, Z., Xu, J., & Shen, C. (2020) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2020.103014 · Cited by 87

Co-expression of MET and CD47 is a novel prognosticator for survival of luminal-type breast cancer patients

Baccelli, I., Stenzinger, A., Vogel, V., Pfitzner, B. M., Klein, C., Wallwiener, M., Scharpff, M., Saini, M., Holland‐Letz, T., Sinn, H., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2385 · Cited by 86

CD47-SIRPα axis blockade in NASH promotes necroptotic hepatocyte clearance by liver macrophages and decreases hepatic fibrosis

Shi, H., Wang, X., Li, F., Gerlach, B. D., Yurdagul, A., Moore, M. P., Zeldin, S., Zhang, H., Cai, B., Zheng, Z., et al. (2022) · Science Translational Medicine · doi:10.1126/scitranslmed.abp8309 · Cited by 85

Targeting tumor-associated macrophages in head and neck squamous cell carcinoma

Li, B., Ren, M., Zhou, X., Han, Q., & Cheng, L. (2020) · Oral Oncology · doi:10.1016/j.oraloncology.2020.104723 · Cited by 87

Red Blood Cell Extracellular Vesicle-Based Drug Delivery: Challenges and Opportunities

Chiangjong, W., Netsirisawan, P., Hongeng, S., & Chutipongtanate, S. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.761362 · Cited by 87

CD47 Blockade Inhibits Tumor Progression through Promoting Phagocytosis of Tumor Cells by M2 Polarized Macrophages in Endometrial Cancer

Gu, S., Ni, T., Wang, J., Liu, Y., Fan, Q., Wang, Y., Huang, T., Chu, Y., Sun, X., & Wang, Y. (2018) · Journal of Immunology Research · doi:10.1155/2018/6156757 · Cited by 85

Clinical Relevance of Immune Checkpoints on Circulating Tumor Cells in Breast Cancer

Papadaki, M. A., Koutsopoulos, A. V., Tsoulfas, P. G., Lagoudaki, E. D., Aggouraki, D., Monastirioti, A. A., Koutoulaki, C., Apostolopoulou, C. A., Merodoulaki, A. C., Papadaki, C., et al. (2020) · Cancers · doi:10.3390/cancers12020376 · Cited by 86

Immune Checkpoint Inhibitors in Cancer Therapy—How to Overcome Drug Resistance?

Lao, Y., Shen, D., Zhang, W., He, R., & Jiang, M. (2022) · Cancers · doi:10.3390/cancers14153575 · Cited by 87

Evolving targets for the treatment of atherosclerosis

Solanki, A., Bhatt, L. K., & Johnston, T. P. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.02.002 · Cited by 83

Immunopathogenic mechanisms and immunoregulatory therapies in MASLD

He, Y., Chen, Y., Qian, S., van Der Merwe, S., Dhar, D., Brenner, D. A., & Tacke, F. (2025) · Cellular & Molecular Immunology · doi:10.1038/s41423-025-01307-5 · Cited by 81

Selective SIRPα blockade reverses tumor T cell exclusion and overcomes cancer immunotherapy resistance

Gauttier, V., Pengam, S., Durand, J., Biteau, K., Mary, C., Morello, A., Néel, M., Porto, G., Teppaz, G., Thépenier, V., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci135528 · Cited by 84

Immunological synapse: structures, molecular mechanisms and therapeutic implications in disease

Chao, Z., Mei, Q., Yang, C., Luo, J., Liu, P., Peng, H., Guo, X., Yin, Z., Li, L., & Wang, Z. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02332-6 · Cited by 96

Recent advances in biomimetic cell membrane–camouflaged nanoparticles for cancer therapy

Alimohammadvand, S., Zenjanab, M. K., Mashinchian, M., Shayegh, J., & Jahanban‐Esfahlan, R. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116951 · Cited by 79

The “Phagocytic Synapse” and Clearance of Apoptotic Cells

Barth, N. D., Marwick, J. A., Vendrell, M., Rossi, A. G., & Dransfield, I. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01708 · Cited by 78

Dual targeting of CTLA-4 and CD47 on T reg cells promotes immunity against solid tumors

Zhang, A., Ren, Z., Tseng, K., Liu, X., Li, H., Lu, C., Cai, Y., Minna, J. D., & Fu, Y. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abg8693 · Cited by 80

Location, function, and ontogeny of pulmonary macrophages during the steady state

Garbi, N., & Lambrecht, B. N. (2017) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-1965-3 · Cited by 89

TMEM30A loss-of-function mutations drive lymphomagenesis and confer therapeutically exploitable vulnerability in B-cell lymphoma

Ennishi, D., Healy, S., Bashashati, A., Saberi, S., Hother, C. E., Mottok, A., Chan, F. C., Chong, L. C., Abraham, L., Kridel, R., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0757-z · Cited by 79

Identification of Glutaminyl Cyclase isoenzyme isoQC as a regulator of SIRPα-CD47 axis

Wu, Z., Weng, L., Zhang, T., Tian, H., Fang, L., Teng, H., Zhang, W., Gao, J., Hao, Y., Li, Y., et al. (2019) · Cell Research · doi:10.1038/s41422-019-0177-0 · Cited by 78

Self-assembling paclitaxel-mediated stimulation of tumor-associated macrophages for postoperative treatment of glioblastoma

Wang, F., Huang, Q., Su, H., Sun, M., Wang, Z., Chen, Z., Zheng, M., Chakroun, R. W., Monroe, M. K., Chen, D., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2204621120 · Cited by 76

The development of small-molecule inhibitors targeting CD47

Yu, W., Ye, Z.-H., Chen, X., Shi, J.-J., & Lu, J. (2020) · Drug Discovery Today · doi:10.1016/j.drudis.2020.11.003 · Cited by 76

Human Intestinal Mononuclear Phagocytes in Health and Inflammatory Bowel Disease

Caër, C., & Wick, M. J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00410 · Cited by 76

The Paradox of Cancer Immune Exclusion: Immune Oncology Next Frontier

Pai, S. I., Cesano, A., & Marincola, F. M. (2020) · Cancer treatment and research · doi:10.1007/978-3-030-38862-1_6 · Cited by 74

The role of CD47-SIRPα immune checkpoint in tumor immune evasion and innate immunotherapy

Li, Z., Li, Y., Gao, J., Fu, Y., Hua, P., Jing, Y., Cai, M., Wang, H., & Tong, T. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119150 · Cited by 76

Multifunctional exosome-mimetics for targeted anti-glioblastoma therapy by manipulating protein corona

Wu, J., Li, Y., Wang, J., Hu, X.-B., Huang, S. Q., Luo, S., & Xiang, D. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-01153-3 · Cited by 73

Advances in cancer stem cell targeting: How to strike the evil at its root

Pützer, B. M., Solanki, M., & Herchenröder, O. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.07.013 · Cited by 73

Interferons are key cytokines acting on pancreatic islets in type 1 diabetes

de Brachène, A. C., Alvelos, M. I., Szymczak, F., Zimath, P. L., Castela, Â., de Souza, B. M., Roca-Rivada, A., Marín‐Cañas, S., Yi, X., Beeck, A. O. D., et al. (2024) · Diabetologia · doi:10.1007/s00125-024-06106-7 · Cited by 72

Enhanced expression of CD47 is associated with off-target resistance to tyrosine kinase inhibitor gefitinib in NSCLC

Nigro, A., Ricciardi, L., Salvato, I., Sabbatino, F., Vitale, M., Crescenzi, M. A., Montico, B., Triggiani, M., Pepe, S., Stellato, C., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2019.03135 · Cited by 70

Loss of myeloid cell-specific SIRPα, but not CD47, attenuates inflammation and suppresses atherosclerosis

Singla, B., Lin, H., Ahn, W., Xu, J., Ma, Q., Sghayyer, M., Dong, K., Cherian‐Shaw, M., Zhou, J., Huo, Y., et al. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab369 · Cited by 70

“Nanodecoys” - Future of drug delivery by encapsulating nanoparticles in natural cell membranes

Imran, M., Jha, L. A., Hasan, N., Shrestha, J., Pangeni, R., Parvez, N., Mohammed, Y., Jha, S. K., & Paudel, K. R. (2022) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2022.121790 · Cited by 69

CD47 Expression in Natural Killer Cells Regulates Homeostasis and Modulates Immune Response to Lymphocytic Choriomeningitis Virus

Nath, P. R., Gangaplara, A., Pal-Nath, D., Mandal, A., Maric, D., Sipes, J. M., Cam, M., Shevach, E. M., & Roberts, D. D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02985 · Cited by 69

New Strategies Using Antibody Combinations to Increase Cancer Treatment Effectiveness

Corraliza-Gorjón, I., Somovilla-Crespo, B., Santamaría, S. S., García‐Sanz, J. A., & Kremer, L. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01804 · Cited by 70

Neutrophils acquire antigen-presenting cell features after phagocytosis of IgG-opsonized erythrocytes

Meinderts, S. M., Baker, G., van Wijk, S. W., Beuger, B. M., Geissler, J., Jansen, M. H., Saris, A., ten Brinke, A., Kuijpers, T. W., van den Berg, T. K., et al. (2019) · Blood Advances · doi:10.1182/bloodadvances.2018028753 · Cited by 68

Monocytes in Tumorigenesis and Tumor Immunotherapy

Chen, X., Li, Y., Xia, H., & Chen, Y. H. (2023) · Cells · doi:10.3390/cells12131673 · Cited by 69

Xenotransplantation: back to the future?

Meier, R. P. H., Müller, Y. D., Balaphas, A., Morel, P., Pascual, M. A., Seebach, J. D., & Bühler, L. H. (2017) · Transplant International · doi:10.1111/tri.13104 · Cited by 68

SIRP/CD47 signaling in neurological disorders

Zhang, H., Li, F., Yang, Y., Chen, J., & Hu, X. (2015) · Brain Research · doi:10.1016/j.brainres.2015.03.012 · Cited by 67

A functional subset of CD8+ T cells during chronic exhaustion is defined by SIRPα expression

Myers, L. M., Tal, M. C., Torrez Dulgeroff, L. B., Carmody, A. B., Messer, R. J., Gulati, G., Yiu, Y. Y., Staron, M. M., Angel, C. L., Sinha, R., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-08637-9 · Cited by 66

Current status of xenotransplantation research and the strategies for preventing xenograft rejection

Zhou, Q., Li, T., Wang, K., Zhang, Q., Geng, Z., Deng, S., Cheng, C., & Wang, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.928173 · Cited by 72

Development of pharmacological immunoregulatory anti-cancer therapeutics: current mechanistic studies and clinical opportunities

Yin, N., Li, X., Zhang, X., Xue, S., Cao, Y., Niedermann, G., Lu, Y., & Xue, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01826-z · Cited by 74

Proteomics of Human Dendritic Cell Subsets Reveals Subset-Specific Surface Markers and Differential Inflammasome Function

Worah, K., Mathan, T. S. M., Manh, T. V., Keerthikumar, S., Schreibelt, G., Tel, J., Boer, T. D., Sköld, A. E., van Spriel, A. B., de Vries, I. J. M., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.08.023 · Cited by 71

CD 47 agonist peptide PKHB 1 induces immunogenic cell death in T‐cell acute lymphoblastic leukemia cells

Uscanga‐Palomeque, A. C., Calvillo‐Rodríguez, K. M., Gómez‐Morales, L., Lardé, E., Denèfle, T., Caballero-Hernández, D. E., Merle‐Béral, H., Susín, S. A., Karoyan, P., Martínez‐Torres, A. C., et al. (2018) · Cancer Science · doi:10.1111/cas.13885 · Cited by 69

An optimal portfolio of photothermal combined immunotherapy

Zeng, W., Li, Z., Chen, H., Zeng, X., & Mei, L. (2022) · Cell Reports Physical Science · doi:10.1016/j.xcrp.2022.100898 · Cited by 66

Regulation of Apoptotic Cell Clearance During Resolution of Inflammation

Arienti, S., Barth, N. D., Dorward, D. A., Rossi, A. G., & Dransfield, I. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00891 · Cited by 65

Long-term leukocyte reconstitution in NSG mice transplanted with human cord blood hematopoietic stem and progenitor cells

Audigé, A., Rochat, M.-A., Li, D., Ivic, S., Fahrny, A., Muller, C. K. S., Gers-Huber, G., Myburgh, R., Bredl, S., Schlaepfer, E., et al. (2017) · BMC Immunology · doi:10.1186/s12865-017-0209-9 · Cited by 64

Differently Charged Super-Paramagnetic Iron Oxide Nanoparticles Preferentially Induced M1-Like Phenotype of Macrophages

Zhang, W., Cao, S., Liang, S., Tan, C. H., Luo, B., Xu, X., & Saw, P. E. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00537 · Cited by 64

Low-density lipoprotein nanomedicines: mechanisms of targeting, biology, and theranostic potential

Di, L., & Maiseyeu, A. (2021) · Drug Delivery · doi:10.1080/10717544.2021.1886199 · Cited by 63

Mechanisms of microglia-mediated synapse turnover and synaptogenesis

Ball, J. B., Green‐Fulgham, S. M., & Watkins, L. R. (2022) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2022.102336 · Cited by 64

Innate allorecognition by monocytic cells and its role in graft rejection

Lakkis, F. G., & Li, X. C. (2017) · American Journal of Transplantation · doi:10.1111/ajt.14436 · Cited by 64

CD47 Blockade and Cowpea Mosaic Virus Nanoparticle In Situ Vaccination Triggers Phagocytosis and Tumor Killing

Wang, C., & Steinmetz, N. F. (2019) · Advanced Healthcare Materials · doi:10.1002/adhm.201801288 · Cited by 63

Immune checkpoints in tumor microenvironment and their relevance to the development of cancer stem cells

Khosravi, N., Mokhtarzadeh, A., Baghbanzadeh, A., Hajiasgharzadeh, K., Khaze, V., Hemmat, N., Safarzadeh, E., & Baradaran, B. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.118005 · Cited by 62

Development of Toll-like Receptor Agonist-Loaded Nanoparticles as Precision Immunotherapy for Reprogramming Tumor-Associated Macrophages

Zhang, Y., Chen, Y., Li, J., Zhu, X., Liu, Y., Wang, X., Wang, H., Yao, Y., Gao, Y., & Chen, Z. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c01453 · Cited by 62

TTI-621 (SIRPαFc), a CD47-blocking cancer immunotherapeutic, triggers phagocytosis of lymphoma cells by multiple polarized macrophage subsets

Lin, G. H. Y., Chai, V., Lee, V., Dodge, K., Truong, T., Wong, M., Johnson, L. D. S., Linderoth, E., Pang, X., Winston, J., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0187262 · Cited by 62

Targeting CD47/TNFAIP8 by miR-155 overcomes drug resistance and inhibits tumor growth through induction of phagocytosis and apoptosis in multiple myeloma

Rastgoo, N., Wu, J., Liu, M., Pourabdollah, M., Atenafu, E. G., Reece, D. E., Chen, W., & Chang, H. (2019) · Haematologica · doi:10.3324/haematol.2019.227579 · Cited by 62

Cancer immunotherapy based on blocking immune suppression mediated by an immune modulator LAIR-1

Xu, L., Wang, S., Li, J., Li, J., & Li, B. (2020) · OncoImmunology · doi:10.1080/2162402x.2020.1740477 · Cited by 61

Delivery of CD47 blocker SIRPα-Fc by CAR-T cells enhances antitumor efficacy

Chen, H., Yang, Y., Deng, Y., Wei, F., Zhao, Q., Liu, Y., Liu, Z., Yu, B., & Huang, Z. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-003737 · Cited by 64

Interactions between dyslipidemia and the immune system and their relevance as putative therapeutic targets in atherosclerosis

Lacy, M., Atzler, D., Liu, R., de Winther, M. P. J., Weber, C., & Lutgens, E. (2018) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2018.08.012 · Cited by 69

The Fully human anti-CD47 antibody SRF231 exerts dual-mechanism antitumor activity via engagement of the activating receptor CD32a

Peluso, M. O., Adam, A., Armet, C. M., Zhang, L., O’Connor, R. W., Lee, B. H., Lake, A. C., Normant, E., Chappel, S. C., Hill, J. A., et al. (2020) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2019-000413 · Cited by 61

Macrocyclic Peptide-Mediated Blockade of the CD47-SIRPα Interaction as a Potential Cancer Immunotherapy

Hazama, D., Yin, Y., Murata, Y., Matsuda, M., Okamoto, T., Tanaka, D., Terasaka, N., Zhao, J., Sakamoto, M., Kakuchi, Y., et al. (2020) · Cell chemical biology · doi:10.1016/j.chembiol.2020.06.008 · Cited by 61

Genetically Engineered‐Cell‐Membrane Nanovesicles for Cancer Immunotherapy

Cheng, Q., Kang, Y., Yao, B. W., Dong, J., Zhu, Y., He, Y., & Ji, X. (2023) · Advanced Science · doi:10.1002/advs.202302131 · Cited by 60

Differential Spinal and Supraspinal Activation of Glia in a Rat Model of Morphine Tolerance

Jokinen, V., Sidorova, Y. A., Viisanen, H., Suleymanova, I., Tiilikainen, H., Li, Z., Lilius, T. O., Mätlik, K., Anttila, J. E., Airavaara, M., et al. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.01.048 · Cited by 60

Targeting macrophages for enhancing CD47 blockade–elicited lymphoma clearance and overcoming tumor-induced immunosuppression

Cao, X., Wang, Y., Zhang, W., Zhong, X., Gunes, E. G., Dang, J., Wang, J., Epstein, A. L., Querfeld, C., Sun, Z., et al. (2022) · Blood · doi:10.1182/blood.2021013901 · Cited by 59

EGFR‐Induced and c‐Src‐Mediated CD47 Phosphorylation Inhibits TRIM21‐Dependent Polyubiquitylation and Degradation of CD47 to Promote Tumor Immune Evasion

Du, L., Su, Z., Wang, S., Meng, Y., Xiao, F., Xu, D., Li, X., Qian, X., Lee, S. B., Lee, J., et al. (2023) · Advanced Science · doi:10.1002/advs.202206380 · Cited by 61

Single-cell mass cytometry reveals complex myeloid cell composition in active lesions of progressive multiple sclerosis

Böttcher, C., van der Poel, M., Fernández-Zapata, C., Schlickeiser, S., Leman, J. K. H., Hsiao, C.-C., Mizee, M. R., Adelia, Vincenten, M. C. J., Kunkel, D., et al. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-01010-8 · Cited by 58

Immunoglobulin superfamily members encoded by viruses and their multiple roles in immune evasion

Farré, D., Martínez‐Vicente, P., Engel, P., & Angulo, A. (2017) · European Journal of Immunology · doi:10.1002/eji.201746984 · Cited by 58

Cell autonomous functions of CD47 in regulating cellular plasticity and metabolic plasticity

Polara, R., Ganesan, R., Pitson, S. M., & Robinson, N. (2024) · Cell Death and Differentiation · doi:10.1038/s41418-024-01347-w · Cited by 59

Resistance Mechanisms towards CD38−Directed Antibody Therapy in Multiple Myeloma

Franssen, L. E., Stege, C. A. M., Zweegman, S., van de Donk, N. W. C. J., & Nijhof, I. S. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm9041195 · Cited by 58

Cancer Immunosurveillance by T Cells

Rao, S., Gharib, K., & Han, A. S. (2018) · International review of cytology · doi:10.1016/bs.ircmb.2018.08.001 · Cited by 60

Neutrophils as immune effector cells in antibody therapy in cancer

Behrens, L. M., van Egmond, M., & van den Berg, T. K. (2022) · Immunological Reviews · doi:10.1111/imr.13159 · Cited by 62

Turning enemies into allies—reprogramming tumor-associated macrophages for cancer therapy

Molgora, M., & Colonna, M. (2021) · Med · doi:10.1016/j.medj.2021.05.001 · Cited by 56

Efferocytosis in the Central Nervous System

Zhao, J., Zhang, W., Wu, T., Wang, H., Mao, J., Liu, J., Zhou, Z., Lin, X., Yan, H., & Wang, Q. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.773344 · Cited by 57

CD47 as a promising therapeutic target in oncology

Hai, Z., Song, S., Ma, J., Yan, Z., Xie, H., Feng, Y., & Che, S. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.757480 · Cited by 58

Immunogenic cell death inducer peptides: A new approach for cancer therapy, current status and future perspectives

Aria, H., & Rezaei, M. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114503 · Cited by 57

Treg Cells Protect Dopaminergic Neurons against MPP+ Neurotoxicity via CD47-SIRPA Interaction

Huang, Y., Liu, Z., Cao, B., Qiu, Y., & Peng, Y.-P. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000464388 · Cited by 56

Coordinated balance of Rac1 and RhoA plays key roles in determining phagocytic appetite

Kim, S.-Y., Kim, S., Bae, D.-J., Park, S., Lee, G.-Y., Park, G.-M., & Kim, I. (2017) · PLoS ONE · doi:10.1371/journal.pone.0174603 · Cited by 62

The CD47-SIRP signalling system: its physiological roles and therapeutic application

Murata, Y., Kotani, T., Ohnishi, H., & Matozaki, T. (2014) · The Journal of Biochemistry · doi:10.1093/jb/mvu017 · Cited by 171

Signal regulatory protein alpha (SIRPα)/CD47 interaction and function

Barclay, A. N. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.01.008 · Cited by 113

1148 Signal-regulatory protein alpha (SIRPα) confers tumor cell resistance to anti-tumor immunity

Weng, C., Hamadene, L., Eghbali, S. Z., Venkatesh, D., Monette, S., Mangarin, L. M. B., Samaan, F., Liu, C., Holland, P. M., Wolchok, J. D., et al. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-sitc2022.1148

Potential New Cancer Immunotherapy: Anti-CD47-SIRPα Antibodies

Lu, Q., Chen, X., Wang, S., Yu, L., Yang, C., & Jiang, G. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s249822 · Cited by 35

CD47 Ligation Repositions the Inhibitory Receptor SIRPA to Suppress Integrin Activation and Phagocytosis

Morrissey, M. A., Kern, N., & Vale, R. D. (2020) · Immunity · doi:10.1016/j.immuni.2020.07.008 · Cited by 255