The Interaction Between Signal Regulatory Protein Alpha (SIRPα) and CD47: Structure, Function, and Therapeutic Target

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The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors

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Dendritic cells: the central partner for cancer immunity

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G protein-coupled receptor 183 mediates the sensitization of Burkitt lymphoma tumors to CD47 immune checkpoint blockade by anti-CD20/PI3Kδi dual therapy

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Activation of RIG‐I/MDA5 Signaling and Inhibition of CD47‐SIRPα Checkpoint with a Dual siRNA‐Assembled Nanoadjuvant for Robust Cancer Immunotherapy

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Translating CD47-targeted therapy in gastrointestinal cancers: Insights from preclinical to clinical studies

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Surfactant Protein D Inhibits Interleukin-12p40 Production by Macrophages Through the SIRPα/ROCK/ERK Signaling Pathway

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Is CD47 a potentially promising therapeutic target in cardiovascular diseases? — Role of CD47 in cardiovascular diseases

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Expression of Calcification and Extracellular Matrix Genes in the Cardiovascular System of the Healthy Domestic Sheep (Ovis aries)

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Prognostic implications of combined high expression of CD47 and MCT1 in breast cancer: a retrospective study during a 10-year period

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Cancer cell membrane targeting and red light-triggered carbon monoxide (CO) release for enhanced chemotherapy

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Deficiency in SIRP‐α cytoplasmic recruitment confers protection from acute kidney injury

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CD47-amyloid-β-CD74 signaling triggers adaptive immunosuppression in sepsis

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Therapeutic applications of cell membrane-coated nanoparticles in oral diseases: Opportunities, challenges, and future perspectives

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Tumor‐Associated Macrophages as Therapeutic Targets: Deciphering Interaction Networks and Advancing Clinical Translation

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Membrane-Mediated Cooperative Interactions of CD47 and SIRPα

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Effects of a humanized CD47 antibody and recombinant SIRPα proteins on triple negative breast carcinoma stem cells

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Anticancer immune responses are hindered by cis interaction of inhibitory checkpoint SIRPα

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Impact of SIRPα polymorphism on transplant outcomes in HLA‐identical living donor kidney transplantation

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Pluripotent Stem Cell-derived Strategies to Treat Acute Liver Failure: Current Status and Future Directions

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Anti-EpCAM Functionalized I-131 Radiolabeled Biomimetic Nanocarrier Sodium/Iodide-Symporter-Mediated Breast-Cancer Treatment

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The role of CD47 in non-neoplastic diseases

Wang, C., Feng, Y., Patel, D., Xie, H., Lv, Y., & Hai, Z. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e22905 · Cited by 11

Loss of CD47 Makes Dendritic Cells See Red

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Contributions of Nonhematopoietic Cells and Mediators to Immune Responses: Implications For Immunotoxicology

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SIRPα on CD11c + cells induces Th17 cell differentiation and subsequent inflammation in the CNS in experimental autoimmune encephalomyelitis

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Low-dose 2-deoxy glucose stabilises tolerogenic dendritic cells and generates potent in vivo immunosuppressive effects

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CD47 limits antibody dependent phagocytosis against non-malignant B cells

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Why Immunotherapy Fails in Multiple Myeloma

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The novel immune landscape of immune‐checkpoint blockade in EBV ‐associated malignancies

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New insights into therapeutic strategies for targeting hepatic macrophages to alleviate liver fibrosis

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Ferroptosis meets biomimetic nano-systems: A novel strategy for targeted cancer therapy

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Sensitization in Transplantation Assessment of Risk 2025 innate working group: The potential role of innate allorecognition in kidney allograft damage

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Design and application of ferritin-based nanomedicine for targeted cancer therapy

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Fluorescent and mass spectrometric evaluation of the phagocytic internalization of a CD47-peptide modified drug-nanocarrier

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Enhanced Macrophages Engulfment by Peptide‐Templated Nanoassemblies Targeting SIRPα and Suppressing Oxidative Stress for Atherosclerosis Pro‐Efferocytotic Therapy

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Clinical outcomes and safety of CD47-targeted immunotherapies across hematologic malignancies: a systematic review of monoclonal antibodies and fusion proteins in combination strategies

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SIRPα - CD47 axis regulates dendritic cell-T cell interactions and TCR activation during T cell priming in spleen

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CD47-SIRPα Controls ADCC Killing of Primary T Cells by PMN Through a Combination of Trogocytosis and NADPH Oxidase Activation

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Reversing Immune Suppression and Potentiating Photothermal Immunotherapy via Bispecific Immune Checkpoint Inhibitor Loaded Hollow Polydopamine Nanospheres

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Nanosystem Delivers Senescence Activators and Immunomodulators to Combat Liver Cancer

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The intratumoral microbiota biomarkers for predicting survival and efficacy of immunotherapy in patients with ovarian serous cystadenocarcinoma

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Fusions of Tumor-derived Endothelial Cells with Dendritic Cells Induces Antitumor Immunity

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E3 ubiquitin ligase HECTD2 mediates melanoma progression and immune evasion

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Expression of CD47 in the pancreatic β‐cells of people with recent‐onset type 1 diabetes varies according to disease endotype

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T-cell membrane coating for improving polymeric nanoparticle-based cancer therapy

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Cell membrane camouflaged nanoparticle strategy and its application in brain disease: a review

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A comparative genomic study across 396 liver biopsies provides deep insight into FGF21 mode of action as a therapeutic agent in metabolic dysfunction‐associated steatotic liver disease

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CD47-mediated tumor microenvironment remodeling: a central mechanism in immune evasion

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Engineered cell membrane-based nano therapies fight infectious diseases

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Promising Targeted Therapies for Hemophagocytic Lymphohistiocytosis: A Translational Perspective Based on Immunopathology

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Shedding light on macrophage immunotherapy in lung cancer

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CD47Binder: Identify CD47 Binding Peptides by Combining Next-Generation Phage Display Data and Multiple Peptide Descriptors

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Multifunctional Nanodrug‐Mediated Immunotherapy in Microsatellite Stable Colorectal Cancer via Promoting m6A Modification and M1‐Like Tumor‐Associated Macrophages Polarization

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Extracellular vesicles epitopes as potential biomarker candidates in patients with traumatic spinal cord injury

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Apoptosis-Related Gene-Mediated Cell Death Pattern Induces Immunosuppression and Immunotherapy Resistance in Gastric Cancer

Yuan, X., Zhou, J., Zhou, L., Huang, Z., Wang, W., Qiu, J., Yang, Q., Zhang, C., & Ma, M. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.921163 · Cited by 8

SIRPα + dendritic cells promote the development of fibroblastic reticular cells in murine peripheral lymph nodes

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Roles of Microglia in Synaptogenesis, Synaptic Pruning, and Synaptic Plasticity in Physiological Conditions and Central Nervous System Disorders

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Targeting SLC22A5 fosters mitophagy inhibition-mediated macrophage immunity against septic acute kidney injury upon CD47-SIRPα axis blockade

Yu, J., Li, J., Hu, B., Huang, X., Yang, X., Liu, Y., Cai, J.-J., Yang, X., Lai, J.-M., Shen, Y., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e26791 · Cited by 9

Mechanisms of allorecognition and xenorecognition in transplantation

Yun, I. H., & Yang, J. (2024) · Clinical Transplantation and Research · doi:10.4285/ctr.24.0056 · Cited by 7

Targeting myeloid cells for hematological malignancies: the present and future

Guan, Z., Zhang, Z., Wang, K., Qiao, S.-K., Ma, T., & Wu, L. (2025) · Biomarker Research · doi:10.1186/s40364-025-00775-1 · Cited by 7

Targeting KRAS in colorectal cancer (Review)

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Targeting CD37 promotes macrophage-dependent phagocytosis of multiple cancer cell types and facilitates tumor clearance in mice

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A novel oncolytic poxvirus carrying CD47 nanomabs in the treatment of pancreatic cancer by reshaping the immune microenvironment

Chen, Z., Cai, Y., Zhao, K., Qiu, A., Zhai, Y., Jiang, S., Pan, J., Zhang, P., Xiong, H., Qian, Y., et al. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217934 · Cited by 7

Immune checkpoints in immune response to glioma: two sides of the same coin

Musatova, O. E., Kumar, V. S., Vinogradov, K., & Rubtsov, Y. P. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1639521 · Cited by 7

Targeting tumor-infiltrating regulatory T cells: combining CD47 and PD-L1 inhibition via a novel aptamer-siRNA chimera

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Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

Wang, W., Mu, S., Zhang, J., Shan, G., Li, X., Wang, R., Guo, T., & He, X. (2026) · Advanced Science · doi:10.1002/advs.202519213 · Cited by 7

Restoration of miR-299-3p promotes macrophage phagocytosis and suppresses malignant phenotypes in breast cancer carcinogenesis via dual-targeting CD47 and ABCE1

Tong, S., Zhu, Y., Leng, Y., Wu, Y., Xiao, X., Zhao, W., & Tan, S. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.111708 · Cited by 7

Immunotherapy for High-Grade Gliomas

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Repurposing FDA‐Approved Compounds for the Discovery of Glutaminyl Cyclase Inhibitors as Drugs Against Alzheimer's Disease

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Erythrocyte Senescent Markers by Flow Cytometry

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Evaluating the evidence for GM-CSF as a host-directed therapy in respiratory infections

David, C., Verney, C., Si‐Tahar, M., & Guillon, A. (2025) · Cytokine · doi:10.1016/j.cyto.2025.156902 · Cited by 7

Mechanical Interactions Impact the Functions of Immune Cells and Their Application in Immunoengineering

Chen, Y., Tran, N. M., & Vining, K. H. (2025) · Advanced Therapeutics · doi:10.1002/adtp.202500067 · Cited by 6

The interplay between M2-like macrophages and Th17.1 cells promotes the progression of early-stage sarcoidosis

Zhao, Y., Zhang, X., Dong, L., Zhu, N., Zhou, D., Li, S., Lv, J., Wumaier, G., Wang, J., Zeng, Y., et al. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02566-5 · Cited by 6

Leishmania Infection-Induced Proteolytic Processing of SIRPα in Macrophages

Hirai, H., Hong, J., Fujii, W., Sanjoba, C., & Goto, Y. (2023) · Pathogens · doi:10.3390/pathogens12040593 · Cited by 6

Dual-Omics Approach Unveils Novel Perspective on the Quality Control of Genetically Engineered Exosomes

Olson, C., Ivanov, K., Boyes, D., Bengford, D., Ku, J., Flojo, R. A. B., Zhang, P., & Lü, B. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16060824 · Cited by 6

A novel anti-CD47 antibody with therapeutic potential for NK/T-cell lymphoma

Qin, L., Li, Y., Zeng, R., He, Y., Chen, X., Xiao, L., & Zhou, H. H. (2024) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2024.2408088 · Cited by 6

Expression of SIRPα-Fc by oncolytic virus enhances antitumor efficacy through tumor microenvironment reprogramming

Yang, Q., Shu, Y., Chen, Y., Qi, Z., Hu, S., Zhang, Y., Yu, Q., Xu, X., Hu, J., Huang, A., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1513555 · Cited by 6

Role of efferocytosis in chronic pain —— From molecular perspective

Zang, H., Ji, X., Yao, W., Wan, L., Zhang, C., Zhu, C., & Liu, T. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.106857 · Cited by 6

Enrichment of CD7+CXCR3+ CAR T cells in infusion products is associated with durable remission in relapsed or refractory diffuse large B-cell lymphoma.

Bartolini, R., Trueb, L., Daoudlarian, D., Joo, V., Noto, A., Stadelmann, R., Gentner, B., Fenwick, C., Perreau, M., Coukos, G., et al. (2025) · Annals of Oncology · doi:10.1016/j.annonc.2025.03.011 · Cited by 7

CD47 Blockade Leads to Chemokine-Dependent Monocyte Infiltration and Loss of B Cells from the Splenic Marginal Zone

Yiu, Y. Y., Hansen, P. S., Dulgeroff, L. B. T., Blacker, G., Myers, L. M., Galloway, S., Gars, E. J., Colace, O., Mansfield, P., Hasenkrug, K. J., et al. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.2100352 · Cited by 6

Myeloid Cell Origins, Differentiation, and Clinical Implications

Weiskopf, K., Schnorr, P. J., Pang, W. W., Chao, M. P., Chhabra, A., Seita, J., Feng, M., & Weissman, I. L. (2017) · ASM Press eBooks · doi:10.1128/9781555819194.ch50 · Cited by 6

A One-Step, Monolayer Culture and Chemical-Based Approach to Generate Insulin-Producing Cells From Human Adipose-Derived Stem Cells to Mitigate Hyperglycemia in STZ-Induced Diabetic Rats

Liang, R.-Y., Zhang, K.-L., Chuang, M., Lin, F., Chen, T., Lin, J., Liang, Y., Li, Y.-A., Chen, C., Wong, P. L. J., et al. (2022) · Cell Transplantation · doi:10.1177/09636897221106995 · Cited by 6

Molecular targets for the treatment of AML in the forthcoming 5th World Health Organization Classification of Haematolymphoid Tumours

Molica, M., & Perrone, S. (2022) · Expert Review of Hematology · doi:10.1080/17474086.2022.2140137 · Cited by 6

AL008 Enhances Myeloid Antitumor Function by Inhibiting SIRPα Signaling and Activating Fc Receptors

Yang, J., Deresa, I., Ho, W.-H., Long, H., Maslyar, D. J., Rosenthal, A., Liang, S. C., & Pincetic, A. (2023) · The Journal of Immunology · doi:10.4049/jimmunol.2200157 · Cited by 6

B7‐H3 drives immunosuppression and Co‐targeting with CD47 is a new therapeutic strategy in β‐catenin activated melanomas

Hsu, M., Martin, T. C., Vyas, N. S., Desman, G. T., Mendelson, K., Horst, B. A. J., Parsons, R. E., & Celebi, J. T. (2023) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.13091 · Cited by 6

Preclinical evaluation of the efficacy of an antibody to human SIRPα for cancer immunotherapy in humanized mouse models

Saito, Y., Iida‐Norita, R., Afroj, T., Refaat, A., Hazama, D., Komori, S., Ohata, S., Takai, T., Oduori, O. S., Kotani, T., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1294814 · Cited by 6

The Combination of Anti-CD47 Antibody with CTLA4 Blockade Enhances Anti-Tumor Immunity in Non-Small Cell Lung Cancer via Normalization of Tumor Vasculature and Reprogramming of the Immune Microenvironment

Zhuang, Z., Zhou, J., Qiu, M., Li, J., Lin, Z., Yi, H., Liu, X., Huang, C., Tang, B., Liu, B., et al. (2024) · Cancers · doi:10.3390/cancers16040832 · Cited by 6

Role of regulatory T cells in CD47/donor‐specific transfusion‐induced immune tolerance in skin‐heart transplantation mice

Hu, Y., Zhou, H., Gao, B., Wang, G., & Wang, Y. (2018) · Transplant Infectious Disease · doi:10.1111/tid.13012 · Cited by 6

Eryptosis (quasi-apoptosis) the human red blood cells. Its role in medicinal therapy

Vaschenko, V. I., & Николаевич, В. В. (2019) · Reviews on Clinical Pharmacology and Drug Therapy · doi:10.17816/rcf1735-38 · Cited by 6

Targeting CD47 Inhibits Tumor Development and Increases Phagocytosis in Oral Squamous Cell Carcinoma

Ye, X., Yang, J.-G., Tan, Y., Chen, X., & Zhou, G. (2020) · Anti-Cancer Agents in Medicinal Chemistry · doi:10.2174/1871520620999200730162915 · Cited by 6

Expression characteristics of immune factors in secondary lymphoid organs of newborn, juvenile and adult yaks (Bos grunniens)

Huang, Y., Cui, Y., Yu, S., Liu, P., Liu, J., He, J., & Sun, J. (2020) · Cell and Tissue Research · doi:10.1007/s00441-020-03219-4 · Cited by 6

SIRP-α instructs alveolar macrophages to stop eating after pneumonia

de Vos, A. F., & van der Poll, T. (2020) · Nature Immunology · doi:10.1038/s41590-020-0680-y · Cited by 6

Overexpressed CD24 and CD47 Indicate a Worse Prognosis in Cervical Cancer

Yu, M., Ni, M., Xu, F., Fang, C., Li, J., Wu, X., & Ke, G. (2025) · Cancer Medicine · doi:10.1002/cam4.71443 · Cited by 5

Immune Cells: Critical Players in Drug Resistance

Khan, S. U., Jan, S., Fatima, K., & Malik, F. A. (2024) · Springer eBooks · doi:10.1007/978-981-97-1666-1_4 · Cited by 5

The CD47-SIRP signalling system: its physiological roles and therapeutic application

Murata, Y., Kotani, T., Ohnishi, H., & Matozaki, T. (2014) · The Journal of Biochemistry · doi:10.1093/jb/mvu017 · Cited by 171

Signal regulatory protein alpha (SIRPα)/CD47 interaction and function

Barclay, A. N. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.01.008 · Cited by 113

1148 Signal-regulatory protein alpha (SIRPα) confers tumor cell resistance to anti-tumor immunity

Weng, C., Hamadene, L., Eghbali, S. Z., Venkatesh, D., Monette, S., Mangarin, L. M. B., Samaan, F., Liu, C., Holland, P. M., Wolchok, J. D., et al. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2022-sitc2022.1148

Potential New Cancer Immunotherapy: Anti-CD47-SIRPα Antibodies

Lu, Q., Chen, X., Wang, S., Yu, L., Yang, C., & Jiang, G. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s249822 · Cited by 35

CD47 Ligation Repositions the Inhibitory Receptor SIRPA to Suppress Integrin Activation and Phagocytosis

Morrissey, M. A., Kern, N., & Vale, R. D. (2020) · Immunity · doi:10.1016/j.immuni.2020.07.008 · Cited by 255