Insights into Cytokine–Receptor Interactions from Cytokine Engineering

Cell Signaling by Receptor Tyrosine Kinases

Lemmon, M. A., & Schlessinger, J. (2010) · Cell · doi:10.1016/j.cell.2010.06.011 · Cited by 7,929

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

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Mechanisms of type-I- and type-II-interferon-mediated signalling

Platanias, L. C. (2005) · Nature reviews. Immunology · doi:10.1038/nri1604 · Cited by 3,631

Differentiation of Effector CD4 T Cell Populations

Zhu, J., Yamane, H., & Paul, W. E. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101212 · Cited by 3,452

Regulation of type I interferon responses

Ivashkiv, L. B., & Donlin, L. T. (2013) · Nature reviews. Immunology · doi:10.1038/nri3581 · Cited by 3,442

Principles of interleukin (IL)-6-type cytokine signalling and its regulation

HEINRICH, P. C., BEHRMANN, I., HAAN, S., HERMANNS, H. M., MÜLLER-NEWEN, G., & SCHAPER, F. (2003) · Biochemical Journal · doi:10.1042/bj20030407 · Cited by 3,272

STATs: transcriptional control and biological impact

Levy, D. E., & Darnell, J. E. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm909 · Cited by 3,201

Interferon-stimulated genes: A complex web of host defenses

Schneider, W. M., Chevillotte, M. D., & Rice, C. M. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120231 · Cited by 3,067

A diverse range of gene products are effectors of the type I interferon antiviral response

Schoggins, J. W., Wilson, S. J., Panis, M., Murphy, M. Y., Jones, C. T., Bieniasz, P. D., & Rice, C. M. (2011) · Nature · doi:10.1038/nature09907 · Cited by 2,412

Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex

de Vos, A. M., Ultsch, M. H., & Kossiakoff, A. A. (1992) · Science · doi:10.1126/science.1549776 · Cited by 2,237

Galectokines: The Promiscuous Relationship between Galectins and Cytokines

Sanjurjo, L., Broekhuizen, E. C., Koenen, R. R., & Thijssen, V. L. (2022) · Biomolecules · doi:10.3390/biom12091286 · Cited by 21

New insights into the stemness of adoptively transferred T cells by γc family cytokines

Luo, M., Gong, W., Zhang, Y., Li, H., Ma, D., Wu, K., Gao, Q., & Fang, Y. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01354-3 · Cited by 21

Current Trends and Innovative Approaches in Cancer Immunotherapy

Kim, J.-C., Maharjan, R., & Park, J. (2024) · AAPS PharmSciTech · doi:10.1208/s12249-024-02883-x · Cited by 25

The interweaved signatures of common-gamma-chain cytokines across immunologic lineages

Baysoy, A., Seddu, K., Salloum, T., Dawson, C. A., Lee, J. J., Yang, L., Gal-Oz, S. T., Ner‐Gaon, H., Tellier, J., Millan, A. J., et al. (2023) · The Journal of Experimental Medicine · doi:10.1084/jem.20222052 · Cited by 19

Engineered cytokine/antibody fusion proteins improve IL-2 delivery to pro-inflammatory cells and promote antitumor activity

Leonard, E. K., Tomala, J., Gould, J. R., Leff, M. I., Lin, J.-X., Li, P., Porter, M. J., Johansen, E., Thompson, L., Cao, S. D., et al. (2024) · JCI Insight · doi:10.1172/jci.insight.173469 · Cited by 20

Activation of the IL-2 Receptor in Podocytes: A Potential Mechanism for Podocyte Injury in Idiopathic Nephrotic Syndrome?

Zea, A. H., Stewart, T., Ascani, J., Tate, D. J., Finkel‐Jimenez, B., Wilk, A. M., Krzysztof Reiss, F., Smoyer, W. E., & Avilés, D. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157907 · Cited by 19

Whole-genome sequencing of the invasive golden apple snail Pomacea canaliculata from Asia reveals rapid expansion and adaptive evolution

Lü, Y., Luo, F., Zhou, A., Yi, C., Chen, H., Li, J., Guo, Y., Xie, Y., Zhang, W., Lin, D., et al. (2024) · GigaScience · doi:10.1093/gigascience/giae064 · Cited by 18

A synthetic biology approach to engineering circuits in immune cells

Hoces, D., Blanco, J. M., & Hernández-López, R. A. (2023) · Immunological Reviews · doi:10.1111/imr.13244 · Cited by 19

A strategy for the selection of monovalent antibodies that span protein dimer interfaces

Spangler, J. B., Moraga, I., Jude, K. M., Savvides, C. S., & García, K. C. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.009213 · Cited by 17

Comparative expression analysis in small cell lung carcinoma reveals neuroendocrine pattern change in primary tumor versus lymph node metastases

Lohinai, Z., Megyesfalvi, Z., Suda, K., Harkó, T., Ren, S., Moldvay, J., László, V., Rivard, C. J., Döme, B., & Hirsch, F. R. (2019) · Translational Lung Cancer Research · doi:10.21037/tlcr.2019.11.30 · Cited by 18

Design and evaluation of novel interferon lambda analogs with enhanced antiviral activity and improved drug attributes

Zou, Z., Yu, D., Zhao, M., Dong, L., Zhao, L. H., Zou, M., Liu, H., Zhang, M., & Sun, H. (2016) · Drug Design Development and Therapy · doi:10.2147/dddt.s91455 · Cited by 19

Senescent Cells with Augmented Cytokine Production for Microvascular Bioengineering and Tissue Repairs

Xiao, Y., Liu, C., Chen, Z., Blatchley, M. R., Kim, D., Zhou, J., Xu, M., Gerecht, S., & Fan, R. (2019) · Advanced Biosystems · doi:10.1002/adbi.201900089 · Cited by 18

Development and Clinical Validation of a Seven-Gene Prognostic Signature Based on Multiple Machine Learning Algorithms in Kidney Cancer

Tian, M., Wang, T., & Wang, P. (2021) · Cell Transplantation · doi:10.1177/0963689720969176 · Cited by 16

Receptor control by membrane-tethered ubiquitin ligases in development and tissue homeostasis

Lebensohn, A. M., Bazán, J. F., & Rohatgi, R. (2022) · Current topics in developmental biology/Current Topics in Developmental Biology · doi:10.1016/bs.ctdb.2022.03.003 · Cited by 17

Cytokine and Chemokine Receptor Patterns of Human Malignant Melanoma Cell Lines

Koroknai, V., Szász, I., Jámbor, K., & Balázs, M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052644 · Cited by 16

Structure of the interleukin-5 receptor complex exemplifies the organizing principle of common beta cytokine signaling

Caveney, N. A., Rodriguez, G. E., Pollmann, C., Meyer, T., Borowska, M. T., Wilson, S. C., Wang, N., Xiang, X., Householder, K. D., Tao, P., et al. (2024) · Molecular Cell · doi:10.1016/j.molcel.2024.03.023 · Cited by 15

IL-6/IL-12 superfamily of cytokines and regulatory lymphocytes play critical roles in the etiology and suppression of CNS autoimmune diseases

Yadav, M. K., Singh, S. P., & Egwuagu, C. E. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1514080 · Cited by 15

Effects of Immune Cells on Intestinal Stem Cells: Prospects for Therapeutic Targets

Ma, L., Yu, J., Zhang, H., Zhao, B. T., Zhang, J., Yang, D., Luo, F., Wang, B., Jin, B., & Liu, J. (2022) · Stem Cell Reviews and Reports · doi:10.1007/s12015-022-10347-7 · Cited by 15

A topological refactoring design strategy yields highly stable granulopoietic proteins

Skokowa, J., Alvarez, B. H., Coles, M. P., Ritter, M. U., Nasri, M., Haaf, J., Aghaallaei, N., Xu, Y., Mir, P., Krahl, A.-C., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30157-2 · Cited by 14

Immune‑related gene expression in skin, inflamed and keloid tissue from patients with keloids

Shan, M., Liu, H., Song, K., Liu, S., Yan, H., & Wang, Y. (2022) · Oncology Letters · doi:10.3892/ol.2022.13192 · Cited by 14

Avian cytokines and their receptors

Bean, A. G. D., & Lowenthal, J. W. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-818708-1.00024-5 · Cited by 13

Interleukins in Platelet Biology: Unraveling the Complex Regulatory Network

Huang, M., Wang, L., Zhang, Q., Zhou, L., Liao, R., Wu, A., Wang, X., Luo, J., Huang, F., Zou, W., et al. (2024) · Pharmaceuticals · doi:10.3390/ph17010109 · Cited by 19

Structural insights into IL-11-mediated signalling and human IL6ST variant-associated immunodeficiency

Gardner, S., Jin, Y., Fyfe, P. K., Voisin, T. B., Bellón, J. S., Pöhler, E., Piehler, J., Moraga, I., & Bubeck, D. (2024) · Nature Communications · doi:10.1038/s41467-024-46235-6 · Cited by 14

CXCL10 could be a prognostic and immunological biomarker in bladder cancer

Yin, T., Mou, S., Zhang, H., Dong, Y., Yan, B., Huang, W., Liu, Y., & Mei, H. (2024) · Discover Oncology · doi:10.1007/s12672-024-00982-6 · Cited by 14

Naturally occurring and synthetic constitutive-active cytokine receptors in disease and therapy

Floss, D. M., & Scheller, J. (2019) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2019.05.007 · Cited by 14

Overexpression of IRF3 Predicts Poor Prognosis in Clear Cell Renal Cell Carcinoma

Wu, J., Leng, X., Pan, Z., Xu, L., & Zhang, H. (2021) · International Journal of General Medicine · doi:10.2147/ijgm.s328225 · Cited by 14

Cryo‐EM structure of the IL‐10 receptor complex provides a blueprint for ligand engineering

Saxton, R. A., & García, K. C. (2021) · FEBS Journal · doi:10.1111/febs.16207 · Cited by 14

Reveal the potential molecular mechanism of circRNA regulating immune-related mRNA through sponge miRNA in the occurrence and immune regulation of papillary thyroid cancer

Wang, B., Shen, W., Li, Y., Li, X., Zhang, L., Zhao, S., & Jin, X. (2023) · Annals of Medicine · doi:10.1080/07853890.2023.2244515 · Cited by 14

Engineering cell signaling modulators from native protein–protein interactions

Zhang, W., Ben-David, M., & Sidhu, S. S. (2016) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2016.11.002 · Cited by 14

Decoding the body language of immunity: Tackling the immune system at the organism level

Chevrier, N. (2019) · Current Opinion in Systems Biology · doi:10.1016/j.coisb.2019.10.010 · Cited by 13

Construction of a mitochondrial dysfunction related signature of diagnosed model to obstructive sleep apnea

Liu, Q., Hao, T., Li, L., Huang, D., Lin, Z., Fang, Y., Wang, D., & Zhang, X. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.1056691 · Cited by 13

Selection of a Full Agonist Combinatorial Antibody that Rescues Leptin Deficiency In Vivo

Tao, P., Kuang, Y., Li, Y., Li, W., Gao, Z., Liu, L., Qiang, M., Zha, Z., Fan, K., Ma, P., et al. (2020) · Advanced Science · doi:10.1002/advs.202000818 · Cited by 14

Advances in ex vivo expansion of hematopoietic stem and progenitor cells for clinical applications

Branco, A., Rayabaram, J., Miranda, C. C., Fernandes‐Platzgummer, A., Fernandes, T. G., Sajja, S., da Silva, C. L., & Vemuri, M. C. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1380950 · Cited by 13

Durable antitumor response via an oncolytic virus encoding decoy-resistant IL-18

Cheng, Y., Zhao, Y., Liu, Y., Zhang, Y., Xu, D., Sun, W., Zhang, M., Miao, Y., He, S., Hou, Y., et al. (2024) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2024-009716 · Cited by 13

Small molecules to regulate the GH/IGF1 axis by inhibiting the growth hormone receptor synthesis

van der Velden, L. M., Maas, P., van Amersfoort, M., Timmermans‐Sprang, E. P. M., Mensinga, A., van der Vaart, E. D., Malergue, F., Viëtor, H. E., Derksen, P. W. B., Klumperman, J., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.926210 · Cited by 12

Reprogramming immune proteins as therapeutics using molecular engineering

Kureshi, R., Bahri, M., & Spangler, J. B. (2017) · Current Opinion in Chemical Engineering · doi:10.1016/j.coche.2017.12.003 · Cited by 12

A chromosome-level genome assembly of Cairina moschata and comparative genomic analyses

Jiang, F., Jiang, Y., Wang, W., Xiao, C., Lin, R., Xie, T., Sung, W.-K. K., Li, S., Jakovlić, I., Chen, J., et al. (2021) · BMC Genomics · doi:10.1186/s12864-021-07897-4 · Cited by 12

Pan-cancer analysis of IFN-γ with possible immunotherapeutic significance: a verification of single-cell sequencing and bulk omics research

Wei, X., Ruan, H., Zhang, Y., Qin, T., Zhang, Y., Qin, Y., & Li, W. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1202150 · Cited by 11

Noncovalently particle-anchored cytokines with prolonged tumor retention safely elicit potent antitumor immunity

Niu, L., Jang, E., Chin, A. L., Huo, Z., Wang, W., Cai, W., & Tong, R. (2024) · Science Advances · doi:10.1126/sciadv.adk7695 · Cited by 11

Advancements in nanoparticles-based therapies for biomedical applications

Lekkala, V. V. V., Reddy, M. C., Reddy, V. C., Kanthirigala, S. K., Chitta, S., Reddy, K. R., & Lomada, D. (2024) · Nano-Structures & Nano-Objects · doi:10.1016/j.nanoso.2024.101365 · Cited by 11

Nanoparticle approaches for manipulating cytokine delivery and neutralization

Wang, R., Kubiatowicz, L. J., Zhang, R., Bao, L., Fang, R. H., & Zhang, L. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1592795 · Cited by 13

Comprehensive analysis of cuproptosis-related lncRNAs model in tumor immune microenvironment and prognostic value of cervical cancer

Wang, Q., & Xu, Y. M. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1065701 · Cited by 11

Distinct Assemblies of Heterodimeric Cytokine Receptors Govern Stemness Programs in Leukemia

Kan, W. L., Dhagat, U., Kaufmann, K. B., Hercus, T. R., Nero, T. L., Zeng, A. G. X., Toubia, J., Barry, E. F., Broughton, S. E., Gomez, G. A., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-22-1396 · Cited by 11

Effect of eleutheroside B1 on non‑coding RNAs and protein profiles of influenza A virus‑infected A549 cells

Yan, W., Chen, J., Wei, Z., Wang, X., Zeng, Z., Tembo, D. L., Wang, Y., & Wang, X. (2020) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2020.4468 · Cited by 11

Current status and relevance of single nucleotide polymorphisms in IL-6-/IL-12-type cytokine receptors

Scheller, J., Berg, A. F., Moll, J. M., Floss, D. M., & Jungesblut, C. (2021) · Cytokine · doi:10.1016/j.cyto.2021.155550 · Cited by 11

Cytokine Activation by Antibody Fragments Targeted to Cytokine-Receptor Signaling Complexes

Kuruganti, S., Miersch, S., Deshpande, A. A., Speir, J. A., Harris, B. D., Schriewer, J. M., Buller, R. M. L., Sidhu, S. S., & Walter, M. R. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.665943 · Cited by 11

Rewiring STAT signaling from the cell surface with Trikine immunotherapeutics

Rodriguez, G. E., Zhao, Y., Nishiga, Y., Peprah, F., Shen, J., Abhiraman, G. C., Ogishi, M., Zhang, C., Saco, J. D., Waghray, D., et al. (2026) · Science · doi:10.1126/science.adx9954 · Cited by 10

Sleep disturbance is associated with perturbations in immune-inflammatory pathways in oncology outpatients undergoing chemotherapy

Calvo‐Schimmel, A., Kober, K. M., Paul, S. M., Cooper, B. A., Harris, C., Shin, J., Hammer, M. J., Conley, Y. P., Dokiparthi, V., Olshen, A. B., et al. (2022) · Sleep Medicine · doi:10.1016/j.sleep.2022.11.014 · Cited by 13

What Can De Novo Protein Design Bring to the Treatment of Hematological Disorders?

Lu, H. J., Cheng, Z., Hu, Y., & Tang, L. V. (2023) · Biology · doi:10.3390/biology12020166 · Cited by 10

Innate Immune Response and Epigenetic Regulation: A Closely Intertwined Tale in Inflammation

Jawale, D., Khandibharad, S., & Singh, S. (2024) · Advanced Biology · doi:10.1002/adbi.202400278 · Cited by 11

Inflammatory Process and Role of Cytokines in Inflammation: An Overview

Muzamil, A., Tahir, H. M., Ali, S., Liaqat, I., Ali, A., & Summer, M. (2022) · Punjab University journal of zoology · doi:10.17582/journal.pujz/2021.36.2.237.252 · Cited by 14

Pathways of topological rank analysis (PoTRA): a novel method to detect pathways involved in hepatocellular carcinoma

Li, C., Liu, L., & Dinu, V. (2018) · PeerJ · doi:10.7717/peerj.4571 · Cited by 9

Identification of Potential Therapeutic Gene Markers in Nasopharyngeal Carcinoma Based on Bioinformatics Analysis

Xue, K., Cao, J., Wang, Y., Zhao, X. B., Yu, D., Jin, C., & Xu, C. (2019) · Clinical and Translational Science · doi:10.1111/cts.12690 · Cited by 9

Machine learning and bioinformatics-based insights into the potential targets of saponins in Paris polyphylla smith against non-small cell lung cancer

Wang, Y., Huang, X., Xian, B., Jiang, H., Zhou, T., Chen, S., Wen, F., & Pei, J. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.1005896 · Cited by 9

Cancer Immunotherapy: Diverse Approaches and Obstacles

Sanatkar, S. A., Heidari, A., & Rezaei, N. (2022) · Current Pharmaceutical Design · doi:10.2174/1381612828666220728160519 · Cited by 9

Alteration of growth performance and characterization of pathological lesions in long-term ammonia-exposed pigs

Oh, B., Park, J., Kim, E., Seo, S., Kim, B., & Oh, S. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.117318 · Cited by 7

Serum cytokine levels in children with community-acquired pneumonia caused by different respiratory pathogens

Duan, Y., Ou, Y., Li, J., Gan, X., & Cao, J. J. (2025) · The Italian Journal of Pediatrics/Italian journal of pediatrics · doi:10.1186/s13052-025-02012-9 · Cited by 7

The tertiary structure of γc cytokines dictates receptor sharing

Reche, P. A. (2019) · Cytokine · doi:10.1016/j.cyto.2019.01.007 · Cited by 7

Nanobodies in cytokine‑mediated immunotherapy and immunoimaging (Review)

Zhang, X., Wang, J., Tan, Y., Chen, C.-T., Tang, S., Zhao, S., Qin, Q., Huang, H., & Duan, S. (2023) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2023.5336 · Cited by 7

Engineering Anticytokine Antibodies for Immune Modulation

Tomala, J., Cao, S. D., & Spangler, J. B. (2024) · The Journal of Immunology · doi:10.4049/jimmunol.2300467 · Cited by 7

IL-1 receptor 1 signaling shapes the development of viral antigen-specific CD4+ T cell responses following COVID-19 mRNA vaccination

Park, H., Shin, M. S., Shin, J. J., Kim, H., Kang, B., Par‐Young, J., Ünlü, S., Afinogenova, Y., Catanzaro, J., Young, J. J., et al. (2024) · EBioMedicine · doi:10.1016/j.ebiom.2024.105114 · Cited by 8

An immune scoring system predicts prognosis and immune characteristics in lung adenocarcinoma brain metastases by RNA sequencing

Xiao, G., Tanzhu, G., Gao, X., Li, L., Liu, Z., Xia, X., & Zhou, R. (2024) · Acta Neuropathologica Communications · doi:10.1186/s40478-024-01895-9 · Cited by 7

The β Common Cytokine Receptor Family Reveals New Functional Paradigms From Structural Complexities

Kan, W. L., Weekley, C. M., Nero, T. L., Hercus, T. R., Yip, K. H., Tumes, D. J., Woodcock, J. M., Ross, D. M., Thomas, D., Teran, D., et al. (2025) · Immunological Reviews · doi:10.1111/imr.13430 · Cited by 7

Gene Network Mechanism of Zhilong Huoxue Tongyu Capsule in Treating Cerebral Ischemia–Reperfusion

Li, N., Sun, J., Chen, J., Bai, X., & Wang, T. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.912392 · Cited by 7

Dimethyl Fumarate (DMF) Alleviated Post-Operative (PO) Pain through the N-Methyl-d-Aspartate (NMDA) Receptors

Casili, G., Lanza, M., Filippone, A., Cucinotta, L., Paterniti, I., Repici, A., Capra, A. P., Cuzzocrea, S., Esposito, E., & Campolo, M. (2022) · Antioxidants · doi:10.3390/antiox11091774 · Cited by 7

Alterations in IL-4, IL-10 and IFN-γ levels synergistically decrease lipid content and protein expression of FAS and mature SREBP-1 in human sebocytes

Shin, J., Kim, K., Ahn, H. Y., Kim, B., & Cho, Y. (2019) · Archives of Dermatological Research · doi:10.1007/s00403-019-01932-x · Cited by 7

Cytokine/Antibody Fusion Protein Design and Evaluation

Fabilane, C. S., Stephenson, A. C., Leonard, E. K., VanDyke, D., & Spangler, J. B. (2024) · Current Protocols · doi:10.1002/cpz1.1061 · Cited by 7

Bidirectional Relationship Between Periodontal Disease and Reproductive Disorders: Focus on Polycystic Ovary Syndrome

Angiolani, F., Gerardi, D., Bernardi, S., Torge, D., Bianchi, S., Piattelli, M., & Varvara, G. (2025) · Oral · doi:10.3390/oral5030067 · Cited by 6

Exploration of prognostic genes and risk signature in breast cancer patients based on RNA binding proteins associated with ferroptosis

Chen, X., Yang, C., Wang, W., He, X., Sun, H., Lyu, W., Zou, K., Fang, S., Dai, Z., & Dong, H. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1025163 · Cited by 6

An engineered interleukin‐11 decoy cytokine inhibits receptor signaling and proliferation in lung adenocarcinoma

McIntosh, B. J., Hartmann, G. G., Yamada‐Hunter, S. A., Liu, P., Williams, C. F., Sage, J., & Cochran, J. R. (2023) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10573 · Cited by 5

Pharmacokinetics, pharmacodynamics, and toxicity of a PD-1-targeted IL-15 in cynomolgus monkeys

Ji, C., Kuang, B., Buetow, B. S., Vitsky, A., Xu, Y., Huang, T.-H., Chaparro‐Riggers, J. F., Kraynov, E. A., & Matsumoto, D. (2024) · PLoS ONE · doi:10.1371/journal.pone.0298240 · Cited by 6

Evaluation of Sapindus mukorossi Gaertn Flower Water Extract on In Vitro Anti-Acne Activity

Zhao, Z., Zhang, A., Song, L., He, C., & He, H. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47050316 · Cited by 6

Lysosomes: multifunctional compartments ruled by a complex regulatory network

Martínez‐Fábregas, J., Tamargo‐Azpilicueta, J., & Díaz‐Moreno, I. (2022) · FEBS Open Bio · doi:10.1002/2211-5463.13387 · Cited by 6

A novel immune signature predicts immunotherapy responsiveness and reveals the landscape of the tumor immune microenvironment in head and neck squamous cell carcinoma

Wang, Q., Zhao, Y., Wang, F., & Tan, G. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.1051051 · Cited by 6

Differential analysis revealing APOC1 to be a diagnostic and prognostic marker for liver metastases of colorectal cancer

Shen, H., Wei, F., & Liu, Q. (2021) · World Journal of Clinical Cases · doi:10.12998/wjcc.v9.i16.3880 · Cited by 6

Messing with βc: A unique receptor with many goals

Kan, W. L., Shing, K. S. C. T., Nero, T. L., Hercus, T. R., Tvorogov, D., Parker, M. W., & Lopez, A. F. (2021) · Seminars in Immunology · doi:10.1016/j.smim.2021.101513 · Cited by 5

Influence of a Polyherbal Choline Source in Dogs: Body Weight Changes, Blood Metabolites, and Gene Expression

Martínez, G. D. M., Hernández-García, P. A., Pérez, F. X. P., Martínez, J. A., Lizarazo-Chaparro, A. C., Martínez-Cortés, I., Campillo-Navarro, M., Lee-Rangel, H. A., de la Torre-Hernández, M. E., & Gloria-Trujillo, A. (2022) · Animals · doi:10.3390/ani12101313 · Cited by 5

A novel pyroptosis-related lncRNA prognostic signature associated with the immune microenvironment in lung squamous cell carcinoma

Zhou, W., & Zhang, W. (2022) · BMC Cancer · doi:10.1186/s12885-022-09790-z · Cited by 6

Identifying New Contributors to Brain Metastasis in Lung Adenocarcinoma: A Transcriptomic Meta-Analysis

Souza, V. G. P., Forder, A., Telkar, N., Stewart, G. L., Carvalho, R. F., Mur, L. A. J., Lam, W. L., & Reis, P. P. (2023) · Cancers · doi:10.3390/cancers15184526 · Cited by 5

Machine learning based identification of hub genes in renal clear cell carcinoma using multi-omics data

Zhang, L., Liu, M., Zhang, Z., Chen, D., Chen, G., & Liu, M. (2022) · Methods · doi:10.1016/j.ymeth.2022.09.008 · Cited by 5

Selection of M7G-related lncRNAs in kidney renal clear cell carcinoma and their putative diagnostic and prognostic role

Zhong, S., Chen, S., Lin, H., Luo, Y., & He, J. (2023) · BMC Urology · doi:10.1186/s12894-023-01357-9 · Cited by 5

De novo modeling and structural characterization of IL9-IL9 receptor complex: a potential drug target for hematopoietic stem cell therapy

Singh, S., Chaturvedi, N., & Rai, G. (2020) · Network Modeling Analysis in Health Informatics and Bioinformatics · doi:10.1007/s13721-020-00236-9 · Cited by 5

Multifunctional antibody-derived IL-12 mimetics: prospects of future clinical development

Lipinski, B., Pekar, L., Evers, A., Unmuth, L., Guarnera, E., & Zielonka, S. (2026) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2026.2613289 · Cited by 5

Effect of Gardeniae Fructus Powder on Growth Performance, Antioxidant Capacity, Intestinal Barrier Function, and Colonic Microbiota of Weaned Piglets

Liu, S., Tian, M., Ma, M., Qiu, Y., Tang, J., Hou, J. G., Lu, Q., Tian, C., Ye, G., Wang, L., et al. (2025) · Animals · doi:10.3390/ani15020221 · Cited by 4

Restoration of tendon repair microenvironment by grapefruit exosome-loaded microneedle system for tendinopathy therapy

Zhang, Y., Zhang, R., Zhang, T., Mu, Y., Juma, T., Li, X., Li, H., Guo, Q., & Cao, Y. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1615650 · Cited by 4

Structure-Guided Stapling of Dimeric Conformations and Linker Engineering Enhance Thermostability and Fine-Tune Activity of Bispecific VHH Cytokine Agonists

Trenker, R., Rokkam, D., Morin, A., Balasubrahmanyam, P., Paredes, V., Cheng, I., Malefyt, R. D. W., Oft, M., Lupardus, P. J., & Vivona, S. (2025) · Antibodies · doi:10.3390/antib14030074 · Cited by 4

Comparative analysis of serum and saliva samples using Raman spectroscopy: a high-throughput investigation in patients with polycystic ovary syndrome and periodontitis

Hu, D., Wang, J., Cheng, T., Li, H., Zhang, F., Zhao, D., Xu, X., Yu, R., Wen, P., Cheng, Y., et al. (2023) · BMC Women s Health · doi:10.1186/s12905-023-02663-y · Cited by 4

Resolving candidate genes of duck ovarian tissue transplantation via RNA-Seq and expression network analyses

Qin, Q., Liu, R., Li, Z., Liu, M., Wu, X., Wang, H., Yang, S., Sun, X., & Yi, X. (2024) · Poultry Science · doi:10.1016/j.psj.2024.103788 · Cited by 4

Dynamic Changes in Lymphocyte Subsets and Inflammation-Immune-Related Proteins in Patients with Thyroid Papillary Carcinoma before and after Radioactive Iodine Therapy

Zhang, J., Shi, L., Zhang, Z., Peng, W., Chen, P., Cao, J., Liu, J., Jin, Z., Lu, K., Wu, Z., et al. (2025) · Journal of Proteome Research · doi:10.1021/acs.jproteome.5c00128 · Cited by 4

Influence of Pregnancy on Whole-Transcriptome Sequencing in the Mammary Gland of Kazakh Mares

Zhang, Z., Zhao-Fa, L. U., Yao, X., Li, L., Meng, J., Wang, J., Zeng, Y., & Ren, W. (2025) · Animals · doi:10.3390/ani15142056 · Cited by 4

Age-Dependent Differences in Radiation-Induced DNA Damage Responses in Intestinal Stem Cells

Zhou, G., Shimura, T., Yoneima, T., Nagamachi, A., Kanai, A., Doi, K., & Sasatani, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms251810213 · Cited by 4

Protein engineering: a driving force toward synthetic immunology

Cox, J. R., & Blazeck, J. (2021) · Trends in biotechnology · doi:10.1016/j.tibtech.2021.09.005 · Cited by 5

Identification of an Innate Immune-Related Prognostic Signature in Early-Stage Lung Squamous Cell Carcinoma

Li, L., Xue, Y., Ma, G., Ji, Z., Bao, S., He, X., Song, L., Yu, Y., Shi, M., & Liu, X. (2021) · International Journal of General Medicine · doi:10.2147/ijgm.s341175 · Cited by 4

In silico mutational analysis and identification of stability centers in human interleukin-4.

Saini, S., Thakur, C. J., Kumar, V., Suhag, A., & Jakhar, N. (2018) · Europe PMC (PubMed Central) · doi:10.22099/mbrc.2018.28855.1310 · Cited by 4

The constitutive high-affinity Met-binding site in the kringle domain is dispensable for the signalling activity of hepatocyte growth factor

Umitsu, M., Sakai, K., Tamura‐Kawakami, K., Matsumoto, K., & Takagi, J. (2020) · The Journal of Biochemistry · doi:10.1093/jb/mvaa006 · Cited by 4

Deficiency of PKCλ/ι alleviates the liver pathologic impairment of Schistosoma japonicum infection by thwarting Th2 response

Mei, C., Yang, Y., Dong, P., Song, L.-J., Zhou, Y., Xu, Y., & Yu, C.-X. (2022) · Parasites & Vectors · doi:10.1186/s13071-022-05283-x · Cited by 5

Structural Basis for Signaling Through Shared Common γ Chain Cytokines

Yang, H., Kureshi, R., & Spangler, J. B. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-9367-9_1 · Cited by 4

Expression levels of key immune indicators and immune checkpoints in manganese-exposed rats

Qi, Y., Si, H., Jin, X., Guo, Y., Xia, J., He, J., Deng, X., Deng, M., Yao, W., & Hao, C. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116029 · Cited by 3

Cytokine circuitry in pancreatic cancer: Targets for overcoming immune checkpoint inhibitor resistance in PDAC

Dhanisha, S. S., Salcedo-Noriega, M. F., Vaish, U., Kannan, A. B., Suryansh, S., Bhandari, S., Chatre, S., Jain, T., Dudeja, V., & Iyer, S. (2026) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2026.01.009 · Cited by 3

Cytokine engineering for targeted immunotherapy

Bakhshi, P., Ho, J. Q., Zaer, N., Webster, T. J., & Zanganeh, S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-21521-6.00011-9

Recent and future perspectives on engineering interferons and other cytokines as therapeutics

Aung, T., Grubbe, W. S., Nusbaum, R. J., & Mendoza, J. L. (2022) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2022.09.005 · Cited by 34

The use of supercytokines, immunocytokines, engager cytokines, and other synthetic cytokines in immunotherapy

Zheng, X., Wu, Y., Bi, J., Huang, Y., Cheng, Y., Li, Y., Wu, Y., Cao, G., & Tian, Z. (2022) · Cellular and Molecular Immunology · doi:10.1038/s41423-021-00786-6 · Cited by 157

Emerging principles of cytokine pharmacology and therapeutics

Saxton, R. A., Glassman, C. R., & García, K. C. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00557-6 · Cited by 223

Engineering cytokine receptors to control cellular functions

Kawahara, M., Ueda, H., & Nagamune, T. (2009) · Biochemical Engineering Journal · doi:10.1016/j.bej.2009.09.010 · Cited by 24