The DOI matches its Crossref record; 203 of the 203 references it cites were found in a registry or an index.
Insights into Cytokine–Receptor Interactions from Cytokine Engineering
Open accessAbstract
Cytokines exert a vast array of immunoregulatory actions critical to human biology and disease. However, the desired immunotherapeutic effects of native cytokines are often mitigated by toxicity or lack of efficacy, either of which results from cytokine receptor pleiotropy and/or undesired activation of off-target cells. As our understanding of the structural principles of cytokine–receptor interactions has advanced, mechanism-based manipulation of cytokine signaling through protein engineering has become an increasingly feasible and powerful approach. Modified cytokines, both agonists and antagonists, have been engineered with narrowed target cell specificities, and they have also yielded important mechanistic insights into cytokine biology and signaling. Here we review the theory and practice of cytokine engineering and rationalize the mechanisms of several engineered cytokines in the context of structure. We discuss specific examples of how structure-based cytokine engineering has opened new opportunities for cytokines as drugs, with a focus on the immunotherapeutic cytokines interferon, interleukin-2, and interleukin-4.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Depending on their dose-dependent selectivity for one or several JAKs, the JAK inhibitors (JAKi) exert a broad immunopharmacological impact because they block the signal transduction pathways of multiple type I (haematopoietic family) and type II (interferon) cytokine receptors17,214.”
From Atopic dermatitis: an expanding therapeutic pipeline for a complex disease (2022) · cites this paper as [214]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Cell Signaling by Receptor Tyrosine Kinases
Lemmon, M. A., & Schlessinger, J. (2010) · Cell · doi:10.1016/j.cell.2010.06.011 · Cited by 7,929
Darnell, J. E., Kerr, L. M., & Stark, G. R. (1994) · Science · doi:10.1126/science.8197455 · Cited by 6,080
Mechanisms of type-I- and type-II-interferon-mediated signalling
Platanias, L. C. (2005) · Nature reviews. Immunology · doi:10.1038/nri1604 · Cited by 3,631
Differentiation of Effector CD4 T Cell Populations
Zhu, J., Yamane, H., & Paul, W. E. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101212 · Cited by 3,452
Regulation of type I interferon responses
Ivashkiv, L. B., & Donlin, L. T. (2013) · Nature reviews. Immunology · doi:10.1038/nri3581 · Cited by 3,442
Principles of interleukin (IL)-6-type cytokine signalling and its regulation
HEINRICH, P. C., BEHRMANN, I., HAAN, S., HERMANNS, H. M., MÜLLER-NEWEN, G., & SCHAPER, F. (2003) · Biochemical Journal · doi:10.1042/bj20030407 · Cited by 3,272
STATs: transcriptional control and biological impact
Levy, D. E., & Darnell, J. E. (2002) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm909 · Cited by 3,201
Interferon-stimulated genes: A complex web of host defenses
Schneider, W. M., Chevillotte, M. D., & Rice, C. M. (2014) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032713-120231 · Cited by 3,067
A diverse range of gene products are effectors of the type I interferon antiviral response
Schoggins, J. W., Wilson, S. J., Panis, M., Murphy, M. Y., Jones, C. T., Bieniasz, P. D., & Rice, C. M. (2011) · Nature · doi:10.1038/nature09907 · Cited by 2,412
Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex
de Vos, A. M., Ultsch, M. H., & Kossiakoff, A. A. (1992) · Science · doi:10.1126/science.1549776 · Cited by 2,237
Research works printed but not linked: 2
- Gesbert F, 2004, Curr. Top. Microbiol. Immunol., 286, 119
- Debinski W, 1995, Clin. Cancer Res., 1, 1253
Cited by
Sorted by citations
Items 201–300 of 309
Role of Seaweeds in Drug Induced Nephrotoxicity
Sohail, N., & Farhat, H. (2022) · Marine Science and Technology Bulletin · doi:10.33714/masteb.1185059 · Cited by 3
Mohammadi, F., Beauparlant, C. J., Bianco, S., Droit, A., Bertrand, N., & Rudkowska, I. (2024) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202400290 · Cited by 3
Rational design of heterodimeric receptors capable of activating target signaling molecules
Kongkrongtong, T., Zhang, R., & Kawahara, M. (2021) · Scientific Reports · doi:10.1038/s41598-021-96396-3 · Cited by 3
Evaluation of genetic and epigenetic changes of Tumor Necrosis Factor-Alpha gene in larynx cancer
Cömert, S., Şen, S., Eryilmaz, O., Doruk, C., Ulusan, M., & Demokan, S. (2022) · Pathology - Research and Practice · doi:10.1016/j.prp.2022.154085 · Cited by 3
Dai, Y., Gao, Y.-P., Chen, L., Liu, J.-S., Zeng, C., Zhou, J., & Wu, H.-L. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.930446 · Cited by 3
Thomas, C., & Tampé, R. (2023) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2023.102570 · Cited by 3
Li, Y., Yang, P., Chen, F., Tang, J., He, Z., Yang, Z., Weng, L., Guo, J., Zeng, L., & Yin, H. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121910 · Cited by 3
Anti‐inflammatory and immunoregulatory effects of colistin sulphate on human PBMCs
Chen, H., Yang, T., Xu, Y., Liang, B., Liu, X., & Cai, Y. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.18322 · Cited by 3
Qin, L.-J., Xu, H., Li, L., Li, S., Xu, S., Chen, K., Yang, T., Wang, F., Zuo, L., Zeng, L., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e30901 · Cited by 3
CytoSIP: an annotated structural atlas for interactions involving cytokines or cytokine receptors
Wang, L., Sun, F., Li, Q., Ma, H., Zhong, J., Zhang, H., Cheng, S., Wu, H., Zhao, Y., Wang, N., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-06289-0 · Cited by 4
Innate and adaptive immunity in cancer
Doshi, A. S., & Asrani, K. H. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-823397-9.00025-9 · Cited by 4
Dembić, Z. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-818731-9.00090-2 · Cited by 3
Cytokine Receptors and Their Ligands
Shing, K. S. C. T., Kan, W. L., Nero, T. L., Hercus, T. R., Tvorogov, D., Metcalfe, R. D., Griffin, M. D. W., de Weerd, N. A., Guthridge, M. A., Hertzog, P. J., et al. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821618-7.00079-1 · Cited by 3
Ren, K., Yu, C., Yang, Q., Zhang, Q., & Li, P. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202503644 · Cited by 3
Protein engineering: status report
Ai, H., Arnold, F. H., Barrick, D., Bayley, H., Brownless, A.-L. R., Campbell, R. E., Castells‐Graells, R., Chaiyen, P., Chica, R. A., Chisholm, L. O., et al. (2026) · Protein Engineering Design and Selection · doi:10.1093/protein/gzag020 · Cited by 2
Self-citationModern T cell technologies for immunotherapy of solid tumors
Kuznetsova, M. S., Shiku, H., Karaulov, A. V., & Sennikov, S. V. (2023) · Medical Immunology (Russia) · doi:10.15789/10.15789/1563-0625-mtc-2444 · Cited by 3
Liu, Z., Zang, M., Li, K., Qi, W., Yuan, H., Chen, L., & Zhang, Y. (2024) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2024.109210 · Cited by 2
Future Research Goals in Immunotherapy
Hulett, T. W., Fox, B. A., Messenheimer, D. J., Marwitz, S., Moudgil, T. L., Afentoulis, M. E., Wegmann, K. W., Ballesteros‐Merino, C., & Jensen, S. M. (2019) · Surgical Oncology Clinics of North America · doi:10.1016/j.soc.2019.02.006 · Cited by 2
Multi-omic analysis reveals HIP-55-dependent regulation of cytokines release
Jiang, Y., Xing, Z., Zhu, B., Wang, W., Sun, Y., Shi, Z., & Li, Z. (2020) · Bioscience Reports · doi:10.1042/bsr20200298 · Cited by 2
Nonclassical Roles for IFN-γ and IL-10 in a Murine Model of Immunoedition
Giúdice, A. D., Pagura, L., Capitani, M. C., Mainetti, L. E., Scharovsky, O. G., Masso, R. J. D., Rico, M. J., & Rozados, V. R. (2020) · Future Science OA · doi:10.2144/fsoa-2019-0108 · Cited by 2
Cancer Immunology and the Evolution of Immunotherapy
Nurieva, R., Divenko, M., & Kim, S. (2021) · Springer eBooks · doi:10.1007/978-3-030-56824-5_1 · Cited by 2
Chen, D., Zhang, C., Zang, Y., Wang, W., & Zhang, J. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.970900 · Cited by 2
Biological activity of recombinant bovine IFN-α and inhibitory effect on BVDV in vitro
Yin, H., Li, S., Chai, C., Zhang, F., Ma, Y., Wu, Y., Fu, C., Diao, Y., Zhou, Y., Zhang, J., et al. (2023) · Microbial Pathogenesis · doi:10.1016/j.micpath.2023.106155 · Cited by 2
Characterization of Immune Cell Subset Expansion in Response to Therapeutic Treatment in Mice
Tomala, J., & Spangler, J. B. (2020) · Methods in molecular biology · doi:10.1007/978-1-0716-0266-9_9 · Cited by 2
Self-citationMultivalent, asymmetric IL-2-Fc fusions provide optimally enhanced regulatory T cell selectivityPreprint
Orcutt-Jahns, B. T., Emmel, P. C., Snyder, E. M., Taylor, S. D., & Meyer, A. S. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.07.03.451002 · Cited by 2
Mechanism of receptor assembly via the pleiotropic adipokine Leptin
Tsirigotaki, A., Dansercoer, A., Verschueren, K. H. G., Marković, I., Pollmann, C., Hafer, M., Felix, J., Birck, C., Van Putte, W., Catteeuw, D., et al. (2022) · doi:10.1101/2022.12.01.518327 · Cited by 2
Li, Z., Liu, Z., Guo, Y., Tang, Y., Li, T., Gao, S., & Xuan, H. (2025) · Pharmacological Research - Modern Chinese Medicine · doi:10.1016/j.prmcm.2025.100660 · Cited by 1
Beta‐Arrestin2‐Biased Activation by Pilocarpine Suppresses Microglial Inflammatory Response
Xie, Y. J., Wang, K., Wang, S., Yao, Y., Wang, D., Hongzhuan, C. H. E. N., Zhao, L., & Xu, J. (2025) · Journal of Neurochemistry · doi:10.1111/jnc.70334 · Cited by 1
Structure-Guided Design of Proteomimetics Targeting the SARS-CoV-2 S-RBD/hACE2 Interface
Ferková, S., Fayolle, A., Boisvert, O., Froehlich, U., Nepveu-Traversy, M.-É., Lavigne, P., Grandbois, M., Sarret, P., & Boudreault, P. (2026) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c03450 · Cited by 1
Dehkhoda, F., Chhabra, Y., Whelan, F., Nowell, C. J., Morris, M. J., Furness, S. G. B., & Brooks, A. J. (2026) · The Journal of Immunology · doi:10.1093/jimmun/vkag118 · Cited by 1
Cytokine Mimetics with Various Modalities
Sakai, K., Sato, H., & Matsumoto, K. (2024) · Israel Journal of Chemistry · doi:10.1002/ijch.202300163 · Cited by 1
Tingting, L. U., Ma, X., Song, X., & Zhao, L. (2024) · Journal of Veterinary Medical Science · doi:10.1292/jvms.24-0082 · Cited by 1
Dashwood, A., Makuyana, N., van der Kant, R., Ghodsinia, A., Hernandez, A. R., Liénart, S., Burton, O. T., Dooley, J., Ali, M. M., Kouser, L., et al. (2025) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2025.03.002 · Cited by 3
Unveiling the Role of DPYS: A New Prognostic Biomarker in Sarcoma
Lyu, G., & Li, D. (2025) · Current Protein and Peptide Science · doi:10.2174/0113892037362065250227064739 · Cited by 1
Innovative synthetic signaling technologies for immunotherapy
VanDyke, D., Wang, W., & Spangler, J. B. (2020) · Current Opinion in Biomedical Engineering · doi:10.1016/j.cobme.2020.05.007 · Cited by 1
Self-citationLi, C.-X., & Dan, L. (2021) · Future Oncology · doi:10.2217/fon-2021-0275 · Cited by 1
Farooqui, A. A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-323-88460-0.00001-1 · Cited by 1
McFarlane, A., Fyfe, P. K., & Moraga, I. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820472-6.00112-2 · Cited by 2
Self-citationReceptors for the Four‐Helical Cytokines
Rose‐John, S. (2017) · Wiley eBooks · doi:10.1002/9780470015902.a0000930.pub3 · Cited by 1
Wang, Y., Zuo, S., Bao, H., Zhang, Z., Chen, Y., Zhang, W., Liu, Q., Lü, Y., Huang, Y., Zheng, W. H., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.02.16.638489 · Cited by 1
Nguyen, D., Truong, T. T. T., Panizzutti, B., Ellis, M. K., Spolding, B., CourtneySwinton, Bortolasci, C. C., Bryce, J., Smith, J., Field, C., et al. (2026) · Research Square · doi:10.21203/rs.3.rs-10015511/v2 · Cited by 1
A Cytokine Receptor Signaling Atlas Reveals How STAT Mosaics Fine-Tune T Cell FunctionPreprint
Tao, P., Rastogi, R., Jiang, H., Zhao, Y., Su, L., Jude, K. M., Kundaje, A. B., & García, K. C. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.08.19.745852 · Cited by 1
Maeda, H., Okada, K., Fujii, T., Oba, M. S., Kawai, M., Hirono, S., Kodera, Y., Sho, M., Akahori, T., Shimizu, Y., et al. (2020) · Clinical and Experimental Gastroenterology · doi:10.2147/ceg.s262082
Lin, Y., Li, C.-X., & Chen, J. (2021) · Research Square · doi:10.21203/rs.3.rs-230598/v1
Adoptive NK cell therapies in children with cancer: Clinical challenges and future possibilities
Nguyen, R., & Furman, W. L. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-824375-6.00018-7
Zhang, T., Guan, Y., & Liu, H. (2020) · Research Square · doi:10.21203/rs.3.rs-42140/v1
Guo, X., Chen, S., Wang, S., Zhang, H., Yin, F., Guo, P., Zhang, X., Liu, X., Yang, Z., & Han, Y. (2022) · Research Square · doi:10.21203/rs.3.rs-1482451/v1
Hannoush, R. N. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.735771636.793568442
Mohammadi, M., & Zinkle, A. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.725372174.793547225
Lyrio, A. M., & Bonfiglioli, R. (2021) · Revista Paulista de Reumatologia · doi:10.46833/reumatologiasp.2021.20.3.22-27
Doshi, A. S. (2021) · Digital Repository Service (Northeastern University) · doi:10.17760/d20416548
Zinc finger DHHC-type palmitoyltransferase 12 is a potential prognostic biomarker in gliomaPreprint
Xu, H., Chen, X., Niu, X., & Pu, J. (2022) · Research Square · doi:10.21203/rs.3.rs-2006847/v1
Identification of anoikis-related genes signature to predict the prognosis in cervical cancerPreprint
Shi, S., Tang, X., Huang, J., Xiang, N., Chen, C., Feng, W., & Liu, H. (2023) · Research Square · doi:10.21203/rs.3.rs-2813411/v1
Kan, W. L., Dhagat, U., Kaufmann, K. B., Hercus, T. R., Nero, T. L., Zeng, A. G. X., Toubia, J., Barry, E. F., Broughton, S. E., Gomez, G. A., et al. (2023) · doi:10.1158/2159-8290.c.6749895.v1
Tuning of granulopoietic signaling by de novo designed agonistsPreprint
Ullrich, T., Pollmann, C., Ritter, M. U., Haaf, J., Aghaallaei, N., Tesakov, I. P., El-Riz, M., Maksymenko, K., Hatskovska, V., Kandabarau, S., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.11.25.568662
CXCL10 could be a prognostic and immunological biomarker in bladder cancerPreprint
殷, 涛., mou, S., Zhang, H., Dong, Y., Yan, B., Huang, W., Liu, Y., & Mei, H. (2024) · Research Square · doi:10.21203/rs.3.rs-3921289/v1
Jiang, F., Jiang, Y., Wang, W., Xiao, C., Lin, R., Xie, T., Sung, W.-K. K., Li, S., Jakovlić, I., Chen, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15086005
Jiang, F., Jiang, Y., Wang, W., Xiao, C., Lin, R., Xie, T., Sung, W.-K. K., Li, S., Jakovlić, I., Chen, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15085963
Jiang, F., Jiang, Y., Wang, W., Xiao, C., Lin, R., Xie, T., Sung, W.-K. K., Li, S., Jakovlić, I., Chen, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15085951
Jiang, F., Jiang, Y., Wang, W., Xiao, C., Lin, R., Xie, T., Sung, W.-K. K., Li, S., Jakovlić, I., Chen, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15086002
Jiang, F., Jiang, Y., Wang, W., Xiao, C., Lin, R., Xie, T., Sung, W.-K. K., Li, S., Jakovlić, I., Chen, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15085957
Jiang, F., Jiang, Y., Wang, W., Xiao, C., Lin, R., Xie, T., Sung, W.-K. K., Li, S., Jakovlić, I., Chen, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15085954
CytoSIP: an annotated structural atlas for interactions involving cytokine or cytokine receptor
Wang, L., Sun, F. Z., Ma, H., Zhong, J., Zhang, H., Cheng, S., Wu, H., Wang, N., Zhao, M., Zhu, P., et al. (2023) · Acta Crystallographica Section A Foundations and Advances · doi:10.1107/s2053273323082396
Dashwood, A., Makuyana, N., van der Kant, R., Ghodsinia, A., Hernandez, A. R., Liénart, S., Burton, O. T., Dooley, J., Ali, M. M., Kouser, L., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.02.610760
Chen, R., Xu, D., Li, H., Wang, Y., Hu, W., & Zhu, J. (2025) · Aquaculture International · doi:10.1007/s10499-024-01763-2
Huang, Y., Zhu, X. M., & Li, D. (2025) · Medicine in Omics · doi:10.1016/j.meomic.2025.100042
Functional Assays for Screening Protein Biotherapeutics
Beresini, M. H., & Loyet, K. M. (2025) · Wiley eBooks · doi:10.1002/9781394236145.ch10
Li, Y., Ou-yang, X.-Y., & Wen, W. (2025) · Medicine · doi:10.1097/md.0000000000042291 · Cited by 1
Evolving Trends in Breast Cancer Immunotherapy: Recent Updates
Sultana, J., Choudhury, P. R., Guha, A., Das, P., Bera, S., Das, J., & Banerjee, S. (2025) · Journal of Current Oncological Trends · doi:10.4103/jcot.jcot_19_24
Tuning of G-CSFR signaling by de novo-designed agonists
Ullrich, T., Pollmann, C., Ritter, M. U., Haaf, J., Aghaallaei, N., Tesakov, I. P., Hatskovska, V., El-Riz, M., Maksymenko, K., Kandabarau, S., et al. (2025) · Molecular Therapy · doi:10.1016/j.ymthe.2025.08.031
He, R., Li, Y., Jiang, L., Luo, M., Wei, S., & Jiang, L. (2025) · Journal of Biosciences and Medicines · doi:10.4236/jbm.2025.139036
Cytokine engineering for targeted immunotherapy
Bakhshi, P., Ho, J. Q., Zaer, N., Webster, T. J., & Zanganeh, S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-21521-6.00011-9
Li, C., Hua, Z., Wang, X., Wen, S., & Sheng, J. (2025) · Microbiology and Immunology · doi:10.1111/1348-0421.70010
Ji, Y., Li, X., Shen, X., Hu, X., Du, Y., Hu, B., Wang, W., & Meng, F. (2025) · Cancer Cell International · doi:10.1186/s12935-025-04043-y
Jiang, F., Jiang, Y., Wang, W., Xiao, C., Lin, R., Xie, T., Sung, W.-K., Li, S., Jakovlić, I., Chen, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15085984
Jiang, F., Jiang, Y., Wang, W., Xiao, C., Lin, R., Xie, T., Sung, W.-K., Li, S., Jakovlić, I., Chen, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15085972
Jiang, F., Jiang, Y., Wang, W., Xiao, C., Lin, R., Xie, T., Sung, W.-K., Li, S., Jakovlić, I., Chen, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15085987
Jiang, F., Jiang, Y., Wang, W., Xiao, C., Lin, R., Xie, T., Sung, W.-K., Li, S., Jakovlić, I., Chen, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15085969
Jiang, F., Jiang, Y., Wang, W., Xiao, C., Lin, R., Xie, T., Sung, W.-K., Li, S., Jakovlić, I., Chen, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15085966
Hu, D., Wang, J., Cheng, T., Li, H., Zhang, F., Zhao, D., Xu, X., Yu, R., Wen, P., Cheng, Y., et al. (2024) · Figshare · doi:10.6084/m9.figshare.24248179
Jiang, F., Jiang, Y., Wang, W., Xiao, C., Lin, R., Xie, T., Sung, W.-K., Li, S., Jakovlić, I., Chen, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15085978
Jiang, F., Jiang, Y., Wang, W., Xiao, C., Lin, R., Xie, T., Sung, W.-K., Li, S., Jakovlić, I., Chen, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15085999
Jiang, F., Jiang, Y., Wang, W., Xiao, C., Lin, R., Xie, T., Sung, W.-K., Li, S., Jakovlić, I., Chen, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15085981
Jiang, F., Jiang, Y., Wang, W., Xiao, C., Lin, R., Xie, T., Sung, W.-K., Li, S., Jakovlić, I., Chen, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15086008
Jiang, F., Jiang, Y., Wang, W., Xiao, C., Lin, R., Xie, T., Sung, W.-K., Li, S., Jakovlić, I., Chen, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15085960
Jiang, F., Jiang, Y., Wang, W., Xiao, C., Lin, R., Xie, T., Sung, W.-K., Li, S., Jakovlić, I., Chen, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15085975
Jiang, F., Jiang, Y., Wang, W., Xiao, C., Lin, R., Xie, T., Sung, W.-K., Li, S., Jakovlić, I., Chen, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15085948
Zhong, S., Chen, S., Lin, H., Luo, Y., & He, J. (2023) · Figshare · doi:10.6084/m9.figshare.24571861
Hu, D., Wang, J., Cheng, T., Li, H., Zhang, F., Zhao, D., Xu, X., Yu, R., Wen, P., Cheng, Y., et al. (2023) · Figshare · doi:10.6084/m9.figshare.24248007
Jiang, F., Jiang, Y., Wang, W., Xiao, C., Lin, R., Xie, T., Sung, W.-K., Li, S., Jakovlić, I., Chen, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15085993
Jiang, F., Jiang, Y., Wang, W., Xiao, C., Lin, R., Xie, T., Sung, W.-K., Li, S., Jakovlić, I., Chen, J., et al. (2021) · Figshare · doi:10.6084/m9.figshare.15085990
Pi, K., Samarkhazan, H. S., Tavakoli, F., Nouri, M., & Servatian, N. (2026) · Stem Cell Reviews and Reports · doi:10.1007/s12015-026-11065-0
The intricate relationship between cytokines and galectins in immune modulation
Gennesse, S. M., Koenen, R. R., & Thijssen, V. L. (2026) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2026.02.002
Fabilane, C. S., Tomala, J., Zdinak, P. M., Chalmers, B. T., Stephenson, A. C., Ariail, E. C., Teeley, E. C., Joglekar, A. V., & Spangler, J. B. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1755812
Self-citation
Metadata
- Authors
- Spangler, J. B., Moraga, I., Mendoza, J. L., & Garcia, K. C.
- Affiliations
- Howard Hughes Medical Institute (US)
- Howard Hughes Medical Institute, Department of Molecular and Cellular Physiology, Department of Structural Biology, Stanford University School of Medicine, Stanford, California 94305;, , ,
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2015-03-21
- Volume
- 33
- Issue
- 1
- Pages
- 139-167
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- PMC
- PMC4445396
- OpenAlex
- W2098212097
- Cited by
- 304
- References
- 202
- Citations by year
- 2026: 19 · 2025: 30 · 2024: 38 · 2023: 32 · 2022: 48 · 2021: 48 · 2020: 24 · 2019: 16 · 2018: 18 · 2017: 18 · 2016: 6 · 2015: 7
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Annual Review of Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Howard Hughes Medical Institute
- National Institutes of Health
- National Cancer Institute (K01CA175127)
- National Institute of Allergy and Infectious Diseases (R01 AI51321, R37AI051321, R01AI051321)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Immunology and Microbiology › Immunology › Monoclonal and Polyclonal Antibodies Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- cytokine engineering, cytokine-cytokine receptor interaction, cytokine signaling, structure-based protein engineering, cytokine antagonists, target cell specificity, cytokine toxicity, immunotherapy, interferon, interleukin-2, IL-4
- MeSH terms
- Animals, Extracellular Space, Genetic Engineering, Humans, Protein Binding, Signal Transduction, Cytokines, Receptors, Cytokine, Protein Transport, Intracellular Space
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review