Double-Stranded RNA Sensors and Modulators in Innate Immunity

The HCV Life Cycle: In vitro Tissue Culture Systems and Therapeutic Targets

Gerold, G., & Pietschmann, T. (2014) · Digestive Diseases · doi:10.1159/000360830 · Cited by 4,871

Principles of Nucleic Acid Structure

Neidle, S., & Sanderson, M. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-369507-9.x5001-8 · Cited by 4,519

Biogenesis of small RNAs in animals

Kim, V. N., Han, J., & Siomi, M. C. (2009) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2632 · Cited by 2,814

A diverse range of gene products are effectors of the type I interferon antiviral response

Schoggins, J. W., Wilson, S. J., Panis, M., Murphy, M. Y., Jones, C. T., Bieniasz, P. D., & Rice, C. M. (2011) · Nature · doi:10.1038/nature09907 · Cited by 2,412

Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses

Chiappinelli, K. B., Strissel, P. L., Desrichard, A., Li, H., Henke, C., Akman, B., Hein, A., Rote, N. S., Cope, L. M., Snyder, A., et al. (2015) · Cell · doi:10.1016/j.cell.2015.07.011 · Cited by 2,022

DNA-Demethylating Agents Target Colorectal Cancer Cells by Inducing Viral Mimicry by Endogenous Transcripts

Roulois, D., Loo Yau, H., Singhania, R., Wang, Y., Danesh, A., Shen, S. Y., Han, H., Liang, G., Jones, P. A., Pugh, T. J., et al. (2015) · Cell · doi:10.1016/j.cell.2015.07.056 · Cited by 1,527

Identification of host proteins required for HIV infection through a functional genomic screen

Brass, A. L., Dykxhoorn, D. M., Benita, Y., Yan, N., Engelman, A., Xavier, R. J., Lieberman, J., & Elledge, S. J. (2008) · Science · doi:10.1126/science.1152725 · Cited by 1,449

Structure and Mechanism of Helicases and Nucleic Acid Translocases

Singleton, M. R., Dillingham, M. S., & Wigley, D. B. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.052305.115300 · Cited by 1,321

MAVS Forms Functional Prion-like Aggregates to Activate and Propagate Antiviral Innate Immune Response

Hou, F., Sun, L., Zheng, H., Skaug, B. A., Jiang, Q., & Chen, Z. J. (2011) · Cell · doi:10.1016/j.cell.2011.06.041 · Cited by 1,306

Analysis of avian Usutu virus infections in Germany from 2011 to 2018 with focus on dsRNA detection to demonstrate viral infections

Störk, T., de le Roi, M., Haverkamp, A.-K., Jesse, S. T., Peters, M. C., Fast, C., Gregor, K. M., Könenkamp, L., Steffen, I., Ludlow, M., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-03638-5 · Cited by 31

Mouse circulating extracellular vesicles contain virus‐derived siRNAs active in antiviral immunity

Zhang, Y., Dai, Y., Wang, J., Xu, Y., Li, Z., Lü, J., Xu, Y., Zhong, J., Ding, S., & Li, Y. (2022) · The EMBO Journal · doi:10.15252/embj.2021109902 · Cited by 31

Exogenous dsRNA triggers sequence-specific RNAi and fungal stress responses to control Magnaporthe oryzae in Brachypodium distachyon

Zheng, Y., Moorlach, B., Jakobs‐Schönwandt, D., Patel, A. V., Pastacaldi, C., Jacob, S., Sede, A. R., Heinlein, M., Poranen, M. M., Kogel, K., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-07554-6 · Cited by 30

Picornaviruses: A View from 3A

Jackson, T., & Belsham, G. J. (2021) · Viruses · doi:10.3390/v13030456 · Cited by 33

Neutrophil extracellular trap-derived double-stranded RNA aggravates PANoptosis in renal ischemia reperfusion injury

Zhuang, S., Li, F., Wang, L., Lai, Z., Li, D., Wu, H., Wu, J., Qu, J., Zhang, X., Zhang, M., et al. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02145-8 · Cited by 30

Three-Dimensional Visualization of Viral Structure, Entry, and Replication Underlying the Spread of SARS-CoV-2

Saville, J. W., Berezuk, A., Srivastava, S. S., & Subramaniam, S. (2022) · Chemical Reviews · doi:10.1021/acs.chemrev.1c01062 · Cited by 32

The multi-functional reovirus σ3 protein is a virulence factor that suppresses stress granule formation and is associated with myocardial injury

Guo, Y., Hinchman, M. M., Lewandrowski, M., Cross, S. T., Sutherland, D. M., Welsh, O. L., Dermody, T. S., & Parker, J. S. L. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009494 · Cited by 28

PACT prevents aberrant activation of PKR by endogenous dsRNA without sequestration

Ahmad, S., Zou, T., Hwang, J., Zhao, L., Wang, X., Davydenko, A., Buchumenski, I., Zhuang, P., Fishbein, A. R., Capcha-Rodriguez, D., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-58433-x · Cited by 29

Multifaceted roles of RNA editing enzyme ADAR1 in innate immunity

Jarmoskaite, I., & Li, J. B. (2024) · RNA · doi:10.1261/rna.079953.124 · Cited by 26

Circular RNA as an Additional Player in the Conflicts Between the Host and the Virus

Choudhary, A., Madbhagat, P., Sreepadmanabh, M., Bhardwaj, V., & Chande, A. G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.602006 · Cited by 24

Ultraviolet light induces HERV expression to activate RIG‐I signalling pathway in keratinocytes

Min, X., Zheng, M., Yu, Y., Wu, J., Kuang, Q., Hu, Z. Q., Ouyang, L., Lu, S., & Zhao, M. (2022) · Experimental Dermatology · doi:10.1111/exd.14568 · Cited by 23

SARS-CoV-2 nucleocapsid protein inhibits the PKR-mediated integrated stress response through RNA-binding domain N2b

Aloise, C., Schipper, J. G., van Vliet, A. L. W., Oymans, J., Donselaar, T., Hurdiss, D. L., de Groot, R. J., & van Kuppeveld, F. J. M. (2023) · PLoS Pathogens · doi:10.1371/journal.ppat.1011582 · Cited by 26

Long COVID Definition, Symptoms, Risk Factors, Epidemiology and Autoimmunity: A Narrative Review

Kozłowski, P., Leszczyńska, A., & Ciepiela, O. (2024) · American Journal of Medicine Open · doi:10.1016/j.ajmo.2024.100068 · Cited by 27

Infection infidelities drive innate immunity

Kagan, J. C. (2023) · Science · doi:10.1126/science.ade9733 · Cited by 26

Advancing cancer treatments: The role of oligonucleotide-based therapies in driving progress

Dume, B. R., Licărete, E., & Banciu, M. (2024) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2024.102256 · Cited by 25

Asparagine drives immune evasion in bladder cancer via RIG-I stability and type I IFN signaling

Wei, W., Li, H., Tian, S., Zhang, C., Liu, J., Tao, W., Cai, T., Dong, Y., Wang, C., Lu, D., et al. (2025) · Journal of Clinical Investigation · doi:10.1172/jci186648 · Cited by 25

The Insufficient Activation of RIG-I–Like Signaling Pathway Contributes to Highly Efficient Replication of Porcine Picornaviruses in IBRS-2 Cells

Zhang, X., Yang, F., Li, K., Cao, W., Ru, Y., Chen, S., Li, S., Liu, X., Zhu, Z., & Zheng, H. (2021) · Molecular & Cellular Proteomics · doi:10.1016/j.mcpro.2021.100147 · Cited by 25

Universal Flu mRNA Vaccine: Promises, Prospects, and Problems

Deviatkin, A. A., Simonov, R. A., Trutneva, K. A., Maznina, A. A., Khavina, E. M., & Volchkov, P. (2022) · Vaccines · doi:10.3390/vaccines10050709 · Cited by 26

Double-Stranded-RNA-Binding Protein 2 Participates in Antiviral Defense

Fátyol, K., Fekete, K. A., & Ludman, M. (2020) · Journal of Virology · doi:10.1128/jvi.00017-20 · Cited by 25

Adenovirus prevents dsRNA formation by promoting efficient splicing of viral RNA

Price, A. M., Steinbock, R. T., Di, C., Hayer, K. E., Li, Y., Herrmann, C., Parenti, N. A., Whelan, J. N., Weiss, S. R., & Weitzman, M. D. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab896 · Cited by 25

Current advances in antiviral RNA interference in mammals

Wang, J., & Li, Y. (2023) · FEBS Journal · doi:10.1111/febs.16728 · Cited by 24

Activation of RNase L in Egyptian Rousette Bat-Derived RoNi/7 Cells Is Dependent Primarily on OAS3 and Independent of MAVS Signaling

Li, Y., Dong, B., Wei, Z., Silverman, R. H., & Weiss, S. R. (2019) · mBio · doi:10.1128/mbio.02414-19 · Cited by 24

MDA5 cleavage by the Leader protease of foot-and-mouth disease virus reveals its pleiotropic effect against the host antiviral response

Rodríguez‐Pulido, M., Martı́nez-Salas, E., Sobrino, F., & Sáiz, M. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-02931-x · Cited by 24

Molecular Mechanisms of Sepsis-Associated Acute Kidney Injury

Hato, T., & Dagher, P. C. (2025) · Journal of the American Society of Nephrology · doi:10.1681/asn.0000000809 · Cited by 24

Regulation of the double-stranded RNA response through ADAR1 licenses metaplastic reprogramming in gastric epithelium

Sáenz, J. B., Vargas, N., Cho, C. J., & Mills, J. C. (2022) · JCI Insight · doi:10.1172/jci.insight.153511 · Cited by 23

Z-RNA biology: a central role in the innate immune response?

Nichols, P. J., Krall, J. B., Henen, M. A., Vögeli, B., & Vicens, Q. (2023) · RNA · doi:10.1261/rna.079429.122 · Cited by 24

SARS-CoV-2 nsp15 preferentially degrades AU-rich dsRNA via its dsRNA nickase activity

Wang, X., & Zhu, B. (2024) · Nucleic Acids Research · doi:10.1093/nar/gkae290 · Cited by 23

RNA Methyltransferase FTSJ3 Regulates the Type I Interferon Pathway to Promote Hepatocellular Carcinoma Immune Evasion

Zhuang, Q., Dai, Z., Xu, X., Bai, S., Zhang, Y., Zheng, Y., Xing, X., Hu, E., Wang, Y., Guo, W., et al. (2023) · Cancer Research · doi:10.1158/0008-5472.can-23-2049 · Cited by 21

Cooperative role of PACT and ADAR1 in preventing aberrant PKR activation by self-derived double-stranded RNA

Manjunath, L., Santiago, G., Ortega, P., Sanchez, A., Oh, S., Garcia, A. N., Li, J., Duong, D., Bournique, E., Bouin, A., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-58412-2 · Cited by 24

Migration of murine intestinal dendritic cell subsets upon intrinsic and extrinsic TLR3 stimulation

López, A. G., Bekiaris, V., Luda, K. M., Hütter, J., Ulmert, I., Muleta, K. G., Nakawesi, J., Kotarsky, K., MALISSEN, B., O’Keeffe, M. A., et al. (2020) · European Journal of Immunology · doi:10.1002/eji.201948497 · Cited by 21

Persistent Enterovirus Infection: Little Deletions, Long Infections

Chapman, N. M. (2022) · Vaccines · doi:10.3390/vaccines10050770 · Cited by 23

Regulation of inflammatory diseases via the control of mRNA decay

Yoshinaga, M., & Takeuchi, O. (2024) · Inflammation and Regeneration · doi:10.1186/s41232-024-00326-5 · Cited by 22

Exploring the Impact of In Vitro-Transcribed mRNA Impurities on Cellular Responses

Camperi, J., Roper, B., Freund, E. C., Leylek, R. A., Nissenbaum, A., Galan, C., Caothien, R. H., Hu, Z., Ko, P., Lee, A., et al. (2024) · Analytical Chemistry · doi:10.1021/acs.analchem.4c04162 · Cited by 20

Multi-Omics Immune Interaction Networks in Lung Cancer Tumorigenesis, Proliferation, and Survival

Ye, Q., Hickey, J., Summers, K., Falatovich, B., Gencheva, M., Eubank, T. D., Ivanov, A. V., & Guo, N. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314978 · Cited by 20

Optogenetic control of the integrated stress response reveals proportional encoding and the stress memory landscape

Batjargal, T., Zappa, F., Grant, R. J., Piscopio, R. A., Chialastri, A., Dey, S. S., Acosta‐Alvear, D., & Wilson, M. Z. (2023) · Cell Systems · doi:10.1016/j.cels.2023.06.001 · Cited by 25

Sterilizing Immunity against COVID-19: Developing Helper T cells I and II activating vaccines is imperative

Kyei-Barffour, I., Akwetey, S. A., Aninagyei, E., Ghartey‐Kwansah, G., & Acheampong, D. O. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112282 · Cited by 21

Plant negative-stranded RNA virus biology and host interactions revitalized by reverse genetics

Li, Z., & Zhao, C. (2021) · Current Opinion in Virology · doi:10.1016/j.coviro.2021.03.003 · Cited by 20

Deubiquitinase USP4 suppresses antitumor immunity by inhibiting IRF3 activation and tumor cell-intrinsic interferon response in colorectal cancer

Zhou, Y., Li, H., Zhang, Y., Zhao, E., Huang, C., Pan, X., Shu, F., Liu, Z., Tang, N., Li, F., et al. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216836 · Cited by 21

Reactive Polymer Targeting dsRNA as Universal Virus Detection Platform with Enhanced Sensitivity

Ku, J., Kim, S., Park, J., Kim, T., Kharbash, R., Shin, E., Char, K., Kim, Y., & Li, S. (2020) · Biomacromolecules · doi:10.1021/acs.biomac.0c00379 · Cited by 20

Significantly Improved Recovery of Recombinant Sonchus Yellow Net Rhabdovirus by Expressing the Negative-Strand Genomic RNA

Ma, X., & Li, Z. (2020) · Viruses · doi:10.3390/v12121459 · Cited by 20

Is Nuclear Factor Erythroid 2-Related Factor 2 a Target for the Intervention of Cytokine Storms?

Liu, Z., Deng, P., Liu, S., Bian, Y., Xu, Y., Zhang, Q., Wang, H., & Pi, J. (2023) · Antioxidants · doi:10.3390/antiox12010172 · Cited by 21

Emerging role of air pollution and meteorological parameters in COVID‐19

Zhao, C., Fang, X., Feng, Y.-T., Fang, X.-H., He, J., & Pan, H. (2021) · Journal of Evidence-Based Medicine · doi:10.1111/jebm.12430 · Cited by 22

Transcriptome-wide changes in gene expression, splicing, and lncRNAs in response to a live attenuated dengue virus vaccine

Kim, E., Che, Y., Dean, H. J., Lorenzo-Redondo, R., Stewart, M. G., Keller, C., Whorf, D., Mills, D. E., Dulin, N. N., Kim, T., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110341 · Cited by 18

Uncovering targets of the Leader protease: Linking RNA ‐mediated pathways and antiviral defense

Sáiz, M., & Martı́nez-Salas, E. (2021) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1645 · Cited by 18

Cytosolic and nuclear recognition of virus and viral evasion

Li, S., Cao, L., Zhang, Z., Kuang, M., Chen, L., Zhao, Y., Luo, Y., Yin, Z., & You, F. (2021) · Molecular Biomedicine · doi:10.1186/s43556-021-00046-z · Cited by 17

A Dual Role of DDX3X in dsRNA-Derived Innate Immune Signaling

Kwon, J., Choi, H., & Han, C. (2022) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2022.912727 · Cited by 19

Proteomics-based determination of double-stranded RNA interactome reveals known and new factors involved in Sindbis virus infection

Girardi, E., Messmer, M., Lopez, P., Fender, A., Chicher, J., Chane-Woon-Ming, B., Hammann, P., & Pfeffer, S. (2022) · RNA · doi:10.1261/rna.079270.122 · Cited by 17

Low-Dose Radiation Therapy for COVID-19: Promises and Pitfalls

Venkatesulu, B. P., Lester, S. C., Hsieh, R. C.-E., Verma, V., Sharon, E., Ahmed, M. M., & Krishnan, S. (2020) · JNCI Cancer Spectrum · doi:10.1093/jncics/pkaa103 · Cited by 18

Redox Homeostasis and Immune Alterations in Coronavirus Disease-19

Bellanti, F., Buglio, A. L., & Vendemiale, G. (2022) · Biology · doi:10.3390/biology11020159 · Cited by 18

Widespread formation of double-stranded RNAs in testisPreprint

Werner, A., Clark, J. E., Samaranayake, C., Casement, J., Zinad, H. S., Sadeq, S., Al-Hashimi, S., Smith, M. A., Kotaja, N., & Mattick, J. S. (2021) · Genome Research · doi:10.1101/gr.265603.120 · Cited by 18

Cytosolic DNA sensors in neurodegenerative diseases: from physiological defenders to pathological culprits

Xie, J., Cheng, J., Ko, H., & Tang, Y. (2024) · EMBO Molecular Medicine · doi:10.1038/s44321-024-00046-w · Cited by 17

Phytochemicals of Withania somnifera as a Future Promising Drug against SARS-CoV-2: Pharmacological Role, Molecular Mechanism, Molecular Docking Evaluation, and Efficient Delivery

Ramli, S., Wu, Y. S., Batumalaie, K., Guad, R. M., Choy, K. W., Kumar, A., Gopinath, S. C. B., Sarker, M. M. R., Subramaniyan, V., Sekar, M., et al. (2023) · Microorganisms · doi:10.3390/microorganisms11041000 · Cited by 16

Leveraging genetics to understand ADAR1-mediated RNA editing in health and disease

Li, J. B., & Walkley, C. R. (2025) · Nature Reviews Genetics · doi:10.1038/s41576-025-00830-5 · Cited by 22

Nanobooster-encapsulated hybrid RNA as anti-tumor viral mimicry

Liu, C., Zhou, Y., Ji, X., Xie, H., Hu, X., Yin, M., Chen, N., Fan, C., & Song, H. (2021) · Nano Today · doi:10.1016/j.nantod.2021.101211 · Cited by 16

ATG4B antagonizes antiviral immunity by GABARAP-directed autophagic degradation of TBK1

Xie, W., Zhang, C., Wang, Z., Chen, H., Gu, T., Zhou, T., Wu, Y., Xia, F., Li, M., Wang, J., et al. (2023) · Autophagy · doi:10.1080/15548627.2023.2233846 · Cited by 16

Nanosponge-mediated oligonucleotide delivery: A cutting-edge technology towards cancer management

Khairnar, P., Kolipaka, T., Pandey, G., Phatale, V., Shah, S., Srinivasarao, D. A., Saraf, S., & Srivastava, S. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.105226 · Cited by 16

A Revision of Herpes Simplex Virus Type 1 Transcription: First, Repress; Then, Express

Dunn, L. E. M., Birkenheuer, C. H., & Baines, J. D. (2024) · Microorganisms · doi:10.3390/microorganisms12020262 · Cited by 17

Contrasting functions of ATP hydrolysis by MDA5 and LGP2 in viral RNA sensing

Singh, R., Wu, Y., Herrero del Valle, A., Leigh, K. E., Mong, S., Cheng, M. T. K., Ferguson, B. J., & Modis, Y. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.105711 · Cited by 16

Nipah Virus V Protein Binding Alters MDA5 Helicase Folding Dynamics

Wagner, N. D., Liu, H., Rohrs, H. W., Amarasinghe, G. K., Gross, M. L., & Leung, D. W. (2021) · ACS Infectious Diseases · doi:10.1021/acsinfecdis.1c00403 · Cited by 16

Evolution of RNA sensing receptors in birds

Magor, K. E. (2022) · Immunogenetics · doi:10.1007/s00251-021-01238-1 · Cited by 16

LINE-1 RNA triggers matrix formation in bone cells via a PKR-mediated inflammatory response

Mangiavacchi, A., Morelli, G., Reppe, S., Saera-Vila, A., Liu, P., Eggerschwiler, B., Zhang, H., Bensaddek, D., Casanova, E. A., Medina‐Gómez, C., et al. (2024) · The EMBO Journal · doi:10.1038/s44318-024-00143-z · Cited by 16

XRN1 deletion induces PKR-dependent cell lethality in interferon-activated cancer cells

Zou, T., Zhou, M., Gupta, A. A., Zhuang, P., Fishbein, A. R., Wei, H. Y., Capcha-Rodriguez, D., Zhang, Z., Cherniack, A. D., & Meyerson, M. M. (2024) · Cell Reports · doi:10.1016/j.celrep.2023.113600 · Cited by 15

Evolutionary Origins and Adaptive Significance of A‐to‐I RNA Editing in Animals and Fungi

Du, Y., Wang, C., Zhang, Y. J., & Liu, H. (2025) · BioEssays · doi:10.1002/bies.202400220 · Cited by 16

Double-stranded RNA induction asa potential dynamic biomarkerfor DNA-demethylating agents

Kang, M., Kharbash, R., Byun, J. M., Jeon, J., Ali, A. A., Ku, D., Yoon, J., Ku, Y., Sohn, J., Lee, S., et al. (2022) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2022.07.014 · Cited by 14

Activation of DDX58/RIG‑I suppresses the growth of tumor cells by inhibiting STAT3/CSE signaling in colon cancer

Deng, Y., Fu, H., Han, X., Li, Y., Zhao, W., Zhao, X., Yu, C., Guo, W., Lei, K., & Wang, T. (2022) · International Journal of Oncology · doi:10.3892/ijo.2022.5410 · Cited by 14

Fowl adenovirus serotype 4 52/55k protein triggers PKR degradation by ubiquitin–proteasome system to evade effective innate immunity

He, Q., Lu, S., Lin, Y. H., Xu, L., Chen, Z., & Wang, Q. (2023) · Veterinary Microbiology · doi:10.1016/j.vetmic.2023.109660 · Cited by 14

Innate sensing of mRNA vaccines

Wuebben, C., Bartok, E., & Hartmann, G. (2022) · Current Opinion in Immunology · doi:10.1016/j.coi.2022.102249 · Cited by 16

Cellular resistance to an oncolytic virus is driven by chronic activation of innate immunity

Larrieux, A., & Sanjuán, R. (2022) · iScience · doi:10.1016/j.isci.2022.105749 · Cited by 13

Orange-spotted grouper nervous necrosis virus-encoded protein A induces interferon expression via RIG-I/MDA5-MAVS-TBK1-IRF3 signaling in fish cells

Huang, S., Huang, Y., Su, T., Huang, R., Su, L., Wu, Y., Weng, S., He, J., & Xie, J. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.04532-22 · Cited by 13

Human coronaviruses: activation and antagonism of innate immune responses

Tanneti, N. S., Stillwell, H. A., & Weiss, S. R. (2024) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00016-23 · Cited by 14

Immune response scenario and vaccine development for SARS-CoV-2 infection

Mohammad, M. H. S. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107439 · Cited by 13

Matrix metalloproteinase 3 restricts viral infection by enhancing host antiviral immunity

Feng, T., Tong, H., Ming, Z., Deng, L., Liu, J., Wu, J., Chen, Z., Yan, Y., & Dai, J. (2022) · Antiviral Research · doi:10.1016/j.antiviral.2022.105388 · Cited by 13

Comparative phylogenetic analysis and transcriptomic profiling of Dengue (DENV-3 genotype I) outbreak in 2021 in Bangladesh

Sarkar, M. M. H., Rahman, M. S., Islam, M. R., Rahman, A., Islam, M. S., Banu, T. A., Akter, S., Goswami, B., Jahan, I., Habib, M. A., et al. (2023) · Virology Journal · doi:10.1186/s12985-023-02030-1 · Cited by 14

Myocardial Oedema as a Consequence of Viral Infection and Persistence—A Narrative Review with Focus on COVID-19 and Post COVID Sequelae

Panagiotides, N. G., Poledniczek, M., Andreas, M., Hülsmann, M., Kocher, A. A., Kopp, C. W., Piechota-Polańczyk, A., Weidenhammer, A., Pávó, N., & Wadowski, P. P. (2024) · Viruses · doi:10.3390/v16010121 · Cited by 12

Emerging Roles of lncRNAs Regulating RNA-Mediated Type-I Interferon Signaling Pathway

Ji, X., Meng, W., Liu, Z., & Mu, X. N. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.811122 · Cited by 12

Avian Reovirus σA Protein Inhibits Type I Interferon Production by Abrogating Interferon Regulatory Factor 7 Activation

Gao, L., Liu, R., Luo, D., Li, K., Qi, X., Liu, C., Zhang, Y., Cui, H., Wang, S., Gao, Y., et al. (2022) · Journal of Virology · doi:10.1128/jvi.01785-22 · Cited by 12

Role of the Innate Immune Response in Glomerular Disease Pathogenesis: Focus on Podocytes

Issa, W., Njeim, R., Carrazco, A., Burke, G. W., & Mitrofanova, A. V. (2024) · Cells · doi:10.3390/cells13131157 · Cited by 13

SARS-CoV-2 infection of intestinal epithelia cells sensed by RIG-I and DHX-15 evokes innate immune response and immune cross-talk

Zhang, L., Zhang, Y., Wang, R., Liu, X., Zhao, J., Tsuda, M., & Li, Y. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.1035711 · Cited by 12

Plausibility of natural immunomodulators in the treatment of COVID-19–A comprehensive analysis and future recommendations

Akter, R., Rahman, M. R., Ahmed, Z. S., & Afrose, A. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e17478 · Cited by 13

Invasion by exogenous RNA: cellular defense strategies and implications for RNA inference

Tang, D., Liu, Y., Wang, C., Li, L., Alfarraj, S. A., Chen, X., & Yan, Y. (2023) · Marine Life Science & Technology · doi:10.1007/s42995-023-00209-7 · Cited by 12

Circular RNAs as emerging regulators in COVID-19 pathogenesis and progression

Gao, X., Fang, D., Liang, Y., Deng, X., Chen, N., Min De, Z. E. N. G., & Luo, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.980231 · Cited by 13

Increased viral tolerance mediates by antiviral RNA interference in bat cells

Dai, Y., Wang, B., Wang, J., Wei, X., Liu, X., Che, X., Li, J., Ng, W. L., Wang, L., & Li, Y. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114581 · Cited by 11

Cholesterol restriction primes antiviral innate immunity via SREBP1-driven noncanonical type I IFNs

Nishimura, T., Kouwaki, T., Takashima, K., Ochi, A., Mtali, Y. S., & Oshiumi, H. (2024) · EMBO Reports · doi:10.1038/s44319-024-00346-9 · Cited by 12

RNase L produces tRNA-derived RNAs that contribute to translation inhibition

Takenaka, Y., Yamada, A., Tomioka, Y., Akiyama, Y., & Ivanov, P. V. (2025) · RNA · doi:10.1261/rna.080419.125 · Cited by 12

Global remodeling of ADP-ribosylation by PARP1 suppresses influenza A virus infection

Zhang, Z., Uribe, I. R., Davis, K. A., McPherson, R. L., Larson, G. P., Badiee, M., Tran, V., Ledwith, M. P., Feltman, E. M., Yú, S., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-66136-6 · Cited by 11

A systemic evaluation of the effect of dsRNA contamination on mRNA vaccine expression and immunogenicity

Jo, S., Lee, J. S., Park, S., Kim, Y., Yoon, S., Lee, S., Cho, S., Cho, Y., Oh, A., Ha, D., et al. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114471 · Cited by 9

Can Immune Suppression and Epigenome Regulation in Placenta Offer Novel Insights into Cancer Immune Evasion and Immunotherapy Resistance?

Hossain, S. M., Lynch‐Sutherland, C. F., Chatterjee, A., Macaulay, E. C., & Eccles, M. R. (2021) · Epigenomes · doi:10.3390/epigenomes5030016 · Cited by 11

miR-451-targeted PSMB8 promotes PRRSV infection by degrading IRF3

Li, S., Guo, S., Liu, F., Yao, Y., Zhu, Y., & Feng, W.-H. (2024) · Journal of Virology · doi:10.1128/jvi.00784-24 · Cited by 10

ATP-dependent one-dimensional movement maintains immune homeostasis by suppressing spontaneous MDA5 filament assembly

Han, X.-P., Rao, M., Chang, Y., Zhu, J., Cheng, J., Li, Y.-T., Wu, Q., Ye, S., Zhang, Q., Zhang, S., et al. (2025) · Cell Research · doi:10.1038/s41422-025-01183-8 · Cited by 10

The IFIT2–IFIT3 antiviral complex targets short 5’ untranslated regions on viral mRNAs for translation inhibition

Glasner, D. R., Todd, C., Cook, B., D’Urso, A., Khosla, S., Estrada, E., Wagner, J. D., Bartels, M. D., Hung, C.-T., Ford, P. W., et al. (2025) · Nature Microbiology · doi:10.1038/s41564-025-02138-w · Cited by 12

The Betacoronavirus PHEV Replicates and Disrupts the Respiratory Epithelia and Upregulates Key Pattern Recognition Receptor Genes and Downstream Mediators, Including IL-8 and IFN-λ

Nelli, R. K., Mora-Díaz, J. C., & Giménez-Lirola, L. G. (2021) · mSphere · doi:10.1128/msphere.00820-21 · Cited by 10

K63‐linked polyubiquitination of LGP2 by Riplet regulates RIG‐I‐dependent innate immune response

Kouwaki, T., Nishimura, T., Wang, G., Nakagawa, R., & Oshiumi, H. (2022) · EMBO Reports · doi:10.15252/embr.202254844 · Cited by 10

The roles of nucleic acid editing in adaptation of zoonotic viruses to humans

Ratcliff, J. D., & Peter Simmonds, K. (2023) · Current Opinion in Virology · doi:10.1016/j.coviro.2023.101326 · Cited by 10

Expression of Toll-like Receptors in Stem Cells of the Apical Papilla and Its Implication for Regenerative Endodontics

Takimoto, K., Widbiller, M., & Diogenes, A. R. (2023) · Cells · doi:10.3390/cells12202502 · Cited by 9

Junctophilin-2 is a double-stranded RNA-binding protein that regulates cardiomyocyte-autonomous innate immune response

Shi, Y., Mirabdali, S., Vetter, S. W., & Guo, A. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.150725 · Cited by 9

SLIRP amplifies antiviral signaling via positive feedback regulation and contributes to autoimmune diseases

Ku, D., Yang, Y., Park, Y., Jang, D., Lee, N., Lee, Y.-K., Lee, K., Lee, J., Han, Y. B., Jang, S., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115588 · Cited by 9

Regulated localization of transposable element RNA during influenza A virus infection

Lork, M., Childs, L. H., Lieber, G., Kwaschik, F. M., König, R., & Hale, B. G. (2025) · EMBO Reports · doi:10.1038/s44319-025-00498-2 · Cited by 8

ADARs: pleiotropy in function, versatility in application

Zhang, Y., Bryant, J., Herron, L., & Mali, P. (2025) · Nucleic Acids Research · doi:10.1093/nar/gkaf672 · Cited by 9

The Chromosome 19 miRNA cluster guards trophoblasts against overacting innate immunity

Mouillet, J., Ouyang, Y., Sadovsky, E., Kothandan, V. K., Sorenson, H. L., Badeau, L. J., Sarkar, S. N., Chu, T., Sorkin, A. D., & Sadovsky, Y. (2025) · Communications Biology · doi:10.1038/s42003-025-08923-x · Cited by 10

Insights into the structure and RNA-binding specificity of Caenorhabditis elegans Dicer-related helicase 3 (DRH-3)

Li, K., Zheng, J., Wirawan, M., Trinh, N. M., Fedorova, O., Griffin, P. R., Pyle, A. M., & Luo, D. (2021) · Nucleic Acids Research · doi:10.1093/nar/gkab712 · Cited by 8

Toward unraveling molecular grammars for dsRNA-binding proteins: substrate recognition to binding mechanisms

Jeon, J., & Kim, Y. (2025) · BMB Reports · doi:10.5483/bmbrep.2025-0067 · Cited by 1

Sensores de ARN de cadena doble en la inmunidad innata

García Japón, B. (2021) · idUS (Universidad de Sevilla)

Sensing of double-stranded RNA in human cells: molecular mechanisms and cellular consequences

Cieslicka, J., Pianka, K., Drążkowska, K., & Sikorski, P. J. (2026) · Biochemical Society Transactions · doi:10.1042/bst20250259 · Cited by 2

Multi-level regulation of cellular recognition of viral dsRNA

Peisley, A., & Hur, S. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1149-4 · Cited by 46

dsRNA Sensing During Viral Infection: Lessons from Plants, Worms, Insects, and Mammals

de Faria, I. J. S., Olmo, R. P., Silva, E. G., & Marques, J. T. (2013) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.2013.0026 · Cited by 28