Cited by 422interferon and immune responsesImmune Response and InflammationRNA regulation and disease

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Double-Stranded RNA Sensors and Modulators in Innate Immunity

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Hur, Sun·2019·Annual Review of Immunology

DOI 10.1146/annurev-immunol-042718-041356PMC PMC7136661

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Abstract

Detection of double-stranded RNAs (dsRNAs) is a central mechanism of innate immune defense in many organisms. We here discuss several families of dsRNA-binding proteins involved in mammalian antiviral innate immunity. These include RIG-I-like receptors, protein kinase R, oligoadenylate synthases, adenosine deaminases acting on RNA, RNA interference systems, and other proteins containing dsRNA-binding domains and helicase domains. Studies suggest that their functions are highly interdependent and that their interdependence could offer keys to understanding the complex regulatory mechanisms for cellular dsRNA homeostasis and antiviral immunity. This review aims to highlight their interconnectivity, as well as their commonalities and differences in their dsRNA recognition mechanisms.

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Authors: Hur, S.
Affiliations: Boston Children's Hospital (US)
Corresponding author: Hur, Sun
ORCID: Hur, Sun
Venue: Annual Review of Immunology
Publisher: Annual Reviews
Published: 2019-04-26
Volume: 37
Issue: 1
Pages: 349-375
ISSN: 0732-0582 (ISSN-L)
1545-3278
DOI: 10.1146/annurev-immunol-042718-041356
PMC: PMC7136661
OpenAlex: W2913776187
Cited by: 420
References: 217
Citations by year: 2026: 46 · 2025: 70 · 2024: 61 · 2023: 56 · 2022: 61 · 2021: 81 · 2020: 34 · 2019: 11
FWCI: 4.03
Type: journal article
Language: en
Open access: bronze
doi.org
Locations: Annual Review of Immunology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Burroughs Wellcome Fund
Francis Crick Institute
National Institutes of Health
National Institute of Allergy and Infectious Diseases (R01AI106912, R01AI111784)
Topics: Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA regulation and disease
Keywords: double-stranded RNA, innate immunity, antiviral immunity, dsRNA-binding proteins, RIG-I-like receptors, PKR, ADAR, RNA interference, helicase
MeSH terms: DEAD Box Protein 58, Animals, Humans, Immunity, Innate, Mammals, Nucleotide Deaminases, RNA, Double-Stranded, Virus Diseases, 2',5'-Oligoadenylate Synthetase, eIF-2 Kinase, RNA Interference, Immunomodulation

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Double-Stranded RNA Sensors and Modulators in Innate Immunity

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