Epidemiology of Sarcopenia

III, L. Joseph Melton; Khosla, Sundeep; Crowson, Cynthia S.; O'Connor, Michael K.; O'Fallon, W. Michael; Riggs, B. Lawrence

doi:10.1111/j.1532-5415.2000.tb04719.x

Cited by 598Nutrition and Health in AgingBody Composition Measurement TechniquesFrailty in Older Adults

Epidemiology of Sarcopenia

III, L. Joseph Melton, Khosla, Sundeep, Crowson, Cynthia S., O'Connor, Michael K., O'Fallon, W. Michael, Riggs, B. Lawrence·2000·Journal of the American Geriatrics Society

DOI 10.1111/j.1532-5415.2000.tb04719.x

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Abstract

OBJECTIVES : To examine patterns of muscle mass change with aging and to estimate the prevalence of sarcopenia. DESIGN : Cross‐sectional survey. SETTING : Population‐based study in Rochester, Minnesota. PARTICIPANTS : Age‐stratified sample of men and women from the community. MEASUREMENTS : Muscle mass estimated from total body scans by dual‐energy X‐ray absorptiometry. Sarcopenia was defined as muscle mass more than 2 standard deviations below the sex‐specific young‐normal mean. RESULTS : Total lean body mass (exclusive of bone) and total skeletal muscle mass both were greater in men than women and declined linearly with age as judged from these cross‐sectional data. Adjustment for height reduced the gender difference. The age‐ and sex‐adjusted prevalence of sarcopenia varied from 6 to 15% among subjects 65 years of age or over, depending on the muscle mass parameter that was evaluated, but prevalence rates were quite sensitive to the normal values used to define cutoff levels. Subjects with sarcopenia appeared to have more physical limitations than the others. CONCLUSIONS : Late in life, a substantial portion of the population reaches low levels of muscle mass that are associated with increased physical disability. However, additional efforts are needed to validate an operational definition of sarcopenia. J Am Geriatr Soc 48:625–630, 2000 .

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Muscle mass decreases with age, and strength and power decrease as well; after age 30, the rate of muscle mass decline is approximately 3-8% per decade, and it is even more rapid after age 60.
“Muscle mass decreases with age, and strength and power decrease as well. After age 30, the rate of mass muscle decline is ~3–8% per decade, and it is even more rapid after age 60. 49 , 50”
From Exercise for sarcopenia in older people: A systematic review and network meta‐analysis (2023) · cites this paper as [50]

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Authors: III, L. J. M., Khosla, S., Crowson, C. S., O'Connor, M. K., O'Fallon, W. M., & Riggs, B. L.
ORCID: Khosla, Sundeep
Crowson, Cynthia S.
Venue: Journal of the American Geriatrics Society
Publisher: Wiley
Published: 2000-06
Volume: 48
Issue: 6
Pages: 625-630
ISSN: 0002-8614 (ISSN-L)
1532-5415
DOI: 10.1111/j.1532-5415.2000.tb04719.x
OpenAlex: W2061933138
Cited by: 598
References: 37
Citations by year: 2026: 12 · 2025: 24 · 2024: 26 · 2023: 33 · 2022: 23 · 2021: 31 · 2020: 31 · 2019: 29 · 2018: 16 · 2017: 27 · 2016: 13 · 2015: 25 · 2014: 29 · 2013: 30 · 2012: 34
FWCI: 7.14
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 5443 d)
Locations: Journal of the American Geriatrics Society (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Arthritis and Musculoskeletal and Skin Diseases (AR 27065, R01AR027065)
Topics: Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
Health Sciences › Medicine › Physiology › Body Composition Measurement Techniques
Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
Keywords: sarcopenia, muscle mass, aging, lean body mass, skeletal muscle mass, prevalence, sex differences, physical disability, older adults, dual-energy X-ray absorptiometry, cut-off values
MeSH terms: Adult, Aged, Aged, 80 and over, Aging, Body Composition, Cross-Sectional Studies, Female, Humans, Male, Middle Aged, Minnesota, Muscular Atrophy, Reference Values, Regression Analysis, Absorptiometry, Photon, Prevalence, Odds Ratio, Postmenopause

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