Cited by 299Oral microbiology and periodontitis researchMicrobial Community Ecology and PhysiologyGut microbiota and health

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Biogeography of the Oral Microbiome: The Site-Specialist Hypothesis

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Mark Welch, Jessica L., Dewhirst, Floyd E., Borisy, Gary G.·2019·Annual Review of Microbiology

DOI 10.1146/annurev-micro-090817-062503PMC PMC7153577

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Abstract

Microbial communities are complex and dynamic, composed of hundreds of taxa interacting across multiple spatial scales. Advances in sequencing and imaging technology have led to great strides in understanding both the composition and the spatial organization of these complex communities. In the human mouth, sequencing results indicate that distinct sites host microbial communities that not only are distinguishable but to a meaningful degree are composed of entirely different microbes. Imaging suggests that the spatial organization of these communities is also distinct. Together, the literature supports the idea that most oral microbes are site specialists. A clear understanding of microbiota structure at different sites in the mouth enables mechanistic studies, informs the generation of hypotheses, and strengthens the position of oral microbiology as a model system for microbial ecology in general.

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Authors: Mark Welch, J. L., Dewhirst, F. E., & Borisy, G. G.
Affiliations: Marine Biological Laboratory, Woods Hole, Massachusetts 02543, USA;
Harvard University (US)
The Forsyth Institute (US)
ORCID: Dewhirst, Floyd E.
Borisy, Gary G.
Venue: Annual Review of Microbiology
Publisher: Annual Reviews
Published: 2019-09-08
Volume: 73
Issue: 1
Pages: 335-358
ISSN: 0066-4227 (ISSN-L)
1545-3251
DOI: 10.1146/annurev-micro-090817-062503
PMC: PMC7153577
OpenAlex: W2949610528
Cited by: 284
References: 111
Citations by year: 2026: 35 · 2025: 41 · 2024: 50 · 2023: 38 · 2022: 42 · 2021: 39 · 2020: 36 · 2019: 3
FWCI: 4.25
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Annual Review of Microbiology (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Dental and Craniofacial Research (R37DE016937, R01DE022586, R01DE016937)
Topics: Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
Keywords: oral microbiota, biogeography, microbial ecology, oral microbiology
MeSH terms: Humans, Mouth, Spatial Analysis, Microbiota

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Biogeography of the Oral Microbiome: The Site-Specialist Hypothesis

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