The DOI matches its Crossref record; 111 of the 111 references it cites were found in a registry or an index.
Biogeography of the Oral Microbiome: The Site-Specialist Hypothesis
Open accessAbstract
Microbial communities are complex and dynamic, composed of hundreds of taxa interacting across multiple spatial scales. Advances in sequencing and imaging technology have led to great strides in understanding both the composition and the spatial organization of these complex communities. In the human mouth, sequencing results indicate that distinct sites host microbial communities that not only are distinguishable but to a meaningful degree are composed of entirely different microbes. Imaging suggests that the spatial organization of these communities is also distinct. Together, the literature supports the idea that most oral microbes are site specialists. A clear understanding of microbiota structure at different sites in the mouth enables mechanistic studies, informs the generation of hypotheses, and strengthens the position of oral microbiology as a model system for microbial ecology in general.
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“The oral cavity as a microbial environment is further complicated by spatial gradients created by salivary flow, nutrient availability, oxygen concentration, saliva, and gingival crevicular fluids,61, 227, 231, 232 in addition to regular environmental disturbances caused by eating and mastication, facial movement related to speaking and expression, and oral hygiene practices.227”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [227]
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“Site specialization is dictated by the ability of a microbe to adhere, colonize, grow, and divide at that site.227, 234”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [227]
In the citing paper
“The nonshedding enamel surfaces, the gingival crevice, the mucosal epithelium of the cheeks, the tongue dorsum, and tonsillar crypts, together present the oral cavity as a complex microbial environment with wide‐ranging topography.227, 228”
From The oral microbiome: Role of key organisms and complex networks in oral health and disease (2021) · cites this paper as [227]
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Cites
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Cited by
Sorted by citations
The oral microbiome: Role of key organisms and complex networks in oral health and disease
Sedghi, L., DiMassa, V., Harrington, A., Lynch, S. V., & Kapila, Y. L. (2021) · Periodontology 2000 · doi:10.1111/prd.12393 · Cited by 755
The oral microbiome: diversity, biogeography and human health
Baker, J. L., Mark Welch, J. L., Kauffman, K. M., McLean, J. S., & He, X. (2024) · Nature Reviews Microbiology · doi:10.1038/s41579-023-00963-6 · Cited by 661
The oralome and its dysbiosis: New insights into oral microbiome-host interactions
Radaic, A., & Kapila, Y. L. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2021.02.010 · Cited by 510
The Nexus Between Periodontal Inflammation and Dysbiosis
Dyke, T. E. V., Bartold, P. M., & Reynolds, E. C. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00511 · Cited by 491
Gradients and consequences of heterogeneity in biofilms
Jo, J., Price‐Whelan, A., & Dietrich, L. E. P. (2022) · Nature Reviews Microbiology · doi:10.1038/s41579-022-00692-2 · Cited by 359
Metadata
- Authors
- Mark Welch, J. L., Dewhirst, F. E., & Borisy, G. G.
- Affiliations
- Marine Biological Laboratory, Woods Hole, Massachusetts 02543, USA;
- Harvard University (US)
- The Forsyth Institute (US)
- Venue
- Annual Review of Microbiology
- Publisher
- Annual Reviews
- Published
- 2019-09-08
- Volume
- 73
- Issue
- 1
- Pages
- 335-358
- ISSN
- 0066-4227 (ISSN-L)
- 1545-3251
- PMC
- PMC7153577
- OpenAlex
- W2949610528
- Cited by
- 284
- References
- 111
- Citations by year
- 2026: 35 · 2025: 41 · 2024: 50 · 2023: 38 · 2022: 42 · 2021: 39 · 2020: 36 · 2019: 3
- FWCI
- 4.25
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Annual Review of Microbiology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Dental and Craniofacial Research (R37DE016937, R01DE022586, R01DE016937)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- oral microbiota, biogeography, microbial ecology, oral microbiology
- MeSH terms
- Humans, Mouth, Spatial Analysis, Microbiota
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