Cited by 459Nerve injury and regenerationNeurogenesis and neuroplasticity mechanismsTraumatic Brain Injury and Neurovascular Disturbances

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Neuronal Intrinsic Mechanisms of Axon Regeneration

Liu, Kai, Tedeschi, Andrea, Park, Kevin Kyungsuk, He, Zhigang·2011·Annual Review of Neuroscience

DOI 10.1146/annurev-neuro-061010-113723

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Abstract

Failure of axon regeneration after central nervous system (CNS) injuries results in permanent functional deficits. Numerous studies in the past suggested that blocking extracellular inhibitory influences alone is insufficient to allow the majority of injured axons to regenerate, pointing to the importance of revisiting the hypothesis that diminished intrinsic regenerative ability critically underlies regeneration failure. Recent studies in different species and using different injury models have started to reveal important cellular and molecular mechanisms within neurons that govern axon regeneration. This review summarizes these observations and discusses possible strategies for stimulating axon regeneration and perhaps functional recovery after CNS injury.

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Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007) · Cell · doi:10.1016/j.cell.2007.11.019 · Cited by 20,221
The Molecular Biology of Axon Guidance
Tessier‐Lavigne, M., & Goodman, C. S. (1996) · Science · doi:10.1126/science.274.5290.1123 · Cited by 3,311
Degeneration and Regeneration of the Nervous System.
(1929) · JAMA · doi:10.1001/jama.1929.02710220063037 · Cited by 2,908
Defining the role of mTOR in cancer
Guertin, D. A., & Sabatini, D. M. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.05.008 · Cited by 2,833
Neurotrophin-regulated signalling pathways
Reichardt, L. F. (2006) · Philosophical Transactions of the Royal Society B: Biological Sciences · doi:10.1098/rstb.2006.1894 · Cited by 2,195
The Biology of Cancer
Weinberg, R. A., & Weinberg, R. A. (2006) · W.W. Norton eBooks · doi:10.1201/9780203852569 · Cited by 1,806
Axonal Elongation into Peripheral Nervous System "Bridges" After Central Nervous System Injury in Adult Rats
David, S., & Aguayo, A. J. (1981) · Science · doi:10.1126/science.6171034 · Cited by 1,698
Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway
Park, K. K., Liu, K., Hu, Y., Smith, P. D., Wang, C., Cai, B., Xu, B., Connolly, L., Kramvis, I., Sahin, M., et al. (2008) · Science · doi:10.1126/science.1161566 · Cited by 1,686
Self-citation
Growing roles for the mTOR pathway
Sarbassov, D. D., Ali, S. M., & Sabatini, D. M. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.09.009 · Cited by 1,590
Glial inhibition of CNS axon regeneration
Yiu, G. C., & He, Z. (2006) · Nature reviews. Neuroscience · doi:10.1038/nrn1956 · Cited by 1,525
Self-citation

Show all 151 references

Research works printed but not linked: 3

Fishman HM, 2003, News Physiol. Sci., 18, 115
Lasek RJ, Hoffman PN. 1976. The neuronal cytoskeleton, axonal transport and axonal growth. In Cold Spring Harbor Laboratory Conference on Cell Proliferation, Cell Motility. Vol. 3, ed. R Goldman, T Pollard, J Rosenbaum, pp. 1021–49. Cold Spring Harbor, NY: Cold Spring Harbor Lab. Press
Nakazawa T, 2002, Invest. Ophthalmol. Vis. Sci., 43, 3319

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Avci, H. X., Lebrun, C., Wehrlé, R., Doulazmi, M., Chatonnet, F., Morel, M., Ema, M., Vodjdani, G., Sotelo, C., Flamant, F., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119853109 · Cited by 66
Targeting mTOR as a novel therapeutic strategy for traumatic CNS injuries
Don, A. S. A., Tsang, C. K., Kazdoba, T. M., D’Arcangelo, G., Young, W., & Zheng, X. (2012) · Drug Discovery Today · doi:10.1016/j.drudis.2012.04.010 · Cited by 68
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Li, S., He, Q., Wang, H., Tang, X., Ho, K. W., Gao, X., Zhang, Q., Shen, Y., Cheung, A. S. T., Wong, F., et al. (2014) · Neurobiology of Disease · doi:10.1016/j.nbd.2014.09.019 · Cited by 63
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Ying, Z., Zhai, R., McLean, N. A., Johnston, J. M., Misra, V., & Verge, V. M. K. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0012-15.2015 · Cited by 62
Altered long noncoding RNA expressions in dorsal root ganglion after rat sciatic nerve injury
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Central nervous system regeneration does not occur
Illis, L. S. (2011) · Spinal Cord · doi:10.1038/sc.2011.132 · Cited by 62
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Farrukh, A., Zhao, S., & del Campo, A. (2018) · Frontiers in Materials · doi:10.3389/fmats.2018.00062 · Cited by 58
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Chen, W., Lu, N., Ding, Y., Wang, Y., Chan, L. T., Wang, X., Gao, X., Jiang, S., & Liu, K. (2016) · eNeuro · doi:10.1523/eneuro.0358-16.2016 · Cited by 59
Self-citation
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Rigoni, M., & Negro, S. (2020) · Cells · doi:10.3390/cells9081768 · Cited by 57
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Chen, M., & Zheng, B. (2014) · Trends in Neurosciences · doi:10.1016/j.tins.2014.08.008 · Cited by 63
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Li, H., Kuwajima, T., Oakley, D. H., Nikulina, E., Hou, J., Yang, W. S., Lowry, E. R., Lamas, N. J., Mathis, M. W., Croft, G. F., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.06.013 · Cited by 57
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Wang, Z., Mehra, V., Simpson, M. T., Maunze, B., Chakraborty, A., Holan, L., Eastwood, E., Blackmore, M. G., & Venkatesh, I. (2018) · Scientific Reports · doi:10.1038/s41598-018-31101-5 · Cited by 62
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Li, F., Lo, T. Y., Miles, L., Wang, Q., Noristani, H. N., Li, D., Niu, J., Trombley, S., Goldshteyn, J. I., Wang, C., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24131-7 · Cited by 55
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Lau, B. Y. B., Fogerson, S. M., Walsh, R. B., & Morgan, J. R. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2013.09.004 · Cited by 54
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Shin, J. E., & Cho, Y. (2017) · Molecules and Cells · doi:10.14348/molcells.2017.2311 · Cited by 57
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Teotia, P., Hook, M. J. V., Fischer, D., & Ahmad, I. (2019) · Development · doi:10.1242/dev.178012 · Cited by 52
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Soares, L., Parisi, M. J., & Bonini, N. M. (2014) · Scientific Reports · doi:10.1038/srep06199 · Cited by 46
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Ong, W., Pinese, C., & Chew, S. Y. (2019) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2019.03.004 · Cited by 46
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Fink, K. L., Strittmatter, S. M., & Cafferty, W. B. J. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.3165-15.2015 · Cited by 43
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Xiong, J., Ge, X., Pan, D., Zhu, Y., Zhou, Y., Gao, Y., Wang, H., Wang, X., Gu, Y., Wu, Y., et al. (2025) · Cell Death and Differentiation · doi:10.1038/s41418-025-01467-x · Cited by 41
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Zhang, S., Burda, J. E., Anderson, M. A., Zhao, Z., Ao, Y., Cheng, Y., Sun, Y. E., Deming, T. J., & Sofroniew, M. V. (2015) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.5b00153 · Cited by 40
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D evelopmental C hromatin R estriction of P ro‐ G rowth G ene N etworks A cts as an E pigenetic B arrier to A xon R egeneration in C ortical N eurons
Venkatesh, I., Mehra, V., Wang, Z., Callif, B. L., & Blackmore, M. G. (2018) · Developmental Neurobiology · doi:10.1002/dneu.22605 · Cited by 40
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Li, S., & Nathan, F. M. (2017) · Neural Regeneration Research · doi:10.4103/1673-5374.221144 · Cited by 39
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Wu, D., Lee, S., Luo, J., Xia, H., Gushchina, S. V., Richardson, P. M., Yeh, J., Krügel, U., Franke, H., Zhang, Y., et al. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.1660-17.2017 · Cited by 39
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Wang, X.-Q., Zhang, L., Xia, Z., Chen, J., Fang, Y., & Ding, Y. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01312-y · Cited by 39
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Zheng, H., Guo, X., Kang, S., Li, Z., Tian, T., Li, J., Wang, F., Yu, P., Chang, S., & Chang, Y. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05688-1 · Cited by 39
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Demmings, M. D., Chagas, L. D. S., Traetta, M. E., Rodrigues, R. S., Acutain, M. F., Barykin, E. P., Datusalia, A. K., German‐Castelan, L., Mattera, V. S., Mazengenya, P., et al. (2024) · Journal of Neurochemistry · doi:10.1111/jnc.16258 · Cited by 44
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Liu, C.-M., Hur, E., & Zhou, F. (2012) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2012.00003 · Cited by 41
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Czarnecki, L. A., Moberly, A. H., Turkel, D. J., Rubinstein, T., Pottackal, J., Rosenthal, M. C., McCandlish, E. F., Buckley, B., & McGann, J. P. (2012) · Toxicological Sciences · doi:10.1093/toxsci/kfs030 · Cited by 38
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Hilton, B. J., Assinck, P., Duncan, G. J., Lu, D. C.-T., Lo, S. W., & Tetzlaff, W. (2013) · Journal of Neurotrauma · doi:10.1089/neu.2012.2734 · Cited by 37
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Nagai, J., Kitamura, Y., Owada, K., Yamashita, N., Takei, K., Goshima, Y., & Ohshima, T. (2015) · Scientific Reports · doi:10.1038/srep08269 · Cited by 37
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Koch, J. C., Solis, G. P., Bodrikov, V., Michel, U., Haralampieva, D., Shypitsyna, A., Tönges, L., Bähr, M., Lingor, P., & Stuermer, C. A. O. (2012) · Neurobiology of Disease · doi:10.1016/j.nbd.2012.11.007 · Cited by 37
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Mao, S., Huang, T., Chen, Y., Shen, L., Zhou, S., Zhang, S., & Yu, B. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-2027-x · Cited by 38
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York, E. M., Petit, A., & Roskams, A. J. (2013) · Neurotherapeutics · doi:10.1007/s13311-013-0228-z · Cited by 37
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Klaw, M. C., Xu, C., & Tom, V. J. (2013) · Molecular Therapy — Nucleic Acids · doi:10.1038/mtna.2013.34 · Cited by 36
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Liu, S., Jia, J., Zhou, H., Zhang, C., Liu, L., Liu, J., Lu, L., Li, X., Kang, Y., Lou, Y., et al. (2019) · Molecular Medicine Reports · doi:10.3892/mmr.2019.10670 · Cited by 37
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Wang, J., Hu, B., Cao, F., Sun, S., Zhang, Y., & Zhu, Q. (2015) · Brain Research · doi:10.1016/j.brainres.2015.07.052 · Cited by 36
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Zhao, L., Xiao, J., Li, S., Guo, Y., Fu, R., Hua, S., Du, Y., & Xu, S. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14275 · Cited by 38
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Zhou, S., Yi, S., Wang, Q., Zhao, L., Qin, J., Wang, Y., & Yu, B. (2017) · Neural Regeneration Research · doi:10.4103/1673-5374.217351 · Cited by 35
Reprogramming axonal behavior by axon-specific viral transduction
Walker, B. A., Hengst, U., Kim, H. J., Jeon, N. L., Schmidt, E. F., Heintz, N., Milner, T. A., & Jaffrey, S. R. (2012) · Gene Therapy · doi:10.1038/gt.2011.217 · Cited by 34
Disease Modification for Parkinson's Disease: Axonal Regeneration and Trophic Factors
Kordower, J. H., & Burke, R. E. (2018) · Movement Disorders · doi:10.1002/mds.27383 · Cited by 34
Axonal fusion: An alternative and efficient mechanism of nerve repair
Neumann, B., Linton, C., Giordano-Santini, R., & Hilliard, M. A. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.11.004 · Cited by 34
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Ribas, V. T., & Costa, M. R. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00231 · Cited by 34
Multi-Omic Analyses of Growth Cones at Different Developmental Stages Provides Insight into Pathways in Adult Neuroregeneration
Chauhan, M. Z., Arcuri, J., Park, K. K., Zafar, M. K., Fatmi, R., Hackam, A. S., Yin, Y., Benowitz, L. I., Goldberg, J. L., Samarah, M., et al. (2020) · iScience · doi:10.1016/j.isci.2020.100836 · Cited by 32
Self-citation
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Saijilafu, & Zhou, F. (2012) · Journal of Visualized Experiments · doi:10.3791/4141 · Cited by 33
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Liang, P., Liu, J., Xiong, J., Liu, Q., Zhao, J., Liang, H., Zhao, L., & Tang, H. (2014) · Cell Transplantation · doi:10.3727/096368914x684989 · Cited by 33
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Wang, J., Chen, Y., Chen, L., Duan, Y., Kuang, X., Zhao, P., Li, C., Li, Y., Xiao, Y., Jin, H., et al. (2020) · Translational Neuroscience · doi:10.1515/tnsci-2020-0119 · Cited by 32
Cytokines that promote nerve regeneration
Zigmond, R. E. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.08.017 · Cited by 34
Advances and Limitations of Current Epigenetic Studies Investigating Mammalian Axonal Regeneration
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Cho, Y., Liberto, V. D., Carlin, D., Abe, N., Li, K. H., Burlingame, A. L., Guan, S., Michaelevski, I., & Cavalli, V. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.536607 · Cited by 29
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Ho, M.-H., Tsai, Y., Chen, C.-Y., Yang, A., Burnouf, T., Wang, Y., Chiang, Y. H., Hoffer, B. J., & Chou, S. (2024) · Journal of Biomedical Science · doi:10.1186/s12929-024-01083-w · Cited by 29
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Austin, T. O., Matamoros, A. J., Friedman, J. M., Friedman, A., Nacharaju, P., Yu, W., Sharp, D. J., & Baas, P. W. (2017) · Scientific Reports · doi:10.1038/s41598-017-10250-z · Cited by 29
miR-221-3p Inhibits Schwann Cell Myelination
Zhao, L., Yuan, Y., Li, P., Pan, J., Qin, J., Liu, Y., Zhang, Y., Tian, F., Yu, B., & Zhou, S. (2018) · Neuroscience · doi:10.1016/j.neuroscience.2018.03.019 · Cited by 29
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Sun, S., Xu, Y., Yu, N., Zhang, M., Wang, J., Wan, D., Tian, Z., & Zhu, H. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03459-9 · Cited by 28
Inhibition of Poly-ADP-Ribosylation Fails to Increase Axonal Regeneration or Improve Functional Recovery after Adult Mammalian CNS Injury
Wang, X., Sekine, Y., Byrne, A. B., Cafferty, W. B. J., Hammarlund, M., & Strittmatter, S. M. (2016) · eNeuro · doi:10.1523/eneuro.0270-16.2016 · Cited by 28
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Wu, D., Klaw, M. C., Connors, T. M., Kholodilov, N. G., Burke, R. E., Côté, M., & Tom, V. J. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.08.011 · Cited by 28
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Ueno, M., Nakamura, Y., Nakagawa, H., Niehaus, J. K., Maezawa, M., Gu, Z., Kumanogoh, A., Takebayashi, H., Lu, Q. R., Takada, M., et al. (2020) · Cerebral Cortex · doi:10.1093/cercor/bhaa142 · Cited by 28
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Authors: Liu, K., Tedeschi, A., Park, K. K., & He, Z.
Affiliations: Harvard University (US)
ORCID: Liu, Kai
Tedeschi, Andrea
Park, Kevin Kyungsuk
He, Zhigang
Venue: Annual Review of Neuroscience
Publisher: Annual Reviews
Published: 2011-07-21
Volume: 34
Issue: 1
Pages: 131-152
ISSN: 0147-006X (ISSN-L)
1545-4126
DOI: 10.1146/annurev-neuro-061010-113723
OpenAlex: W2141003407
Cited by: 458
References: 151
Citations by year: 2026: 15 · 2025: 18 · 2024: 30 · 2023: 30 · 2022: 15 · 2021: 28 · 2020: 26 · 2019: 31 · 2018: 35 · 2017: 33 · 2016: 52 · 2015: 36 · 2014: 33 · 2013: 30 · 2012: 40
FWCI: 3.29
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Neuroscience (publishedVersion)
PubMed (publishedVersion)
Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords: axon regeneration, central nervous system injury, functional recovery
MeSH terms: Cyclic AMP, Animals, Axons, Axonal Transport, Central Nervous System Diseases, Humans, Inflammation, Models, Neurological, Nerve Regeneration, Neurons, Cytokines, Suppressor of Cytokine Signaling Proteins

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Neuronal Intrinsic Mechanisms of Axon Regeneration

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