Cited by 459Nerve injury and regenerationNeurogenesis and neuroplasticity mechanismsTraumatic Brain Injury and Neurovascular Disturbances

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Neuronal Intrinsic Mechanisms of Axon Regeneration

Liu, Kai, Tedeschi, Andrea, Park, Kevin Kyungsuk, He, Zhigang·2011·Annual Review of Neuroscience

DOI 10.1146/annurev-neuro-061010-113723

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Abstract

Failure of axon regeneration after central nervous system (CNS) injuries results in permanent functional deficits. Numerous studies in the past suggested that blocking extracellular inhibitory influences alone is insufficient to allow the majority of injured axons to regenerate, pointing to the importance of revisiting the hypothesis that diminished intrinsic regenerative ability critically underlies regeneration failure. Recent studies in different species and using different injury models have started to reveal important cellular and molecular mechanisms within neurons that govern axon regeneration. This review summarizes these observations and discusses possible strategies for stimulating axon regeneration and perhaps functional recovery after CNS injury.

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Additional file 1 of Enhancing structural plasticity of PC12 neurons during differentiation and neurite regeneration with a catalytically inactive mutant version of the zRICH protein
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Additional file 6 of Enhancing structural plasticity of PC12 neurons during differentiation and neurite regeneration with a catalytically inactive mutant version of the zRICH protein
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Additional file 5 of Discovery of therapeutic targets for spinal cord injury based on molecular mechanisms of axon regeneration after conditioning lesion
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Additional file 3 of Enhancing structural plasticity of PC12 neurons during differentiation and neurite regeneration with a catalytically inactive mutant version of the zRICH protein
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Additional file 7 of Enhancing structural plasticity of PC12 neurons during differentiation and neurite regeneration with a catalytically inactive mutant version of the zRICH protein
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Additional file 3 of Discovery of therapeutic targets for spinal cord injury based on molecular mechanisms of axon regeneration after conditioning lesion
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Additional file 5 of Enhancing structural plasticity of PC12 neurons during differentiation and neurite regeneration with a catalytically inactive mutant version of the zRICH protein
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Additional file 1 of Discovery of therapeutic targets for spinal cord injury based on molecular mechanisms of axon regeneration after conditioning lesion
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Additional file 7 of Discovery of therapeutic targets for spinal cord injury based on molecular mechanisms of axon regeneration after conditioning lesion
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Authors: Liu, K., Tedeschi, A., Park, K. K., & He, Z.
Affiliations: Harvard University (US)
ORCID: Liu, Kai
Tedeschi, Andrea
Park, Kevin Kyungsuk
He, Zhigang
Venue: Annual Review of Neuroscience
Publisher: Annual Reviews
Published: 2011-07-21
Volume: 34
Issue: 1
Pages: 131-152
ISSN: 0147-006X (ISSN-L)
1545-4126
DOI: 10.1146/annurev-neuro-061010-113723
OpenAlex: W2141003407
Cited by: 458
References: 151
Citations by year: 2026: 15 · 2025: 18 · 2024: 30 · 2023: 30 · 2022: 15 · 2021: 28 · 2020: 26 · 2019: 31 · 2018: 35 · 2017: 33 · 2016: 52 · 2015: 36 · 2014: 33 · 2013: 30 · 2012: 40
FWCI: 3.29
Type: journal article
Language: en
Open access: closed
Locations: Annual Review of Neuroscience (publishedVersion)
PubMed (publishedVersion)
Rare & Special e-Zone (The Hong Kong University of Science and Technology) (submittedVersion)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Health Sciences › Medicine › Clinical Neurology › Traumatic Brain Injury and Neurovascular Disturbances
Keywords: axon regeneration, central nervous system injury, functional recovery
MeSH terms: Cyclic AMP, Animals, Axons, Axonal Transport, Central Nervous System Diseases, Humans, Inflammation, Models, Neurological, Nerve Regeneration, Neurons, Cytokines, Suppressor of Cytokine Signaling Proteins

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Neuronal Intrinsic Mechanisms of Axon Regeneration

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