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Manganese Is Essential for Neuronal Health
Open accessAbstract
The understanding of manganese (Mn) biology, in particular its cellular regulation and role in neurological disease, is an area of expanding interest. Mn is an essential micronutrient that is required for the activity of a diverse set of enzymatic proteins (e.g., arginase and glutamine synthase). Although necessary for life, Mn is toxic in excess. Thus, maintaining appropriate levels of intracellular Mn is critical. Unlike other essential metals, cell-level homeostatic mechanisms of Mn have not been identified. In this review, we discuss common forms of Mn exposure, absorption, and transport via regulated uptake/exchange at the gut and blood-brain barrier and via biliary excretion. We present the current understanding of cellular uptake and efflux as well as subcellular storage and transport of Mn. In addition, we highlight the Mn-dependent and Mn-responsive pathways implicated in the growing evidence of its role in Parkinson's disease and Huntington's disease. We conclude with suggestions for future focuses of Mn health-related research.
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Cites
Cloning and characterization of a mammalian proton-coupled metal-ion transporter
Gunshin, H., Mackenzie, B., Berger, U. V., Gunshin, Y., Romero, M. F., Boron, W. F., Nussberger, S., Gollan, J. L., & Hediger, M. A. (1997) · Nature · doi:10.1038/41343 · Cited by 3,166
Heterogeneity in the distribution and morphology of microglia in the normal adult mouse brain
Lawson, L. J., Perry, V. H., Dri, P., & Gordon, S. (1990) · Neuroscience · doi:10.1016/0306-4522(90)90229-w · Cited by 2,045
Ramirez, A., Heimbach, A., Gründemann, J., Stiller, B., Hampshire, D., Cid, L. P., Goebel, I., Mubaidin, A. F., Wriekat, A.-L., Roeper, J., et al. (2006) · Nature Genetics · doi:10.1038/ng1884 · Cited by 1,208
Keller, J. N., Kindy, M. S., Holtsberg, F. W., St. Clair, D. K., Yen, H.-C., Germeyer, A., Steiner, S. M., Bruce-Keller, A. J., Hutchins, J. B., & Mattson, M. P. (1998) · The Journal of Neuroscience · doi:10.1523/jneurosci.18-02-00687.1998 · Cited by 863
Structure of a unique binuclear manganese cluster in arginase
Kanyo, Z. F., Scolnick, L. R., Ash, D. E., & Christianson, D. W. (1996) · Nature · doi:10.1038/383554a0 · Cited by 441
Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD.
(2006) · Journal of Neuroinflammation · doi:10.1186/1742-2094-3-27 · Cited by 393
Forbes, J. R., & Gros, P. (2003) · Blood · doi:10.1182/blood-2003-02-0425 · Cited by 288
Ceruloplasmin dysfunction and therapeutic potential for Parkinson disease
Ayton, S., Lei, P., Duce, J. A., Wong, B. X. W., Sedjahtera, A., Adlard, P. A., Bush, A. I., & Finkelstein, D. I. (2013) · Annals of Neurology · doi:10.1002/ana.23817 · Cited by 264
Zou, J., Wang, Y.-X., Dou, F.-F., Lü, H.-Z., Ma, Z.-W., Lu, P.-H., & Xu, X.-M. (2010) · Neurochemistry International · doi:10.1016/j.neuint.2009.12.021 · Cited by 181
Yang, J., Gonon, A. T., Sjöquist, P.-O., Lundberg, J. O., & Pernow, J. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1307058110 · Cited by 147
Cited by
Lv, M., Chen, M., Zhang, R., Zhang, W., Wang, C., Zhang, Y., Wei, X., Guan, Y., Liu, J., Feng, K., et al. (2020) · Cell Research · doi:10.1038/s41422-020-00395-4 · Cited by 1,040
Wang, C., Guan, Y., Lv, M., Zhang, R., Guo, Z., Wei, X., Du, X., Yang, J., Li, T., Wan, Y., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.03.017 · Cited by 869
Berger, M. M., Shenkin, A., Schweinlin, A., Amrein, K., Augsburger, M., Biesalski, H.-K., Bischoff, S. C., Casaer, M. P., Gundogan, K., Lepp, H.-L., et al. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.02.015 · Cited by 615
The role of zinc, copper, manganese and iron in neurodegenerative diseases
Mezzaroba, L., Alfieri, D. F., Colado Simão, A. N., & Vissoci Reiche, E. M. (2019) · NeuroToxicology · doi:10.1016/j.neuro.2019.07.007 · Cited by 524
Sarkar, S., Rokad, D., Malovic, E., Luo, J., Harischandra, D. S., Jin, H., Anantharam, V., Huang, X., Lewis, M., Kanthasamy, A., et al. (2019) · Science Signaling · doi:10.1126/scisignal.aat9900 · Cited by 171
Yi, M., Niu, M., Zhang, J., Li, S., Zhu, S., Yan, Y., Li, N., Zhou, P., Chu, Q., & Wu, K. (2021) · Journal of Hematology & Oncology · doi:10.1186/s13045-021-01155-6 · Cited by 163
The elements of life: A biocentric tour of the periodic table
(2023) · Advances in Microbial Physiology · doi:10.1016/bs.ampbs.2022.11.001 · Cited by 71
Ganini, D., Santos, J. H., Bonini, M. G., & Mason, R. P. (2018) · Cell Chemical Biology · doi:10.1016/j.chembiol.2018.01.007 · Cited by 59
Molecular mechanisms of SLC30A10-mediated manganese transport
Shen, X., Zhang, J. K., Sun, P., Zhong, H., He, R., Wang, S., Guo, X., & Yang, H. (2025) · Nature Communications · doi:10.1038/s41467-025-63616-7 · Cited by 14
Targeting Metal Homeostasis as a Therapeutic Strategy for Alzheimer’s Disease
Department of Biomedical, M. A. N. S., Vilella, A., Daini, E., Department of Biomedical, M. A. N. S., De Benedictis, C. A., Cellular Neurobiology and Neuro-Nanotechnology Lab, D. O. B. S., Grabrucker, A. M., Cellular Neurobiology and Neuro-Nanotechnology Lab, D. O. B. S., Bernal Institute, U. O. L., & Health Research Institute (HRI), U. O. L. (2020) · Alzheimer’s Disease: Drug Discovery · doi:10.36255/exonpublications.alzheimersdisease.2020.ch5 · Cited by 12
Metadata
- Authors
- Horning, K. J., Caito, S. W., Tipps, K. G., Bowman, A. B., & Aschner, M.
- Venue
- Annual Review of Nutrition
- Publisher
- Annual Reviews
- Published
- 2015-07-17
- Volume
- 35
- Issue
- 1
- Pages
- 71-108
- ISSN
- 0199-9885 (ISSN-L)
- 1545-4312
- OpenAlex
- W2117821054
- Cited by
- 602
- References
- 11
- FWCI
- 2.78
- Type
- journal article
- Language
- en
- Open access
- green
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